PubMed:34764359
Annnotations
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1338-1350 | Disease | denotes | glioblastoma | http://purl.obolibrary.org/obo/MONDO_0018177|http://purl.obolibrary.org/obo/MONDO_0020690 |
| T3 | 1855-1868 | Disease | denotes | hyperglycemia | http://purl.obolibrary.org/obo/MONDO_0002909 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 1338-1350 | Phenotype | denotes | glioblastoma | HP:0012174 |
| T2 | 1855-1868 | Phenotype | denotes | hyperglycemia | HP:0003074 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 8-16 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T2 | 206-214 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T3 | 1404-1412 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 8-16 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T2 | 206-214 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T3 | 1404-1412 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 1338-1350 | Phenotype | denotes | glioblastoma | HP:0012174 |
| T2 | 1855-1868 | Phenotype | denotes | hyperglycemia | HP:0003074 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1338-1350 | Disease | denotes | glioblastoma | http://purl.obolibrary.org/obo/MONDO_0018177|http://purl.obolibrary.org/obo/MONDO_0020690 |
| T3 | 1855-1868 | Disease | denotes | hyperglycemia | http://purl.obolibrary.org/obo/MONDO_0002909 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 166-173 | Body_part | denotes | cytosol | http://purl.obolibrary.org/obo/GO_0005829 |
| T2 | 175-182 | Body_part | denotes | nucleus | http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-77 | Sentence | denotes | Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass. |
| T2 | 78-201 | Sentence | denotes | O-GlcNAcylation is a prevalent form of glycosylation that regulates proteins within the cytosol, nucleus, and mitochondria. |
| T3 | 202-307 | Sentence | denotes | The O-GlcNAc modification can affect protein cellular localization, function, and signaling interactions. |
| T4 | 308-405 | Sentence | denotes | The specific impact of O-GlcNAcylation on mitochondrial morphology and function has been elusive. |
| T5 | 406-592 | Sentence | denotes | In this manuscript, the role of O-GlcNAcylation on mitochondrial fission, oxidative phosphorylation (Oxphos), and the activity of electron transport chain (ETC) complexes were evaluated. |
| T6 | 593-805 | Sentence | denotes | In a cellular environment with hyper O-GlcNAcylation due to the deletion of O-GlcNAcase (OGA), mitochondria showed a dramatic reduction in size and a corresponding increase in number and total mitochondrial mass. |
| T7 | 806-964 | Sentence | denotes | Because of the increased mitochondrial content, OGA knockout cells exhibited comparable coupled mitochondrial Oxphos and ATP levels when compared to WT cells. |
| T8 | 965-1179 | Sentence | denotes | However, we observed reduced protein levels for complex I and II when comparing normalized mitochondrial content and reduced linked activity for complexes I and III when examining individual ETC complex activities. |
| T9 | 1180-1357 | Sentence | denotes | In assessing mitochondrial fission, we observed increased amounts of O-GlcNAcylated dynamin-related protein 1 (Drp1) in cells genetically null for OGA and in glioblastoma cells. |
| T10 | 1358-1574 | Sentence | denotes | Individual regions of Drp1 were evaluated for O-GlcNAc modifications, and we found that this post-translational modification (PTM) was not limited to the previously characterized residues in the variable domain (VD). |
| T11 | 1575-1677 | Sentence | denotes | Additional modification sites are predicted in the GTPase domain, which may influence enzyme activity. |
| T12 | 1678-1869 | Sentence | denotes | Collectively, these results highlight the impact of O-GlcNAcylation on mitochondrial dynamics and ETC function and mimic the changes that may occur during glucose toxicity from hyperglycemia. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 8-16 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T2 | 206-214 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T3 | 1404-1412 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 8-16 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T2 | 206-214 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T3 | 1404-1412 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 166-173 | Body_part | denotes | cytosol | http://purl.obolibrary.org/obo/GO_0005829 |
| T2 | 175-182 | Body_part | denotes | nucleus | http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125 |