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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-103 Sentence denotes Sensitive inflammatory biomarkers of acute fine particulate matter exposure among healthy young adults:
T2 104-179 Sentence denotes Findings from a randomized, double-blind crossover trial on air filtration.
T3 180-344 Sentence denotes The short-term alteration of peripheral cytokines may be an early adverse health effect of PM2.5 exposure and may be further associated with cardiovascular disease.
T4 345-657 Sentence denotes We conducted a randomized, double-blind crossover trial using true or sham air filtration among 54 healthy college students in Beijing to investigate the potential benefits of short-term indoor air filtration and the adverse health effects of time-weighted personal PM2.5 exposure through inflammatory cytokines.
T5 658-808 Sentence denotes The participants randomly received true or sham air filtration intervention for a week, and the treatment was changed after a two-week washout period.
T6 809-917 Sentence denotes Peripheral blood samples were collected after each intervention period to measure 38 inflammatory cytokines.
T7 918-1054 Sentence denotes A linear mixed-effects model was applied to estimate the impacts of air purification or a 10 μg/m3 PM2.5 exposure increase on cytokines.
T8 1055-1146 Sentence denotes Lag effects of PM2.5 exposure were analyzed using single-day and moving average lag models.
T9 1147-1318 Sentence denotes Air filtration reduced indoor and time-weighted average personal PM2.5 concentrations by 69.0% (from 33.6 to 10.4 μg/m3) and 40.3% (from 40.6 to 24.3 μg/m3), respectively.
T10 1319-1436 Sentence denotes We observed a significant association of PM2.5 exposure with growth-regulated alpha protein (GRO-α) of -11.3% (95%CI:
T11 1437-1451 Sentence denotes 17.0%, -5.4%).
T12 1452-2025 Sentence denotes In the lag models, significant associations between personal PM2.5 exposure and interleukin-1 receptor antagonist (IL-1Ra), monocyte chemotactic protein (MCP-1), and eotaxin were obtained at lag0, while associations with cytokines including vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), fibroblast growth factor-2 (FGF-2), granulocyte colony-stimulating factor (G-CSF), macrophage inflammatory protein-1β (MIP-1β), IL-4, tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) were noted at relatively long lagged exposure windows (lag5-lag6).
T13 2026-2117 Sentence denotes No significant alteration in cytokines was observed under true air filtration intervention.
T14 2118-2200 Sentence denotes Our study indicates the effectiveness of air filtration on indoor PM2.5 reduction.
T15 2201-2294 Sentence denotes PM2.5 exposure may decrease GRO-α levels and change different cytokine levels time-varyingly.
T16 2295-2398 Sentence denotes Further study is still needed to explore the mechanisms of PM2.5 exposure on the inflammatory response.
T1 0-103 Sentence denotes Sensitive inflammatory biomarkers of acute fine particulate matter exposure among healthy young adults:
T2 104-179 Sentence denotes Findings from a randomized, double-blind crossover trial on air filtration.
T3 180-344 Sentence denotes The short-term alteration of peripheral cytokines may be an early adverse health effect of PM2.5 exposure and may be further associated with cardiovascular disease.
T4 345-657 Sentence denotes We conducted a randomized, double-blind crossover trial using true or sham air filtration among 54 healthy college students in Beijing to investigate the potential benefits of short-term indoor air filtration and the adverse health effects of time-weighted personal PM2.5 exposure through inflammatory cytokines.
T5 658-808 Sentence denotes The participants randomly received true or sham air filtration intervention for a week, and the treatment was changed after a two-week washout period.
T6 809-917 Sentence denotes Peripheral blood samples were collected after each intervention period to measure 38 inflammatory cytokines.
T7 918-1054 Sentence denotes A linear mixed-effects model was applied to estimate the impacts of air purification or a 10 μg/m3 PM2.5 exposure increase on cytokines.
T8 1055-1146 Sentence denotes Lag effects of PM2.5 exposure were analyzed using single-day and moving average lag models.
T9 1147-1318 Sentence denotes Air filtration reduced indoor and time-weighted average personal PM2.5 concentrations by 69.0% (from 33.6 to 10.4 μg/m3) and 40.3% (from 40.6 to 24.3 μg/m3), respectively.
T10 1319-1436 Sentence denotes We observed a significant association of PM2.5 exposure with growth-regulated alpha protein (GRO-α) of -11.3% (95%CI:
T11 1437-1451 Sentence denotes 17.0%, -5.4%).
T12 1452-2025 Sentence denotes In the lag models, significant associations between personal PM2.5 exposure and interleukin-1 receptor antagonist (IL-1Ra), monocyte chemotactic protein (MCP-1), and eotaxin were obtained at lag0, while associations with cytokines including vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), fibroblast growth factor-2 (FGF-2), granulocyte colony-stimulating factor (G-CSF), macrophage inflammatory protein-1β (MIP-1β), IL-4, tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) were noted at relatively long lagged exposure windows (lag5-lag6).
T13 2026-2117 Sentence denotes No significant alteration in cytokines was observed under true air filtration intervention.
T14 2118-2200 Sentence denotes Our study indicates the effectiveness of air filtration on indoor PM2.5 reduction.
T15 2201-2294 Sentence denotes PM2.5 exposure may decrease GRO-α levels and change different cytokine levels time-varyingly.
T16 2295-2398 Sentence denotes Further study is still needed to explore the mechanisms of PM2.5 exposure on the inflammatory response.