> top > docs > PubMed:35432566 > annotations

PubMed:35432566 JSONTXT

Annnotations TAB JSON ListView MergeView

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-86 Sentence denotes Efficacy and Safety of Zuojin Pill for the Treatment of Chronic Nonatrophic Gastritis:
T2 87-133 Sentence denotes A Randomized Active-Controlled Clinical Trial.
T3 134-144 Sentence denotes Objective:
T4 145-242 Sentence denotes Zuojin pill (ZJP) is used as the classical prescription for a wide variety of digestive diseases.
T5 243-355 Sentence denotes However, there is a lack of direct evidence for its use in the treatment of chronic nonatrophic gastritis (CNG).
T6 356-439 Sentence denotes In particular, there is a lack of rigorous trials of randomized controlled designs.
T7 440-566 Sentence denotes In this study, a randomized active-controlled clinical trial was performed to verify the efficacy and safety of ZJP in detail.
T8 567-575 Sentence denotes Methods:
T9 576-660 Sentence denotes Patients with CNG were divided into the ZJP group and the Marzulene-S granule group.
T10 661-740 Sentence denotes Patients were enrolled from September 2019 to February 2021 (ChiCTR2000040549).
T11 741-818 Sentence denotes Endoscopy and histology scores were evaluated as the primary outcome measure.
T12 819-939 Sentence denotes The Helicobacter pylori positive rate and the disappearance rate of symptoms were also measured to reflect the outcomes.
T13 940-1008 Sentence denotes Finally, adverse events were also calculated as the index of safety.
T14 1009-1017 Sentence denotes Results:
T15 1018-1143 Sentence denotes A total of 68 eligible patients were enrolled in this trial and randomly divided into two groups with baseline comparability.
T16 1144-1284 Sentence denotes ZJP was able to improve the red plaques as well as bile reflux scores compared with Marzulene-S granule (P=0.043 and P=0.019, respectively).
T17 1285-1373 Sentence denotes Moreover, it also remarkably alleviated the active chronic inflammation score (P=0.043).
T18 1374-1465 Sentence denotes However, there was no difference between the Helicobacter pylori positivity rate (P=0.752).
T19 1466-1638 Sentence denotes The symptom scores of abdominal distension (P=0.004), belching (P=0.010), and loss of appetite (P=0.019) were alleviated by ZJP, but nausea and vomiting were not (P=0.616).
T20 1639-1703 Sentence denotes ZJP can also be considered safe with no obvious adverse effects.
T21 1704-1780 Sentence denotes Conclusion: ZJP might decrease mucosal injury and alleviate symptoms in CNG.
T22 1781-1901 Sentence denotes In addition, more large-scale clinical trials should be carried out to further confirm its clinical efficacy and safety.
T1 0-86 Sentence denotes Efficacy and Safety of Zuojin Pill for the Treatment of Chronic Nonatrophic Gastritis:
T2 87-133 Sentence denotes A Randomized Active-Controlled Clinical Trial.
T3 134-144 Sentence denotes Objective:
T4 145-242 Sentence denotes Zuojin pill (ZJP) is used as the classical prescription for a wide variety of digestive diseases.
T5 243-355 Sentence denotes However, there is a lack of direct evidence for its use in the treatment of chronic nonatrophic gastritis (CNG).
T6 356-439 Sentence denotes In particular, there is a lack of rigorous trials of randomized controlled designs.
T7 440-566 Sentence denotes In this study, a randomized active-controlled clinical trial was performed to verify the efficacy and safety of ZJP in detail.
T8 567-575 Sentence denotes Methods:
T9 576-660 Sentence denotes Patients with CNG were divided into the ZJP group and the Marzulene-S granule group.
T10 661-740 Sentence denotes Patients were enrolled from September 2019 to February 2021 (ChiCTR2000040549).
T11 741-818 Sentence denotes Endoscopy and histology scores were evaluated as the primary outcome measure.
T12 819-939 Sentence denotes The Helicobacter pylori positive rate and the disappearance rate of symptoms were also measured to reflect the outcomes.
T13 940-1008 Sentence denotes Finally, adverse events were also calculated as the index of safety.
T14 1009-1017 Sentence denotes Results:
T15 1018-1143 Sentence denotes A total of 68 eligible patients were enrolled in this trial and randomly divided into two groups with baseline comparability.
T16 1144-1284 Sentence denotes ZJP was able to improve the red plaques as well as bile reflux scores compared with Marzulene-S granule (P=0.043 and P=0.019, respectively).
T17 1285-1373 Sentence denotes Moreover, it also remarkably alleviated the active chronic inflammation score (P=0.043).
T18 1374-1465 Sentence denotes However, there was no difference between the Helicobacter pylori positivity rate (P=0.752).
T19 1466-1638 Sentence denotes The symptom scores of abdominal distension (P=0.004), belching (P=0.010), and loss of appetite (P=0.019) were alleviated by ZJP, but nausea and vomiting were not (P=0.616).
T20 1639-1703 Sentence denotes ZJP can also be considered safe with no obvious adverse effects.
T21 1704-1780 Sentence denotes Conclusion: ZJP might decrease mucosal injury and alleviate symptoms in CNG.
T22 1781-1901 Sentence denotes In addition, more large-scale clinical trials should be carried out to further confirm its clinical efficacy and safety.