PubMed:3461217 JSONTXT

{"project":"bc5cdr-valid-experiment","denotations":[{"id":"T1","span":{"begin":28,"end":43},"obj":"Disease"},{"id":"T2","span":{"begin":85,"end":107},"obj":"Chemical"},{"id":"T3","span":{"begin":112,"end":124},"obj":"Chemical"},{"id":"T4","span":{"begin":201,"end":225},"obj":"Disease"},{"id":"T5","span":{"begin":227,"end":230},"obj":"Disease"},{"id":"T6","span":{"begin":258,"end":280},"obj":"Chemical"},{"id":"T7","span":{"begin":301,"end":324},"obj":"Chemical"},{"id":"T8","span":{"begin":327,"end":329},"obj":"Chemical"},{"id":"T9","span":{"begin":362,"end":367},"obj":"Disease"},{"id":"T10","span":{"begin":524,"end":526},"obj":"Disease"},{"id":"T11","span":{"begin":550,"end":552},"obj":"Chemical"},{"id":"T12","span":{"begin":567,"end":569},"obj":"Chemical"},{"id":"T13","span":{"begin":581,"end":586},"obj":"Disease"},{"id":"T14","span":{"begin":650,"end":665},"obj":"Disease"}],"text":"Production of autochthonous prostate cancer in Lobund-Wistar rats by treatments with N-nitroso-N-methylurea and testosterone.\nMore than 50% of Lobund-Wistar (L-W) strain rats developed large, palpable prostate adenocarcinomas (PAs) following treatments with N-nitroso-N-methylurea (CAS: 684-93-5) and testosterone propionate [(TP) CAS: 57-85-2], and most of the tumor-bearing rats manifested metastatic lesions. The incubation periods averaged 10.6 months. Within the same timeframe, no L-W rat developed a similar palpable PA when treated only with TP. In L-W rats, TP acted as a tumor enhancement agent, with primary emphasis on the development of prostate cancer."}