PubMed:35296731
Annnotations
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 105-117 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
| T2 | 515-526 | Cell | denotes | cancer cell | http://purl.obolibrary.org/obo/CL:0001064 |
| T3 | 553-565 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
| T4 | 1710-1721 | Cell | denotes | cancer cell | http://purl.obolibrary.org/obo/CL:0001064 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 96-111 | Disease | denotes | cervical cancer | http://purl.obolibrary.org/obo/MONDO_0002974|http://purl.obolibrary.org/obo/MONDO_0005131 |
| T3 | 515-521 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T4 | 544-559 | Disease | denotes | cervical cancer | http://purl.obolibrary.org/obo/MONDO_0002974|http://purl.obolibrary.org/obo/MONDO_0005131 |
| T6 | 659-674 | Disease | denotes | cervical cancer | http://purl.obolibrary.org/obo/MONDO_0002974|http://purl.obolibrary.org/obo/MONDO_0005131 |
| T8 | 1364-1379 | Disease | denotes | cervical cancer | http://purl.obolibrary.org/obo/MONDO_0002974|http://purl.obolibrary.org/obo/MONDO_0005131 |
| T10 | 1408-1414 | Disease | denotes | cervix | http://purl.obolibrary.org/obo/MONDO_0021230 |
| T11 | 1701-1716 | Disease | denotes | cervical cancer | http://purl.obolibrary.org/obo/MONDO_0002974|http://purl.obolibrary.org/obo/MONDO_0005131 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 1408-1414 | Body_part | denotes | cervix | http://purl.obolibrary.org/obo/MAT_0000292 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 348-356 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 348-356 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 105-111 | Phenotype | denotes | cancer | HP:0002664 |
| T2 | 515-521 | Phenotype | denotes | cancer | HP:0002664 |
| T3 | 553-559 | Phenotype | denotes | cancer | HP:0002664 |
| T4 | 668-674 | Phenotype | denotes | cancer | HP:0002664 |
| T5 | 1373-1379 | Phenotype | denotes | cancer | HP:0002664 |
| T6 | 1710-1716 | Phenotype | denotes | cancer | HP:0002664 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 96-111 | Disease | denotes | cervical cancer | http://purl.obolibrary.org/obo/MONDO_0002974|http://purl.obolibrary.org/obo/MONDO_0005131 |
| T3 | 515-521 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T4 | 544-559 | Disease | denotes | cervical cancer | http://purl.obolibrary.org/obo/MONDO_0002974|http://purl.obolibrary.org/obo/MONDO_0005131 |
| T6 | 659-674 | Disease | denotes | cervical cancer | http://purl.obolibrary.org/obo/MONDO_0002974|http://purl.obolibrary.org/obo/MONDO_0005131 |
| T8 | 1364-1379 | Disease | denotes | cervical cancer | http://purl.obolibrary.org/obo/MONDO_0002974|http://purl.obolibrary.org/obo/MONDO_0005131 |
| T10 | 1408-1414 | Disease | denotes | cervix | http://purl.obolibrary.org/obo/MONDO_0021230 |
| T11 | 1701-1716 | Disease | denotes | cervical cancer | http://purl.obolibrary.org/obo/MONDO_0002974|http://purl.obolibrary.org/obo/MONDO_0005131 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 1358-1363 | OrganismTaxon | denotes | human | 9606 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 105-117 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
| T2 | 515-526 | Cell | denotes | cancer cell | http://purl.obolibrary.org/obo/CL:0001064 |
| T3 | 553-565 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
| T4 | 1710-1721 | Cell | denotes | cancer cell | http://purl.obolibrary.org/obo/CL:0001064 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 1203-1218 | Body_part | denotes | plasma membrane | http://purl.obolibrary.org/obo/GO_0005886 |
| T2 | 1408-1414 | Body_part | denotes | cervix | http://purl.obolibrary.org/obo/UBERON_0000002 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 1408-1414 | Body_part | denotes | cervix | http://purl.obolibrary.org/obo/MAT_0000292 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-118 | Sentence | denotes | Increased O-GlcNAcylation promotes IGF-1 receptor/PhosphatidyI Inositol-3 kinase/Akt pathway in cervical cancer cells. |
| T2 | 119-304 | Sentence | denotes | O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) is a reversible post-translational modification on serine and threonine residues of cytosolic, nuclear and mitochondrial proteins. |
| T3 | 305-442 | Sentence | denotes | O-GlcNAcylation level is regulated by OGT (O-GlcNAc transferase), which adds GlcNAc on proteins, and OGA (O-GlcNAcase), which removes it. |
| T4 | 443-566 | Sentence | denotes | Abnormal level of protein O-GlcNAcylation has been observed in numerous cancer cell types, including cervical cancer cells. |
| T5 | 567-695 | Sentence | denotes | In the present study, we have evaluated the effect of increasing protein O-GlcNAcylation on cervical cancer-derived CaSki cells. |
| T6 | 696-924 | Sentence | denotes | We observed that pharmacological enhancement of protein O-GlcNAcylation by Thiamet G (an inhibitor of OGA) and glucosamine (which provides UDP-GlcNAc substrate to OGT) increases CaSki cells proliferation, migration and survival. |
| T7 | 925-1101 | Sentence | denotes | Moreover, we showed that increased O-GlcNAcylation promotes IGF-1 receptor (IGF1R) autophosphorylation, possibly through inhibition of protein tyrosine-phosphatase 1B activity. |
| T8 | 1102-1263 | Sentence | denotes | This was associated with increased IGF-1-induced phosphatidyl-Inositol 3-phosphate production at the plasma membrane and increased Akt activation in CaSki cells. |
| T9 | 1264-1543 | Sentence | denotes | Finally, we showed that protein O-GlcNAcylation and Akt phosphorylation levels were higher in human cervical cancer samples compared to healthy cervix tissues, and a highly positive correlation was observed between O-GlcNAcylation level and Akt phosphorylation in theses tissues. |
| T10 | 1544-1747 | Sentence | denotes | Together, our results indicate that increased O-GlcNAcylation, by activating IGF1R/ Phosphatidyl inositol 3-Kinase (PI-3K)/Akt signaling, may participate in cervical cancer cell growth and proliferation. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 348-356 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 348-356 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 1358-1363 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 1203-1218 | Body_part | denotes | plasma membrane | http://purl.obolibrary.org/obo/GO_0005886 |
| T2 | 1408-1414 | Body_part | denotes | cervix | http://purl.obolibrary.org/obo/UBERON_0000002 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 105-111 | Phenotype | denotes | cancer | HP:0002664 |
| T2 | 515-521 | Phenotype | denotes | cancer | HP:0002664 |
| T3 | 553-559 | Phenotype | denotes | cancer | HP:0002664 |
| T4 | 668-674 | Phenotype | denotes | cancer | HP:0002664 |
| T5 | 1373-1379 | Phenotype | denotes | cancer | HP:0002664 |
| T6 | 1710-1716 | Phenotype | denotes | cancer | HP:0002664 |