PubMed:35202342 JSONTXT

{"project":"Test-merged","denotations":[{"id":"23536","span":{"begin":90,"end":94},"obj":"Species"},{"id":"23537","span":{"begin":57,"end":67},"obj":"Disease"},{"id":"23538","span":{"begin":126,"end":147},"obj":"Disease"},{"id":"23539","span":{"begin":109,"end":125},"obj":"Disease"},{"id":"23540","span":{"begin":1075,"end":1087},"obj":"Disease"},{"id":"23541","span":{"begin":452,"end":460},"obj":"CellLine"},{"id":"23542","span":{"begin":265,"end":270},"obj":"Species"},{"id":"23543","span":{"begin":1252,"end":1257},"obj":"Species"},{"id":"23544","span":{"begin":1160,"end":1163},"obj":"Disease"},{"id":"23545","span":{"begin":461,"end":466},"obj":"Species"},{"id":"23546","span":{"begin":314,"end":317},"obj":"Species"},{"id":"23547","span":{"begin":813,"end":817},"obj":"Species"},{"id":"23548","span":{"begin":601,"end":608},"obj":"Chemical"},{"id":"23549","span":{"begin":340,"end":359},"obj":"Disease"},{"id":"23550","span":{"begin":622,"end":626},"obj":"Species"},{"id":"23551","span":{"begin":1360,"end":1366},"obj":"Species"},{"id":"23552","span":{"begin":149,"end":165},"obj":"Disease"},{"id":"23553","span":{"begin":190,"end":209},"obj":"Disease"},{"id":"23554","span":{"begin":1411,"end":1431},"obj":"Disease"},{"id":"23555","span":{"begin":167,"end":170},"obj":"Disease"},{"id":"23556","span":{"begin":1119,"end":1123},"obj":"Species"}],"attributes":[{"id":"A23536","pred":"resolved_to","subj":"23536","obj":"10116"},{"id":"A23537","pred":"resolved_to","subj":"23537","obj":"MESH:D003872"},{"id":"A23538","pred":"resolved_to","subj":"23538","obj":"MESH:D006201"},{"id":"A23539","pred":"resolved_to","subj":"23539","obj":"MESH:D014256"},{"id":"A23540","pred":"resolved_to","subj":"23540","obj":"MESH:D012871"},{"id":"A23541","pred":"resolved_to","subj":"23541","obj":"CVCL:C0MW"},{"id":"A23542","pred":"resolved_to","subj":"23542","obj":"9606"},{"id":"A23543","pred":"resolved_to","subj":"23543","obj":"9606"},{"id":"A23544","pred":"resolved_to","subj":"23544","obj":"MESH:D014256"},{"id":"A23545","pred":"resolved_to","subj":"23545","obj":"10090"},{"id":"A23546","pred":"resolved_to","subj":"23546","obj":"9606"},{"id":"A23547","pred":"resolved_to","subj":"23547","obj":"10116"},{"id":"A23548","pred":"resolved_to","subj":"23548","obj":"MESH:D000438"},{"id":"A23549","pred":"resolved_to","subj":"23549","obj":"MESH:D020773"},{"id":"A23550","pred":"resolved_to","subj":"23550","obj":"10116"},{"id":"A23551","pred":"resolved_to","subj":"23551","obj":"9606"},{"id":"A23552","pred":"resolved_to","subj":"23552","obj":"MESH:D014256"},{"id":"A23553","pred":"resolved_to","subj":"23553","obj":"MESH:D012090"},{"id":"A23554","pred":"resolved_to","subj":"23554","obj":"MESH:D012090"},{"id":"A23555","pred":"resolved_to","subj":"23555","obj":"MESH:D014256"},{"id":"A23556","pred":"resolved_to","subj":"23556","obj":"10116"}],"text":"Predictive Value of Grooming Behavior for Development of Dermatitis in Selectively Bred P Rats as a Model of Trichotillomania Hair Pulling Disorder.\nTrichotillomania (TTM) is a body-focused repetitive disorder affecting as much as 0.5 to 2% of the population, with women four times more likely to be affected than men. This disorder causes impairment in daily function and significant distress. A potential animal model for this disorder is the inbred C57BL/6J mouse which displays clinical signs and behavioral characteristics similar to those described for people affected by this disorder. Because alcohol-preferring P rats also display similar clinical signs and behavioral characteristics, it was hypothesized that this selectively bred stock could be an additional animal model. In this study, 112 female P rats were recorded on digital media for 15 min after being sprayed with a mist of water and assessed for grooming patterns-oral, manual, and scratching. Significant elevations in scratching and oral grooming behavior were predictive of the future development of skin lesions. These findings suggest that P rats may be an additional model to study TTM, with the advantage of increased genetic variation (i.e., non-inbred) which mirrors the human population. The use of this model may help to identify preventative and therapeutic interventions for humans and other animals with similar body-focused repetitive disorders."}