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PubMed:37345258 JSONTXT

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Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 55-61 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T2 405-411 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T3 869-875 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T4 1797-1803 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1564-1569 OrganismTaxon denotes human 9606

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 164-172 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T4 764-773 Body_part denotes backbones http://purl.obolibrary.org/obo/UBERON_0001130
T5 1421-1426 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T6 1599-1604 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T7 1651-1657 Body_part denotes plasma http://purl.obolibrary.org/obo/UBERON_0001969

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-95 Sentence denotes O-Glycopeptide Truncation Strategy for Heterogeneous O-GalNAc Glycoproteomics Characterization.
T2 96-271 Sentence denotes Mucin-type O-glycosylation (or O-GalNAcylation) takes place on most membrane and secretory proteins and is vital in regulating protein functions and many biological processes.
T3 272-459 Sentence denotes O-GalNAcylation generally exhibits highly diverse and dense O-glycans linked to carrier proteins, which challenges the analysis of O-GalNAc glycoproteome using conventional methodologies.
T4 460-588 Sentence denotes Here, we report an O-glycopeptide truncation strategy for the characterization of protein O-GalNAcylation in biological samples.
T5 589-730 Sentence denotes The O-glycopeptide truncation strategy utilizes proteases or O-glycopeptidases for targeted cleavage of the enriched tryptic O-glycopeptides.
T6 731-908 Sentence denotes It simplifies the O-glycopeptide backbones, O-glycans, or both, and has been shown to aid the improvement of the analytical coverage of O-GalNAc glycopeptides and glycoproteins.
T7 909-1060 Sentence denotes Tryptic O-glycopeptides covered with O-glycan clusters and terminal sialic acids could be well isolated by the hydrophilic-based enrichment approaches.
T8 1061-1292 Sentence denotes The enriched O-glycopeptides are then enzymatically truncated into shorter or less multiply O-glycosylated peptides, which are more favorable for mass spectrometry detection and database search in general bottom-up glycoproteomics.
T9 1293-1410 Sentence denotes We also investigate different proteolysis which could be well integrated into the O-glycopeptide truncation strategy.
T10 1411-1689 Sentence denotes For large-scale analysis, we exploit different truncation schemes and identify nearly 2000 O-glycopeptides corresponding to 391 glycoproteins from 75 μL human serum, achieving the deepest-scale coverage of O-glycoproteins compared to other plasma/serum O-glycoproteomic studies.
T11 1690-1842 Sentence denotes Together, the O-glycopeptide truncation strategy has great potential to facilitate the in-depth study of O-GalNAc glycoproteomics in biological samples.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 55-61 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T2 405-411 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T3 869-875 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T4 1797-1803 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1564-1569 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 164-172 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T4 764-773 Body_part denotes backbones http://purl.obolibrary.org/obo/UBERON_0001130
T5 1421-1426 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T6 1599-1604 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T7 1651-1657 Body_part denotes plasma http://purl.obolibrary.org/obo/UBERON_0001969