PubMed:36753889 JSONTXT

{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":89,"end":106},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":235,"end":253},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"1082643"},{"id":"A2","pred":"db_id","subj":"T2","obj":"1082643"}],"text":"Discovery of pentacyclic triterpenoid glycosides with anti-proliferative activities from Ardisialindleyana.\nOne new pentacyclic triterpenoid glycoside, ardisiapunine E (1), along with two known compounds were isolated from the root of Ardisia lindleyana D.Dietr. Their structures were elucidated by 1H and 13C NMR, DEPT, HMBC, HSQC, 1H-1H COSY and NOESY spectroscopic analyses, ESI-MS, and literature. Compounds 1-3 exhibited obvious anti-proliferative activities against the HeLa cell line in a dose- and time-dependent manner by inducing G2/M phase arrest and apoptosis in vitro, both consisting of pentacyclic triterpenes and sugar. Hence, this study identified a new and two known pentacyclic triterpenoid glycosides promoting apoptosis as a potential anti-proliferative agent."}