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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-205 Sentence denotes In vitro comparison of major memory-support dietary supplements for their effectiveness in reduction/inhibition of beta-amyloid protein fibrils and tau protein tangles: key primary targets for memory loss.
T2 206-434 Sentence denotes Memory loss is primarily caused by the accumulation of both brain plaques [(consisting of beta-amyloid protein (Aβ) 1-42)] and neurofibrillary tangles (consisting of paired helical and straight filaments containing tau protein).
T3 435-551 Sentence denotes Neuroinflammation is the third key and important factor that leads to accelerated memory loss and eventual dementia.
T4 552-726 Sentence denotes Brain plaques, tangles and inflammation is the trilogy mainly responsible for causing memory loss that has now been documented for over 20 years in the scientific literature.
T5 727-1055 Sentence denotes The present investigation used in vitro quantitative methods to directly compare the ability of major memory-support dietary supplements to reduce pre-formed Aβ 1-42 fibrils (21 supplements tested) and tau protein paired helical/straight filaments (13 supplements tested)-two of the three most important targets for memory loss.
T6 1056-1444 Sentence denotes Additionally, 18 different manufacturers of cat's claw (Uncaria tomentosa) were directly compared for their ability to inhibit/reduce Aβ 1-42 fibrils and/or tau paired helical/straight filaments based on recent findings that PTI-00703 cat's claw is a specific and potent inhibitor/reducer of all three targets -brain plaques, tangles and inflammation (Snow et al. in Sci Rep 9:561, 2019).
T7 1445-1660 Sentence denotes In the present investigation quantitative Thioflavin T fluorometry was used on a comparative weight-to-weight basis at increasing concentrations with ingredients tested from the actual capsules the consumer ingests.
T8 1661-1844 Sentence denotes Major memory-support dietary supplements were directly compared for their ability to inhibit and disaggregate/reduce both Aβ 1-42 fibrils and/or tau paired helical/straight filaments.
T9 1845-2267 Sentence denotes Dietary supplements touted to enhance memory comparatively tested included Prevagen, FOCUSfactor, PROCERA AVH, Alpha Brain, NAD+OVIM, BRAIN JUICE, Cebria, EXCELEROL, NOOCUBE, US Doctor's Clinical Brain Power ADVANCED, healthycell pro, LUMONOL, Brain Awake, BRAIN ARMOR, brainMD (BRAIN & MEMORY POWER BOOST), Brain Support, Clarity (BRAIN HEALTH FORMULA), brainMD (NEUROVITE PLUS), neuriva (Original and Plus) and percepta.
T10 2268-2419 Sentence denotes This is the first paper to actually comparatively test these memory-support supplements for their ability to reduce Aβ fibrils and tau protein tangles.
T11 2420-2784 Sentence denotes Percepta (PTI-00703 cat's claw and a specific oolong tea extract) was determined to be the most effective and potent memory support dietary supplement to disaggregate/disrupt Aβ 1-42 fibrils (range of 25-89%) and tau paired helical/straight filaments (range of 26-86%) at all 3-4 doses tested in comparison to other major memory-support dietary supplements tested.
T12 2785-2942 Sentence denotes This was at least more than double (> 50%) for percepta reducing Aβ 1-42 fibrils and in comparison to the other 20 memory-support dietary supplements tested.
T13 2943-3596 Sentence denotes The ranking order for memory-support supplement effects based on reducing Aβ 1-42 fibrils (Aβ 1-42: memory-support supplement at 1:0.1 weight-to-weight in a 3-day study) was percepta (69.6% reduction) >>> Alpha Brain (34.9% reduction) = US Doctor's Clinical Brain Power ADVANCED (32.4%) = BRAIN JUICE (30.1%) = neuriva Plus (27%) = neuriva Original (27%) > NEUROVITE PLUS (22.9%) = NOOCUBE (19.9%) = EXCELEROL (17.3%) = healthycell pro (17.2%) > Prevagen (12.9%) > PROCERA AVH (6.5%) = FOCUSfactor (5.5%) > Cebria (0%) = Brain Awake (0%) = Brain Support (0%) = brainMD (BRAIN & MEMORY POWER BOOST) (0%) = NAD+OVIM (0%) = BRAIN ARMOR (0%) = LUMONOL (0%).
T14 3597-4080 Sentence denotes The ranking order for memory support supplement effects on reducing tau paired helical/straight filaments (tau:memory supplement at 1:1 weight-to-weight at 3 days) was percepta (85.7% reduction) >>> neuriva Plus (57.9%) >> BRAIN JUICE (41.9%) = EXCELEROL (41.0%) = neuriva Original (38.4%) = US Doctor's Clinical Brain Power ADVANCED (38.3%) = healthycell pro (37.6%) >> Alpha Brain (27.9%) >> NOOCUBE (17.6%) >> FOCUSfactor (8.7%) > Cebria (3.6%) = PROCERA AVH (0%) = Prevagen (0%).
T15 4081-4258 Sentence denotes Congo red staining, Thioflavin S fluorescence, circular dichroism (CD) spectroscopy and electron microscopy confirmed the positive results observed with the supplement percepta.
T16 4259-4406 Sentence denotes CD spectroscopy demonstrated that percepta caused a marked inhibition of beta-sheet secondary folding of tau protein into paired helical filaments.
T17 4407-4657 Sentence denotes PTI-00703 cat's claw (main ingredient in percepta) was also identified as the most potent cat's claw bark powder (Uncaria tomentosa) to reduce and inhibit Aβ 1-42 fibrils and tau tangles in comparison to 17 other manufacturers of cat's claw extracts.
T18 4658-5000 Sentence denotes Although there are thousands of brain memory-support dietary supplements in the marketplace today, none of them have been directly compared and analyzed for their ability to reduce and/or inhibit two major targets of memory loss i.e. Aβ 1-42 fibrils and tau paired helical/straight filaments (major constituents of brain plaques and tangles).
T19 5001-5388 Sentence denotes In our comparison studies, we show that percepta has the most potent ability to disaggregate/reduce Aβ 1-42 fibrils and tau protein paired helical/straight filaments as demonstrated by a variety of methods most likely due to the specific polyphenol content in PTI-00703 cat's claw (i.e. polyphenols and proanthocyanidins) as we have previously shown (Snow et al. in Sci Rep 9:561, 2019).
T20 5389-5611 Sentence denotes Memory-support dietary supplements tested that also contained polyphenols and/or cat's claw in their product demonstrated some Aβ fibril and tau protein tangle reducing activity, but were much less effective than percepta.
T21 5612-5924 Sentence denotes Percepta's main ingredient, PTI-00703 cat's claw, has previously been shown to reduce brain amyloid plaques and Aβ 1-42/40 insoluble/soluble levels in brain (in plaque-producing transgenic mice) with marked concurrent memory improvements (shown by Morris water maze testing) (Snow et al. in Sci Rep 9:561, 2019).
T22 5925-6154 Sentence denotes The present investigation further confirms that percepta is one of the best dietary supplements that causes a marked reduction and inhibition of Aβ fibrils and tau tangle filaments -two important major targets for memory-support.
T23 6155-6434 Sentence denotes In addition, PTI-00703 cat's claw was the most effective cat's claw (Uncaria tomentosa) ingredient for reducing /disaggregating and inhibiting Aβ 1-42 fibrils and tau protein paired helical/straight filaments in comparison to 17 other manufacturers of cat's claw extracts tested.
T1 0-205 Sentence denotes In vitro comparison of major memory-support dietary supplements for their effectiveness in reduction/inhibition of beta-amyloid protein fibrils and tau protein tangles: key primary targets for memory loss.
T2 206-434 Sentence denotes Memory loss is primarily caused by the accumulation of both brain plaques [(consisting of beta-amyloid protein (Aβ) 1-42)] and neurofibrillary tangles (consisting of paired helical and straight filaments containing tau protein).
T3 435-551 Sentence denotes Neuroinflammation is the third key and important factor that leads to accelerated memory loss and eventual dementia.
T4 552-726 Sentence denotes Brain plaques, tangles and inflammation is the trilogy mainly responsible for causing memory loss that has now been documented for over 20 years in the scientific literature.
T5 727-1055 Sentence denotes The present investigation used in vitro quantitative methods to directly compare the ability of major memory-support dietary supplements to reduce pre-formed Aβ 1-42 fibrils (21 supplements tested) and tau protein paired helical/straight filaments (13 supplements tested)-two of the three most important targets for memory loss.
T6 1056-1444 Sentence denotes Additionally, 18 different manufacturers of cat's claw (Uncaria tomentosa) were directly compared for their ability to inhibit/reduce Aβ 1-42 fibrils and/or tau paired helical/straight filaments based on recent findings that PTI-00703 cat's claw is a specific and potent inhibitor/reducer of all three targets -brain plaques, tangles and inflammation (Snow et al. in Sci Rep 9:561, 2019).
T7 1445-1660 Sentence denotes In the present investigation quantitative Thioflavin T fluorometry was used on a comparative weight-to-weight basis at increasing concentrations with ingredients tested from the actual capsules the consumer ingests.
T8 1661-1844 Sentence denotes Major memory-support dietary supplements were directly compared for their ability to inhibit and disaggregate/reduce both Aβ 1-42 fibrils and/or tau paired helical/straight filaments.
T9 1845-2267 Sentence denotes Dietary supplements touted to enhance memory comparatively tested included Prevagen, FOCUSfactor, PROCERA AVH, Alpha Brain, NAD+OVIM, BRAIN JUICE, Cebria, EXCELEROL, NOOCUBE, US Doctor's Clinical Brain Power ADVANCED, healthycell pro, LUMONOL, Brain Awake, BRAIN ARMOR, brainMD (BRAIN & MEMORY POWER BOOST), Brain Support, Clarity (BRAIN HEALTH FORMULA), brainMD (NEUROVITE PLUS), neuriva (Original and Plus) and percepta.
T10 2268-2419 Sentence denotes This is the first paper to actually comparatively test these memory-support supplements for their ability to reduce Aβ fibrils and tau protein tangles.
T11 2420-2784 Sentence denotes Percepta (PTI-00703 cat's claw and a specific oolong tea extract) was determined to be the most effective and potent memory support dietary supplement to disaggregate/disrupt Aβ 1-42 fibrils (range of 25-89%) and tau paired helical/straight filaments (range of 26-86%) at all 3-4 doses tested in comparison to other major memory-support dietary supplements tested.
T12 2785-2942 Sentence denotes This was at least more than double (> 50%) for percepta reducing Aβ 1-42 fibrils and in comparison to the other 20 memory-support dietary supplements tested.
T13 2943-3596 Sentence denotes The ranking order for memory-support supplement effects based on reducing Aβ 1-42 fibrils (Aβ 1-42: memory-support supplement at 1:0.1 weight-to-weight in a 3-day study) was percepta (69.6% reduction) >>> Alpha Brain (34.9% reduction) = US Doctor's Clinical Brain Power ADVANCED (32.4%) = BRAIN JUICE (30.1%) = neuriva Plus (27%) = neuriva Original (27%) > NEUROVITE PLUS (22.9%) = NOOCUBE (19.9%) = EXCELEROL (17.3%) = healthycell pro (17.2%) > Prevagen (12.9%) > PROCERA AVH (6.5%) = FOCUSfactor (5.5%) > Cebria (0%) = Brain Awake (0%) = Brain Support (0%) = brainMD (BRAIN & MEMORY POWER BOOST) (0%) = NAD+OVIM (0%) = BRAIN ARMOR (0%) = LUMONOL (0%).
T14 3597-4080 Sentence denotes The ranking order for memory support supplement effects on reducing tau paired helical/straight filaments (tau:memory supplement at 1:1 weight-to-weight at 3 days) was percepta (85.7% reduction) >>> neuriva Plus (57.9%) >> BRAIN JUICE (41.9%) = EXCELEROL (41.0%) = neuriva Original (38.4%) = US Doctor's Clinical Brain Power ADVANCED (38.3%) = healthycell pro (37.6%) >> Alpha Brain (27.9%) >> NOOCUBE (17.6%) >> FOCUSfactor (8.7%) > Cebria (3.6%) = PROCERA AVH (0%) = Prevagen (0%).
T15 4081-4258 Sentence denotes Congo red staining, Thioflavin S fluorescence, circular dichroism (CD) spectroscopy and electron microscopy confirmed the positive results observed with the supplement percepta.
T16 4259-4406 Sentence denotes CD spectroscopy demonstrated that percepta caused a marked inhibition of beta-sheet secondary folding of tau protein into paired helical filaments.
T17 4407-4657 Sentence denotes PTI-00703 cat's claw (main ingredient in percepta) was also identified as the most potent cat's claw bark powder (Uncaria tomentosa) to reduce and inhibit Aβ 1-42 fibrils and tau tangles in comparison to 17 other manufacturers of cat's claw extracts.
T18 4658-5000 Sentence denotes Although there are thousands of brain memory-support dietary supplements in the marketplace today, none of them have been directly compared and analyzed for their ability to reduce and/or inhibit two major targets of memory loss i.e. Aβ 1-42 fibrils and tau paired helical/straight filaments (major constituents of brain plaques and tangles).
T19 5001-5388 Sentence denotes In our comparison studies, we show that percepta has the most potent ability to disaggregate/reduce Aβ 1-42 fibrils and tau protein paired helical/straight filaments as demonstrated by a variety of methods most likely due to the specific polyphenol content in PTI-00703 cat's claw (i.e. polyphenols and proanthocyanidins) as we have previously shown (Snow et al. in Sci Rep 9:561, 2019).
T20 5389-5611 Sentence denotes Memory-support dietary supplements tested that also contained polyphenols and/or cat's claw in their product demonstrated some Aβ fibril and tau protein tangle reducing activity, but were much less effective than percepta.
T21 5612-5924 Sentence denotes Percepta's main ingredient, PTI-00703 cat's claw, has previously been shown to reduce brain amyloid plaques and Aβ 1-42/40 insoluble/soluble levels in brain (in plaque-producing transgenic mice) with marked concurrent memory improvements (shown by Morris water maze testing) (Snow et al. in Sci Rep 9:561, 2019).
T22 5925-6154 Sentence denotes The present investigation further confirms that percepta is one of the best dietary supplements that causes a marked reduction and inhibition of Aβ fibrils and tau tangle filaments -two important major targets for memory-support.
T23 6155-6434 Sentence denotes In addition, PTI-00703 cat's claw was the most effective cat's claw (Uncaria tomentosa) ingredient for reducing /disaggregating and inhibiting Aβ 1-42 fibrils and tau protein paired helical/straight filaments in comparison to 17 other manufacturers of cat's claw extracts tested.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 120-127 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T2 301-308 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T3 435-452 Disease denotes Neuroinflammation http://purl.obolibrary.org/obo/MONDO_0004466
T4 542-550 Disease denotes dementia http://purl.obolibrary.org/obo/MONDO_0001627
T5 579-591 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T6 1394-1406 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T7 5704-5711 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 193-204 Phenotype denotes memory loss HP:0002354
T2 206-217 Phenotype denotes Memory loss HP:0002354
T3 333-356 Phenotype denotes neurofibrillary tangles HP:0002185
T4 435-452 Phenotype denotes Neuroinflammation HP:0033429
T5 517-528 Phenotype denotes memory loss HP:0002354
T6 542-550 Phenotype denotes dementia HP:0000726
T7 638-649 Phenotype denotes memory loss HP:0002354
T8 1043-1054 Phenotype denotes memory loss HP:0002354
T9 4381-4405 Phenotype denotes paired helical filaments HP:0002185
T10 4875-4886 Phenotype denotes memory loss HP:0002354

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1112-1129 OrganismTaxon denotes Uncaria tomentosa 128375
T2 4521-4538 OrganismTaxon denotes Uncaria tomentosa 128375
T3 5801-5805 OrganismTaxon denotes mice 10088
T4 6224-6241 OrganismTaxon denotes Uncaria tomentosa 128375

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 266-271 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T2 552-557 Body_part denotes Brain http://purl.obolibrary.org/obo/MAT_0000098
T3 1106-1110 Body_part denotes claw http://purl.obolibrary.org/obo/MAT_0000158
T4 1297-1301 Body_part denotes claw http://purl.obolibrary.org/obo/MAT_0000158
T5 1367-1372 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T6 1962-1967 Body_part denotes Brain http://purl.obolibrary.org/obo/MAT_0000098
T7 1979-1984 Body_part denotes BRAIN http://purl.obolibrary.org/obo/MAT_0000098
T8 2041-2046 Body_part denotes Brain http://purl.obolibrary.org/obo/MAT_0000098
T9 2089-2094 Body_part denotes Brain http://purl.obolibrary.org/obo/MAT_0000098
T10 2102-2107 Body_part denotes BRAIN http://purl.obolibrary.org/obo/MAT_0000098
T11 2124-2129 Body_part denotes BRAIN http://purl.obolibrary.org/obo/MAT_0000098
T12 2153-2158 Body_part denotes Brain http://purl.obolibrary.org/obo/MAT_0000098
T13 2177-2182 Body_part denotes BRAIN http://purl.obolibrary.org/obo/MAT_0000098
T14 2446-2450 Body_part denotes claw http://purl.obolibrary.org/obo/MAT_0000158
T15 3154-3159 Body_part denotes Brain http://purl.obolibrary.org/obo/MAT_0000098
T16 3201-3206 Body_part denotes Brain http://purl.obolibrary.org/obo/MAT_0000098
T17 3232-3237 Body_part denotes BRAIN http://purl.obolibrary.org/obo/MAT_0000098
T18 3464-3469 Body_part denotes Brain http://purl.obolibrary.org/obo/MAT_0000098
T19 3483-3488 Body_part denotes Brain http://purl.obolibrary.org/obo/MAT_0000098
T20 3513-3518 Body_part denotes BRAIN http://purl.obolibrary.org/obo/MAT_0000098
T21 3564-3569 Body_part denotes BRAIN http://purl.obolibrary.org/obo/MAT_0000098
T22 3820-3825 Body_part denotes BRAIN http://purl.obolibrary.org/obo/MAT_0000098
T23 3910-3915 Body_part denotes Brain http://purl.obolibrary.org/obo/MAT_0000098
T24 3974-3979 Body_part denotes Brain http://purl.obolibrary.org/obo/MAT_0000098
T25 4423-4427 Body_part denotes claw http://purl.obolibrary.org/obo/MAT_0000158
T26 4503-4507 Body_part denotes claw http://purl.obolibrary.org/obo/MAT_0000158
T27 4643-4647 Body_part denotes claw http://purl.obolibrary.org/obo/MAT_0000158
T28 4690-4695 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T29 4973-4978 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T30 5277-5281 Body_part denotes claw http://purl.obolibrary.org/obo/MAT_0000158
T31 5476-5480 Body_part denotes claw http://purl.obolibrary.org/obo/MAT_0000158
T32 5656-5660 Body_part denotes claw http://purl.obolibrary.org/obo/MAT_0000158
T33 5698-5703 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T34 5763-5768 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T35 6184-6188 Body_part denotes claw http://purl.obolibrary.org/obo/MAT_0000158
T36 6218-6222 Body_part denotes claw http://purl.obolibrary.org/obo/MAT_0000158
T37 6413-6417 Body_part denotes claw http://purl.obolibrary.org/obo/MAT_0000158

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 266-271 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T3 552-557 Body_part denotes Brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T5 1106-1110 Body_part denotes claw http://purl.obolibrary.org/obo/UBERON_0001705
T6 1297-1301 Body_part denotes claw http://purl.obolibrary.org/obo/UBERON_0001705
T7 1367-1372 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T9 1962-1967 Body_part denotes Brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T11 2041-2046 Body_part denotes Brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T13 2089-2094 Body_part denotes Brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T15 2153-2158 Body_part denotes Brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T17 2446-2450 Body_part denotes claw http://purl.obolibrary.org/obo/UBERON_0001705
T18 3154-3159 Body_part denotes Brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T20 3201-3206 Body_part denotes Brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T22 3464-3469 Body_part denotes Brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T24 3483-3488 Body_part denotes Brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T26 3910-3915 Body_part denotes Brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T28 3974-3979 Body_part denotes Brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T30 4423-4427 Body_part denotes claw http://purl.obolibrary.org/obo/UBERON_0001705
T31 4503-4507 Body_part denotes claw http://purl.obolibrary.org/obo/UBERON_0001705
T32 4643-4647 Body_part denotes claw http://purl.obolibrary.org/obo/UBERON_0001705
T33 4690-4695 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T35 4973-4978 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T37 5277-5281 Body_part denotes claw http://purl.obolibrary.org/obo/UBERON_0001705
T38 5476-5480 Body_part denotes claw http://purl.obolibrary.org/obo/UBERON_0001705
T39 5519-5525 Body_part denotes fibril http://purl.obolibrary.org/obo/GO_0099512
T40 5656-5660 Body_part denotes claw http://purl.obolibrary.org/obo/UBERON_0001705
T41 5698-5703 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T43 5763-5768 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T45 5773-5779 Body_part denotes plaque http://purl.obolibrary.org/obo/UBERON_0016482
T46 6184-6188 Body_part denotes claw http://purl.obolibrary.org/obo/UBERON_0001705
T47 6218-6222 Body_part denotes claw http://purl.obolibrary.org/obo/UBERON_0001705
T48 6413-6417 Body_part denotes claw http://purl.obolibrary.org/obo/UBERON_0001705