PubMed:34909296 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/34909296","sourcedb":"PubMed","sourceid":"34909296","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/34909296","text":"Effects of Different Progesterone Doses on the Concentrations of Proinflammatory and Anti-inflammatory Cytokines in Pregnant Women With Threatened Abortion.\nBackground and objective This study aimed to investigate how different doses of progesterone influence the concentrations of interleukin-6 (IL-6) and tumor necrotizing factor-alpha (TNF-α), which are proinflammatory cytokines, as well as that of IL-10, which is an anti-inflammatory cytokine, in pregnant women with threatened abortion. Materials and methods This is a prospective, single-center, randomized controlled trial conducted with 221 patients with a threatened abortion diagnosis. Group 1 consisted of IL-6, IL-10, and TNF-α values in pre-treatment blood samples from 221 patients diagnosed with imminent abortion. Group 2 included 81 patients who received natural oral 100 mg micronized progesterone MP twice a day for two weeks. Group 3 included 83 patients who were administered oral 200 mg of natural micronized progesterone MP twice a day for two weeks. Group 4 included 57 patients who received oral 200 mg of natural micronized progesterone MP twice a day for two weeks, and one depot progesterone was added to the treatment by administering it at a dosage of 500 mg/day intramuscularly. Results IL-6 values between groups were lower in group 4 compared to group 3 (p=0.007). When IL-10 values were compared between the groups, the IL-10 ratio was highest in group 4 and lowest in group 2 (p\u003c0.001, p=0.003, p\u003c0.001). When the TNF-α values between the groups were compared, the value in group 4 was decreased compared to groups 1 and 2 (p=0.031, p\u003c0.001). In the logistic regression analysis, the IL-6 value above 12.01 increased the abortion imminens rate 1.01 times, and a TNF-α value above 11.04 increased the abortion imminens rate 1.21 times. Conclusion Progesterone used to treat imminent abortion reduces the levels of proinflammatory cytokines, such as IL-6 and TNF-α, while increasing those of anti-inflammatory cytokine IL-10 in proportion to the dose administered. Progesterone can prevent imminent abortion by generating an anti-inflammatory environment.","tracks":[{"project":"Linmchun_800_3","denotations":[{"id":"T1","span":{"begin":136,"end":155},"obj":"DP"},{"id":"T2","span":{"begin":473,"end":492},"obj":"DP"},{"id":"T3","span":{"begin":617,"end":636},"obj":"DP"},{"id":"T5","span":{"begin":868,"end":870},"obj":"CI"},{"id":"T7","span":{"begin":996,"end":998},"obj":"CI"},{"id":"T9","span":{"begin":1115,"end":1117},"obj":"CI"},{"id":"T10","span":{"begin":21,"end":33},"obj":"CI"},{"id":"T11","span":{"begin":1159,"end":1171},"obj":"CI"},{"id":"T12","span":{"begin":1833,"end":1845},"obj":"CI"},{"id":"T13","span":{"begin":2050,"end":2062},"obj":"CI"},{"id":"T14","span":{"begin":237,"end":249},"obj":"CI"},{"id":"T15","span":{"begin":983,"end":995},"obj":"CI"},{"id":"T16","span":{"begin":855,"end":867},"obj":"CI"},{"id":"T17","span":{"begin":1102,"end":1114},"obj":"CI"}],"attributes":[{"subj":"T1","pred":"source","obj":"Linmchun_800_3"},{"subj":"T2","pred":"source","obj":"Linmchun_800_3"},{"subj":"T3","pred":"source","obj":"Linmchun_800_3"},{"subj":"T5","pred":"source","obj":"Linmchun_800_3"},{"subj":"T7","pred":"source","obj":"Linmchun_800_3"},{"subj":"T9","pred":"source","obj":"Linmchun_800_3"},{"subj":"T10","pred":"source","obj":"Linmchun_800_3"},{"subj":"T11","pred":"source","obj":"Linmchun_800_3"},{"subj":"T12","pred":"source","obj":"Linmchun_800_3"},{"subj":"T13","pred":"source","obj":"Linmchun_800_3"},{"subj":"T14","pred":"source","obj":"Linmchun_800_3"},{"subj":"T15","pred":"source","obj":"Linmchun_800_3"},{"subj":"T16","pred":"source","obj":"Linmchun_800_3"},{"subj":"T17","pred":"source","obj":"Linmchun_800_3"}]},{"project":"luoyt2021_800_3","denotations":[{"id":"T1","span":{"begin":21,"end":33},"obj":"CI"},{"id":"T2","span":{"begin":2050,"end":2062},"obj":"CI"},{"id":"T4","span":{"begin":1833,"end":1845},"obj":"CI"},{"id":"T5","span":{"begin":1159,"end":1171},"obj":"CI"},{"id":"T6","span":{"begin":1102,"end":1114},"obj":"CI"},{"id":"T7","span":{"begin":983,"end":995},"obj":"CI"},{"id":"T8","span":{"begin":855,"end":867},"obj":"CI"},{"id":"T9","span":{"begin":237,"end":249},"obj":"CI"},{"id":"T10","span":{"begin":1115,"end":1117},"obj":"CI"},{"id":"T11","span":{"begin":996,"end":998},"obj":"CI"},{"id":"T12","span":{"begin":868,"end":870},"obj":"CI"},{"id":"T13","span":{"begin":617,"end":636},"obj":"DP"},{"id":"T14","span":{"begin":473,"end":492},"obj":"DP"},{"id":"T15","span":{"begin":136,"end":155},"obj":"DP"}],"attributes":[{"subj":"T1","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T2","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T4","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T5","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T6","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T7","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T8","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T9","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T10","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T11","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T12","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T13","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T14","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T15","pred":"source","obj":"luoyt2021_800_3"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Linmchun_800_3","color":"#d893ec","default":true},{"id":"luoyt2021_800_3","color":"#93ecbe"}]}]}}