PubMed:37344517
Annnotations
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 210-216 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T2 | 221-237 | Disease | denotes | viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 210-216 | Phenotype | denotes | cancer | HP:0002664 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 706-724 | Glycan | denotes | galactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 706-724 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | galactosylceramide | http://www.glycoepitope.jp/epitopes/EP0074 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 210-216 | Phenotype | denotes | cancer | HP:0002664 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 210-216 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T2 | 221-237 | Disease | denotes | viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 60-65 | OrganismTaxon | denotes | human | 9606 |
| T2 | 1491-1496 | OrganismTaxon | denotes | human | 9606 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 84-97 | Cell | denotes | Killer T cell | http://purl.obolibrary.org/obo/CL:0000794 |
| T2 | 91-97 | Cell | denotes | T cell | http://purl.obolibrary.org/obo/CL:0000084 |
| T3 | 383-393 | Cell | denotes | lymphocyte | http://purl.obolibrary.org/obo/CL:0000542 |
| T4 | 514-548 | Cell | denotes | peripheral blood mononuclear cells | http://purl.obolibrary.org/obo/CL:0000842|http://purl.obolibrary.org/obo/CL:2000001 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 91-97 | Body_part | denotes | T cell | http://purl.obolibrary.org/obo/CL_0000084 |
| T2 | 383-393 | Body_part | denotes | lymphocyte | http://purl.obolibrary.org/obo/CL_0000542 |
| T3 | 514-548 | Body_part | denotes | peripheral blood mononuclear cells | http://purl.obolibrary.org/obo/CL_0000842|http://purl.obolibrary.org/obo/CL_2000001 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 525-530 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-107 | Sentence | denotes | The effect of blocking immune checkpoints LAG-3 and PD-1 on human invariant Natural Killer T cell function. |
| T2 | 108-251 | Sentence | denotes | Invariant Natural Killer T (iNKT) cells undergo immune exhaustion during chronic activation caused by cancer and viral infections, such as HIV. |
| T3 | 252-420 | Sentence | denotes | Exhaustion is marked by cell dysfunction and increased expression of immune checkpoint proteins programmed cell-death-1 (PD-1) and lymphocyte-activation-gene-3 (LAG-3). |
| T4 | 421-503 | Sentence | denotes | We hypothesize that blockade of PD-1 and/or LAG-3 will enhance iNKT cell function. |
| T5 | 504-733 | Sentence | denotes | Utilizing peripheral blood mononuclear cells from healthy donors, LAG-3 and PD-1 expression on iNKT cells was assessed using flow cytometry following in vitro stimulation with iNKT-specific stimulant α-galactosylceramide (n = 4). |
| T6 | 734-905 | Sentence | denotes | Efficacy of anti-LAG-3 and/or anti-PD-1 antibody blockades in enhancing iNKT cell function was assessed by determining proliferative capacity and IFN-γ production (n = 9). |
| T7 | 906-1101 | Sentence | denotes | LAG-3 and PD-1 expression on iNKT cells peaked at Day 4 (98.8%; p ≤ 0.0001 and 98.8%; p = 0.005, respectively), followed by steep decrease by Day 10, coinciding with peak iNKT cell proliferation. |
| T8 | 1102-1400 | Sentence | denotes | In a 10-day blocking assay, both the anti-PD-1 alone and dual anti-PD-1 and anti-LAG-3 significantly increased iNKT proliferation (6 and 6.29 log2 fold-change respectively) compared to the no blockade control (ANOVA-p = 0.0005) with the dual blockade system being more effective (t-test-p = 0.013). |
| T9 | 1401-1573 | Sentence | denotes | This provides proof-of-concept for LAG-3 and PD-1 as immunotherapeutic targets to enhance human iNKT cell function, with the long-term goal of addressing immune exhaustion. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 706-724 | Glycan | denotes | galactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 706-724 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | galactosylceramide | http://www.glycoepitope.jp/epitopes/EP0074 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 60-65 | OrganismTaxon | denotes | human | 9606 |
| T2 | 1491-1496 | OrganismTaxon | denotes | human | 9606 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 525-530 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 91-97 | Body_part | denotes | T cell | http://purl.obolibrary.org/obo/CL_0000084 |
| T2 | 383-393 | Body_part | denotes | lymphocyte | http://purl.obolibrary.org/obo/CL_0000542 |
| T3 | 514-548 | Body_part | denotes | peripheral blood mononuclear cells | http://purl.obolibrary.org/obo/CL_0000842|http://purl.obolibrary.org/obo/CL_2000001 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 84-97 | Cell | denotes | Killer T cell | http://purl.obolibrary.org/obo/CL:0000794 |
| T2 | 91-97 | Cell | denotes | T cell | http://purl.obolibrary.org/obo/CL:0000084 |
| T3 | 383-393 | Cell | denotes | lymphocyte | http://purl.obolibrary.org/obo/CL:0000542 |
| T4 | 514-548 | Cell | denotes | peripheral blood mononuclear cells | http://purl.obolibrary.org/obo/CL:0000842|http://purl.obolibrary.org/obo/CL:2000001 |