PubMed:33417259 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"2","span":{"begin":0,"end":8},"obj":"Disease"},{"id":"3","span":{"begin":26,"end":43},"obj":"Disease"},{"id":"43","span":{"begin":163,"end":184},"obj":"Disease"},{"id":"44","span":{"begin":222,"end":241},"obj":"Disease"},{"id":"45","span":{"begin":243,"end":251},"obj":"Disease"},{"id":"46","span":{"begin":263,"end":310},"obj":"Species"},{"id":"47","span":{"begin":312,"end":322},"obj":"Species"},{"id":"48","span":{"begin":479,"end":486},"obj":"Disease"},{"id":"49","span":{"begin":498,"end":507},"obj":"Disease"},{"id":"50","span":{"begin":526,"end":534},"obj":"Species"},{"id":"51","span":{"begin":596,"end":616},"obj":"Disease"},{"id":"52","span":{"begin":636,"end":644},"obj":"Disease"},{"id":"53","span":{"begin":645,"end":653},"obj":"Species"},{"id":"54","span":{"begin":669,"end":686},"obj":"Disease"},{"id":"55","span":{"begin":769,"end":777},"obj":"Disease"},{"id":"56","span":{"begin":778,"end":786},"obj":"Species"},{"id":"57","span":{"begin":795,"end":812},"obj":"Disease"},{"id":"58","span":{"begin":882,"end":890},"obj":"Disease"},{"id":"59","span":{"begin":891,"end":899},"obj":"Species"},{"id":"60","span":{"begin":956,"end":963},"obj":"Disease"},{"id":"61","span":{"begin":971,"end":980},"obj":"Disease"},{"id":"62","span":{"begin":1098,"end":1105},"obj":"Disease"},{"id":"63","span":{"begin":1139,"end":1148},"obj":"Disease"},{"id":"64","span":{"begin":1179,"end":1200},"obj":"Disease"},{"id":"65","span":{"begin":1221,"end":1229},"obj":"Species"},{"id":"66","span":{"begin":1294,"end":1299},"obj":"Disease"},{"id":"67","span":{"begin":1319,"end":1327},"obj":"Disease"},{"id":"68","span":{"begin":1345,"end":1361},"obj":"Disease"},{"id":"69","span":{"begin":1371,"end":1381},"obj":"Chemical"},{"id":"70","span":{"begin":1386,"end":1395},"obj":"Chemical"},{"id":"71","span":{"begin":1453,"end":1470},"obj":"Disease"},{"id":"72","span":{"begin":1501,"end":1509},"obj":"Disease"},{"id":"73","span":{"begin":1546,"end":1562},"obj":"Disease"},{"id":"74","span":{"begin":1601,"end":1611},"obj":"Chemical"},{"id":"75","span":{"begin":1669,"end":1690},"obj":"Disease"},{"id":"76","span":{"begin":1742,"end":1750},"obj":"Disease"},{"id":"77","span":{"begin":1785,"end":1795},"obj":"Chemical"},{"id":"78","span":{"begin":1817,"end":1824},"obj":"Disease"},{"id":"79","span":{"begin":1826,"end":1835},"obj":"Disease"},{"id":"80","span":{"begin":1839,"end":1847},"obj":"Disease"},{"id":"81","span":{"begin":1848,"end":1856},"obj":"Species"}],"attributes":[{"id":"A71","pred":"tao:has_database_id","subj":"71","obj":"MESH:D004408"},{"id":"A80","pred":"tao:has_database_id","subj":"80","obj":"MESH:C000657245"},{"id":"A78","pred":"tao:has_database_id","subj":"78","obj":"MESH:D000857"},{"id":"A43","pred":"tao:has_database_id","subj":"43","obj":"MESH:D004408"},{"id":"A50","pred":"tao:has_database_id","subj":"50","obj":"Tax:9606"},{"id":"A73","pred":"tao:has_database_id","subj":"73","obj":"MESH:D013921"},{"id":"A66","pred":"tao:has_database_id","subj":"66","obj":"MESH:D005334"},{"id":"A75","pred":"tao:has_database_id","subj":"75","obj":"MESH:D004408"},{"id":"A46","pred":"tao:has_database_id","subj":"46","obj":"Tax:2697049"},{"id":"A68","pred":"tao:has_database_id","subj":"68","obj":"MESH:D013921"},{"id":"A65","pred":"tao:has_database_id","subj":"65","obj":"Tax:9606"},{"id":"A48","pred":"tao:has_database_id","subj":"48","obj":"MESH:D000857"},{"id":"A3","pred":"tao:has_database_id","subj":"3","obj":"MESH:D004408"},{"id":"A56","pred":"tao:has_database_id","subj":"56","obj":"Tax:9606"},{"id":"A55","pred":"tao:has_database_id","subj":"55","obj":"MESH:C000657245"},{"id":"A60","pred":"tao:has_database_id","subj":"60","obj":"MESH:D000857"},{"id":"A67","pred":"tao:has_database_id","subj":"67","obj":"MESH:D012220"},{"id":"A81","pred":"tao:has_database_id","subj":"81","obj":"Tax:9606"},{"id":"A2","pred":"tao:has_database_id","subj":"2","obj":"MESH:C000657245"},{"id":"A64","pred":"tao:has_database_id","subj":"64","obj":"MESH:D004408"},{"id":"A44","pred":"tao:has_database_id","subj":"44","obj":"MESH:D018352"},{"id":"A49","pred":"tao:has_database_id","subj":"49","obj":"MESH:D004408"},{"id":"A53","pred":"tao:has_database_id","subj":"53","obj":"Tax:9606"},{"id":"A52","pred":"tao:has_database_id","subj":"52","obj":"MESH:C000657245"},{"id":"A79","pred":"tao:has_database_id","subj":"79","obj":"MESH:D004408"},{"id":"A45","pred":"tao:has_database_id","subj":"45","obj":"MESH:C000657245"},{"id":"A51","pred":"tao:has_database_id","subj":"51","obj":"MESH:C000657245"},{"id":"A70","pred":"tao:has_database_id","subj":"70","obj":"MESH:D001663"},{"id":"A69","pred":"tao:has_database_id","subj":"69","obj":"MESH:D003404"},{"id":"A59","pred":"tao:has_database_id","subj":"59","obj":"Tax:9606"},{"id":"A62","pred":"tao:has_database_id","subj":"62","obj":"MESH:D000857"},{"id":"A47","pred":"tao:has_database_id","subj":"47","obj":"Tax:2697049"},{"id":"A61","pred":"tao:has_database_id","subj":"61","obj":"MESH:D004408"},{"id":"A76","pred":"t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with and without anosmia/dysgeusia: A case-control study.\nBACKGROUND: Various new clinical signs and symptoms such as dysfunction of smell and taste i.e. anosmia and dysgeusia have emerged ever since the pandemic coronavirus disease (COVID-19) caused by Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) begun. The objective of this retrospective case control study was to identify clinical presentation and factors associated with 'new loss/change of smell (anosmia) or taste (dysgeusia)' at admission in patients positive by RT-PCR (real time polymerase chain reaction) for SARS-CoV-2 infection METHODS: All adult COVID-19 patients with new onset anosmia/dysgeusia at admission were included in study group. Equal number of age and gender matched COVID-19 patients without anosmia/dysgeusia at admission were included in control group.\nRESULTS: A total of 261 COVID-19 patients were admitted during study period of which 55 (21%) had anosmia and or dysgeusia. The mean (SD) age was 36(13) years. Majority were males (58%, n=32).Co-morbidity was present in 38% of cases (n=21).Anosmia (96%, n=53) was more common than dysgeusia (75%, n=41). Presence of both ansomia and dysgeusia was noted in 71% of patients(n=39).On comparing cases with controls, in univariate analysis, fever (higher in cases), rhinitis (lower in cases),thrombocytopenia,elevated creatinine and bilirubin (all higher in cases) were significantly associated with anosmia/dysgeusia.On multivariate analysis only rhinitis [OR: 95% CI:0.28 (0.09, 0.83);0.02] thrombocytopenia [0.99 (0.99, 0.99);0.01] and elevated creatinine [7.6 (1.5, 37.6);0.01] remained significant.\nCONCLUSION: Anosmia and dysgeusia were noted in more than 1/5th of cases. Absence of rhinitis, low platelet counts and elevated creatinine were associated with anosmia/ dysgeusia in COVID-19 patients. This article is protected by copyright. All rights reserved."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T1","span":{"begin":26,"end":33},"obj":"Phenotype"},{"id":"T2","span":{"begin":34,"end":43},"obj":"Phenotype"},{"id":"T3","span":{"begin":163,"end":170},"obj":"Phenotype"},{"id":"T4","span":{"begin":175,"end":184},"obj":"Phenotype"},{"id":"T5","span":{"begin":479,"end":486},"obj":"Phenotype"},{"id":"T6","span":{"begin":498,"end":507},"obj":"Phenotype"},{"id":"T7","span":{"begin":669,"end":676},"obj":"Phenotype"},{"id":"T8","span":{"begin":677,"end":686},"obj":"Phenotype"},{"id":"T9","span":{"begin":795,"end":802},"obj":"Phenotype"},{"id":"T10","span":{"begin":803,"end":812},"obj":"Phenotype"},{"id":"T11","span":{"begin":956,"end":963},"obj":"Phenotype"},{"id":"T12","span":{"begin":971,"end":980},"obj":"Phenotype"},{"id":"T13","span":{"begin":1098,"end":1105},"obj":"Phenotype"},{"id":"T14","span":{"begin":1139,"end":1148},"obj":"Phenotype"},{"id":"T15","span":{"begin":1191,"end":1200},"obj":"Phenotype"},{"id":"T16","span":{"begin":1294,"end":1299},"obj":"Phenotype"},{"id":"T17","span":{"begin":1319,"end":1327},"obj":"Phenotype"},{"id":"T18","span":{"begin":1345,"end":1361},"obj":"Phenotype"},{"id":"T19","span":{"begin":1362,"end":1381},"obj":"Phenotype"},{"id":"T20","span":{"begin":1453,"end":1460},"obj":"Phenotype"},{"id":"T21","span":{"begin":1501,"end":1509},"obj":"Phenotype"},{"id":"T22","span":{"begin":1546,"end":1562},"obj":"Phenotype"},{"id":"T23","span":{"begin":1592,"end":1611},"obj":"Phenotype"},{"id":"T24","span":{"begin":1669,"end":1676},"obj":"Phenotype"},{"id":"T25","span":{"begin":1681,"end":1690},"obj":"Phenotype"},{"id":"T26","span":{"begin":1742,"end":1750},"obj":"Phenotype"},{"id":"T27","span":{"begin":1752,"end":1771},"obj":"Phenotype"},{"id":"T28","span":{"begin":1776,"end":1795},"obj":"Phenotype"},{"id":"T29","span":{"begin":1817,"end":1824},"obj":"Phenotype"},{"id":"T30","span":{"begin":1826,"end":1835},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0000458"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0031249"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0000458"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0031249"},{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0000458"},{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0031249"},{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0000458"},{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0031249"},{"id":"A9","pred":"hp_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/HP_0000458"},{"id":"A10","pred":"hp_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/HP_0031249"},{"id":"A11","pred":"hp_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/HP_0000458"},{"id":"A12","pred":"hp_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/HP_0031249"},{"id":"A13","pred":"hp_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/HP_0000458"},{"id":"A14","pred":"hp_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/HP_0031249"},{"id":"A15","pred":"hp_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/HP_0031249"},{"id":"A16","pred":"hp_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/HP_0001945"},{"id":"A17","pred":"hp_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/HP_0012384"},{"id":"A18","pred":"hp_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/HP_0001873"},{"id":"A19","pred":"hp_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/HP_0003259"},{"id":"A20","pred":"hp_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/HP_0000458"},{"id":"A21","pred":"hp_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/HP_0012384"},{"id":"A22","pred":"hp_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/HP_0001873"},{"id":"A23","pred":"hp_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/HP_0003259"},{"id":"A24","pred":"hp_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/HP_0000458"},{"id":"A25","pred":"hp_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/HP_0031249"},{"id":"A26","pred":"hp_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/HP_0012384"},{"id":"A27","pred":"hp_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/HP_0001873"},{"id":"A28","pred":"hp_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/HP_0003259"},{"id":"A29","pred":"hp_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/HP_0000458"},{"id":"A30","pred":"hp_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/HP_0031249"}],"text":"COVID-19 with and without anosmia/dysgeusia: A case-control study.\nBACKGROUND: Various new clinical signs and symptoms such as dysfunction of smell and taste i.e. anosmia and dysgeusia have emerged ever since the pandemic coronavirus disease (COVID-19) caused by Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) begun. The objective of this retrospective case control study was to identify clinical presentation and factors associated with 'new loss/change of smell (anosmia) or taste (dysgeusia)' at admission in patients positive by RT-PCR (real time polymerase chain reaction) for SARS-CoV-2 infection METHODS: All adult COVID-19 patients with new onset anosmia/dysgeusia at admission were included in study group. Equal number of age and gender matched COVID-19 patients without anosmia/dysgeusia at admission were included in control group.\nRESULTS: A total of 261 COVID-19 patients were admitted during study period of which 55 (21%) had anosmia and or dysgeusia. The mean (SD) age was 36(13) years. Majority were males (58%, n=32).Co-morbidity was present in 38% of cases (n=21).Anosmia (96%, n=53) was more common than dysgeusia (75%, n=41). Presence of both ansomia and dysgeusia was noted in 71% of patients(n=39).On comparing cases with controls, in univariate analysis, fever (higher in cases), rhinitis (lower in cases),thrombocytopenia,elevated creatinine and bilirubin (all higher in cases) were significantly associated with anosmia/dysgeusia.On multivariate analysis only rhinitis [OR: 95% CI:0.28 (0.09, 0.83);0.02] thrombocytopenia [0.99 (0.99, 0.99);0.01] and elevated creatinine [7.6 (1.5, 37.6);0.01] remained significant.\nCONCLUSION: Anosmia and dysgeusia were noted in more than 1/5th of cases. Absence of rhinitis, low platelet counts and elevated creatinine were associated with anosmia/ dysgeusia in COVID-19 patients. This article is protected by copyright. All rights reserved."}

{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":44},"obj":"Sentence"},{"id":"T2","span":{"begin":45,"end":66},"obj":"Sentence"},{"id":"T3","span":{"begin":67,"end":78},"obj":"Sentence"},{"id":"T4","span":{"begin":79,"end":330},"obj":"Sentence"},{"id":"T5","span":{"begin":331,"end":625},"obj":"Sentence"},{"id":"T6","span":{"begin":626,"end":729},"obj":"Sentence"},{"id":"T7","span":{"begin":730,"end":857},"obj":"Sentence"},{"id":"T8","span":{"begin":858,"end":866},"obj":"Sentence"},{"id":"T9","span":{"begin":867,"end":981},"obj":"Sentence"},{"id":"T10","span":{"begin":982,"end":1017},"obj":"Sentence"},{"id":"T11","span":{"begin":1018,"end":1161},"obj":"Sentence"},{"id":"T12","span":{"begin":1162,"end":1514},"obj":"Sentence"},{"id":"T13","span":{"begin":1515,"end":1656},"obj":"Sentence"},{"id":"T14","span":{"begin":1657,"end":1668},"obj":"Sentence"},{"id":"T15","span":{"begin":1669,"end":1730},"obj":"Sentence"},{"id":"T16","span":{"begin":1731,"end":1857},"obj":"Sentence"},{"id":"T17","span":{"begin":1858,"end":1897},"obj":"Sentence"},{"id":"T18","span":{"begin":1898,"end":1918},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"COVID-19 with and without anosmia/dysgeusia: A case-control study.\nBACKGROUND: Various new clinical signs and symptoms such as dysfunction of smell and taste i.e. anosmia and dysgeusia have emerged ever since the pandemic coronavirus disease (COVID-19) caused by Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) begun. The objective of this retrospective case control study was to identify clinical presentation and factors associated with 'new loss/change of smell (anosmia) or taste (dysgeusia)' at admission in patients positive by RT-PCR (real time polymerase chain reaction) for SARS-CoV-2 infection METHODS: All adult COVID-19 patients with new onset anosmia/dysgeusia at admission were included in study group. Equal number of age and gender matched COVID-19 patients without anosmia/dysgeusia at admission were included in control group.\nRESULTS: A total of 261 COVID-19 patients were admitted during study period of which 55 (21%) had anosmia and or dysgeusia. The mean (SD) age was 36(13) years. Majority were males (58%, n=32).Co-morbidity was present in 38% of cases (n=21).Anosmia (96%, n=53) was more common than dysgeusia (75%, n=41). Presence of both ansomia and dysgeusia was noted in 71% of patients(n=39).On comparing cases with controls, in univariate analysis, fever (higher in cases), rhinitis (lower in cases),thrombocytopenia,elevated creatinine and bilirubin (all higher in cases) were significantly associated with anosmia/dysgeusia.On multivariate analysis only rhinitis [OR: 95% CI:0.28 (0.09, 0.83);0.02] thrombocytopenia [0.99 (0.99, 0.99);0.01] and elevated creatinine [7.6 (1.5, 37.6);0.01] remained significant.\nCONCLUSION: Anosmia and dysgeusia were noted in more than 1/5th of cases. Absence of rhinitis, low platelet counts and elevated creatinine were associated with anosmia/ dysgeusia in COVID-19 patients. This article is protected by copyright. All rights reserved."}