> top > docs > PubMed:34047722 > annotations

PubMed:34047722 JSONTXT

Annnotations TAB JSON ListView MergeView

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-132 Sentence denotes Early Goal-Directed Therapy With and Without Intermittent Superior Vena Cava Oxygen Saturation Monitoring in Pediatric Septic Shock:
T2 133-163 Sentence denotes A Randomized Controlled Trial.
T3 164-174 Sentence denotes OBJECTIVE:
T4 175-337 Sentence denotes To compare early goal-directed therapy (EGDT) 'with' and 'without' intermittent superior vena cava oxygen saturation (ScvO2) monitoring in pediatric septic shock.
T5 338-345 Sentence denotes DESIGN:
T6 346-385 Sentence denotes Open label randomized controlled trial.
T7 386-394 Sentence denotes SETTING:
T8 395-451 Sentence denotes Pediatric intensive care unit in a tertiary care center.
T9 452-465 Sentence denotes PARTICIPANTS:
T10 466-517 Sentence denotes Children aged 1 month to 12 year with septic shock.
T11 518-531 Sentence denotes INTERVENTION:
T12 532-668 Sentence denotes Patients not responding to fluid resuscitation (up to 40 mL/kg) were randomized to EGDT 'with' (n=59) and 'without' (n=61) ScvO2 groups.
T13 669-839 Sentence denotes Resuscitation was guided by ScvO2 monitoring at 1-hour, 3-hour, and later on six-hourly in the 'with' ScvO2 group, and by clinical variables in the 'without' ScvO2 group.
T14 840-848 Sentence denotes OUTCOME:
T15 849-896 Sentence denotes Primary outcome was all-cause 28-day mortality.
T16 897-1129 Sentence denotes Secondary outcomes were time to and proportion of patients achieving therapeutic endpoints (at 6 hours and PICU stay), need for organ supports, new organ dysfunction (at 24 hours and PICU stay), and length of PICU and hospital stay.
T17 1130-1138 Sentence denotes RESULTS:
T18 1139-1233 Sentence denotes The study was stopped after interim analysis due to lower mortality in the intervention group.
T19 1234-1409 Sentence denotes There was significantly lower all-cause 28-day mortality in EDGT with ScvO2 than without ScvO2 group [37.3% vs. 57.5%, adjusted hazard ratio 0.57, 95%CI 0.33 to 0.97, P=0.04].
T20 1410-1520 Sentence denotes Therapeutic endpoints were achieved early in 'with' ScvO2 group [mean (SD) 3.6 (1.6) vs. 4.2 (1.6) h, P=0.03].
T21 1521-1670 Sentence denotes Organ dysfunction by sequential organ assessment score during PICU stay was lower in 'with' ScvO2 group [median (IQR) 5 (2,11) vs. 8 (3,13); P=0.03].
T22 1671-1735 Sentence denotes There was no significant difference in other secondary outcomes.
T23 1736-1884 Sentence denotes CONCLUSIONS: EGDT with intermittent ScvO2 monitoring was associated with reduced mortality and improved organ dysfunction in pediatric septic shock.
T1 0-132 Sentence denotes Early Goal-Directed Therapy With and Without Intermittent Superior Vena Cava Oxygen Saturation Monitoring in Pediatric Septic Shock:
T2 133-163 Sentence denotes A Randomized Controlled Trial.
T3 164-174 Sentence denotes OBJECTIVE:
T4 175-337 Sentence denotes To compare early goal-directed therapy (EGDT) 'with' and 'without' intermittent superior vena cava oxygen saturation (ScvO2) monitoring in pediatric septic shock.
T5 338-345 Sentence denotes DESIGN:
T6 346-385 Sentence denotes Open label randomized controlled trial.
T7 386-394 Sentence denotes SETTING:
T8 395-451 Sentence denotes Pediatric intensive care unit in a tertiary care center.
T9 452-465 Sentence denotes PARTICIPANTS:
T10 466-517 Sentence denotes Children aged 1 month to 12 year with septic shock.
T11 518-531 Sentence denotes INTERVENTION:
T12 532-668 Sentence denotes Patients not responding to fluid resuscitation (up to 40 mL/kg) were randomized to EGDT 'with' (n=59) and 'without' (n=61) ScvO2 groups.
T13 669-839 Sentence denotes Resuscitation was guided by ScvO2 monitoring at 1-hour, 3-hour, and later on six-hourly in the 'with' ScvO2 group, and by clinical variables in the 'without' ScvO2 group.
T14 840-848 Sentence denotes OUTCOME:
T15 849-896 Sentence denotes Primary outcome was all-cause 28-day mortality.
T16 897-1129 Sentence denotes Secondary outcomes were time to and proportion of patients achieving therapeutic endpoints (at 6 hours and PICU stay), need for organ supports, new organ dysfunction (at 24 hours and PICU stay), and length of PICU and hospital stay.
T17 1130-1138 Sentence denotes RESULTS:
T18 1139-1233 Sentence denotes The study was stopped after interim analysis due to lower mortality in the intervention group.
T19 1234-1409 Sentence denotes There was significantly lower all-cause 28-day mortality in EDGT with ScvO2 than without ScvO2 group [37.3% vs. 57.5%, adjusted hazard ratio 0.57, 95%CI 0.33 to 0.97, P=0.04].
T20 1410-1520 Sentence denotes Therapeutic endpoints were achieved early in 'with' ScvO2 group [mean (SD) 3.6 (1.6) vs. 4.2 (1.6) h, P=0.03].
T21 1521-1670 Sentence denotes Organ dysfunction by sequential organ assessment score during PICU stay was lower in 'with' ScvO2 group [median (IQR) 5 (2,11) vs. 8 (3,13); P=0.03].
T22 1671-1735 Sentence denotes There was no significant difference in other secondary outcomes.
T23 1736-1884 Sentence denotes CONCLUSIONS: EGDT with intermittent ScvO2 monitoring was associated with reduced mortality and improved organ dysfunction in pediatric septic shock.

chenxin_473849_800_3

Id Subject Object Predicate Lexical cue
T1 504-516 DP denotes septic shock
T2 324-336 DP denotes septic shock
T3 1871-1883 DP denotes septic shock
T4 119-131 DP denotes Septic Shock

yangbin123xm_800_3

Id Subject Object Predicate Lexical cue
T1 119-131 DP denotes Septic Shock
T2 324-336 DP denotes septic shock
T3 504-516 DP denotes septic shock
T4 1871-1883 DP denotes septic shock