PubMed:33576494 / 574-912 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/33576494","sourcedb":"PubMed","sourceid":"33576494","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/33576494","text":"Here, we immunized cytidine monophosphate-N-acetylneuraminic acid hydroxylase and α1,3-galactosyl-transferase (GGTA1) double KO pigs with the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike receptor binding domain to produce glyco-humanized polyclonal neutralizing antibodies lacking Neu5Gc and α1,3-galactose epitopes.","tracks":[{"project":"LitCovid-sentences","denotations":[{"id":"T4","span":{"begin":0,"end":338},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T4","pred":"source","obj":"LitCovid-sentences"}]},{"project":"Covid19_manual_annotation_v2","denotations":[{"id":"T1","span":{"begin":142,"end":189},"obj":"Species"},{"id":"T19","span":{"begin":260,"end":270},"obj":"Type"},{"id":"T2","span":{"begin":191,"end":201},"obj":"Species"},{"id":"T21","span":{"begin":250,"end":259},"obj":"Type"},{"id":"T24","span":{"begin":244,"end":249},"obj":"Glycan"},{"id":"T25","span":{"begin":271,"end":294},"obj":"Gene"},{"id":"T30","span":{"begin":128,"end":132},"obj":"Species"},{"id":"T37","span":{"begin":111,"end":116},"obj":"Gene"},{"id":"T38","span":{"begin":19,"end":77},"obj":"Gene"},{"id":"T50","span":{"begin":303,"end":309},"obj":"Glycan"},{"id":"T53","span":{"begin":314,"end":328},"obj":"Glycan"},{"id":"T56","span":{"begin":329,"end":337},"obj":"Biological"},{"id":"T58","span":{"begin":203,"end":208},"obj":"Gene"},{"id":"T60","span":{"begin":209,"end":232},"obj":"Phenomena"},{"id":"T61","span":{"begin":9,"end":18},"obj":"Infection"},{"id":"T62","span":{"begin":125,"end":127},"obj":"Without"},{"id":"T63","span":{"begin":295,"end":302},"obj":"Without"},{"id":"T64","span":{"begin":236,"end":243},"obj":"PositiveRegulation"}],"relations":[{"id":"R40","pred":"of_a","subj":"T53","obj":"T56"},{"id":"R31","pred":"is_a","subj":"T1","obj":"T61"},{"id":"R32","pred":"is_a","subj":"T30","obj":"T62"},{"id":"R33","pred":"is_a","subj":"T62","obj":"T37"},{"id":"R34","pred":"is_a","subj":"T62","obj":"T38"},{"id":"R36","pred":"is_a","subj":"T64","obj":"T25"},{"id":"R37","pred":"is_a","subj":"T25","obj":"T63"},{"id":"R38","pred":"is_a","subj":"T63","obj":"T56"},{"id":"R39","pred":"of_a","subj":"T50","obj":"T56"},{"id":"R25","pred":"of_a","subj":"T19","obj":"T25"},{"id":"R26","pred":"of_a","subj":"T21","obj":"T25"},{"id":"R27","pred":"of_a","subj":"T24","obj":"T25"},{"id":"R28","pred":"abbreviation","subj":"T2","obj":"T1"},{"id":"R29","pred":"of_a","subj":"T58","obj":"T60"},{"id":"R30","pred":"to","subj":"T61","obj":"T30"},{"id":"R67","pred":"of_a","subj":"T1","obj":"T58"},{"id":"R68","pred":"cause_of","subj":"T61","obj":"T64"}],"attributes":[{"id":"A2","pred":"tao:has_database_id","subj":"T2","obj":"Tax:2697049"},{"id":"A39","pred":"tao:has_database_id","subj":"T53","obj":"https://glytoucan.org/Structures/Glycans/G09546QO"},{"id":"A18","pred":"tao:has_database_id","subj":"T25","obj":"MESH:D057134"},{"id":"A1","pred":"tao:has_database_id","subj":"T1","obj":"Tax:2697049"},{"id":"A21","pred":"tao:has_database_id","subj":"T30","obj":"Tax:9823"},{"id":"A26","pred":"tao:has_database_id","subj":"T37","obj":"Gene:396733"},{"id":"A54","pred":"Memo","subj":"T60","obj":"MESH:D000072417"},{"id":"A40","pred":"tao:has_database_id","subj":"T58","obj":"Gene:43740568"},{"id":"A17","pred":"tao:has_database_id","subj":"T24","obj":"MESH:D006031"},{"id":"A49","pred":"tao:has_database_id","subj":"T56","obj":"MESH:D000939"},{"id":"A27","pred":"tao:has_database_id","subj":"T38","obj":"Gene:396918"},{"id":"A36","pred":"tao:has_database_id","subj":"T50","obj":"https://glytoucan.org/Structures/Glycans/G43724HA"},{"id":"A63","pred":"tao:has_database_id","subj":"T50","obj":"MESH:D009438"},{"id":"A51","pred":"tao:has_database_id","subj":"T61","obj":"MESH:D012327"},{"subj":"T1","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T19","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T2","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T21","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T24","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T25","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T30","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T37","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T38","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T50","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T53","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T56","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T58","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T60","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T61","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T62","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T63","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T64","pred":"source","obj":"Covid19_manual_annotation_v2"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"BioProject","uri":"https://www.ncbi.nlm.nih.gov/bioproject/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"},{"prefix":"HP","uri":"https://hpo.jax.org/app/browse/term/HP:"},{"prefix":"BioSample","uri":"https://www.ncbi.nlm.nih.gov/biosample/"}]},{"project":"Zoonoses","denotations":[{"id":"T1","span":{"begin":142,"end":189},"obj":"Species"},{"id":"T19","span":{"begin":260,"end":270},"obj":"Type"},{"id":"T2","span":{"begin":191,"end":201},"obj":"Species"},{"id":"T21","span":{"begin":250,"end":259},"obj":"Type"},{"id":"T24","span":{"begin":244,"end":249},"obj":"Glycan"},{"id":"T25","span":{"begin":271,"end":294},"obj":"Gene"},{"id":"T30","span":{"begin":128,"end":132},"obj":"Species"},{"id":"T37","span":{"begin":111,"end":116},"obj":"Gene"},{"id":"T38","span":{"begin":19,"end":77},"obj":"Gene"},{"id":"T50","span":{"begin":303,"end":309},"obj":"Glycan"},{"id":"T53","span":{"begin":314,"end":328},"obj":"Glycan"},{"id":"T56","span":{"begin":329,"end":337},"obj":"Biological"},{"id":"T58","span":{"begin":203,"end":208},"obj":"Gene"},{"id":"T60","span":{"begin":209,"end":232},"obj":"Phenomena"},{"id":"T61","span":{"begin":9,"end":18},"obj":"Infection"},{"id":"T62","span":{"begin":125,"end":127},"obj":"Without"},{"id":"T63","span":{"begin":295,"end":302},"obj":"Without"},{"id":"T64","span":{"begin":236,"end":243},"obj":"PositiveRegulation"}],"relations":[{"id":"R25","pred":"of_a","subj":"T19","obj":"T25"},{"id":"R26","pred":"of_a","subj":"T21","obj":"T25"},{"id":"R27","pred":"of_a","subj":"T24","obj":"T25"},{"id":"R28","pred":"abbreviation","subj":"T2","obj":"T1"},{"id":"R29","pred":"of_a","subj":"T58","obj":"T60"},{"id":"R30","pred":"to","subj":"T61","obj":"T30"},{"id":"R31","pred":"is_a","subj":"T1","obj":"T61"},{"id":"R32","pred":"is_a","subj":"T30","obj":"T62"},{"id":"R33","pred":"is_a","subj":"T62","obj":"T37"},{"id":"R34","pred":"is_a","subj":"T62","obj":"T38"},{"id":"R36","pred":"is_a","subj":"T64","obj":"T25"},{"id":"R37","pred":"is_a","subj":"T25","obj":"T63"},{"id":"R38","pred":"is_a","subj":"T63","obj":"T56"},{"id":"R39","pred":"of_a","subj":"T50","obj":"T56"},{"id":"R40","pred":"of_a","subj":"T53","obj":"T56"},{"id":"R67","pred":"of_a","subj":"T1","obj":"T58"},{"id":"R68","pred":"cause_of","subj":"T61","obj":"T64"}],"attributes":[{"id":"A27","pred":"tao:has_database_id","subj":"T38","obj":"Gene:396918"},{"id":"A18","pred":"tao:has_database_id","subj":"T25","obj":"MESH:D057134"},{"id":"A2","pred":"tao:has_database_id","subj":"T2","obj":"Tax:2697049"},{"id":"A49","pred":"tao:has_database_id","subj":"T56","obj":"MESH:D000939"},{"id":"A17","pred":"tao:has_database_id","subj":"T24","obj":"MESH:D006031"},{"id":"A36","pred":"tao:has_database_id","subj":"T50","obj":"https://glytoucan.org/Structures/Glycans/G43724HA"},{"id":"A63","pred":"tao:has_database_id","subj":"T50","obj":"MESH:D009438"},{"id":"A21","pred":"tao:has_database_id","subj":"T30","obj":"Tax:9823"},{"id":"A26","pred":"tao:has_database_id","subj":"T37","obj":"Gene:396733"},{"id":"A51","pred":"tao:has_database_id","subj":"T61","obj":"MESH:D012327"},{"id":"A1","pred":"tao:has_database_id","subj":"T1","obj":"Tax:2697049"},{"id":"A40","pred":"tao:has_database_id","subj":"T58","obj":"Gene:43740568"},{"id":"A54","pred":"Memo","subj":"T60","obj":"MESH:D000072417"},{"id":"A39","pred":"tao:has_database_id","subj":"T53","obj":"https://glytoucan.org/Structures/Glycans/G09546QO"},{"subj":"T1","pred":"source","obj":"Zoonoses"},{"subj":"T19","pred":"source","obj":"Zoonoses"},{"subj":"T2","pred":"source","obj":"Zoonoses"},{"subj":"T21","pred":"source","obj":"Zoonoses"},{"subj":"T24","pred":"source","obj":"Zoonoses"},{"subj":"T25","pred":"source","obj":"Zoonoses"},{"subj":"T30","pred":"source","obj":"Zoonoses"},{"subj":"T37","pred":"source","obj":"Zoonoses"},{"subj":"T38","pred":"source","obj":"Zoonoses"},{"subj":"T50","pred":"source","obj":"Zoonoses"},{"subj":"T53","pred":"source","obj":"Zoonoses"},{"subj":"T56","pred":"source","obj":"Zoonoses"},{"subj":"T58","pred":"source","obj":"Zoonoses"},{"subj":"T60","pred":"source","obj":"Zoonoses"},{"subj":"T61","pred":"source","obj":"Zoonoses"},{"subj":"T62","pred":"source","obj":"Zoonoses"},{"subj":"T63","pred":"source","obj":"Zoonoses"},{"subj":"T64","pred":"source","obj":"Zoonoses"}]},{"project":"Inflammaging","denotations":[{"id":"T4","span":{"begin":0,"end":338},"obj":"Sentence"},{"id":"T4","span":{"begin":0,"end":338},"obj":"Sentence"}],"attributes":[{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"}]},{"project":"Covid19_manual_annotation","denotations":[{"id":"T1","span":{"begin":142,"end":189},"obj":"Species"},{"id":"T19","span":{"begin":260,"end":270},"obj":"Type"},{"id":"T2","span":{"begin":191,"end":201},"obj":"Species"},{"id":"T21","span":{"begin":250,"end":259},"obj":"Type"},{"id":"T24","span":{"begin":244,"end":249},"obj":"Modification"},{"id":"T25","span":{"begin":271,"end":294},"obj":"Biological"},{"id":"T30","span":{"begin":128,"end":132},"obj":"Species"},{"id":"T37","span":{"begin":111,"end":116},"obj":"Gene"},{"id":"T38","span":{"begin":19,"end":77},"obj":"Gene"},{"id":"T50","span":{"begin":303,"end":309},"obj":"Glycan"},{"id":"T53","span":{"begin":314,"end":328},"obj":"Glycan"},{"id":"T56","span":{"begin":329,"end":337},"obj":"Biological"},{"id":"T58","span":{"begin":203,"end":208},"obj":"Gene"},{"id":"T60","span":{"begin":209,"end":232},"obj":"Biological"},{"id":"T61","span":{"begin":9,"end":18},"obj":"Immunize"},{"id":"T62","span":{"begin":125,"end":127},"obj":"Without"},{"id":"T63","span":{"begin":295,"end":302},"obj":"Without"},{"id":"T64","span":{"begin":236,"end":243},"obj":"Produce"}],"relations":[{"id":"R25","pred":"of_a","subj":"T19","obj":"T25"},{"id":"R26","pred":"of_a","subj":"T21","obj":"T25"},{"id":"R27","pred":"of_a","subj":"T24","obj":"T25"},{"id":"R28","pred":"abbreviation","subj":"T2","obj":"T1"},{"id":"R29","pred":"of_a","subj":"T58","obj":"T60"},{"id":"R30","pred":"is_a","subj":"T61","obj":"T30"},{"id":"R31","pred":"against","subj":"T1","obj":"T61"},{"id":"R32","pred":"is_a","subj":"T30","obj":"T62"},{"id":"R33","pred":"is_a","subj":"T62","obj":"T37"},{"id":"R34","pred":"is_a","subj":"T62","obj":"T38"},{"id":"R35","pred":"is_a","subj":"T62","obj":"T64"},{"id":"R36","pred":"is_a","subj":"T64","obj":"T25"},{"id":"R37","pred":"is_a","subj":"T25","obj":"T63"},{"id":"R38","pred":"is_a","subj":"T63","obj":"T56"},{"id":"R39","pred":"of_a","subj":"T50","obj":"T56"},{"id":"R40","pred":"of_a","subj":"T53","obj":"T56"}],"attributes":[{"id":"A18","pred":"tao:has_database_id","subj":"T25","obj":"MESH:D057134"},{"id":"A40","pred":"tao:has_database_id","subj":"T58","obj":"Gene:43740568"},{"id":"A2","pred":"tao:has_database_id","subj":"T2","obj":"Tax:2697049"},{"id":"A26","pred":"tao:has_database_id","subj":"T37","obj":"Gene:396733"},{"id":"A17","pred":"tao:has_database_id","subj":"T24","obj":"MESH:D006031"},{"id":"A39","pred":"tao:has_database_id","subj":"T53","obj":"https://glytoucan.org/Structures/Glycans/G09546QO"},{"id":"A27","pred":"tao:has_database_id","subj":"T38","obj":"Gene:396918"},{"id":"A36","pred":"tao:has_database_id","subj":"T50","obj":"https://glytoucan.org/Structures/Glycans/G43724HA"},{"id":"A21","pred":"tao:has_database_id","subj":"T30","obj":"Tax:9823"},{"id":"A1","pred":"tao:has_database_id","subj":"T1","obj":"Tax:2697049"},{"subj":"T1","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T19","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T2","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T21","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T24","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T25","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T30","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T37","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T38","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T50","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T53","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T56","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T58","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T60","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T61","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T62","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T63","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T64","pred":"source","obj":"Covid19_manual_annotation"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-sentences","color":"#93ecc8","default":true},{"id":"Covid19_manual_annotation_v2","color":"#ecae93"},{"id":"Zoonoses","color":"#9493ec"},{"id":"Inflammaging","color":"#abec93"},{"id":"Covid19_manual_annotation","color":"#ec93c5"}]}]}}