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PubMed:36939991 JSONTXT

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GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 49-52 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T2 403-406 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T3 734-737 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 74-77 Disease denotes CHF http://purl.obolibrary.org/obo/MONDO_0005009
T2 723-726 Disease denotes CHF http://purl.obolibrary.org/obo/MONDO_0005009

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 49-52 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T2 49-52 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T3 403-406 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T4 403-406 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T5 734-737 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T6 734-737 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 49-52 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK
T3 403-406 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK
T5 734-737 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 74-77 Phenotype denotes CHF HP:0001635
T2 723-726 Phenotype denotes CHF HP:0001635

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 49-52 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T2 403-406 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T3 734-737 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-114 Sentence denotes Synthesis and biological activity of ganglioside GM3 analogues with a (S)-CHF-Sialoside linkage and an alkyne tag.
T2 115-343 Sentence denotes The alkyne tag, consisting of only two carbons, is widely used as a bioorthogonal functional group due to its compactness and nonpolar structure, and various probes consisting of lipids bearing an alkyne tag have been developed.
T3 344-524 Sentence denotes Here, we designed and synthesized analogues of ganglioside GM3 bearing an alkyne tag in the fatty acid moiety and evaluated the effect of the alkyne tag on the biological activity.
T4 525-771 Sentence denotes To eliminate the influence of other factors such as degradation of the glycan chain when evaluating biological activity in a cellular environment, we introduced the tag into sialidase-resistant (S)-CHF-linked GM3 analogues developed by our group.
T5 772-891 Sentence denotes The designed analogues were efficiently synthesized by tuning the protecting group of the glucosylsphingosine acceptor.
T6 892-1025 Sentence denotes The growth-promoting effect of these analogues on Had-1 cells was dramatically altered depending upon the position of the alkyne tag.