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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 120-134 Body_part denotes alveolar cells http://purl.org/sig/ont/fma/fma62499
T2 129-134 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T3 236-240 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T4 326-330 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T5 640-644 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T6 823-827 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T7 828-832 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T8 882-886 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T9 1014-1028 Body_part denotes alveolar cells http://purl.org/sig/ont/fma/fma62499
T10 1023-1028 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T11 1144-1148 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 326-330 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T2 640-644 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T3 669-693 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T4 823-827 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 372-397 Phenotype denotes respiratory insufficiency http://purl.obolibrary.org/obo/HP_0002093
T2 433-445 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T3 658-663 Phenotype denotes edema http://purl.obolibrary.org/obo/HP_0000969
T4 772-787 Phenotype denotes thromboembolism http://purl.obolibrary.org/obo/HP_0001907

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 0-8 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 136-144 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T3 172-180 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T4 293-301 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T5 303-311 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 433-445 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T7 582-590 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T8 1133-1141 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 1229-1237 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 129-134 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 236-240 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 326-330 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T4 326-330 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T5 343-344 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 475-476 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 640-644 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T8 640-644 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T9 807-808 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 817-822 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T11 823-827 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T12 823-827 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T13 828-832 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T14 882-886 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T15 1023-1028 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16 1144-1148 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 81-92 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T2 190-201 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T3 675-686 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T4 936-946 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T5 948-959 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 97-108 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T2 489-499 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T3 559-571 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T4 741-752 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T5 964-975 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3 0-10 Species denotes SARS-CoV-2 Tax:2697049
4 63-73 Gene denotes kallikrein Gene:9622
5 75-92 Gene denotes renin-angiotensin
27 136-146 Species denotes SARS-CoV-2 Tax:2697049
28 172-180 Disease denotes COVID-19 MESH:C000657245
29 190-221 Gene denotes angiotensin converting enzyme-2 Gene:59272
30 223-227 Gene denotes ACE2 Gene:59272
31 293-301 Disease denotes COVID-19 MESH:C000657245
32 303-313 Species denotes SARS-CoV-2 Tax:2697049
33 372-397 Disease denotes respiratory insufficiency MESH:D012131
34 405-427 Disease denotes cardiovascular failure MESH:D002318
35 433-445 Disease denotes coagulopathy MESH:D001778
36 464-468 Gene denotes ACE2 Gene:59272
37 582-590 Disease denotes COVID-19 MESH:C000657245
38 602-612 Gene denotes kallikrein Gene:9622
39 658-663 Disease denotes edema MESH:D004487
40 705-731 Disease denotes cardiovascular instability MESH:D002318
41 772-787 Disease denotes thromboembolism MESH:D013923
42 817-822 Species denotes human Tax:9606
43 936-946 Gene denotes bradykinin Gene:3827
44 1006-1010 Gene denotes ACE2 Gene:59272
45 1116-1120 Gene denotes ACE2 Gene:59272
46 1133-1143 Species denotes SARS-CoV-2 Tax:2697049
47 1229-1237 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-135 Sentence denotes SARS-CoV-2 receptor is co-expressed with elements of the kinin-kallikrein, renin-angiotensin and coagulation systems in alveolar cells.
T2 136-256 Sentence denotes SARS-CoV-2, the pathogenic agent of COVID-19, employs angiotensin converting enzyme-2 (ACE2) as its cell entry receptor.
T3 257-446 Sentence denotes Clinical data reveal that in severe COVID-19, SARS-CoV-2 infects the lung, leading to a frequently lethal triad of respiratory insufficiency, acute cardiovascular failure, and coagulopathy.
T4 447-788 Sentence denotes Physiologically, ACE2 plays a role in the regulation of three systems that could potentially be involved in the pathogenesis of severe COVID-19: the kinin-kallikrein system, resulting in acute lung inflammatory edema; the renin-angiotensin system, promoting cardiovascular instability; and the coagulation system, leading to thromboembolism.
T5 789-1238 Sentence denotes Here we assembled a healthy human lung cell atlas meta-analysis with ~ 130,000 public single-cell transcriptomes and show that key elements of the bradykinin, angiotensin and coagulation systems are co-expressed with ACE2 in alveolar cells and associated with their differentiation dynamics, which could explain how changes in ACE2 promoted by SARS-CoV-2 cell entry result in the development of the three most severe clinical components of COVID-19.

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 326-330 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135
T2 640-644 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135
T3 823-827 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 0-10 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T2 136-146 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T3 172-180 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T4 293-301 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T5 303-313 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T6 433-445 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T7 582-590 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T8 1133-1143 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T9 1229-1237 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 0-8 OrganismTaxon denotes SARS-CoV 694009
T2 136-144 OrganismTaxon denotes SARS-CoV 694009
T3 303-311 OrganismTaxon denotes SARS-CoV 694009
T4 817-822 OrganismTaxon denotes human 9606
T5 1133-1141 OrganismTaxon denotes SARS-CoV 694009

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 120-134 Body_part denotes alveolar cells http://purl.obolibrary.org/obo/CL_4033057
T2 326-330 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T3 640-644 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T4 669-693 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T5 823-827 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T6 1014-1028 Body_part denotes alveolar cells http://purl.obolibrary.org/obo/CL_4033057

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 372-397 Phenotype denotes respiratory insufficiency HP:0002093
T2 433-445 Phenotype denotes coagulopathy HP:0003256
T3 658-663 Phenotype denotes edema HP:0000969
T4 772-787 Phenotype denotes thromboembolism HP:0001907

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 120-134 Cell denotes alveolar cells http://purl.obolibrary.org/obo/CL:4033057
T2 1014-1028 Cell denotes alveolar cells http://purl.obolibrary.org/obo/CL:4033057