PubMed:36519389 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/36519389","sourcedb":"PubMed","sourceid":"36519389","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/36519389","text":"Weight and Metabolic Changes After Switching From Tenofovir Alafenamide/Emtricitabine (FTC)+Dolutegravir (DTG), Tenofovir Disoproxil Fumarate (TDF)/FTC + DTG, and TDF/FTC/Efavirenz to TDF/Lamivudine/DTG.\nParticipants randomized to first-line tenofovir alafenamide (TAF)/emtricitabine (FTC)+dolutegravir (DTG), tenofovir disoproxil fumarate (TDF)/FTC + DTG, or TDF/FTC/efavirenz (EFV) for 192 weeks were then switched to TDF/lamivudine (3TC)/DTG for 52 weeks. Participants switching either TAF/FTC + DTG or TDF/FTC/EFV to TDF/3TC/DTG showed statistically significant reductions in weight, low-density lipoprotein, triglycerides, glucose and glycated hemoglobin.","tracks":[{"project":"luoyt2021_800_3","denotations":[{"id":"T1","span":{"begin":50,"end":71},"obj":"CI"},{"id":"T10","span":{"begin":364,"end":367},"obj":"CI"},{"id":"T11","span":{"begin":346,"end":349},"obj":"CI"},{"id":"T12","span":{"begin":285,"end":288},"obj":"CI"},{"id":"T13","span":{"begin":167,"end":170},"obj":"CI"},{"id":"T14","span":{"begin":148,"end":151},"obj":"CI"},{"id":"T15","span":{"begin":92,"end":104},"obj":"CI"},{"id":"T16","span":{"begin":106,"end":109},"obj":"CI"},{"id":"T17","span":{"begin":529,"end":532},"obj":"CI"},{"id":"T18","span":{"begin":441,"end":444},"obj":"CI"},{"id":"T19","span":{"begin":499,"end":502},"obj":"CI"},{"id":"T20","span":{"begin":352,"end":355},"obj":"CI"},{"id":"T21","span":{"begin":304,"end":307},"obj":"CI"},{"id":"T22","span":{"begin":199,"end":202},"obj":"CI"},{"id":"T23","span":{"begin":154,"end":157},"obj":"CI"},{"id":"T24","span":{"begin":143,"end":146},"obj":"CI"},{"id":"T25","span":{"begin":163,"end":166},"obj":"CI"},{"id":"T26","span":{"begin":184,"end":187},"obj":"CI"},{"id":"T27","span":{"begin":368,"end":377},"obj":"CI"},{"id":"T28","span":{"begin":379,"end":382},"obj":"CI"},{"id":"T29","span":{"begin":420,"end":423},"obj":"CI"},{"id":"T3","span":{"begin":242,"end":263},"obj":"CI"},{"id":"T30","span":{"begin":424,"end":434},"obj":"CI"},{"id":"T31","span":{"begin":310,"end":339},"obj":"CI"},{"id":"T32","span":{"begin":341,"end":344},"obj":"CI"},{"id":"T33","span":{"begin":506,"end":509},"obj":"CI"},{"id":"T34","span":{"begin":510,"end":513},"obj":"CI"},{"id":"T35","span":{"begin":514,"end":517},"obj":"CI"},{"id":"T36","span":{"begin":521,"end":524},"obj":"CI"},{"id":"T37","span":{"begin":525,"end":528},"obj":"CI"},{"id":"T38","span":{"begin":436,"end":439},"obj":"CI"},{"id":"T4","span":{"begin":265,"end":268},"obj":"CI"},{"id":"T5","span":{"begin":112,"end":141},"obj":"CI"},{"id":"T6","span":{"begin":489,"end":492},"obj":"CI"},{"id":"T7","span":{"begin":72,"end":85},"obj":"CI"},{"id":"T8","span":{"begin":87,"end":90},"obj":"CI"},{"id":"T9","span":{"begin":493,"end":496},"obj":"CI"},{"id":"T39","span":{"begin":360,"end":363},"obj":"CI"},{"id":"T40","span":{"begin":270,"end":283},"obj":"CI"},{"id":"T41","span":{"begin":188,"end":198},"obj":"CI"},{"id":"T42","span":{"begin":290,"end":302},"obj":"CI"},{"id":"T43","span":{"begin":171,"end":180},"obj":"CI"}],"attributes":[{"subj":"T1","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T10","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T11","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T12","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T13","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T14","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T15","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T16","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T17","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T18","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T19","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T20","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T21","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T22","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T23","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T24","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T25","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T26","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T27","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T28","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T29","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T3","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T30","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T31","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T32","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T33","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T34","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T35","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T36","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T37","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T38","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T4","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T5","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T6","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T7","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T8","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T9","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T39","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T40","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T41","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T42","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T43","pred":"source","obj":"luoyt2021_800_3"}]},{"project":"Linmchun_800_3","denotations":[{"id":"T1","span":{"begin":242,"end":263},"obj":"CI"},{"id":"T10","span":{"begin":154,"end":157},"obj":"CI"},{"id":"T11","span":{"begin":163,"end":166},"obj":"CI"},{"id":"T12","span":{"begin":167,"end":170},"obj":"CI"},{"id":"T13","span":{"begin":171,"end":180},"obj":"CI"},{"id":"T14","span":{"begin":184,"end":187},"obj":"CI"},{"id":"T15","span":{"begin":188,"end":198},"obj":"CI"},{"id":"T16","span":{"begin":199,"end":202},"obj":"CI"},{"id":"T17","span":{"begin":265,"end":268},"obj":"CI"},{"id":"T18","span":{"begin":270,"end":283},"obj":"CI"},{"id":"T19","span":{"begin":285,"end":288},"obj":"CI"},{"id":"T2","span":{"begin":50,"end":71},"obj":"CI"},{"id":"T20","span":{"begin":290,"end":302},"obj":"CI"},{"id":"T21","span":{"begin":304,"end":307},"obj":"CI"},{"id":"T22","span":{"begin":310,"end":339},"obj":"CI"},{"id":"T23","span":{"begin":341,"end":344},"obj":"CI"},{"id":"T24","span":{"begin":346,"end":349},"obj":"CI"},{"id":"T25","span":{"begin":352,"end":355},"obj":"CI"},{"id":"T26","span":{"begin":360,"end":363},"obj":"CI"},{"id":"T27","span":{"begin":364,"end":367},"obj":"CI"},{"id":"T28","span":{"begin":368,"end":377},"obj":"CI"},{"id":"T29","span":{"begin":379,"end":382},"obj":"CI"},{"id":"T3","span":{"begin":72,"end":85},"obj":"CI"},{"id":"T30","span":{"begin":420,"end":423},"obj":"CI"},{"id":"T31","span":{"begin":424,"end":434},"obj":"CI"},{"id":"T32","span":{"begin":441,"end":444},"obj":"CI"},{"id":"T33","span":{"begin":489,"end":492},"obj":"CI"},{"id":"T34","span":{"begin":493,"end":496},"obj":"CI"},{"id":"T35","span":{"begin":499,"end":502},"obj":"CI"},{"id":"T36","span":{"begin":506,"end":509},"obj":"CI"},{"id":"T37","span":{"begin":510,"end":513},"obj":"CI"},{"id":"T38","span":{"begin":514,"end":517},"obj":"CI"},{"id":"T39","span":{"begin":521,"end":524},"obj":"CI"},{"id":"T4","span":{"begin":87,"end":90},"obj":"CI"},{"id":"T40","span":{"begin":529,"end":532},"obj":"CI"},{"id":"T5","span":{"begin":92,"end":104},"obj":"CI"},{"id":"T6","span":{"begin":106,"end":109},"obj":"CI"},{"id":"T7","span":{"begin":112,"end":141},"obj":"CI"},{"id":"T8","span":{"begin":143,"end":146},"obj":"CI"},{"id":"T9","span":{"begin":148,"end":151},"obj":"CI"},{"id":"T41","span":{"begin":525,"end":528},"obj":"CI"},{"id":"T42","span":{"begin":436,"end":439},"obj":"CI"}],"attributes":[{"subj":"T1","pred":"source","obj":"Linmchun_800_3"},{"subj":"T10","pred":"source","obj":"Linmchun_800_3"},{"subj":"T11","pred":"source","obj":"Linmchun_800_3"},{"subj":"T12","pred":"source","obj":"Linmchun_800_3"},{"subj":"T13","pred":"source","obj":"Linmchun_800_3"},{"subj":"T14","pred":"source","obj":"Linmchun_800_3"},{"subj":"T15","pred":"source","obj":"Linmchun_800_3"},{"subj":"T16","pred":"source","obj":"Linmchun_800_3"},{"subj":"T17","pred":"source","obj":"Linmchun_800_3"},{"subj":"T18","pred":"source","obj":"Linmchun_800_3"},{"subj":"T19","pred":"source","obj":"Linmchun_800_3"},{"subj":"T2","pred":"source","obj":"Linmchun_800_3"},{"subj":"T20","pred":"source","obj":"Linmchun_800_3"},{"subj":"T21","pred":"source","obj":"Linmchun_800_3"},{"subj":"T22","pred":"source","obj":"Linmchun_800_3"},{"subj":"T23","pred":"source","obj":"Linmchun_800_3"},{"subj":"T24","pred":"source","obj":"Linmchun_800_3"},{"subj":"T25","pred":"source","obj":"Linmchun_800_3"},{"subj":"T26","pred":"source","obj":"Linmchun_800_3"},{"subj":"T27","pred":"source","obj":"Linmchun_800_3"},{"subj":"T28","pred":"source","obj":"Linmchun_800_3"},{"subj":"T29","pred":"source","obj":"Linmchun_800_3"},{"subj":"T3","pred":"source","obj":"Linmchun_800_3"},{"subj":"T30","pred":"source","obj":"Linmchun_800_3"},{"subj":"T31","pred":"source","obj":"Linmchun_800_3"},{"subj":"T32","pred":"source","obj":"Linmchun_800_3"},{"subj":"T33","pred":"source","obj":"Linmchun_800_3"},{"subj":"T34","pred":"source","obj":"Linmchun_800_3"},{"subj":"T35","pred":"source","obj":"Linmchun_800_3"},{"subj":"T36","pred":"source","obj":"Linmchun_800_3"},{"subj":"T37","pred":"source","obj":"Linmchun_800_3"},{"subj":"T38","pred":"source","obj":"Linmchun_800_3"},{"subj":"T39","pred":"source","obj":"Linmchun_800_3"},{"subj":"T4","pred":"source","obj":"Linmchun_800_3"},{"subj":"T40","pred":"source","obj":"Linmchun_800_3"},{"subj":"T5","pred":"source","obj":"Linmchun_800_3"},{"subj":"T6","pred":"source","obj":"Linmchun_800_3"},{"subj":"T7","pred":"source","obj":"Linmchun_800_3"},{"subj":"T8","pred":"source","obj":"Linmchun_800_3"},{"subj":"T9","pred":"source","obj":"Linmchun_800_3"},{"subj":"T41","pred":"source","obj":"Linmchun_800_3"},{"subj":"T42","pred":"source","obj":"Linmchun_800_3"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"luoyt2021_800_3","color":"#bc93ec","default":true},{"id":"Linmchun_800_3","color":"#93eca2"}]}]}}