PubMed:33888837
Annnotations
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 188-205 | Disease | denotes | bacterial disease | http://purl.obolibrary.org/obo/MONDO_0005113 |
| T2 | 606-615 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 782-788 | Glycan | denotes | chitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 782-788 | Glycan | denotes | chitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 1220-1236 | Cell | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL:0000066 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 188-205 | Disease | denotes | bacterial disease | MONDO:0005113 |
| T2 | 606-615 | Disease | denotes | infection | MONDO:0005550 |
GlyCosmos15-Taxon
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 86-109 | Organism | denotes | Melissococcus plutonius | 33970 |
| T2 | 153-176 | Organism | denotes | Melissococcus plutonius | 33970 |
| T3 | 336-339 | Organism | denotes | bee | 34735|7460 |
| T5 | 1306-1309 | Organism | denotes | bee | 34735|7460 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 209-214 | Body_part | denotes | honey | http://purl.obolibrary.org/obo/UBERON_0036016 |
| T2 | 442-448 | Body_part | denotes | midgut | http://purl.obolibrary.org/obo/UBERON_0001045 |
| T3 | 476-479 | Body_part | denotes | sac | http://purl.obolibrary.org/obo/UBERON_0009856 |
| T4 | 533-550 | Body_part | denotes | midgut epithelium | http://purl.obolibrary.org/obo/UBERON_0003352 |
| T5 | 678-695 | Body_part | denotes | midgut epithelium | http://purl.obolibrary.org/obo/UBERON_0003352 |
| T6 | 1185-1188 | Body_part | denotes | sac | http://purl.obolibrary.org/obo/UBERON_0009856 |
| T7 | 1213-1219 | Body_part | denotes | midgut | http://purl.obolibrary.org/obo/UBERON_0001045 |
| T8 | 1220-1236 | Body_part | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL_0000066 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-117 | Sentence | denotes | Peritrophic matrix-degrading proteins are dispensable virulence factors in a virulent Melissococcus plutonius strain. |
| T2 | 118-220 | Sentence | denotes | European foulbrood (EFB) caused by Melissococcus plutonius is a major bacterial disease of honey bees. |
| T3 | 221-332 | Sentence | denotes | Strains of the causative agent exhibit genetic heterogeneity, and the degree of virulence varies among strains. |
| T4 | 333-551 | Sentence | denotes | In bee larvae orally infected with the highly virulent strains, ingested bacterial cells colonize the larval midgut and proliferate within the sac of the peritrophic matrix (PM), a barrier lining the midgut epithelium. |
| T5 | 552-696 | Sentence | denotes | However, the barrier is degraded during the course of infection, and M. plutonius cells eventually directly interact with the midgut epithelium. |
| T6 | 697-1018 | Sentence | denotes | As M. plutonius possesses genes encoding putative PM-degrading proteins (enhancin, a chitin-binding domain-containing protein and endo-α-N-acetylgalactosaminidase), we constructed PM-degrading protein gene-knockout mutants from a highly virulent M. plutonius strain and investigated their role in the pathogenesis of EFB. |
| T7 | 1019-1199 | Sentence | denotes | In larvae infected with the triple-knockout mutant, which has no PM-degrading protein genes, M. plutonius that proliferated in the larval midguts was confined to the sac of the PM. |
| T8 | 1200-1515 | Sentence | denotes | However, the midgut epithelial cells degenerated over time, and the mutant killed approximately 70-80% of bee brood, suggesting that although the PM-degrading proteins are involved in the penetration of the PM by M. plutonius, they are not indispensable virulence factors in the highly virulent M. plutonius strain. |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 442-448 | Body_part | denotes | midgut | FMA:45617 |
| T2 | 533-539 | Body_part | denotes | midgut | FMA:45617 |
| T3 | 540-550 | Body_part | denotes | epithelium | FMA:9639 |
| T4 | 678-684 | Body_part | denotes | midgut | FMA:45617 |
| T5 | 685-695 | Body_part | denotes | epithelium | FMA:9639 |
| T6 | 1157-1164 | Body_part | denotes | midguts | FMA:45617 |
| T7 | 1213-1219 | Body_part | denotes | midgut | FMA:45617 |
| T8 | 1220-1236 | Body_part | denotes | epithelial cells | FMA:66768 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 422-430 | Body_part | denotes | colonize | http://purl.obolibrary.org/obo/MAT_0000526 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 86-109 | OrganismTaxon | denotes | Melissococcus plutonius | 33970 |
| T2 | 153-176 | OrganismTaxon | denotes | Melissococcus plutonius | 33970 |
| T3 | 336-339 | OrganismTaxon | denotes | bee | 34735|7460 |
| T5 | 1306-1309 | OrganismTaxon | denotes | bee | 34735|7460 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 422-430 | Body_part | denotes | colonize | http://purl.obolibrary.org/obo/MAT_0000526 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 209-214 | Body_part | denotes | honey | http://purl.obolibrary.org/obo/UBERON_0036016 |
| T2 | 442-448 | Body_part | denotes | midgut | http://purl.obolibrary.org/obo/UBERON_0001045 |
| T3 | 476-479 | Body_part | denotes | sac | http://purl.obolibrary.org/obo/UBERON_0009856 |
| T4 | 533-550 | Body_part | denotes | midgut epithelium | http://purl.obolibrary.org/obo/UBERON_0003352 |
| T5 | 678-695 | Body_part | denotes | midgut epithelium | http://purl.obolibrary.org/obo/UBERON_0003352 |
| T6 | 1185-1188 | Body_part | denotes | sac | http://purl.obolibrary.org/obo/UBERON_0009856 |
| T7 | 1213-1219 | Body_part | denotes | midgut | http://purl.obolibrary.org/obo/UBERON_0001045 |
| T8 | 1220-1236 | Body_part | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL_0000066 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 1220-1236 | Cell | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL:0000066 |