PubMed:34013615 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/34013615","sourcedb":"PubMed","sourceid":"34013615","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/34013615","text":"Green-light laser en bloc resection versus conventional transurethral resection for initial non-muscle-invasive bladder cancer: A randomized controlled trial.\nOBJECTIVE: To compare the safety and outcomes between green-light laser en bloc resection and transurethral resection of bladder tumor.\nMETHODS: A single-center, randomized controlled trial was carried out from August 2014 to September 2018. Patients with initial non-muscle-invasive bladder cancer were randomized to green-light laser en bloc resection or transurethral resection of bladder tumor. The primary outcomes were pathological findings and perioperative events. The secondary outcome was tumor recurrence.\nRESULTS: A total of 233 patients were randomized to the transurethral resection of bladder tumor group (117 patients) and the green-light laser en bloc resection group (116 patients). The resection time was longer in the green-light laser en bloc resection group (P = 0.022); however, no differences were identified in overall operative time (P = 0.255). Nine patients (7.7%) had an obturator nerve reflex during transurethral resection of bladder tumor. The estimated volume of blood loss was significantly lower in the green-light laser en bloc resection group (P = 0.012). The green-light laser en bloc resection group had a higher rate of T1 bladder cancer (P = 0.031). A total of 104 patients (89.7%) treated with green-light laser en bloc resection had detrusor muscle presence in the specimen, whereas 37 (31.9%) patients had the presence of muscularis mucosae, which was significantly higher than the corresponding number of transurethral resection of bladder tumor patients (P = 0.005 and 0.002, respectively). After a median follow-up period of 48 months, just five patients had tumor recurrence (three in the transurethral resection of bladder tumor group and two in the green-light laser en bloc resection group), and there was no difference between these two groups.\nCONCLUSIONS: Compared with transurethral resection of bladder tumor, green-light laser en bloc resection is more effective due to less obturator nerve reflex and the same recurrence rate. Most importantly, green-light laser en bloc resection can provide better tumor specimens for pathological examinations.","tracks":[{"project":"maxiaofeng52_800_3","denotations":[{"id":"T1","span":{"begin":112,"end":126},"obj":"DP"},{"id":"T2","span":{"begin":443,"end":457},"obj":"DP"},{"id":"T3","span":{"begin":1322,"end":1336},"obj":"DP"},{"id":"T4","span":{"begin":543,"end":556},"obj":"DP"},{"id":"T5","span":{"begin":280,"end":293},"obj":"DP"},{"id":"T6","span":{"begin":759,"end":772},"obj":"DP"},{"id":"T7","span":{"begin":1116,"end":1129},"obj":"DP"},{"id":"T8","span":{"begin":1636,"end":1649},"obj":"DP"},{"id":"T9","span":{"begin":1823,"end":1836},"obj":"DP"},{"id":"T10","span":{"begin":2010,"end":2023},"obj":"DP"}],"attributes":[{"subj":"T1","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T2","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T3","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T4","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T5","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T6","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T7","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T8","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T9","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T10","pred":"source","obj":"maxiaofeng52_800_3"}]},{"project":"wangzhuo19_800_3","denotations":[{"id":"T1","span":{"begin":759,"end":772},"obj":"DP"},{"id":"T2","span":{"begin":280,"end":293},"obj":"DP"},{"id":"T3","span":{"begin":543,"end":556},"obj":"DP"},{"id":"T4","span":{"begin":1116,"end":1129},"obj":"DP"},{"id":"T5","span":{"begin":1636,"end":1649},"obj":"DP"},{"id":"T6","span":{"begin":1823,"end":1836},"obj":"DP"},{"id":"T7","span":{"begin":2010,"end":2023},"obj":"DP"},{"id":"T8","span":{"begin":112,"end":126},"obj":"DP"},{"id":"T9","span":{"begin":443,"end":457},"obj":"DP"},{"id":"T10","span":{"begin":1322,"end":1336},"obj":"DP"}],"attributes":[{"subj":"T1","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T2","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T3","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T4","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T5","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T6","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T7","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T8","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T9","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T10","pred":"source","obj":"wangzhuo19_800_3"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"maxiaofeng52_800_3","color":"#eca593","default":true},{"id":"wangzhuo19_800_3","color":"#939bec"}]}]}}