PubMed:36977722
Annnotations
GlyCosmos15-Species
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| 17991 | 153-158 | Species | denotes | human | 9606 |
| 17996 | 970-975 | Species | denotes | mouse | 10090 |
| 18005 | 295-300 | Species | denotes | human | 9606 |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 106-116 | Glycan | denotes | Tn antigen | https://api.glycosmos.org/wurcs2image/latest/png/binary/G57321FI |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 22-28 | Disease | denotes | tumors | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T2 | 159-169 | Disease | denotes | carcinomas | http://purl.obolibrary.org/obo/MONDO_0004993 |
| T3 | 866-879 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
| T4 | 930-935 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T5 | 1052-1057 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T6 | 1079-1085 | Disease | denotes | tumors | http://purl.obolibrary.org/obo/MONDO_0005070 |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 106-116 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Tn antigen | http://www.glycoepitope.jp/epitopes/EP0021 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 159-169 | Phenotype | denotes | carcinomas | HP:0030731 |
| T2 | 866-879 | Phenotype | denotes | breast cancer | HP:0003002 |
| T3 | 930-935 | Phenotype | denotes | tumor | HP:0002664 |
| T4 | 1052-1057 | Phenotype | denotes | tumor | HP:0002664 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 153-158 | OrganismTaxon | denotes | human | 9606 |
| T2 | 295-300 | OrganismTaxon | denotes | human | 9606 |
| T3 | 970-975 | OrganismTaxon | denotes | mouse | 10088|10090 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 873-884 | Cell | denotes | cancer cell | http://purl.obolibrary.org/obo/CL:0001064 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 734-749 | Body_part | denotes | extracellularly | http://purl.obolibrary.org/obo/GO_0005576 |
| T2 | 866-872 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 106-116 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Tn antigen | http://www.glycoepitope.jp/epitopes/EP0021 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-74 | Sentence | denotes | Targeting Tn-positive tumors with an afucosylated recombinant anti-Tn IgG. |
| T2 | 75-234 | Sentence | denotes | The aberrant expression of the Tn antigen (CD175) on surface glycoproteins of human carcinomas is associated with tumorigenesis, metastasis, and poor survival. |
| T3 | 235-342 | Sentence | denotes | To target this antigen, we developed Remab6, a recombinant, human chimeric anti-Tn-specific monoclonal IgG. |
| T4 | 343-477 | Sentence | denotes | However, this antibody lacks antibody-dependent cell cytotoxicity (ADCC) effector activity, due to core fucosylation of its N-glycans. |
| T5 | 478-603 | Sentence | denotes | Here we describe the generation of an afucosylated Remab6 (Remab6-AF) in HEK293 cells in which the FX gene is deleted (FXKO). |
| T6 | 604-803 | Sentence | denotes | These cells cannot synthesize GDP-fucose through the de novo pathway, and lack fucosylated glycans, although they can incorporate extracellularly-supplied fucose through their intact salvage pathway. |
| T7 | 804-982 | Sentence | denotes | Remab6-AF has strong ADCC activity against Tn+ colorectal and breast cancer cell lines in vitro, and is effective in reducing tumor size in an in vivo xenotransplant mouse model. |
| T8 | 983-1086 | Sentence | denotes | Thus, Remab6-AF should be considered as a potential therapeutic anti-tumor antibody against Tn+ tumors. |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 106-116 | Glycan | denotes | Tn antigen | https://api.glycosmos.org/wurcs2image/latest/png/binary/G57321FI |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 159-169 | Disease | denotes | carcinomas | MONDO:0004993 |
| T2 | 866-879 | Disease | denotes | breast cancer | MONDO:0004989|MONDO:0007254 |
| T4 | 930-935 | Disease | denotes | tumor | MONDO:0005070 |
| T5 | 1052-1057 | Disease | denotes | tumor | MONDO:0005070 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 866-872 | Body_part | denotes | breast | FMA:9601 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 153-158 | OrganismTaxon | denotes | human | 9606 |
| T2 | 295-300 | OrganismTaxon | denotes | human | 9606 |
| T3 | 970-975 | OrganismTaxon | denotes | mouse | 10088|10090 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 734-749 | Body_part | denotes | extracellularly | http://purl.obolibrary.org/obo/GO_0005576 |
| T2 | 866-872 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 159-169 | Phenotype | denotes | carcinomas | HP:0030731 |
| T2 | 866-879 | Phenotype | denotes | breast cancer | HP:0003002 |
| T3 | 930-935 | Phenotype | denotes | tumor | HP:0002664 |
| T4 | 1052-1057 | Phenotype | denotes | tumor | HP:0002664 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 873-884 | Cell | denotes | cancer cell | http://purl.obolibrary.org/obo/CL:0001064 |