PubMed:33216553
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1422-1428 | Glycan_Motif | denotes | Neu5Ac | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-156 | Sentence | denotes | Comprehensive Analysis of the Proteome and PTMomes of C2C12 Myoblasts Reveals that Sialylation Plays a Role in the Differentiation of Skeletal Muscle Cells. |
| T2 | 157-274 | Sentence | denotes | The C2C12 myoblast is a model that has been used extensively to study the process of skeletal muscle differentiation. |
| T3 | 275-406 | Sentence | denotes | Proteomics has advanced our understanding of skeletal muscle biology and also the differentiation process of skeletal muscle cells. |
| T4 | 407-591 | Sentence | denotes | However, there is still no comprehensive analysis of C2C12 myoblast proteomes, which is important for the understanding of key drivers for the differentiation of skeletal muscle cells. |
| T5 | 592-744 | Sentence | denotes | Here, we conducted multidimensional proteome profiling to get a comprehensive analysis of proteomes and PTMomes of C2C12 myoblasts with a TiSH strategy. |
| T6 | 745-923 | Sentence | denotes | A total of 8313 protein groups were identified, including 7827 protein groups from nonmodified peptides, 3803 phosphoproteins, and 977 formerly sialylated N-linked glycoproteins. |
| T7 | 924-1101 | Sentence | denotes | Integrated analysis of proteomic and PTMomic data showed that almost all of the kinases and transcription factors in the muscle cell differentiation pathway were phosphorylated. |
| T8 | 1102-1206 | Sentence | denotes | Further analysis indicated that sialylation might play a role in the differentiation of C2C12 myoblasts. |
| T9 | 1207-1353 | Sentence | denotes | Further functional analysis demonstrated that C2C12 myoblasts showed a decreased level of sialylation during skeletal muscle cell differentiation. |
| T10 | 1354-1504 | Sentence | denotes | Inhibition of sialylation with the sialyltransferase inhibitor 3Fax-Neu5Ac resulted in the lower expression of MHC and suppression of myoblast fusion. |
| T11 | 1505-1615 | Sentence | denotes | In all, these results indicate that sialylation has an effect on the differentiation of skeletal muscle cells. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1422-1428 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 134-149 | http://purl.obolibrary.org/obo/MAT_0000302 | denotes | Skeletal Muscle |
| T2 | 242-257 | http://purl.obolibrary.org/obo/MAT_0000302 | denotes | skeletal muscle |
| T3 | 251-257 | http://purl.obolibrary.org/obo/MAT_0000025 | denotes | muscle |
| T4 | 320-335 | http://purl.obolibrary.org/obo/MAT_0000302 | denotes | skeletal muscle |
| T5 | 329-335 | http://purl.obolibrary.org/obo/MAT_0000025 | denotes | muscle |
| T6 | 384-399 | http://purl.obolibrary.org/obo/MAT_0000302 | denotes | skeletal muscle |
| T7 | 393-399 | http://purl.obolibrary.org/obo/MAT_0000025 | denotes | muscle |
| T8 | 569-584 | http://purl.obolibrary.org/obo/MAT_0000302 | denotes | skeletal muscle |
| T9 | 578-584 | http://purl.obolibrary.org/obo/MAT_0000025 | denotes | muscle |
| T10 | 1045-1051 | http://purl.obolibrary.org/obo/MAT_0000025 | denotes | muscle |
| T11 | 1316-1331 | http://purl.obolibrary.org/obo/MAT_0000302 | denotes | skeletal muscle |
| T12 | 1325-1331 | http://purl.obolibrary.org/obo/MAT_0000025 | denotes | muscle |
| T13 | 1593-1608 | http://purl.obolibrary.org/obo/MAT_0000302 | denotes | skeletal muscle |
| T14 | 1602-1608 | http://purl.obolibrary.org/obo/MAT_0000025 | denotes | muscle |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1422-1428 | Glycan | denotes | Neu5Ac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 60-69 | Cell | denotes | Myoblasts | http://purl.obolibrary.org/obo/CL:0000056 |
| T2 | 134-155 | Cell | denotes | Skeletal Muscle Cells | http://purl.obolibrary.org/obo/CL:0000188 |
| T3 | 167-175 | Cell | denotes | myoblast | http://purl.obolibrary.org/obo/CL:0000056 |
| T4 | 384-405 | Cell | denotes | skeletal muscle cells | http://purl.obolibrary.org/obo/CL:0000188 |
| T5 | 466-474 | Cell | denotes | myoblast | http://purl.obolibrary.org/obo/CL:0000056 |
| T6 | 569-590 | Cell | denotes | skeletal muscle cells | http://purl.obolibrary.org/obo/CL:0000188 |
| T7 | 713-722 | Cell | denotes | myoblasts | http://purl.obolibrary.org/obo/CL:0000056 |
| T8 | 1045-1056 | Cell | denotes | muscle cell | http://purl.obolibrary.org/obo/CL:0000187 |
| T9 | 1196-1205 | Cell | denotes | myoblasts | http://purl.obolibrary.org/obo/CL:0000056 |
| T10 | 1259-1268 | Cell | denotes | myoblasts | http://purl.obolibrary.org/obo/CL:0000056 |
| T11 | 1316-1336 | Cell | denotes | skeletal muscle cell | http://purl.obolibrary.org/obo/CL:0000188 |
| T12 | 1325-1336 | Cell | denotes | muscle cell | http://purl.obolibrary.org/obo/CL:0000187 |
| T13 | 1488-1496 | Cell | denotes | myoblast | http://purl.obolibrary.org/obo/CL:0000056 |
| T14 | 1593-1614 | Cell | denotes | skeletal muscle cells | http://purl.obolibrary.org/obo/CL:0000188 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 134-155 | Body_part | denotes | Skeletal Muscle Cells | http://purl.obolibrary.org/obo/CL_0000188 |
| T2 | 167-175 | Body_part | denotes | myoblast | http://purl.obolibrary.org/obo/CL_0000056 |
| T3 | 242-257 | Body_part | denotes | skeletal muscle | http://purl.obolibrary.org/obo/UBERON_0001134|http://purl.obolibrary.org/obo/UBERON_0014892|http://purl.obolibrary.org/obo/UBERON_0014895 |
| T6 | 320-335 | Body_part | denotes | skeletal muscle | http://purl.obolibrary.org/obo/UBERON_0001134|http://purl.obolibrary.org/obo/UBERON_0014892|http://purl.obolibrary.org/obo/UBERON_0014895 |
| T9 | 384-405 | Body_part | denotes | skeletal muscle cells | http://purl.obolibrary.org/obo/CL_0000188 |
| T10 | 466-474 | Body_part | denotes | myoblast | http://purl.obolibrary.org/obo/CL_0000056 |
| T11 | 569-590 | Body_part | denotes | skeletal muscle cells | http://purl.obolibrary.org/obo/CL_0000188 |
| T12 | 713-722 | Body_part | denotes | myoblasts | http://purl.obolibrary.org/obo/CL_0000056 |
| T13 | 1045-1056 | Body_part | denotes | muscle cell | http://purl.obolibrary.org/obo/CL_0000187 |
| T14 | 1196-1205 | Body_part | denotes | myoblasts | http://purl.obolibrary.org/obo/CL_0000056 |
| T15 | 1259-1268 | Body_part | denotes | myoblasts | http://purl.obolibrary.org/obo/CL_0000056 |
| T16 | 1316-1336 | Body_part | denotes | skeletal muscle cell | http://purl.obolibrary.org/obo/CL_0000188 |
| T17 | 1488-1496 | Body_part | denotes | myoblast | http://purl.obolibrary.org/obo/CL_0000056 |
| T18 | 1593-1614 | Body_part | denotes | skeletal muscle cells | http://purl.obolibrary.org/obo/CL_0000188 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 134-149 | Body_part | denotes | Skeletal Muscle | http://purl.obolibrary.org/obo/MAT_0000302 |
| T2 | 242-257 | Body_part | denotes | skeletal muscle | http://purl.obolibrary.org/obo/MAT_0000302 |
| T3 | 320-335 | Body_part | denotes | skeletal muscle | http://purl.obolibrary.org/obo/MAT_0000302 |
| T4 | 384-399 | Body_part | denotes | skeletal muscle | http://purl.obolibrary.org/obo/MAT_0000302 |
| T5 | 569-584 | Body_part | denotes | skeletal muscle | http://purl.obolibrary.org/obo/MAT_0000302 |
| T6 | 1045-1051 | Body_part | denotes | muscle | http://purl.obolibrary.org/obo/MAT_0000025 |
| T7 | 1316-1331 | Body_part | denotes | skeletal muscle | http://purl.obolibrary.org/obo/MAT_0000302 |
| T8 | 1593-1608 | Body_part | denotes | skeletal muscle | http://purl.obolibrary.org/obo/MAT_0000302 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-156 | Sentence | denotes | Comprehensive Analysis of the Proteome and PTMomes of C2C12 Myoblasts Reveals that Sialylation Plays a Role in the Differentiation of Skeletal Muscle Cells. |
| T2 | 157-274 | Sentence | denotes | The C2C12 myoblast is a model that has been used extensively to study the process of skeletal muscle differentiation. |
| T3 | 275-406 | Sentence | denotes | Proteomics has advanced our understanding of skeletal muscle biology and also the differentiation process of skeletal muscle cells. |
| T4 | 407-591 | Sentence | denotes | However, there is still no comprehensive analysis of C2C12 myoblast proteomes, which is important for the understanding of key drivers for the differentiation of skeletal muscle cells. |
| T5 | 592-744 | Sentence | denotes | Here, we conducted multidimensional proteome profiling to get a comprehensive analysis of proteomes and PTMomes of C2C12 myoblasts with a TiSH strategy. |
| T6 | 745-923 | Sentence | denotes | A total of 8313 protein groups were identified, including 7827 protein groups from nonmodified peptides, 3803 phosphoproteins, and 977 formerly sialylated N-linked glycoproteins. |
| T7 | 924-1101 | Sentence | denotes | Integrated analysis of proteomic and PTMomic data showed that almost all of the kinases and transcription factors in the muscle cell differentiation pathway were phosphorylated. |
| T8 | 1102-1206 | Sentence | denotes | Further analysis indicated that sialylation might play a role in the differentiation of C2C12 myoblasts. |
| T9 | 1207-1353 | Sentence | denotes | Further functional analysis demonstrated that C2C12 myoblasts showed a decreased level of sialylation during skeletal muscle cell differentiation. |
| T10 | 1354-1504 | Sentence | denotes | Inhibition of sialylation with the sialyltransferase inhibitor 3Fax-Neu5Ac resulted in the lower expression of MHC and suppression of myoblast fusion. |
| T11 | 1505-1615 | Sentence | denotes | In all, these results indicate that sialylation has an effect on the differentiation of skeletal muscle cells. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-156 | Sentence | denotes | Comprehensive Analysis of the Proteome and PTMomes of C2C12 Myoblasts Reveals that Sialylation Plays a Role in the Differentiation of Skeletal Muscle Cells. |
| T2 | 157-274 | Sentence | denotes | The C2C12 myoblast is a model that has been used extensively to study the process of skeletal muscle differentiation. |
| T3 | 275-406 | Sentence | denotes | Proteomics has advanced our understanding of skeletal muscle biology and also the differentiation process of skeletal muscle cells. |
| T4 | 407-591 | Sentence | denotes | However, there is still no comprehensive analysis of C2C12 myoblast proteomes, which is important for the understanding of key drivers for the differentiation of skeletal muscle cells. |
| T5 | 592-744 | Sentence | denotes | Here, we conducted multidimensional proteome profiling to get a comprehensive analysis of proteomes and PTMomes of C2C12 myoblasts with a TiSH strategy. |
| T6 | 745-923 | Sentence | denotes | A total of 8313 protein groups were identified, including 7827 protein groups from nonmodified peptides, 3803 phosphoproteins, and 977 formerly sialylated N-linked glycoproteins. |
| T7 | 924-1101 | Sentence | denotes | Integrated analysis of proteomic and PTMomic data showed that almost all of the kinases and transcription factors in the muscle cell differentiation pathway were phosphorylated. |
| T8 | 1102-1206 | Sentence | denotes | Further analysis indicated that sialylation might play a role in the differentiation of C2C12 myoblasts. |
| T9 | 1207-1353 | Sentence | denotes | Further functional analysis demonstrated that C2C12 myoblasts showed a decreased level of sialylation during skeletal muscle cell differentiation. |
| T10 | 1354-1504 | Sentence | denotes | Inhibition of sialylation with the sialyltransferase inhibitor 3Fax-Neu5Ac resulted in the lower expression of MHC and suppression of myoblast fusion. |
| T11 | 1505-1615 | Sentence | denotes | In all, these results indicate that sialylation has an effect on the differentiation of skeletal muscle cells. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1422-1428 | Glycan | denotes | Neu5Ac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 134-149 | Body_part | denotes | Skeletal Muscle | http://purl.obolibrary.org/obo/MAT_0000302 |
| T2 | 242-257 | Body_part | denotes | skeletal muscle | http://purl.obolibrary.org/obo/MAT_0000302 |
| T3 | 320-335 | Body_part | denotes | skeletal muscle | http://purl.obolibrary.org/obo/MAT_0000302 |
| T4 | 384-399 | Body_part | denotes | skeletal muscle | http://purl.obolibrary.org/obo/MAT_0000302 |
| T5 | 569-584 | Body_part | denotes | skeletal muscle | http://purl.obolibrary.org/obo/MAT_0000302 |
| T6 | 1045-1051 | Body_part | denotes | muscle | http://purl.obolibrary.org/obo/MAT_0000025 |
| T7 | 1316-1331 | Body_part | denotes | skeletal muscle | http://purl.obolibrary.org/obo/MAT_0000302 |
| T8 | 1593-1608 | Body_part | denotes | skeletal muscle | http://purl.obolibrary.org/obo/MAT_0000302 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 134-155 | Body_part | denotes | Skeletal Muscle Cells | http://purl.obolibrary.org/obo/CL_0000188 |
| T2 | 167-175 | Body_part | denotes | myoblast | http://purl.obolibrary.org/obo/CL_0000056 |
| T3 | 242-257 | Body_part | denotes | skeletal muscle | http://purl.obolibrary.org/obo/UBERON_0001134|http://purl.obolibrary.org/obo/UBERON_0014892|http://purl.obolibrary.org/obo/UBERON_0014895 |
| T6 | 320-335 | Body_part | denotes | skeletal muscle | http://purl.obolibrary.org/obo/UBERON_0001134|http://purl.obolibrary.org/obo/UBERON_0014892|http://purl.obolibrary.org/obo/UBERON_0014895 |
| T9 | 384-405 | Body_part | denotes | skeletal muscle cells | http://purl.obolibrary.org/obo/CL_0000188 |
| T10 | 466-474 | Body_part | denotes | myoblast | http://purl.obolibrary.org/obo/CL_0000056 |
| T11 | 569-590 | Body_part | denotes | skeletal muscle cells | http://purl.obolibrary.org/obo/CL_0000188 |
| T12 | 713-722 | Body_part | denotes | myoblasts | http://purl.obolibrary.org/obo/CL_0000056 |
| T13 | 1045-1056 | Body_part | denotes | muscle cell | http://purl.obolibrary.org/obo/CL_0000187 |
| T14 | 1196-1205 | Body_part | denotes | myoblasts | http://purl.obolibrary.org/obo/CL_0000056 |
| T15 | 1259-1268 | Body_part | denotes | myoblasts | http://purl.obolibrary.org/obo/CL_0000056 |
| T16 | 1316-1336 | Body_part | denotes | skeletal muscle cell | http://purl.obolibrary.org/obo/CL_0000188 |
| T17 | 1488-1496 | Body_part | denotes | myoblast | http://purl.obolibrary.org/obo/CL_0000056 |
| T18 | 1593-1614 | Body_part | denotes | skeletal muscle cells | http://purl.obolibrary.org/obo/CL_0000188 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 60-69 | Cell | denotes | Myoblasts | http://purl.obolibrary.org/obo/CL:0000056 |
| T2 | 134-155 | Cell | denotes | Skeletal Muscle Cells | http://purl.obolibrary.org/obo/CL:0000188 |
| T3 | 167-175 | Cell | denotes | myoblast | http://purl.obolibrary.org/obo/CL:0000056 |
| T4 | 384-405 | Cell | denotes | skeletal muscle cells | http://purl.obolibrary.org/obo/CL:0000188 |
| T5 | 466-474 | Cell | denotes | myoblast | http://purl.obolibrary.org/obo/CL:0000056 |
| T6 | 569-590 | Cell | denotes | skeletal muscle cells | http://purl.obolibrary.org/obo/CL:0000188 |
| T7 | 713-722 | Cell | denotes | myoblasts | http://purl.obolibrary.org/obo/CL:0000056 |
| T8 | 1045-1056 | Cell | denotes | muscle cell | http://purl.obolibrary.org/obo/CL:0000187 |
| T9 | 1196-1205 | Cell | denotes | myoblasts | http://purl.obolibrary.org/obo/CL:0000056 |
| T10 | 1259-1268 | Cell | denotes | myoblasts | http://purl.obolibrary.org/obo/CL:0000056 |
| T11 | 1316-1336 | Cell | denotes | skeletal muscle cell | http://purl.obolibrary.org/obo/CL:0000188 |
| T12 | 1325-1336 | Cell | denotes | muscle cell | http://purl.obolibrary.org/obo/CL:0000187 |
| T13 | 1488-1496 | Cell | denotes | myoblast | http://purl.obolibrary.org/obo/CL:0000056 |
| T14 | 1593-1614 | Cell | denotes | skeletal muscle cells | http://purl.obolibrary.org/obo/CL:0000188 |