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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-66 Sentence denotes The Effects of Modified Intermittent Fasting in Psoriasis (MANGO):
T2 67-140 Sentence denotes Protocol for a Two-Arm Pilot Randomized Controlled Open Cross-over Study.
T3 141-152 Sentence denotes BACKGROUND:
T4 153-276 Sentence denotes Psoriasis is a complex disease associated with multiple comorbidities, including metabolic syndrome and leaky gut syndrome.
T5 277-380 Sentence denotes Dietary lifestyle interventions have been reported to affect the disease in terms of lesional severity.
T6 381-482 Sentence denotes It remains unclear how diets affect these comorbidities and the general health in psoriasis patients.
T7 483-597 Sentence denotes Modified intermittent fasting (MIF) on 2 nonconsecutive days has shown beneficial effects on metabolic parameters.
T8 598-696 Sentence denotes A significant advantage of MIF over the currently investigated dietary changes is its feasibility.
T9 697-707 Sentence denotes OBJECTIVE:
T10 708-806 Sentence denotes Here, we aim to study the effects of MIF on skin, gut, and metabolic health in psoriasis patients.
T11 807-815 Sentence denotes METHODS:
T12 816-922 Sentence denotes A 2-arm pilot randomized controlled open cross-over study will be performed in 24 patients with psoriasis.
T13 923-1123 Sentence denotes Patients will be randomized 1:1 to either start with 12 weeks of MIF and go on a subsequent regular diet for another 12 weeks or start with 12 weeks of regular diet and do subsequent MIF for 12 weeks.
T14 1124-1452 Sentence denotes The following parameters will be assessed: demographics, disease phenotype, medical and familial history, psoriasis severity, dermatology-specific and general quality of life, nutritional and physical habits, mental and intestinal health, intestinal and cutaneous integrity, inflammatory and metabolic markers, and satisfaction.
T15 1453-1461 Sentence denotes RESULTS:
T16 1462-1521 Sentence denotes A total of 24 participants have been enrolled in the study.
T17 1522-1564 Sentence denotes The final visit is foreseen for June 2021.
T18 1565-1577 Sentence denotes CONCLUSIONS:
T19 1578-1711 Sentence denotes The aim is to uncover the effects of MIF on psoriasis severity and gut health integrity through clinical and molecular investigation.
T20 1712-1893 Sentence denotes More precisely, we want to map the evolution of the different markers, such as psoriasis severity, permeability, and inflammation, in response to MIF as compared to a regular diet,.
T21 1894-2116 Sentence denotes Understanding how dietary lifestyles can affect epithelial lineages, such as the skin and gut, will greatly improve our understanding of the development of psoriasis and may offer a nonpharmacological venue for treatments.
T22 2117-2136 Sentence denotes TRIAL REGISTRATION:
T23 2137-2217 Sentence denotes ClinicalTrials.gov NCT04418791; https://clinicaltrials.gov/ct2/show/NCT04418791.
T24 2218-2290 Sentence denotes INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/26405.
T1 0-66 Sentence denotes The Effects of Modified Intermittent Fasting in Psoriasis (MANGO):
T2 67-140 Sentence denotes Protocol for a Two-Arm Pilot Randomized Controlled Open Cross-over Study.
T3 141-152 Sentence denotes BACKGROUND:
T4 153-276 Sentence denotes Psoriasis is a complex disease associated with multiple comorbidities, including metabolic syndrome and leaky gut syndrome.
T5 277-380 Sentence denotes Dietary lifestyle interventions have been reported to affect the disease in terms of lesional severity.
T6 381-482 Sentence denotes It remains unclear how diets affect these comorbidities and the general health in psoriasis patients.
T7 483-597 Sentence denotes Modified intermittent fasting (MIF) on 2 nonconsecutive days has shown beneficial effects on metabolic parameters.
T8 598-696 Sentence denotes A significant advantage of MIF over the currently investigated dietary changes is its feasibility.
T9 697-707 Sentence denotes OBJECTIVE:
T10 708-806 Sentence denotes Here, we aim to study the effects of MIF on skin, gut, and metabolic health in psoriasis patients.
T11 807-815 Sentence denotes METHODS:
T12 816-922 Sentence denotes A 2-arm pilot randomized controlled open cross-over study will be performed in 24 patients with psoriasis.
T13 923-1123 Sentence denotes Patients will be randomized 1:1 to either start with 12 weeks of MIF and go on a subsequent regular diet for another 12 weeks or start with 12 weeks of regular diet and do subsequent MIF for 12 weeks.
T14 1124-1452 Sentence denotes The following parameters will be assessed: demographics, disease phenotype, medical and familial history, psoriasis severity, dermatology-specific and general quality of life, nutritional and physical habits, mental and intestinal health, intestinal and cutaneous integrity, inflammatory and metabolic markers, and satisfaction.
T15 1453-1461 Sentence denotes RESULTS:
T16 1462-1521 Sentence denotes A total of 24 participants have been enrolled in the study.
T17 1522-1564 Sentence denotes The final visit is foreseen for June 2021.
T18 1565-1577 Sentence denotes CONCLUSIONS:
T19 1578-1711 Sentence denotes The aim is to uncover the effects of MIF on psoriasis severity and gut health integrity through clinical and molecular investigation.
T20 1712-1893 Sentence denotes More precisely, we want to map the evolution of the different markers, such as psoriasis severity, permeability, and inflammation, in response to MIF as compared to a regular diet,.
T21 1894-2116 Sentence denotes Understanding how dietary lifestyles can affect epithelial lineages, such as the skin and gut, will greatly improve our understanding of the development of psoriasis and may offer a nonpharmacological venue for treatments.
T22 2117-2136 Sentence denotes TRIAL REGISTRATION:
T23 2137-2217 Sentence denotes ClinicalTrials.gov NCT04418791; https://clinicaltrials.gov/ct2/show/NCT04418791.
T24 2218-2290 Sentence denotes INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/26405.