PubMed:35568196
Annnotations
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 41-44 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T2 | 208-212 | Disease | denotes | CARD | http://purl.obolibrary.org/obo/MONDO_0002145 |
| T3 | 215-218 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T4 | 305-308 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T5 | 394-397 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T6 | 664-667 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T7 | 755-758 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T8 | 833-836 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T9 | 915-918 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T10 | 957-960 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T11 | 1030-1033 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T12 | 1089-1092 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T13 | 1188-1191 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T14 | 1227-1230 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T15 | 1314-1317 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T16 | 1328-1331 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T17 | 1518-1522 | Disease | denotes | CARD | http://purl.obolibrary.org/obo/MONDO_0002145 |
| T18 | 1526-1529 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T19 | 1618-1621 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T20 | 1716-1720 | Disease | denotes | CARD | http://purl.obolibrary.org/obo/MONDO_0002145 |
| T21 | 1832-1835 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 441-450 | http://purl.obolibrary.org/obo/MAT_0000491 | denotes | proximity |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1290-1297 | Glycan | denotes | maltose | https://api.glycosmos.org/wurcs2image/latest/png/binary/G44653LT |
| T2 | 1421-1428 | Glycan | denotes | amylose | https://api.glycosmos.org/wurcs2image/latest/png/binary/G05740LL |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 41-44 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T2 | 208-212 | Disease | denotes | CARD | http://purl.obolibrary.org/obo/MONDO_0002145 |
| T3 | 215-218 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T4 | 305-308 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T5 | 394-397 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T6 | 664-667 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T7 | 755-758 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T8 | 833-836 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T9 | 915-918 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T10 | 957-960 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T11 | 1030-1033 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T12 | 1089-1092 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T13 | 1188-1191 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T14 | 1227-1230 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T15 | 1314-1317 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T16 | 1328-1331 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T17 | 1518-1522 | Disease | denotes | CARD | http://purl.obolibrary.org/obo/MONDO_0002145 |
| T18 | 1526-1529 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T19 | 1618-1621 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
| T20 | 1716-1720 | Disease | denotes | CARD | http://purl.obolibrary.org/obo/MONDO_0002145 |
| T21 | 1832-1835 | Disease | denotes | ASC | http://purl.obolibrary.org/obo/MONDO_0019018 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 335-344 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 335-344 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 441-450 | Body_part | denotes | proximity | http://purl.obolibrary.org/obo/MAT_0000491 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-126 | Sentence | denotes | The central inflammasome adaptor protein ASC activates the inflammasome after transition from a soluble to an insoluble state. |
| T2 | 127-304 | Sentence | denotes | Apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD) (ASC) is a 22 kDa protein that functions as the central adaptor for inflammasome assembly. |
| T3 | 305-515 | Sentence | denotes | ASC forms insoluble specks in monocytes undergoing pyroptosis, and the polymerization of ASC provides a template of CARDs that leads to proximity-mediated autoactivation of caspase-1 in canonical inflammasomes. |
| T4 | 516-624 | Sentence | denotes | However, specks are insoluble protein complexes, and solubility is typically important for protein function. |
| T5 | 625-768 | Sentence | denotes | Therefore, we sought to define whether ASC specks comprise active inflammasome complexes or are simply the end stage of exhausted ASC polymers. |
| T6 | 769-961 | Sentence | denotes | Using a THP-1 cell-lysing model of caspase-1 activation that is ASC dependent, we compared caspase-1 activation induced by preassembled insoluble ASC specks and soluble monomeric forms of ASC. |
| T7 | 962-1126 | Sentence | denotes | Unexpectedly, after controlling for the concentration dependence of ASC oligomerization, we found that only insoluble forms of ASC promoted caspase-1 autocatalysis. |
| T8 | 1127-1192 | Sentence | denotes | This link to insolubility was recapitulated with recombinant ASC. |
| T9 | 1193-1435 | Sentence | denotes | We show that purified recombinant ASC spontaneously precipitated and was functional, whereas the maltose-binding protein-ASC fusion to ASC (promoting enhanced solubility) was inactive until induced to insolubility by binding to amylose beads. |
| T10 | 1436-1582 | Sentence | denotes | This functional link to insolubility also held true for the Y146A mutation of the CARD of ASC, which avoids insolubility and caspase-1 activation. |
| T11 | 1583-1746 | Sentence | denotes | Thus, we conclude that the role of ASC insolubility in inflammasome function is inextricably linked to its pyrin domain-mediated and CARD-mediated polymerizations. |
| T12 | 1747-1847 | Sentence | denotes | These findings will support future studies into the molecular mechanisms controlling ASC solubility. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1290-1297 | Glycan | denotes | maltose | https://api.glycosmos.org/wurcs2image/latest/png/binary/G44653LT |
| T2 | 1421-1428 | Glycan | denotes | amylose | https://api.glycosmos.org/wurcs2image/latest/png/binary/G05740LL |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 335-344 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 441-450 | Body_part | denotes | proximity | http://purl.obolibrary.org/obo/MAT_0000491 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 335-344 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |