PubMed:33195060 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/33195060","sourcedb":"PubMed","sourceid":"33195060","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/33195060","text":"Hijacking SARS-CoV-2/ACE2 Receptor Interaction by Natural and Semi-synthetic Steroidal Agents Acting on Functional Pockets on the Receptor Binding Domain.\nThe coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by the severe acute respiratory syndrome coronavirus (SARS)-CoV-2. In light of the urgent need to identify novel approaches to be used in the emergency phase, we have embarked on an exploratory campaign aimed at repurposing natural substances and clinically available drugs as potential anti-SARS-CoV2-2 agents by targeting viral proteins. Here we report on a strategy based on the virtual screening of druggable pockets located in the central β-sheet core of the SARS-CoV-2 Spike's protein receptor binding domain (RBD). By combining an in silico approach and molecular in vitro testing we have been able to identify several triterpenoid/steroidal agents that inhibit interaction of the Spike RBD with the carboxypeptidase domain of the Angiotensin Converting Enzyme (ACE2). In detail, we provide evidence that potential binding sites exist in the RBD of the SARS CoV-2 Spike protein and that occupancy of these pockets reduces the ability of the RBD to bind to the ACE2 consensus in vitro. Naturally occurring and clinically available triterpenoids such as glycyrrhetinic and oleanolic acids, as well as primary and secondary bile acids and their amidated derivatives such as glyco-ursodeoxycholic acid and semi-synthetic derivatives such as obeticholic acid reduces the RBD/ACE2 binding. In aggregate, these results might help to define novel approaches to COVID-19 based on SARS-CoV-2 entry inhibitors.","tracks":[{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":154},"obj":"Sentence"},{"id":"T2","span":{"begin":155,"end":301},"obj":"Sentence"},{"id":"T3","span":{"begin":302,"end":574},"obj":"Sentence"},{"id":"T4","span":{"begin":575,"end":756},"obj":"Sentence"},{"id":"T5","span":{"begin":757,"end":1010},"obj":"Sentence"},{"id":"T6","span":{"begin":1011,"end":1226},"obj":"Sentence"},{"id":"T7","span":{"begin":1227,"end":1525},"obj":"Sentence"},{"id":"T8","span":{"begin":1526,"end":1641},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-sentences"},{"subj":"T2","pred":"source","obj":"LitCovid-sentences"},{"subj":"T3","pred":"source","obj":"LitCovid-sentences"},{"subj":"T4","pred":"source","obj":"LitCovid-sentences"},{"subj":"T5","pred":"source","obj":"LitCovid-sentences"},{"subj":"T6","pred":"source","obj":"LitCovid-sentences"},{"subj":"T7","pred":"source","obj":"LitCovid-sentences"},{"subj":"T8","pred":"source","obj":"LitCovid-sentences"}]},{"project":"Covid19_manual_annotation_v2","denotations":[{"id":"T1","span":{"begin":185,"end":193},"obj":"Disease"},{"id":"T10","span":{"begin":726,"end":749},"obj":"Phenomena"},{"id":"T11","span":{"begin":751,"end":754},"obj":"Phenomena"},{"id":"T12","span":{"begin":929,"end":932},"obj":"Phenomena"},{"id":"T13","span":{"begin":1084,"end":1087},"obj":"Phenomena"},{"id":"T14","span":{"begin":1183,"end":1186},"obj":"Phenomena"},{"id":"T15","span":{"begin":1508,"end":1511},"obj":"Phenomena"},{"id":"T16","span":{"begin":1004,"end":1008},"obj":"Gene"},{"id":"T17","span":{"begin":21,"end":25},"obj":"Gene"},{"id":"T18","span":{"begin":1202,"end":1206},"obj":"Gene"},{"id":"T19","span":{"begin":1512,"end":1516},"obj":"Gene"},{"id":"T2","span":{"begin":1595,"end":1603},"obj":"Disease"},{"id":"T20","span":{"begin":973,"end":1002},"obj":"Gene"},{"id":"T21","span":{"begin":130,"end":153},"obj":"Phenomena"},{"id":"T22","span":{"begin":923,"end":928},"obj":"Gene"},{"id":"T23","span":{"begin":710,"end":725},"obj":"Gene"},{"id":"T24","span":{"begin":1106,"end":1119},"obj":"Gene"},{"id":"T25","span":{"begin":200,"end":227},"obj":"Disease"},{"id":"T26","span":{"begin":77,"end":93},"obj":"Chemical"},{"id":"T27","span":{"begin":874,"end":883},"obj":"Chemical"},{"id":"T28","span":{"begin":861,"end":873},"obj":"Chemical"},{"id":"T29","span":{"begin":1272,"end":1285},"obj":"Chemical"},{"id":"T3","span":{"begin":159,"end":183},"obj":"Disease"},{"id":"T30","span":{"begin":459,"end":477},"obj":"Chemical"},{"id":"T31","span":{"begin":482,"end":508},"obj":"Chemical"},{"id":"T32","span":{"begin":896,"end":903},"obj":"Inhibition"},{"id":"T33","span":{"begin":1630,"end":1640},"obj":"Chemical"},{"id":"T34","span":{"begin":904,"end":915},"obj":"Phenomena"},{"id":"T35","span":{"begin":773,"end":782},"obj":"Condition"},{"id":"T36","span":{"begin":942,"end":965},"obj":"Phenomena"},{"id":"T37","span":{"begin":638,"end":655},"obj":"Phenomena"},{"id":"T38","span":{"begin":679,"end":686},"obj":"Phenomena"},{"id":"T39","span":{"begin":1323,"end":1328},"obj":"Chemical"},{"id":"T4","span":{"begin":527,"end":538},"obj":"Species"},{"id":"T40","span":{"begin":1363,"end":1373},"obj":"Chemical"},{"id":"T41","span":{"begin":1294,"end":1308},"obj":"Chemical"},{"id":"T42","span":{"begin":1313,"end":1328},"obj":"Chemical"},{"id":"T43","span":{"begin":1384,"end":1404},"obj":"Chemical"},{"id":"T44","span":{"begin":1363,"end":1373},"obj":"Chemical"},{"id":"T45","span":{"begin":1413,"end":1439},"obj":"Chemical"},{"id":"T47","span":{"begin":1479,"end":1495},"obj":"Chemical"},{"id":"T48","span":{"begin":1444,"end":1470},"obj":"Chemical"},{"id":"T49","span":{"begin":1496,"end":1503},"obj":"NegativeRegulation"},{"id":"T5","span":{"begin":1095,"end":1105},"obj":"Species"},{"id":"T50","span":{"begin":1517,"end":1524},"obj":"Phenomena"},{"id":"T51","span":{"begin":35,"end":46},"obj":"Phenomena"},{"id":"T52","span":{"begin":0,"end":9},"obj":"Inhibition"},{"id":"T55","span":{"begin":50,"end":57},"obj":"Type"},{"id":"T56","span":{"begin":62,"end":76},"obj":"Type"},{"id":"T6","span":{"begin":242,"end":300},"obj":"Species"},{"id":"T7","span":{"begin":10,"end":20},"obj":"Species"},{"id":"T8","span":{"begin":699,"end":709},"obj":"Species"},{"id":"T9","span":{"begin":1613,"end":1623},"obj":"Species"}],"relations":[{"id":"R1","pred":"abbreviation","subj":"T1","obj":"T3"},{"id":"R11","pred":"of_a","subj":"T5","obj":"T24"},{"id":"R12","pred":"of_a","subj":"T22","obj":"T12"},{"id":"R14","pred":"has_status","subj":"T32","obj":"T35"},{"id":"R15","pred":"abbreviation","subj":"T11","obj":"T10"},{"id":"R16","pred":"of_a","subj":"T8","obj":"T23"},{"id":"R18","pred":"of_a","subj":"T10","obj":"T38"},{"id":"R19","pred":"of_a","subj":"T38","obj":"T37"},{"id":"R2","pred":"cause_of","subj":"T6","obj":"T3"},{"id":"R20","pred":"of_a","subj":"T20","obj":"T36"},{"id":"R21","pred":"-","subj":"T41","obj":"T39"},{"id":"R31","pred":"is_a","subj":"T44","obj":"T49"},{"id":"R32","pred":"is_a","subj":"T45","obj":"T49"},{"id":"R33","pred":"is_a","subj":"T48","obj":"T49"},{"id":"R34","pred":"is_a","subj":"T47","obj":"T49"},{"id":"R35","pred":"cause_of","subj":"T9","obj":"T2"},{"id":"R37","pred":"against","subj":"T4","obj":"T31"},{"id":"R38","pred":"against","subj":"T4","obj":"T30"},{"id":"R39","pred":"is_a","subj":"T7","obj":"T51"},{"id":"R4","pred":"abbreviation","subj":"T16","obj":"T20"},{"id":"R45","pred":"of_a","subj":"T55","obj":"T26"},{"id":"R46","pred":"of_a","subj":"T56","obj":"T26"},{"id":"R23","pred":"-","subj":"T44","obj":"T43"},{"id":"R26","pred":"is_a","subj":"T49","obj":"T50"},{"id":"R27","pred":"is_a","subj":"T29","obj":"T49"},{"id":"R28","pred":"is_a","subj":"T41","obj":"T49"},{"id":"R29","pred":"is_a","subj":"T42","obj":"T49"},{"id":"R3","pred":"is_a","subj":"T25","obj":"T3"},{"id":"R30","pred":"is_a","subj":"T40","obj":"T49"},{"id":"R47","pred":"has_role","subj":"T26","obj":"T52"},{"id":"R49","pred":"of_a","subj":"T7","obj":"T21"},{"id":"R5","pred":"has_role","subj":"T28","obj":"T32"},{"id":"R51","pred":"against","subj":"T52","obj":"T51"},{"id":"R52","pred":"against","subj":"T32","obj":"T34"},{"id":"R53","pred":"against","subj":"T33","obj":"T2"},{"id":"R54","pred":"to","subj":"T51","obj":"T17"},{"id":"R55","pred":"to","subj":"T34","obj":"T20"},{"id":"R56","pred":"to","subj":"T50","obj":"T19"},{"id":"R57","pred":"is_a","subj":"T24","obj":"T50"},{"id":"R59","pred":"of_a","subj":"T23","obj":"T10"},{"id":"R6","pred":"has_role","subj":"T27","obj":"T32"},{"id":"R60","pred":"of_a","subj":"T24","obj":"T13"},{"id":"R7","pred":"is_a","subj":"T22","obj":"T34"}],"attributes":[{"id":"A13","pred":"tao:has_database_id","subj":"T19","obj":"Gene:59272"},{"id":"A27","pred":"ForCovid19","subj":"T30","obj":"drug"},{"id":"A42","pred":"Memo","subj":"T11","obj":"MESH:D000072417"},{"id":"A2","pred":"tao:has_database_id","subj":"T2","obj":"MESH:C000657245"},{"id":"A60","pred":"Memo","subj":"T44","obj":"synthetic"},{"id":"A40","pred":"Memo","subj":"T21","obj":"MESH:D000072417"},{"id":"A46","pred":"Memo","subj":"T15","obj":"MESH:D000072417"},{"id":"A24","pred":"tao:has_database_id","subj":"T29","obj":"MESH:D014315"},{"id":"A26","pred":"ForCovid19","subj":"T29","obj":"drug"},{"id":"A32","pred":"tao:has_database_id","subj":"T40","obj":"MESH:D001647"},{"id":"A59","pred":"Memo","subj":"T40","obj":"synthetic"},{"id":"A10","pred":"tao:has_database_id","subj":"T16","obj":"Gene:59272"},{"id":"A50","pred":"Memo","subj":"T51","obj":"MESH:D053585"},{"id":"A21","pred":"tao:has_database_id","subj":"T27","obj":"MESH:D013256"},{"id":"A22","pred":"ForCovid19","subj":"T27","obj":"drug"},{"id":"A36","pred":"ForCovid19","subj":"T33","obj":"drug"},{"id":"A5","pred":"tao:has_database_id","subj":"T5","obj":"Tax:2697049"},{"id":"A8","pred":"tao:has_database_id","subj":"T8","obj":"Tax:2697049"},{"id":"A61","pred":"Memo","subj":"T43","obj":"synthetic"},{"id":"A4","pred":"tao:has_database_id","subj":"T4","obj":"Tax:2697049"},{"id":"A30","pred":"tao:has_database_id","subj":"T39","obj":"MESH:D006034"},{"id":"A56","pred":"ForCovid19","subj":"T39","obj":"drug"},{"id":"A3","pred":"tao:has_database_id","subj":"T3","obj":"MESH:C000657245"},{"id":"A31","pred":"tao:has_database_id","subj":"T42","obj":"MESH:D009828"},{"id":"A54","pred":"ForCovid19","subj":"T42","obj":"drug"},{"id":"A34","pred":"tao:has_database_id","subj":"T47","obj":"MESH:C464660"},{"id":"A57","pred":"tao:has_database_id","subj":"T45","obj":"MESH:C024033"},{"id":"A58","pred":"correct/standard/original word","subj":"T45","obj":"glycoursodeoxycholic acid"},{"id":"A7","pred":"tao:has_database_id","subj":"T7","obj":"Tax:2697049"},{"id":"A17","pred":"tao:has_database_id","subj":"T24","obj":"Gene:43740568"},{"id":"A53","pred":"Memo","subj":"T36","obj":"MESH:D000072417"},{"id":"A11","pred":"tao:has_database_id","subj":"T17","obj":"Gene:59272"},{"id":"A15","pred":"tao:has_database_id","subj":"T22","obj":"Gene:43740568"},{"id":"A28","pred":"ForCovid19","subj":"T31","obj":"drug"},{"id":"A44","pred":"Memo","subj":"T12","obj":"MESH:D000072417"},{"id":"A52","pred":"tao:has_database_id","subj":"T50","obj":"MESH:D053585"},{"id":"A41","pred":"Memo","subj":"T10","obj":"MESH:D000072417"},{"id":"A51","pred":"Memo","subj":"T34","obj":"MESH:D053585"},{"id":"A9","pred":"tao:has_database_id","subj":"T9","obj":"Tax:2697049"},{"id":"A16","pred":"tao:has_database_id","subj":"T23","obj":"Gene:43740568"},{"id":"A38","pred":"tao:has_database_id","subj":"T25","obj":"MESH:D012141"},{"id":"A20","pred":"ForCovid19","subj":"T26","obj":"drug"},{"id":"A39","pred":"Memo","subj":"T26","obj":"MESH:D013256"},{"id":"A14","pred":"tao:has_database_id","subj":"T20","obj":"Gene:59272"},{"id":"A6","pred":"tao:has_database_id","subj":"T6","obj":"Tax:2697049"},{"id":"A1","pred":"tao:has_database_id","subj":"T1","obj":"MESH:C000657245"},{"id":"A12","pred":"tao:has_database_id","subj":"T18","obj":"Gene:59272"},{"id":"A23","pred":"tao:has_database_id","subj":"T28","obj":"MESH:D014315"},{"id":"A25","pred":"ForCovid19","subj":"T28","obj":"drug"},{"id":"A29","pred":"tao:has_database_id","subj":"T41","obj":"MESH:D006034"},{"id":"A37","pred":"tao:has_database_id","subj":"T38","obj":"MESH:D000072757"},{"id":"A43","pred":"Memo","subj":"T13","obj":"MESH:D000072417"},{"id":"A45","pred":"Memo","subj":"T14","obj":"MESH:D000072417"},{"id":"A55","pred":"ForCovid19","subj":"T41","obj":"drug"},{"subj":"T1","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T10","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T11","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T12","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T13","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T14","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T15","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T16","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T17","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T18","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T19","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T2","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T20","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T21","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T22","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T23","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T24","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T25","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T26","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T27","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T28","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T29","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T3","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T30","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T31","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T32","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T33","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T34","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T35","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T36","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T37","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T38","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T39","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T4","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T40","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T41","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T42","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T43","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T44","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T45","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T47","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T48","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T49","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T5","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T50","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T51","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T52","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T55","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T56","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T6","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T7","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T8","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T9","pred":"source","obj":"Covid19_manual_annotation_v2"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"BioProject","uri":"https://www.ncbi.nlm.nih.gov/bioproject/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"},{"prefix":"HP","uri":"https://hpo.jax.org/app/browse/term/HP:"},{"prefix":"BioSample","uri":"https://www.ncbi.nlm.nih.gov/biosample/"}]},{"project":"Zoonoses","denotations":[{"id":"T1","span":{"begin":185,"end":193},"obj":"Disease"},{"id":"T10","span":{"begin":726,"end":749},"obj":"Phenomena"},{"id":"T11","span":{"begin":751,"end":754},"obj":"Phenomena"},{"id":"T13","span":{"begin":1084,"end":1087},"obj":"Phenomena"},{"id":"T14","span":{"begin":1183,"end":1186},"obj":"Phenomena"},{"id":"T17","span":{"begin":21,"end":25},"obj":"Gene"},{"id":"T18","span":{"begin":1202,"end":1206},"obj":"Gene"},{"id":"T2","span":{"begin":1595,"end":1603},"obj":"Disease"},{"id":"T21","span":{"begin":130,"end":153},"obj":"Phenomena"},{"id":"T23","span":{"begin":710,"end":725},"obj":"Gene"},{"id":"T24","span":{"begin":1106,"end":1119},"obj":"Gene"},{"id":"T25","span":{"begin":200,"end":227},"obj":"Disease"},{"id":"T26","span":{"begin":77,"end":93},"obj":"Chemical"},{"id":"T3","span":{"begin":159,"end":183},"obj":"Disease"},{"id":"T30","span":{"begin":459,"end":477},"obj":"Chemical"},{"id":"T31","span":{"begin":482,"end":508},"obj":"Chemical"},{"id":"T33","span":{"begin":1630,"end":1640},"obj":"Chemical"},{"id":"T37","span":{"begin":638,"end":655},"obj":"Phenomena"},{"id":"T38","span":{"begin":679,"end":686},"obj":"Phenomena"},{"id":"T4","span":{"begin":527,"end":538},"obj":"Species"},{"id":"T5","span":{"begin":1095,"end":1105},"obj":"Species"},{"id":"T51","span":{"begin":35,"end":46},"obj":"Phenomena"},{"id":"T52","span":{"begin":0,"end":9},"obj":"Inhibition"},{"id":"T55","span":{"begin":50,"end":57},"obj":"Type"},{"id":"T56","span":{"begin":62,"end":76},"obj":"Type"},{"id":"T6","span":{"begin":242,"end":300},"obj":"Species"},{"id":"T7","span":{"begin":10,"end":20},"obj":"Species"},{"id":"T8","span":{"begin":699,"end":709},"obj":"Species"},{"id":"T9","span":{"begin":1613,"end":1623},"obj":"Species"},{"id":"T12","span":{"begin":929,"end":932},"obj":"Phenomena"},{"id":"T16","span":{"begin":1004,"end":1008},"obj":"Gene"},{"id":"T20","span":{"begin":973,"end":1002},"obj":"Gene"},{"id":"T22","span":{"begin":923,"end":928},"obj":"Gene"},{"id":"T27","span":{"begin":874,"end":883},"obj":"Chemical"},{"id":"T28","span":{"begin":861,"end":873},"obj":"Chemical"},{"id":"T32","span":{"begin":896,"end":903},"obj":"Inhibition"},{"id":"T34","span":{"begin":904,"end":915},"obj":"Phenomena"},{"id":"T35","span":{"begin":773,"end":782},"obj":"Condition"},{"id":"T36","span":{"begin":942,"end":965},"obj":"Phenomena"},{"id":"T15","span":{"begin":1508,"end":1511},"obj":"Phenomena"},{"id":"T19","span":{"begin":1512,"end":1516},"obj":"Gene"},{"id":"T29","span":{"begin":1272,"end":1285},"obj":"Chemical"},{"id":"T39","span":{"begin":1323,"end":1328},"obj":"Chemical"},{"id":"T40","span":{"begin":1363,"end":1373},"obj":"Chemical"},{"id":"T41","span":{"begin":1294,"end":1308},"obj":"Chemical"},{"id":"T42","span":{"begin":1313,"end":1328},"obj":"Chemical"},{"id":"T43","span":{"begin":1384,"end":1404},"obj":"Chemical"},{"id":"T44","span":{"begin":1363,"end":1373},"obj":"Chemical"},{"id":"T45","span":{"begin":1413,"end":1439},"obj":"Chemical"},{"id":"T47","span":{"begin":1479,"end":1495},"obj":"Chemical"},{"id":"T48","span":{"begin":1444,"end":1470},"obj":"Chemical"},{"id":"T49","span":{"begin":1496,"end":1503},"obj":"NegativeRegulation"},{"id":"T50","span":{"begin":1517,"end":1524},"obj":"Phenomena"}],"relations":[{"id":"R45","pred":"of_a","subj":"T55","obj":"T26"},{"id":"R46","pred":"of_a","subj":"T56","obj":"T26"},{"id":"R12","pred":"of_a","subj":"T22","obj":"T12"},{"id":"R14","pred":"has_status","subj":"T32","obj":"T35"},{"id":"R20","pred":"of_a","subj":"T20","obj":"T36"},{"id":"R4","pred":"abbreviation","subj":"T16","obj":"T20"},{"id":"R5","pred":"has_role","subj":"T28","obj":"T32"},{"id":"R52","pred":"against","subj":"T32","obj":"T34"},{"id":"R55","pred":"to","subj":"T34","obj":"T20"},{"id":"R6","pred":"has_role","subj":"T27","obj":"T32"},{"id":"R7","pred":"is_a","subj":"T22","obj":"T34"},{"id":"R21","pred":"-","subj":"T41","obj":"T39"},{"id":"R23","pred":"-","subj":"T44","obj":"T43"},{"id":"R26","pred":"is_a","subj":"T49","obj":"T50"},{"id":"R27","pred":"is_a","subj":"T29","obj":"T49"},{"id":"R28","pred":"is_a","subj":"T41","obj":"T49"},{"id":"R29","pred":"is_a","subj":"T42","obj":"T49"},{"id":"R30","pred":"is_a","subj":"T40","obj":"T49"},{"id":"R31","pred":"is_a","subj":"T44","obj":"T49"},{"id":"R32","pred":"is_a","subj":"T45","obj":"T49"},{"id":"R33","pred":"is_a","subj":"T48","obj":"T49"},{"id":"R34","pred":"is_a","subj":"T47","obj":"T49"},{"id":"R56","pred":"to","subj":"T50","obj":"T19"},{"id":"R1","pred":"abbreviation","subj":"T1","obj":"T3"},{"id":"R11","pred":"of_a","subj":"T5","obj":"T24"},{"id":"R15","pred":"abbreviation","subj":"T11","obj":"T10"},{"id":"R16","pred":"of_a","subj":"T8","obj":"T23"},{"id":"R18","pred":"of_a","subj":"T10","obj":"T38"},{"id":"R19","pred":"of_a","subj":"T38","obj":"T37"},{"id":"R2","pred":"cause_of","subj":"T6","obj":"T3"},{"id":"R3","pred":"is_a","subj":"T25","obj":"T3"},{"id":"R35","pred":"cause_of","subj":"T9","obj":"T2"},{"id":"R37","pred":"against","subj":"T4","obj":"T31"},{"id":"R38","pred":"against","subj":"T4","obj":"T30"},{"id":"R39","pred":"is_a","subj":"T7","obj":"T51"},{"id":"R47","pred":"has_role","subj":"T26","obj":"T52"},{"id":"R49","pred":"of_a","subj":"T7","obj":"T21"},{"id":"R51","pred":"against","subj":"T52","obj":"T51"},{"id":"R53","pred":"against","subj":"T33","obj":"T2"},{"id":"R54","pred":"to","subj":"T51","obj":"T17"},{"id":"R59","pred":"of_a","subj":"T23","obj":"T10"},{"id":"R60","pred":"of_a","subj":"T24","obj":"T13"}],"attributes":[{"id":"A16","pred":"tao:has_database_id","subj":"T23","obj":"Gene:43740568"},{"id":"A60","pred":"Memo","subj":"T43","obj":"MESH:D000076742"},{"id":"A1","pred":"tao:has_database_id","subj":"T1","obj":"MESH:D000086382"},{"id":"A31","pred":"tao:has_database_id","subj":"T42","obj":"MESH:D009828"},{"id":"A69","pred":"ForZoonoses","subj":"T42","obj":"drug"},{"id":"A7","pred":"tao:has_database_id","subj":"T7","obj":"Tax:2697049"},{"id":"A50","pred":"Memo","subj":"T51","obj":"MESH:D053585"},{"id":"A32","pred":"tao:has_database_id","subj":"T40","obj":"MESH:D001647"},{"id":"A61","pred":"Memo","subj":"T40","obj":"MESH:D000076742"},{"id":"A42","pred":"Memo","subj":"T11","obj":"MESH:D000072417"},{"id":"A46","pred":"Memo","subj":"T15","obj":"MESH:D000072417"},{"id":"A29","pred":"tao:has_database_id","subj":"T41","obj":"MESH:D006034"},{"id":"A68","pred":"ForZoonoses","subj":"T41","obj":"drug"},{"id":"A37","pred":"tao:has_database_id","subj":"T38","obj":"MESH:D000072757"},{"id":"A13","pred":"tao:has_database_id","subj":"T19","obj":"Gene:59272"},{"id":"A12","pred":"tao:has_database_id","subj":"T18","obj":"Gene:59272"},{"id":"A40","pred":"Memo","subj":"T21","obj":"MESH:D000072417"},{"id":"A21","pred":"tao:has_database_id","subj":"T27","obj":"MESH:D013256"},{"id":"A66","pred":"ForZoonoses","subj":"T27","obj":"drug"},{"id":"A10","pred":"tao:has_database_id","subj":"T16","obj":"Gene:59272"},{"id":"A24","pred":"tao:has_database_id","subj":"T29","obj":"MESH:D014315"},{"id":"A67","pred":"ForZoonoses","subj":"T29","obj":"drug"},{"id":"A6","pred":"tao:has_database_id","subj":"T6","obj":"Tax:2697049"},{"id":"A41","pred":"Memo","subj":"T10","obj":"MESH:D000072417"},{"id":"A11","pred":"tao:has_database_id","subj":"T17","obj":"Gene:59272"},{"id":"A57","pred":"tao:has_database_id","subj":"T45","obj":"MESH:C024033"},{"id":"A58","pred":"correct/standard/original word","subj":"T45","obj":"glycoursodeoxycholic acid"},{"id":"A5","pred":"tao:has_database_id","subj":"T5","obj":"Tax:2697049"},{"id":"A9","pred":"tao:has_database_id","subj":"T9","obj":"Tax:2697049"},{"id":"A23","pred":"tao:has_database_id","subj":"T28","obj":"MESH:D014315"},{"id":"A65","pred":"ForZoonoses","subj":"T28","obj":"drug"},{"id":"A43","pred":"Memo","subj":"T13","obj":"MESH:D000072417"},{"id":"A3","pred":"tao:has_database_id","subj":"T3","obj":"MESH:D000086382"},{"id":"A64","pred":"ForZoonoses","subj":"T31","obj":"drug"},{"id":"A71","pred":"ForZoonoses","subj":"T33","obj":"drug"},{"id":"A51","pred":"Memo","subj":"T34","obj":"MESH:D053585"},{"id":"A30","pred":"tao:has_database_id","subj":"T39","obj":"MESH:D006034"},{"id":"A70","pred":"ForZoonoses","subj":"T39","obj":"drug"},{"id":"A34506","pred":"tao:has_database_id","subj":"T35","obj":"MESH:D003198"},{"id":"A38","pred":"tao:has_database_id","subj":"T25","obj":"MESH:D012141"},{"id":"A17","pred":"tao:has_database_id","subj":"T24","obj":"Gene:43740568"},{"id":"A34","pred":"tao:has_database_id","subj":"T47","obj":"MESH:C464660"},{"id":"A4","pred":"tao:has_database_id","subj":"T4","obj":"Tax:2697049"},{"id":"A63","pred":"ForZoonoses","subj":"T30","obj":"drug"},{"id":"A45","pred":"Memo","subj":"T14","obj":"MESH:D000072417"},{"id":"A2","pred":"tao:has_database_id","subj":"T2","obj":"MESH:D000086382"},{"id":"A39","pred":"Memo","subj":"T26","obj":"MESH:D013256"},{"id":"A62","pred":"ForZoonoses","subj":"T26","obj":"drug"},{"id":"A14","pred":"tao:has_database_id","subj":"T20","obj":"Gene:59272"},{"id":"A52","pred":"tao:has_database_id","subj":"T50","obj":"MESH:D053585"},{"id":"A44","pred":"Memo","subj":"T12","obj":"MESH:D000072417"},{"id":"A15","pred":"tao:has_database_id","subj":"T22","obj":"Gene:43740568"},{"id":"A59","pred":"Memo","subj":"T44","obj":"MESH:D000076742"},{"id":"A8","pred":"tao:has_database_id","subj":"T8","obj":"Tax:2697049"},{"id":"A53","pred":"Memo","subj":"T36","obj":"MESH:D000072417"},{"subj":"T1","pred":"source","obj":"Zoonoses"},{"subj":"T10","pred":"source","obj":"Zoonoses"},{"subj":"T11","pred":"source","obj":"Zoonoses"},{"subj":"T13","pred":"source","obj":"Zoonoses"},{"subj":"T14","pred":"source","obj":"Zoonoses"},{"subj":"T17","pred":"source","obj":"Zoonoses"},{"subj":"T18","pred":"source","obj":"Zoonoses"},{"subj":"T2","pred":"source","obj":"Zoonoses"},{"subj":"T21","pred":"source","obj":"Zoonoses"},{"subj":"T23","pred":"source","obj":"Zoonoses"},{"subj":"T24","pred":"source","obj":"Zoonoses"},{"subj":"T25","pred":"source","obj":"Zoonoses"},{"subj":"T26","pred":"source","obj":"Zoonoses"},{"subj":"T3","pred":"source","obj":"Zoonoses"},{"subj":"T30","pred":"source","obj":"Zoonoses"},{"subj":"T31","pred":"source","obj":"Zoonoses"},{"subj":"T33","pred":"source","obj":"Zoonoses"},{"subj":"T37","pred":"source","obj":"Zoonoses"},{"subj":"T38","pred":"source","obj":"Zoonoses"},{"subj":"T4","pred":"source","obj":"Zoonoses"},{"subj":"T5","pred":"source","obj":"Zoonoses"},{"subj":"T51","pred":"source","obj":"Zoonoses"},{"subj":"T52","pred":"source","obj":"Zoonoses"},{"subj":"T55","pred":"source","obj":"Zoonoses"},{"subj":"T56","pred":"source","obj":"Zoonoses"},{"subj":"T6","pred":"source","obj":"Zoonoses"},{"subj":"T7","pred":"source","obj":"Zoonoses"},{"subj":"T8","pred":"source","obj":"Zoonoses"},{"subj":"T9","pred":"source","obj":"Zoonoses"},{"subj":"T12","pred":"source","obj":"Zoonoses"},{"subj":"T16","pred":"source","obj":"Zoonoses"},{"subj":"T20","pred":"source","obj":"Zoonoses"},{"subj":"T22","pred":"source","obj":"Zoonoses"},{"subj":"T27","pred":"source","obj":"Zoonoses"},{"subj":"T28","pred":"source","obj":"Zoonoses"},{"subj":"T32","pred":"source","obj":"Zoonoses"},{"subj":"T34","pred":"source","obj":"Zoonoses"},{"subj":"T35","pred":"source","obj":"Zoonoses"},{"subj":"T36","pred":"source","obj":"Zoonoses"},{"subj":"T15","pred":"source","obj":"Zoonoses"},{"subj":"T19","pred":"source","obj":"Zoonoses"},{"subj":"T29","pred":"source","obj":"Zoonoses"},{"subj":"T39","pred":"source","obj":"Zoonoses"},{"subj":"T40","pred":"source","obj":"Zoonoses"},{"subj":"T41","pred":"source","obj":"Zoonoses"},{"subj":"T42","pred":"source","obj":"Zoonoses"},{"subj":"T43","pred":"source","obj":"Zoonoses"},{"subj":"T44","pred":"source","obj":"Zoonoses"},{"subj":"T45","pred":"source","obj":"Zoonoses"},{"subj":"T47","pred":"source","obj":"Zoonoses"},{"subj":"T48","pred":"source","obj":"Zoonoses"},{"subj":"T49","pred":"source","obj":"Zoonoses"},{"subj":"T50","pred":"source","obj":"Zoonoses"}]},{"project":"Covid19_manual_annotation","denotations":[{"id":"T1","span":{"begin":185,"end":193},"obj":"Disease"},{"id":"T2","span":{"begin":1595,"end":1603},"obj":"Disease"},{"id":"T3","span":{"begin":159,"end":183},"obj":"Disease"},{"id":"T4","span":{"begin":527,"end":538},"obj":"Species"},{"id":"T5","span":{"begin":1095,"end":1105},"obj":"Species"},{"id":"T6","span":{"begin":242,"end":300},"obj":"Species"},{"id":"T7","span":{"begin":10,"end":20},"obj":"Species"},{"id":"T8","span":{"begin":699,"end":709},"obj":"Species"},{"id":"T9","span":{"begin":1613,"end":1623},"obj":"Species"},{"id":"T10","span":{"begin":726,"end":749},"obj":"Biological"},{"id":"T11","span":{"begin":751,"end":754},"obj":"Biological"},{"id":"T12","span":{"begin":929,"end":932},"obj":"Biological"},{"id":"T13","span":{"begin":1084,"end":1087},"obj":"Biological"},{"id":"T14","span":{"begin":1183,"end":1186},"obj":"Biological"},{"id":"T15","span":{"begin":1508,"end":1511},"obj":"Biological"},{"id":"T16","span":{"begin":1004,"end":1008},"obj":"Gene"},{"id":"T17","span":{"begin":21,"end":25},"obj":"Gene"},{"id":"T18","span":{"begin":1202,"end":1206},"obj":"Gene"},{"id":"T19","span":{"begin":1512,"end":1516},"obj":"Gene"},{"id":"T20","span":{"begin":973,"end":1002},"obj":"Gene"},{"id":"T21","span":{"begin":130,"end":153},"obj":"Biological"},{"id":"T22","span":{"begin":923,"end":928},"obj":"Gene"},{"id":"T23","span":{"begin":710,"end":725},"obj":"Gene"},{"id":"T24","span":{"begin":1106,"end":1119},"obj":"Gene"},{"id":"T25","span":{"begin":200,"end":227},"obj":"Disease"},{"id":"T26","span":{"begin":77,"end":86},"obj":"Chemical"},{"id":"T27","span":{"begin":874,"end":883},"obj":"Chemical"},{"id":"T28","span":{"begin":861,"end":873},"obj":"Chemical"},{"id":"T29","span":{"begin":1272,"end":1285},"obj":"Chemical"},{"id":"T30","span":{"begin":459,"end":477},"obj":"Chemical"},{"id":"T31","span":{"begin":482,"end":508},"obj":"Chemical"},{"id":"T32","span":{"begin":896,"end":903},"obj":"Interrupt"},{"id":"T33","span":{"begin":1630,"end":1640},"obj":"Chemical"},{"id":"T34","span":{"begin":904,"end":915},"obj":"Bind"},{"id":"T35","span":{"begin":773,"end":782},"obj":"Condition"},{"id":"T36","span":{"begin":942,"end":965},"obj":"Biological"},{"id":"T37","span":{"begin":638,"end":655},"obj":"Biological"},{"id":"T38","span":{"begin":671,"end":691},"obj":"Biological"},{"id":"T39","span":{"begin":1323,"end":1328},"obj":"Chemical"},{"id":"T40","span":{"begin":1363,"end":1373},"obj":"Chemical"},{"id":"T41","span":{"begin":1294,"end":1308},"obj":"Chemical"},{"id":"T42","span":{"begin":1313,"end":1328},"obj":"Chemical"},{"id":"T43","span":{"begin":1384,"end":1404},"obj":"Chemical"},{"id":"T44","span":{"begin":1363,"end":1373},"obj":"Chemical"},{"id":"T45","span":{"begin":1419,"end":1439},"obj":"Chemical"},{"id":"T46","span":{"begin":1413,"end":1418},"obj":"Glycan"},{"id":"T47","span":{"begin":1479,"end":1495},"obj":"Chemical"},{"id":"T48","span":{"begin":1444,"end":1470},"obj":"Chemical"},{"id":"T49","span":{"begin":1496,"end":1503},"obj":"NegativeRegulation"},{"id":"T50","span":{"begin":1517,"end":1524},"obj":"Bind"},{"id":"T51","span":{"begin":35,"end":46},"obj":"Bind"},{"id":"T52","span":{"begin":0,"end":9},"obj":"Interrupt"}],"relations":[{"id":"R20","pred":"of_a","subj":"T20","obj":"T36"},{"id":"R21","pred":"-","subj":"T41","obj":"T39"},{"id":"R22","pred":"with","subj":"T46","obj":"T45"},{"id":"R23","pred":"-","subj":"T44","obj":"T43"},{"id":"R24","pred":"of_a","subj":"T15","obj":"T50"},{"id":"R25","pred":"to","subj":"T19","obj":"T50"},{"id":"R26","pred":"is_a","subj":"T49","obj":"T50"},{"id":"R27","pred":"is_a","subj":"T29","obj":"T49"},{"id":"R28","pred":"is_a","subj":"T41","obj":"T49"},{"id":"R29","pred":"is_a","subj":"T42","obj":"T49"},{"id":"R30","pred":"is_a","subj":"T40","obj":"T49"},{"id":"R31","pred":"is_a","subj":"T44","obj":"T49"},{"id":"R32","pred":"is_a","subj":"T45","obj":"T49"},{"id":"R33","pred":"is_a","subj":"T48","obj":"T49"},{"id":"R34","pred":"is_a","subj":"T47","obj":"T49"},{"id":"R1","pred":"abbreviation","subj":"T1","obj":"T3"},{"id":"R2","pred":"cause_of","subj":"T6","obj":"T3"},{"id":"R3","pred":"is_a","subj":"T25","obj":"T3"},{"id":"R4","pred":"abbreviation","subj":"T16","obj":"T20"},{"id":"R5","pred":"is_a","subj":"T28","obj":"T32"},{"id":"R6","pred":"is_a","subj":"T27","obj":"T32"},{"id":"R7","pred":"is_a","subj":"T22","obj":"T34"},{"id":"R8","pred":"to","subj":"T20","obj":"T34"},{"id":"R10","pred":"is_a","subj":"T32","obj":"T34"},{"id":"R11","pred":"of_a","subj":"T5","obj":"T24"},{"id":"R12","pred":"of_a","subj":"T22","obj":"T12"},{"id":"R13","pred":"of_a","subj":"T24","obj":"T13"},{"id":"R14","pred":"has_status","subj":"T32","obj":"T35"},{"id":"R15","pred":"abbreviation","subj":"T11","obj":"T10"},{"id":"R16","pred":"of_a","subj":"T8","obj":"T23"},{"id":"R17","pred":"of_a","subj":"T23","obj":"T10"},{"id":"R18","pred":"of_a","subj":"T10","obj":"T38"},{"id":"R19","pred":"of_a","subj":"T38","obj":"T37"},{"id":"R35","pred":"cause_of","subj":"T9","obj":"T2"},{"id":"R36","pred":"against","subj":"T2","obj":"T33"},{"id":"R37","pred":"against","subj":"T4","obj":"T31"},{"id":"R38","pred":"against","subj":"T4","obj":"T30"},{"id":"R39","pred":"is_a","subj":"T7","obj":"T51"},{"id":"R40","pred":"to","subj":"T17","obj":"T51"},{"id":"R41","pred":"is_a","subj":"T26","obj":"T52"},{"id":"R42","pred":"is_a","subj":"T52","obj":"T51"}],"attributes":[{"id":"A2","pred":"tao:has_database_id","subj":"T2","obj":"MESH:C000657245"},{"id":"A16","pred":"tao:has_database_id","subj":"T23","obj":"Gene:43740568"},{"id":"A30","pred":"tao:has_database_id","subj":"T39","obj":"D006034"},{"id":"A29","pred":"tao:has_database_id","subj":"T41","obj":"D006034"},{"id":"A3","pred":"tao:has_database_id","subj":"T3","obj":"MESH:C000657245"},{"id":"A27","pred":"ForCovid19","subj":"T30","obj":"drug"},{"id":"A15","pred":"tao:has_database_id","subj":"T22","obj":"Gene:43740568"},{"id":"A1","pred":"tao:has_database_id","subj":"T1","obj":"MESH:C000657245"},{"id":"A31","pred":"tao:has_database_id","subj":"T42","obj":"D009828"},{"id":"A23","pred":"tao:has_database_id","subj":"T28","obj":"D014315"},{"id":"A25","pred":"ForCovid19","subj":"T28","obj":"drug"},{"id":"A7","pred":"tao:has_database_id","subj":"T7","obj":"Tax:2697049"},{"id":"A17","pred":"tao:has_database_id","subj":"T24","obj":"Gene:43740568"},{"id":"A28","pred":"ForCovid19","subj":"T31","obj":"drug"},{"id":"A33","pred":"tao:has_database_id","subj":"T45","obj":"MESH:D014580"},{"id":"A9","pred":"tao:has_database_id","subj":"T9","obj":"Tax:2697049"},{"id":"A5","pred":"tao:has_database_id","subj":"T5","obj":"Tax:2697049"},{"id":"A4","pred":"tao:has_database_id","subj":"T4","obj":"Tax:2697049"},{"id":"A35","pred":"ForCovid19","subj":"T33","obj":"inhibitor"},{"id":"A36","pred":"ForCovid19","subj":"T33","obj":"drug"},{"id":"A10","pred":"tao:has_database_id","subj":"T16","obj":"Gene:59272"},{"id":"A21","pred":"tao:has_database_id","subj":"T27","obj":"D013256"},{"id":"A22","pred":"ForCovid19","subj":"T27","obj":"drug"},{"id":"A34","pred":"tao:has_database_id","subj":"T47","obj":"MESH:C464660"},{"id":"A6","pred":"tao:has_database_id","subj":"T6","obj":"Tax:2697049"},{"id":"A8","pred":"tao:has_database_id","subj":"T8","obj":"Tax:2697049"},{"id":"A11","pred":"tao:has_database_id","subj":"T17","obj":"Gene:59272"},{"id":"A13","pred":"tao:has_database_id","subj":"T19","obj":"Gene:59272"},{"id":"A12","pred":"tao:has_database_id","subj":"T18","obj":"Gene:59272"},{"id":"A14","pred":"tao:has_database_id","subj":"T20","obj":"Gene:59272"},{"id":"A32","pred":"tao:has_database_id","subj":"T40","obj":"MESH:D001647"},{"id":"A19","pred":"tao:has_database_id","subj":"T26","obj":"D013256"},{"id":"A20","pred":"ForCovid19","subj":"T26","obj":"drug"},{"id":"A24","pred":"tao:has_database_id","subj":"T29","obj":"D014315"},{"id":"A26","pred":"ForCovid19","subj":"T29","obj":"drug"},{"id":"A18","pred":"tao:has_database_id","subj":"T25","obj":"D012141"},{"subj":"T1","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T2","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T3","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T4","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T5","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T6","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T7","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T8","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T9","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T10","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T11","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T12","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T13","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T14","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T15","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T16","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T17","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T18","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T19","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T20","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T21","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T22","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T23","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T24","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T25","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T26","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T27","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T28","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T29","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T30","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T31","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T32","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T33","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T34","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T35","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T36","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T37","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T38","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T39","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T40","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T41","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T42","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T43","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T44","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T45","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T46","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T47","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T48","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T49","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T50","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T51","pred":"source","obj":"Covid19_manual_annotation"},{"subj":"T52","pred":"source","obj":"Covid19_manual_annotation"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-sentences","color":"#eca093","default":true},{"id":"Covid19_manual_annotation_v2","color":"#939fec"},{"id":"Zoonoses","color":"#b9ec93"},{"id":"Covid19_manual_annotation","color":"#ec93d3"}]}]}}