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PubMed:34298022 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-56 Sentence denotes Systemic Inflammation in Preclinical Ulcerative Colitis.
T2 57-75 Sentence denotes BACKGROUND & AIMS:
T3 76-125 Sentence denotes Preclinical ulcerative colitis is poorly defined.
T4 126-250 Sentence denotes We aimed to characterize the preclinical systemic inflammation in ulcerative colitis, using a comprehensive set of proteins.
T5 251-259 Sentence denotes METHODS:
T6 260-452 Sentence denotes We obtained plasma samples biobanked from individuals who developed ulcerative colitis later in life (n = 72) and matched healthy controls (n = 140) within a population-based screening cohort.
T7 453-535 Sentence denotes We measured 92 proteins related to inflammation using a proximity extension assay.
T8 536-690 Sentence denotes The biologic relevance of these findings was validated in an inception cohort of patients with ulcerative colitis (n = 101) and healthy controls (n = 50).
T9 691-902 Sentence denotes To examine the influence of genetic and environmental factors on these markers, a cohort of healthy twin siblings of patients with ulcerative colitis (n = 41) and matched healthy controls (n = 37) were explored.
T10 903-911 Sentence denotes RESULTS:
T11 912-1108 Sentence denotes Six proteins (MMP10, CXCL9, CCL11, SLAMF1, CXCL11 and MCP-1) were up-regulated (P < .05) in preclinical ulcerative colitis compared with controls based on both univariate and multivariable models.
T12 1109-1314 Sentence denotes Ingenuity Pathway Analyses identified several potential key regulators, including interleukin-1β, tumor necrosis factor, interferon-gamma, oncostatin M, nuclear factor-κB, interleukin-6, and interleukin-4.
T13 1315-1405 Sentence denotes For validation, we built a multivariable model to predict disease in the inception cohort.
T14 1406-1559 Sentence denotes The model discriminated treatment-naïve patients with ulcerative colitis from controls with leave-one-out cross-validation (area under the curve = 0.92).
T15 1560-1781 Sentence denotes Consistently, MMP10, CXCL9, CXCL11, and MCP-1, but not CCL11 and SLAMF1, were significantly up-regulated among the healthy twin siblings, even though their relative abundances seemed higher in incident ulcerative colitis.
T16 1782-1794 Sentence denotes CONCLUSIONS:
T17 1795-1898 Sentence denotes A set of inflammatory proteins are up-regulated several years before a diagnosis of ulcerative colitis.
T18 1899-2070 Sentence denotes These proteins were highly predictive of an ulcerative colitis diagnosis, and some seemed to be up-regulated already at exposure to genetic and environmental risk factors.
T1 0-56 Sentence denotes Systemic Inflammation in Preclinical Ulcerative Colitis.
T2 57-75 Sentence denotes BACKGROUND & AIMS:
T3 76-125 Sentence denotes Preclinical ulcerative colitis is poorly defined.
T4 126-250 Sentence denotes We aimed to characterize the preclinical systemic inflammation in ulcerative colitis, using a comprehensive set of proteins.
T5 251-259 Sentence denotes METHODS:
T6 260-452 Sentence denotes We obtained plasma samples biobanked from individuals who developed ulcerative colitis later in life (n = 72) and matched healthy controls (n = 140) within a population-based screening cohort.
T7 453-535 Sentence denotes We measured 92 proteins related to inflammation using a proximity extension assay.
T8 536-690 Sentence denotes The biologic relevance of these findings was validated in an inception cohort of patients with ulcerative colitis (n = 101) and healthy controls (n = 50).
T9 691-902 Sentence denotes To examine the influence of genetic and environmental factors on these markers, a cohort of healthy twin siblings of patients with ulcerative colitis (n = 41) and matched healthy controls (n = 37) were explored.
T10 903-911 Sentence denotes RESULTS:
T11 912-1108 Sentence denotes Six proteins (MMP10, CXCL9, CCL11, SLAMF1, CXCL11 and MCP-1) were up-regulated (P < .05) in preclinical ulcerative colitis compared with controls based on both univariate and multivariable models.
T12 1109-1314 Sentence denotes Ingenuity Pathway Analyses identified several potential key regulators, including interleukin-1β, tumor necrosis factor, interferon-gamma, oncostatin M, nuclear factor-κB, interleukin-6, and interleukin-4.
T13 1315-1405 Sentence denotes For validation, we built a multivariable model to predict disease in the inception cohort.
T14 1406-1559 Sentence denotes The model discriminated treatment-naïve patients with ulcerative colitis from controls with leave-one-out cross-validation (area under the curve = 0.92).
T15 1560-1781 Sentence denotes Consistently, MMP10, CXCL9, CXCL11, and MCP-1, but not CCL11 and SLAMF1, were significantly up-regulated among the healthy twin siblings, even though their relative abundances seemed higher in incident ulcerative colitis.
T16 1782-1794 Sentence denotes CONCLUSIONS:
T17 1795-1898 Sentence denotes A set of inflammatory proteins are up-regulated several years before a diagnosis of ulcerative colitis.
T18 1899-2070 Sentence denotes These proteins were highly predictive of an ulcerative colitis diagnosis, and some seemed to be up-regulated already at exposure to genetic and environmental risk factors.