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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-117 Sentence denotes The nuclear receptor RORα preserves cardiomyocyte mitochondrial function by regulating caveolin-3-mediated mitophagy.
T2 118-231 Sentence denotes Preserving optimal mitochondrial function is critical in the heart, which is the most ATP-avid organ in the body.
T3 232-437 Sentence denotes Recently, we showed that global deficiency of the nuclear receptor RORα in the "staggerer" mouse exacerbates angiotensin II-induced cardiac hypertrophy and compromises cardiomyocyte mitochondrial function.
T4 438-525 Sentence denotes However, the mechanisms underlying these observations have not been defined previously.
T5 526-709 Sentence denotes Here, we used pharmacological and genetic gain- and loss-of-function tools to demonstrate that RORα regulates cardiomyocyte mitophagy to preserve mitochondrial abundance and function.
T6 710-880 Sentence denotes We found that cardiomyocyte mitochondria in staggerer mice with lack of functional RORα were less numerous and exhibited fewer mitophagy events than those in WT controls.
T7 881-1098 Sentence denotes The hearts of our novel cardiomyocyte-specific RORα KO mouse line demonstrated impaired contractile function, enhanced oxidative stress, increased apoptosis, and reduced autophagic flux relative to Cre(-) littermates.
T8 1099-1251 Sentence denotes We found that cardiomyocyte mitochondria in "staggerer" mice with lack of functional RORα were upregulated by hypoxia, a classical inducer of mitophagy.
T9 1252-1390 Sentence denotes The loss of RORα blunted mitophagy and broadly compromised mitochondrial function in normoxic and hypoxic conditions in vivo and in vitro.
T10 1391-1598 Sentence denotes We also show that RORα is a direct transcriptional regulator of the mitophagy mediator caveolin-3 in cardiomyocytes and that enhanced expression of RORα increases caveolin-3 abundance and enhances mitophagy.
T11 1599-1782 Sentence denotes Finally, knockdown of RORα impairs cardiomyocyte mitophagy, compromises mitochondrial function, and induces apoptosis, but these defects could be rescued by caveolin-3 overexpression.
T12 1783-1991 Sentence denotes Collectively, these findings reveal a novel role for RORα in regulating mitophagy through caveolin-3 and expand our currently limited understanding of the mechanisms underlying RORα-mediated cardioprotection.
T1 0-117 Sentence denotes The nuclear receptor RORα preserves cardiomyocyte mitochondrial function by regulating caveolin-3-mediated mitophagy.
T2 118-231 Sentence denotes Preserving optimal mitochondrial function is critical in the heart, which is the most ATP-avid organ in the body.
T3 232-437 Sentence denotes Recently, we showed that global deficiency of the nuclear receptor RORα in the "staggerer" mouse exacerbates angiotensin II-induced cardiac hypertrophy and compromises cardiomyocyte mitochondrial function.
T4 438-525 Sentence denotes However, the mechanisms underlying these observations have not been defined previously.
T5 526-709 Sentence denotes Here, we used pharmacological and genetic gain- and loss-of-function tools to demonstrate that RORα regulates cardiomyocyte mitophagy to preserve mitochondrial abundance and function.
T6 710-880 Sentence denotes We found that cardiomyocyte mitochondria in staggerer mice with lack of functional RORα were less numerous and exhibited fewer mitophagy events than those in WT controls.
T7 881-1098 Sentence denotes The hearts of our novel cardiomyocyte-specific RORα KO mouse line demonstrated impaired contractile function, enhanced oxidative stress, increased apoptosis, and reduced autophagic flux relative to Cre(-) littermates.
T8 1099-1251 Sentence denotes We found that cardiomyocyte mitochondria in "staggerer" mice with lack of functional RORα were upregulated by hypoxia, a classical inducer of mitophagy.
T9 1252-1390 Sentence denotes The loss of RORα blunted mitophagy and broadly compromised mitochondrial function in normoxic and hypoxic conditions in vivo and in vitro.
T10 1391-1598 Sentence denotes We also show that RORα is a direct transcriptional regulator of the mitophagy mediator caveolin-3 in cardiomyocytes and that enhanced expression of RORα increases caveolin-3 abundance and enhances mitophagy.
T11 1599-1782 Sentence denotes Finally, knockdown of RORα impairs cardiomyocyte mitophagy, compromises mitochondrial function, and induces apoptosis, but these defects could be rescued by caveolin-3 overexpression.
T12 1783-1991 Sentence denotes Collectively, these findings reveal a novel role for RORα in regulating mitophagy through caveolin-3 and expand our currently limited understanding of the mechanisms underlying RORα-mediated cardioprotection.

GlyCosmos6-CLO

Id Subject Object Predicate Lexical cue
T1 36-49 http://purl.obolibrary.org/obo/CL_0000746 denotes cardiomyocyte
T2 323-328 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T3 400-413 http://purl.obolibrary.org/obo/CL_0000746 denotes cardiomyocyte
T4 636-649 http://purl.obolibrary.org/obo/CL_0000746 denotes cardiomyocyte
T5 724-737 http://purl.obolibrary.org/obo/CL_0000746 denotes cardiomyocyte
T6 905-918 http://purl.obolibrary.org/obo/CL_0000746 denotes cardiomyocyte
T7 936-941 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T8 1113-1126 http://purl.obolibrary.org/obo/CL_0000746 denotes cardiomyocyte
T9 1492-1506 http://purl.obolibrary.org/obo/CL_0000746 denotes cardiomyocytes
T10 1634-1647 http://purl.obolibrary.org/obo/CL_0000746 denotes cardiomyocyte

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 179-184 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T2 885-891 http://purl.obolibrary.org/obo/MAT_0000036 denotes hearts

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 323-328 OrganismTaxon denotes mouse NCBItxid:10088|NCBItxid:10090
T3 764-768 OrganismTaxon denotes mice NCBItxid:10088|NCBItxid:10095
T5 936-941 OrganismTaxon denotes mouse NCBItxid:10088|NCBItxid:10090
T7 1155-1159 OrganismTaxon denotes mice NCBItxid:10088|NCBItxid:10095