PubMed:37392852
Annnotations
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 22-25 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | 3A7 | http://www.glycoepitope.jp/epitopes/AN0057 |
| T2 | 132-135 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | 3A7 | http://www.glycoepitope.jp/epitopes/AN0057 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-103 | Sentence | denotes | Human cytochrome P450 3A7 binding four copies of its native substrate dehydroepiandrosterone 3-sulfate. |
| T2 | 104-224 | Sentence | denotes | Human fetal cytochrome P450 3A7 (CYP3A7) is involved in both xenobiotic metabolism and the estriol biosynthetic pathway. |
| T3 | 225-413 | Sentence | denotes | Although much is understood about cytochrome P450 3A4 and its role in adult drug metabolism, CYP3A7 is poorly characterized in terms of its interactions with both categories of substrates. |
| T4 | 414-836 | Sentence | denotes | Herein, a crystallizable mutated form of CYP3A7 was saturated with its primary endogenous substrate dehydroepiandrosterone 3-sulfate (DHEA-S) to yield a 2.6 Å X-ray structure revealing the unexpected capacity to simultaneously bind four copies of DHEA-S. Two DHEA-S molecules are located in the active site proper, one in a ligand access channel, and one on the hydrophobic F'-G' surface normally embedded in the membrane. |
| T5 | 837-990 | Sentence | denotes | While neither DHEA-S binding nor metabolism exhibit cooperative kinetics, the current structure is consistent with cooperativity common to CYP3A enzymes. |
| T6 | 991-1105 | Sentence | denotes | Overall, this information suggests that mechanism(s) of CYP3A7 interactions with steroidal substrates are complex. |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 22-25 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | 3A7 | http://www.glycoepitope.jp/epitopes/AN0057 |
| T2 | 132-135 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | 3A7 | http://www.glycoepitope.jp/epitopes/AN0057 |
GlyCosmos15-Taxon
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 0-5 | Organism | denotes | Human | 9606 |
| T2 | 104-109 | Organism | denotes | Human | 9606 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 827-835 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/UBERON_0000094 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 0-5 | OrganismTaxon | denotes | Human | 9606 |
| T2 | 104-109 | OrganismTaxon | denotes | Human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 827-835 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |