PubMed:34035403
Annnotations
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 79-99 | Phenotype | denotes | renal cell carcinoma | HP:0005584 |
| T2 | 101-121 | Phenotype | denotes | Renal cell carcinoma | HP:0005584 |
| T3 | 123-126 | Phenotype | denotes | RCC | HP:0005584 |
| T4 | 305-310 | Phenotype | denotes | tumor | HP:0002664 |
| T5 | 492-495 | Phenotype | denotes | RCC | HP:0005584 |
| T6 | 827-830 | Phenotype | denotes | RCC | HP:0005584 |
| T7 | 910-913 | Phenotype | denotes | RCC | HP:0005584 |
| T8 | 973-976 | Phenotype | denotes | RCC | HP:0005584 |
| T9 | 997-1000 | Phenotype | denotes | RCC | HP:0005584 |
| T10 | 1193-1196 | Phenotype | denotes | RCC | HP:0005584 |
| T11 | 1662-1665 | Phenotype | denotes | RCC | HP:0005584 |
| T12 | 1685-1688 | Phenotype | denotes | RCC | HP:0005584 |
| T13 | 1805-1808 | Phenotype | denotes | RCC | HP:0005584 |
| T14 | 1890-1893 | Phenotype | denotes | RCC | HP:0005584 |
| T15 | 2001-2004 | Phenotype | denotes | RCC | HP:0005584 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 79-99 | Disease | denotes | renal cell carcinoma | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549 |
| T3 | 101-121 | Disease | denotes | Renal cell carcinoma | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549 |
| T5 | 123-126 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
| T9 | 305-310 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T10 | 492-495 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
| T14 | 827-830 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
| T18 | 910-913 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
| T22 | 973-976 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
| T26 | 997-1000 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
| T30 | 1193-1196 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
| T34 | 1662-1665 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
| T38 | 1685-1688 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
| T42 | 1805-1808 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
| T46 | 1890-1893 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
| T50 | 2001-2004 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 24-42 | Glycan | denotes | galactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 24-42 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | galactosylceramide | http://www.glycoepitope.jp/epitopes/EP0074 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 79-99 | Phenotype | denotes | renal cell carcinoma | HP:0005584 |
| T2 | 101-121 | Phenotype | denotes | Renal cell carcinoma | HP:0005584 |
| T3 | 123-126 | Phenotype | denotes | RCC | HP:0005584 |
| T4 | 305-310 | Phenotype | denotes | tumor | HP:0002664 |
| T5 | 492-495 | Phenotype | denotes | RCC | HP:0005584 |
| T6 | 827-830 | Phenotype | denotes | RCC | HP:0005584 |
| T7 | 910-913 | Phenotype | denotes | RCC | HP:0005584 |
| T8 | 973-976 | Phenotype | denotes | RCC | HP:0005584 |
| T9 | 997-1000 | Phenotype | denotes | RCC | HP:0005584 |
| T10 | 1193-1196 | Phenotype | denotes | RCC | HP:0005584 |
| T11 | 1662-1665 | Phenotype | denotes | RCC | HP:0005584 |
| T12 | 1685-1688 | Phenotype | denotes | RCC | HP:0005584 |
| T13 | 1805-1808 | Phenotype | denotes | RCC | HP:0005584 |
| T14 | 1890-1893 | Phenotype | denotes | RCC | HP:0005584 |
| T15 | 2001-2004 | Phenotype | denotes | RCC | HP:0005584 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 79-99 | Disease | denotes | renal cell carcinoma | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549 |
| T3 | 101-121 | Disease | denotes | Renal cell carcinoma | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549 |
| T5 | 123-126 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
| T9 | 305-310 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T10 | 492-495 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
| T14 | 827-830 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
| T18 | 910-913 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
| T22 | 973-976 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
| T26 | 997-1000 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
| T30 | 1193-1196 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
| T34 | 1662-1665 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
| T38 | 1685-1688 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
| T42 | 1805-1808 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
| T46 | 1890-1893 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
| T50 | 2001-2004 | Disease | denotes | RCC | http://purl.obolibrary.org/obo/MONDO_0005086|http://purl.obolibrary.org/obo/MONDO_0005549|http://purl.obolibrary.org/obo/MONDO_0007763|http://purl.obolibrary.org/obo/MONDO_0044874 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 73-78 | OrganismTaxon | denotes | human | 9606 |
| T2 | 831-838 | OrganismTaxon | denotes | patient | 9606 |
| T3 | 1884-1889 | OrganismTaxon | denotes | human | 9606 |
| T4 | 1970-1979 | OrganismTaxon | denotes | prominent | 37571 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-100 | Sentence | denotes | The prognostic value of galactosylceramide-sulfotransferase (Gal3ST1) in human renal cell carcinoma. |
| T2 | 101-270 | Sentence | denotes | Renal cell carcinoma (RCC) is the deadliest primary genitourinary malignancy typically associated with asymptomatic initial presentation and poorly predictable survival. |
| T3 | 271-379 | Sentence | denotes | Next to established risk factors, tumor microenvironment may alter metastatic capacity and immune landscape. |
| T4 | 380-537 | Sentence | denotes | Due to their high concentrations, sulfoglycolipids (sulfatides) were among the first well-described antigens in RCC that are associated with worse prognosis. |
| T5 | 538-702 | Sentence | denotes | As sulfatide detection in routine diagnostics is not possible, we aimed to test the prognostic value of its protein counterpart, sulfatide-producing enzyme Gal3ST1. |
| T6 | 703-846 | Sentence | denotes | We performed retrospective long-term follow up analysis of Gal3ST1 expression as prognostic risk factor in a representative RCC patient cohort. |
| T7 | 847-1013 | Sentence | denotes | We observed differentially regulated Gal3ST1 expression in all RCC types, being significantly more associated with clear cell RCC than to chromophobe RCC (p = 0.001). |
| T8 | 1014-1197 | Sentence | denotes | Surprisingly, in contrast to published observations from in vitro models, we could not confirm an association between Gal3ST1 expression and a malignant clinical behaviour of the RCC. |
| T9 | 1198-1298 | Sentence | denotes | In our cohort, Gal3ST1 did not significantly influence progression-free survival (Hazard Ratio (HR): |
| T10 | 1299-1332 | Sentence | denotes | 1.7 95% CI (0.6-4.9), p = 0.327). |
| T11 | 1333-1504 | Sentence | denotes | Particularly after adjusting for histology, T-stage, N-status and M-status at baseline, we observed no independent prognostic effect (HR = 1.0 95% CI (0.3-3.3), p = 0.96). |
| T12 | 1505-1599 | Sentence | denotes | The analysis of Gal3ST1 mRNA expression in a TCGA dataset supported the results of our cohort. |
| T13 | 1600-1809 | Sentence | denotes | Thus, Gal3ST1 might help to differentiate between chromophobe RCC and other frequent RCC entities but-despite previously published data from cell culture models-does not qualify as a prognostic marker for RCC. |
| T14 | 1810-2017 | Sentence | denotes | Further investigation of regulatory mechanisms of sulfatide metabolism in human RCC microenvironment is necessary to understand the role of this quantitatively prominent glycosphingolipid in RCC progression. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 24-42 | Glycan | denotes | galactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 24-42 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | galactosylceramide | http://www.glycoepitope.jp/epitopes/EP0074 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 73-78 | OrganismTaxon | denotes | human | 9606 |
| T2 | 831-838 | OrganismTaxon | denotes | patient | 9606 |
| T3 | 1884-1889 | OrganismTaxon | denotes | human | 9606 |
| T4 | 1970-1979 | OrganismTaxon | denotes | prominent | 37571 |