PubMed:34146542
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 458-466 | Glycan_Motif | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-107 | Sentence | denotes | Trefoil factor 2 secreted from damaged hepatocytes activates hepatic stellate cells to induce fibrogenesis. |
| T2 | 108-176 | Sentence | denotes | Liver fibrosis is a common characteristic of chronic liver diseases. |
| T3 | 177-387 | Sentence | denotes | The activation of hepatic stellate cells (HSCs) plays a key role in fibrogenesis in response to liver injury, yet the mechanism by which damaged hepatocytes modulate the activation of HSCs is poorly understood. |
| T4 | 388-541 | Sentence | denotes | Our previous studies have established that liver-specific deletion of O-GlcNAc transferase (OGT)leads to hepatocyte necroptosis and spontaneous fibrosis. |
| T5 | 542-683 | Sentence | denotes | Here, we report that OGT-deficient hepatocytes secrete trefoil factor 2 (TFF2) that activates HSCs and contributes to the fibrogenic process. |
| T6 | 684-788 | Sentence | denotes | The expression and secretion of TFF2 are induced in OGT-deficient hepatocytes but not in WT hepatocytes. |
| T7 | 789-933 | Sentence | denotes | TFF2 activates the platelet-derived growth factor receptor beta signaling pathway that promotes the proliferation and migration of primary HSCs. |
| T8 | 934-1025 | Sentence | denotes | TFF2 protein expression is elevated in mice with carbon tetrachloride-induced liver injury. |
| T9 | 1026-1219 | Sentence | denotes | These findings identify TFF2 as a novel factor that mediates intercellular signaling between hepatocytes and HSCs and suggest a role of the hepatic OGT-TFF2 axis in the process of fibrogenesis. |
| T1 | 0-107 | Sentence | denotes | Trefoil factor 2 secreted from damaged hepatocytes activates hepatic stellate cells to induce fibrogenesis. |
| T2 | 108-176 | Sentence | denotes | Liver fibrosis is a common characteristic of chronic liver diseases. |
| T3 | 177-387 | Sentence | denotes | The activation of hepatic stellate cells (HSCs) plays a key role in fibrogenesis in response to liver injury, yet the mechanism by which damaged hepatocytes modulate the activation of HSCs is poorly understood. |
| T4 | 388-541 | Sentence | denotes | Our previous studies have established that liver-specific deletion of O-GlcNAc transferase (OGT)leads to hepatocyte necroptosis and spontaneous fibrosis. |
| T5 | 542-683 | Sentence | denotes | Here, we report that OGT-deficient hepatocytes secrete trefoil factor 2 (TFF2) that activates HSCs and contributes to the fibrogenic process. |
| T6 | 684-788 | Sentence | denotes | The expression and secretion of TFF2 are induced in OGT-deficient hepatocytes but not in WT hepatocytes. |
| T7 | 789-933 | Sentence | denotes | TFF2 activates the platelet-derived growth factor receptor beta signaling pathway that promotes the proliferation and migration of primary HSCs. |
| T8 | 934-1025 | Sentence | denotes | TFF2 protein expression is elevated in mice with carbon tetrachloride-induced liver injury. |
| T9 | 1026-1219 | Sentence | denotes | These findings identify TFF2 as a novel factor that mediates intercellular signaling between hepatocytes and HSCs and suggest a role of the hepatic OGT-TFF2 axis in the process of fibrogenesis. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 108-113 | http://purl.obolibrary.org/obo/MAT_0000097 | denotes | Liver |
| T2 | 161-166 | http://purl.obolibrary.org/obo/MAT_0000097 | denotes | liver |
| T3 | 273-278 | http://purl.obolibrary.org/obo/MAT_0000097 | denotes | liver |
| T4 | 431-436 | http://purl.obolibrary.org/obo/MAT_0000097 | denotes | liver |
| T5 | 1012-1017 | http://purl.obolibrary.org/obo/MAT_0000097 | denotes | liver |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 458-466 | https://glytoucan.org/Structures/Glycans/G49108TO | denotes | O-GlcNAc |
| T2 | 458-466 | https://glytoucan.org/Structures/Glycans/G89565QL | denotes | O-GlcNAc |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 458-466 | http://www.glycoepitope.jp/epitopes/EP0004 | denotes | O-GlcNAc |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 161-175 | Disease | denotes | liver diseases | http://purl.obolibrary.org/obo/MONDO_0005154 |
| T2 | 279-285 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T3 | 1018-1024 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 108-122 | Phenotype | denotes | Liver fibrosis | HP:0001395 |
| T2 | 161-175 | Phenotype | denotes | liver diseases | HP:0001392 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 458-466 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 458-466 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 108-122 | Phenotype | denotes | Liver fibrosis | HP:0001395 |
| T2 | 161-175 | Phenotype | denotes | liver diseases | HP:0001392 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 161-175 | Disease | denotes | liver diseases | http://purl.obolibrary.org/obo/MONDO_0005154 |
| T2 | 279-285 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T3 | 1018-1024 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 973-977 | OrganismTaxon | denotes | mice | 10088 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 39-50 | Cell | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL:0000182 |
| T2 | 61-83 | Cell | denotes | hepatic stellate cells | http://purl.obolibrary.org/obo/CL:0000632 |
| T3 | 195-217 | Cell | denotes | hepatic stellate cells | http://purl.obolibrary.org/obo/CL:0000632 |
| T4 | 219-223 | Cell | denotes | HSCs | http://purl.obolibrary.org/obo/CL:0000632 |
| T5 | 322-333 | Cell | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL:0000182 |
| T6 | 361-365 | Cell | denotes | HSCs | http://purl.obolibrary.org/obo/CL:0000632 |
| T7 | 493-503 | Cell | denotes | hepatocyte | http://purl.obolibrary.org/obo/CL:0000182 |
| T8 | 577-588 | Cell | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL:0000182 |
| T9 | 636-640 | Cell | denotes | HSCs | http://purl.obolibrary.org/obo/CL:0000632 |
| T10 | 750-761 | Cell | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL:0000182 |
| T11 | 776-787 | Cell | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL:0000182 |
| T12 | 808-816 | Cell | denotes | platelet | http://purl.obolibrary.org/obo/CL:0000233 |
| T13 | 928-932 | Cell | denotes | HSCs | http://purl.obolibrary.org/obo/CL:0000632 |
| T14 | 1119-1130 | Cell | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL:0000182 |
| T15 | 1135-1139 | Cell | denotes | HSCs | http://purl.obolibrary.org/obo/CL:0000632 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 39-50 | Body_part | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL_0000182 |
| T2 | 61-83 | Body_part | denotes | hepatic stellate cells | http://purl.obolibrary.org/obo/CL_0000632 |
| T3 | 108-113 | Body_part | denotes | Liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T4 | 161-166 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T5 | 195-217 | Body_part | denotes | hepatic stellate cells | http://purl.obolibrary.org/obo/CL_0000632 |
| T6 | 219-223 | Body_part | denotes | HSCs | http://purl.obolibrary.org/obo/CL_0000632 |
| T7 | 273-278 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T8 | 322-333 | Body_part | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL_0000182 |
| T9 | 361-365 | Body_part | denotes | HSCs | http://purl.obolibrary.org/obo/CL_0000632 |
| T10 | 431-436 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T11 | 493-503 | Body_part | denotes | hepatocyte | http://purl.obolibrary.org/obo/CL_0000182 |
| T12 | 577-588 | Body_part | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL_0000182 |
| T13 | 636-640 | Body_part | denotes | HSCs | http://purl.obolibrary.org/obo/CL_0000632 |
| T14 | 750-761 | Body_part | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL_0000182 |
| T15 | 776-787 | Body_part | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL_0000182 |
| T16 | 808-816 | Body_part | denotes | platelet | http://purl.obolibrary.org/obo/CL_0000233 |
| T17 | 928-932 | Body_part | denotes | HSCs | http://purl.obolibrary.org/obo/CL_0000632 |
| T18 | 1012-1017 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T19 | 1119-1130 | Body_part | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL_0000182 |
| T20 | 1135-1139 | Body_part | denotes | HSCs | http://purl.obolibrary.org/obo/CL_0000632 |
| T21 | 1183-1187 | Body_part | denotes | axis | http://purl.obolibrary.org/obo/UBERON_0001093 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 108-113 | Body_part | denotes | Liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T2 | 161-166 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T3 | 273-278 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T4 | 431-436 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T5 | 1012-1017 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-107 | Sentence | denotes | Trefoil factor 2 secreted from damaged hepatocytes activates hepatic stellate cells to induce fibrogenesis. |
| T2 | 108-176 | Sentence | denotes | Liver fibrosis is a common characteristic of chronic liver diseases. |
| T3 | 177-387 | Sentence | denotes | The activation of hepatic stellate cells (HSCs) plays a key role in fibrogenesis in response to liver injury, yet the mechanism by which damaged hepatocytes modulate the activation of HSCs is poorly understood. |
| T4 | 388-541 | Sentence | denotes | Our previous studies have established that liver-specific deletion of O-GlcNAc transferase (OGT)leads to hepatocyte necroptosis and spontaneous fibrosis. |
| T5 | 542-683 | Sentence | denotes | Here, we report that OGT-deficient hepatocytes secrete trefoil factor 2 (TFF2) that activates HSCs and contributes to the fibrogenic process. |
| T6 | 684-788 | Sentence | denotes | The expression and secretion of TFF2 are induced in OGT-deficient hepatocytes but not in WT hepatocytes. |
| T7 | 789-933 | Sentence | denotes | TFF2 activates the platelet-derived growth factor receptor beta signaling pathway that promotes the proliferation and migration of primary HSCs. |
| T8 | 934-1025 | Sentence | denotes | TFF2 protein expression is elevated in mice with carbon tetrachloride-induced liver injury. |
| T9 | 1026-1219 | Sentence | denotes | These findings identify TFF2 as a novel factor that mediates intercellular signaling between hepatocytes and HSCs and suggest a role of the hepatic OGT-TFF2 axis in the process of fibrogenesis. |
| T1 | 0-107 | Sentence | denotes | Trefoil factor 2 secreted from damaged hepatocytes activates hepatic stellate cells to induce fibrogenesis. |
| T2 | 108-176 | Sentence | denotes | Liver fibrosis is a common characteristic of chronic liver diseases. |
| T3 | 177-387 | Sentence | denotes | The activation of hepatic stellate cells (HSCs) plays a key role in fibrogenesis in response to liver injury, yet the mechanism by which damaged hepatocytes modulate the activation of HSCs is poorly understood. |
| T4 | 388-541 | Sentence | denotes | Our previous studies have established that liver-specific deletion of O-GlcNAc transferase (OGT)leads to hepatocyte necroptosis and spontaneous fibrosis. |
| T5 | 542-683 | Sentence | denotes | Here, we report that OGT-deficient hepatocytes secrete trefoil factor 2 (TFF2) that activates HSCs and contributes to the fibrogenic process. |
| T6 | 684-788 | Sentence | denotes | The expression and secretion of TFF2 are induced in OGT-deficient hepatocytes but not in WT hepatocytes. |
| T7 | 789-933 | Sentence | denotes | TFF2 activates the platelet-derived growth factor receptor beta signaling pathway that promotes the proliferation and migration of primary HSCs. |
| T8 | 934-1025 | Sentence | denotes | TFF2 protein expression is elevated in mice with carbon tetrachloride-induced liver injury. |
| T9 | 1026-1219 | Sentence | denotes | These findings identify TFF2 as a novel factor that mediates intercellular signaling between hepatocytes and HSCs and suggest a role of the hepatic OGT-TFF2 axis in the process of fibrogenesis. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-107 | Sentence | denotes | Trefoil factor 2 secreted from damaged hepatocytes activates hepatic stellate cells to induce fibrogenesis. |
| T2 | 108-176 | Sentence | denotes | Liver fibrosis is a common characteristic of chronic liver diseases. |
| T3 | 177-387 | Sentence | denotes | The activation of hepatic stellate cells (HSCs) plays a key role in fibrogenesis in response to liver injury, yet the mechanism by which damaged hepatocytes modulate the activation of HSCs is poorly understood. |
| T4 | 388-541 | Sentence | denotes | Our previous studies have established that liver-specific deletion of O-GlcNAc transferase (OGT)leads to hepatocyte necroptosis and spontaneous fibrosis. |
| T5 | 542-683 | Sentence | denotes | Here, we report that OGT-deficient hepatocytes secrete trefoil factor 2 (TFF2) that activates HSCs and contributes to the fibrogenic process. |
| T6 | 684-788 | Sentence | denotes | The expression and secretion of TFF2 are induced in OGT-deficient hepatocytes but not in WT hepatocytes. |
| T7 | 789-933 | Sentence | denotes | TFF2 activates the platelet-derived growth factor receptor beta signaling pathway that promotes the proliferation and migration of primary HSCs. |
| T8 | 934-1025 | Sentence | denotes | TFF2 protein expression is elevated in mice with carbon tetrachloride-induced liver injury. |
| T9 | 1026-1219 | Sentence | denotes | These findings identify TFF2 as a novel factor that mediates intercellular signaling between hepatocytes and HSCs and suggest a role of the hepatic OGT-TFF2 axis in the process of fibrogenesis. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 458-466 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 458-466 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 973-977 | OrganismTaxon | denotes | mice | 10088 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 108-113 | Body_part | denotes | Liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T2 | 161-166 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T3 | 273-278 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T4 | 431-436 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T5 | 1012-1017 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 39-50 | Body_part | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL_0000182 |
| T2 | 61-83 | Body_part | denotes | hepatic stellate cells | http://purl.obolibrary.org/obo/CL_0000632 |
| T3 | 108-113 | Body_part | denotes | Liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T4 | 161-166 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T5 | 195-217 | Body_part | denotes | hepatic stellate cells | http://purl.obolibrary.org/obo/CL_0000632 |
| T6 | 219-223 | Body_part | denotes | HSCs | http://purl.obolibrary.org/obo/CL_0000632 |
| T7 | 273-278 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T8 | 322-333 | Body_part | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL_0000182 |
| T9 | 361-365 | Body_part | denotes | HSCs | http://purl.obolibrary.org/obo/CL_0000632 |
| T10 | 431-436 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T11 | 493-503 | Body_part | denotes | hepatocyte | http://purl.obolibrary.org/obo/CL_0000182 |
| T12 | 577-588 | Body_part | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL_0000182 |
| T13 | 636-640 | Body_part | denotes | HSCs | http://purl.obolibrary.org/obo/CL_0000632 |
| T14 | 750-761 | Body_part | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL_0000182 |
| T15 | 776-787 | Body_part | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL_0000182 |
| T16 | 808-816 | Body_part | denotes | platelet | http://purl.obolibrary.org/obo/CL_0000233 |
| T17 | 928-932 | Body_part | denotes | HSCs | http://purl.obolibrary.org/obo/CL_0000632 |
| T18 | 1012-1017 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T19 | 1119-1130 | Body_part | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL_0000182 |
| T20 | 1135-1139 | Body_part | denotes | HSCs | http://purl.obolibrary.org/obo/CL_0000632 |
| T21 | 1183-1187 | Body_part | denotes | axis | http://purl.obolibrary.org/obo/UBERON_0001093 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 39-50 | Cell | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL:0000182 |
| T2 | 61-83 | Cell | denotes | hepatic stellate cells | http://purl.obolibrary.org/obo/CL:0000632 |
| T3 | 195-217 | Cell | denotes | hepatic stellate cells | http://purl.obolibrary.org/obo/CL:0000632 |
| T4 | 219-223 | Cell | denotes | HSCs | http://purl.obolibrary.org/obo/CL:0000632 |
| T5 | 322-333 | Cell | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL:0000182 |
| T6 | 361-365 | Cell | denotes | HSCs | http://purl.obolibrary.org/obo/CL:0000632 |
| T7 | 493-503 | Cell | denotes | hepatocyte | http://purl.obolibrary.org/obo/CL:0000182 |
| T8 | 577-588 | Cell | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL:0000182 |
| T9 | 636-640 | Cell | denotes | HSCs | http://purl.obolibrary.org/obo/CL:0000632 |
| T10 | 750-761 | Cell | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL:0000182 |
| T11 | 776-787 | Cell | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL:0000182 |
| T12 | 808-816 | Cell | denotes | platelet | http://purl.obolibrary.org/obo/CL:0000233 |
| T13 | 928-932 | Cell | denotes | HSCs | http://purl.obolibrary.org/obo/CL:0000632 |
| T14 | 1119-1130 | Cell | denotes | hepatocytes | http://purl.obolibrary.org/obo/CL:0000182 |
| T15 | 1135-1139 | Cell | denotes | HSCs | http://purl.obolibrary.org/obo/CL:0000632 |