PubMed:33423867 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/33423867","sourcedb":"PubMed","sourceid":"33423867","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/33423867","text":"Coronavirus disease 2019 pandemic and allogeneic hematopoietic stem cell transplantation: a single center reappraisal.\nBACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has deeply modified the complex logistical process underlying allogeneic hematopoietic stem cell transplant practices.\nAIM: In light of these changes, the authors compared data relative to allogeneic transplants carried out from 2018 at their center before (n = 167) and during the pandemic (n = 45).\nMETHODS: The authors examined patient characteristics, donor and graft types, cell doses and main transplant outcomes. Moreover, the authors evaluated the rise of costs attributable to additional COVID-19-related procedures as well as the risk of adverse events these procedures conveyed to grafts or recipients.\nRESULTS: Overall, the number of transplants did not decrease during the pandemic, whereas patients at high relapse risk were prioritized. Transplants were mainly from matched unrelated donors, with a significant decrease in haploidentical related donors. Moreover, the use of bone marrow as a graft for haploidentical transplant was almost abandoned. Cryopreservation was introduced for all related and unrelated apheresis products, with a median storage time of 20 days. Notably, transplant outcomes (engraftment, acute graft-versus-host disease and non-relapse mortality) with cryopreserved products were comparable to those with fresh products.\nCONCLUSIONS: Considering that the emergency situation may persist for months, cryopreserving allogeneic grafts can offer a lifesaving opportunity for patients whose allogeneic transplant cannot be postponed until after the end of the COVID-19 pandemic.","tracks":[{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":118},"obj":"Sentence"},{"id":"T2","span":{"begin":119,"end":130},"obj":"Sentence"},{"id":"T3","span":{"begin":131,"end":298},"obj":"Sentence"},{"id":"T4","span":{"begin":299,"end":303},"obj":"Sentence"},{"id":"T5","span":{"begin":304,"end":480},"obj":"Sentence"},{"id":"T6","span":{"begin":481,"end":489},"obj":"Sentence"},{"id":"T7","span":{"begin":490,"end":599},"obj":"Sentence"},{"id":"T8","span":{"begin":600,"end":793},"obj":"Sentence"},{"id":"T9","span":{"begin":794,"end":802},"obj":"Sentence"},{"id":"T10","span":{"begin":803,"end":931},"obj":"Sentence"},{"id":"T11","span":{"begin":932,"end":1048},"obj":"Sentence"},{"id":"T12","span":{"begin":1049,"end":1144},"obj":"Sentence"},{"id":"T13","span":{"begin":1145,"end":1265},"obj":"Sentence"},{"id":"T14","span":{"begin":1266,"end":1441},"obj":"Sentence"},{"id":"T15","span":{"begin":1442,"end":1454},"obj":"Sentence"},{"id":"T16","span":{"begin":1455,"end":1694},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-sentences"},{"subj":"T2","pred":"source","obj":"LitCovid-sentences"},{"subj":"T3","pred":"source","obj":"LitCovid-sentences"},{"subj":"T4","pred":"source","obj":"LitCovid-sentences"},{"subj":"T5","pred":"source","obj":"LitCovid-sentences"},{"subj":"T6","pred":"source","obj":"LitCovid-sentences"},{"subj":"T7","pred":"source","obj":"LitCovid-sentences"},{"subj":"T8","pred":"source","obj":"LitCovid-sentences"},{"subj":"T9","pred":"source","obj":"LitCovid-sentences"},{"subj":"T10","pred":"source","obj":"LitCovid-sentences"},{"subj":"T11","pred":"source","obj":"LitCovid-sentences"},{"subj":"T12","pred":"source","obj":"LitCovid-sentences"},{"subj":"T13","pred":"source","obj":"LitCovid-sentences"},{"subj":"T14","pred":"source","obj":"LitCovid-sentences"},{"subj":"T15","pred":"source","obj":"LitCovid-sentences"},{"subj":"T16","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1","span":{"begin":0,"end":24},"obj":"Disease"},{"id":"11","span":{"begin":135,"end":159},"obj":"Disease"},{"id":"12","span":{"begin":161,"end":169},"obj":"Disease"},{"id":"13","span":{"begin":511,"end":518},"obj":"Species"},{"id":"14","span":{"begin":677,"end":685},"obj":"Disease"},{"id":"15","span":{"begin":884,"end":892},"obj":"Species"},{"id":"16","span":{"begin":1315,"end":1340},"obj":"Disease"},{"id":"17","span":{"begin":1357,"end":1366},"obj":"Disease"},{"id":"18","span":{"begin":1592,"end":1600},"obj":"Species"},{"id":"19","span":{"begin":1676,"end":1684},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"tao:has_database_id","subj":"1","obj":"MESH:C000657245"},{"id":"A11","pred":"tao:has_database_id","subj":"11","obj":"MESH:C000657245"},{"id":"A12","pred":"tao:has_database_id","subj":"12","obj":"MESH:C000657245"},{"id":"A13","pred":"tao:has_database_id","subj":"13","obj":"Tax:9606"},{"id":"A14","pred":"tao:has_database_id","subj":"14","obj":"MESH:C000657245"},{"id":"A15","pred":"tao:has_database_id","subj":"15","obj":"Tax:9606"},{"id":"A16","pred":"tao:has_database_id","subj":"16","obj":"MESH:D006086"},{"id":"A17","pred":"tao:has_database_id","subj":"17","obj":"MESH:D003643"},{"id":"A18","pred":"tao:has_database_id","subj":"18","obj":"Tax:9606"},{"id":"A19","pred":"tao:has_database_id","subj":"19","obj":"MESH:C000657245"},{"subj":"1","pred":"source","obj":"LitCovid-PubTator"},{"subj":"11","pred":"source","obj":"LitCovid-PubTator"},{"subj":"12","pred":"source","obj":"LitCovid-PubTator"},{"subj":"13","pred":"source","obj":"LitCovid-PubTator"},{"subj":"14","pred":"source","obj":"LitCovid-PubTator"},{"subj":"15","pred":"source","obj":"LitCovid-PubTator"},{"subj":"16","pred":"source","obj":"LitCovid-PubTator"},{"subj":"17","pred":"source","obj":"LitCovid-PubTator"},{"subj":"18","pred":"source","obj":"LitCovid-PubTator"},{"subj":"19","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-sentences","color":"#93ec9b","default":true},{"id":"LitCovid-PubTator","color":"#ec93a4"}]}]}}