PubMed:33170884 / 2474-2724 JSONTXT

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T9","span":{"begin":140,"end":143},"obj":"Disease"}],"attributes":[{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A10","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"}],"text":"Thus, this same three residue sequence acts as a stabilizer of the RBD in the Up conformation through its interactions with its neighboring NTD chain and a kind of latch in the Down state conformation through its interactions with its own SD1 domain."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T24","span":{"begin":47,"end":48},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T25","span":{"begin":154,"end":155},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T26","span":{"begin":239,"end":242},"obj":"http://purl.obolibrary.org/obo/CLO_0008975"}],"text":"Thus, this same three residue sequence acts as a stabilizer of the RBD in the Up conformation through its interactions with its neighboring NTD chain and a kind of latch in the Down state conformation through its interactions with its own SD1 domain."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T15","span":{"begin":49,"end":59},"obj":"Chemical"}],"attributes":[{"id":"A15","pred":"chebi_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_77966"}],"text":"Thus, this same three residue sequence acts as a stabilizer of the RBD in the Up conformation through its interactions with its neighboring NTD chain and a kind of latch in the Down state conformation through its interactions with its own SD1 domain."}

{"project":"LitCovid-sentences","denotations":[{"id":"T12","span":{"begin":0,"end":250},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Thus, this same three residue sequence acts as a stabilizer of the RBD in the Up conformation through its interactions with its neighboring NTD chain and a kind of latch in the Down state conformation through its interactions with its own SD1 domain."}

{"project":"Covid19_manual_annotation_v2","denotations":[{"id":"T11","span":{"begin":67,"end":70},"obj":"Phenomena"},{"id":"T121","span":{"begin":78,"end":93},"obj":"Condition"},{"id":"T122","span":{"begin":177,"end":187},"obj":"Condition"},{"id":"T53","span":{"begin":140,"end":143},"obj":"Phenomena"},{"id":"T65","span":{"begin":239,"end":249},"obj":"Phenomena"},{"id":"T86","span":{"begin":49,"end":59},"obj":"PositiveRegulation"},{"id":"T87","span":{"begin":164,"end":169},"obj":"NegativeRegulation"},{"id":"T88","span":{"begin":11,"end":29},"obj":"Variation"},{"id":"T89","span":{"begin":213,"end":225},"obj":"Phenomena"},{"id":"T90","span":{"begin":106,"end":118},"obj":"Phenomena"}],"relations":[{"id":"R29","pred":"is_a","subj":"T86","obj":"T90"},{"id":"R108","pred":"to","subj":"T90","obj":"T53"},{"id":"R110","pred":"is_a","subj":"T121","obj":"T86"},{"id":"R111","pred":"to","subj":"T89","obj":"T65"},{"id":"R117","pred":"is_a","subj":"T122","obj":"T87"},{"id":"R31","pred":"is_a","subj":"T87","obj":"T89"}],"attributes":[{"id":"A99","pred":"Memo","subj":"T65","obj":"MESH:D000072417"},{"id":"A90","pred":"Memo","subj":"T89","obj":"MESH:D053585"},{"id":"A102","pred":"Memo","subj":"T53","obj":"MESH:D000072417"},{"id":"A89","pred":"Memo","subj":"T90","obj":"MESH:D053585"},{"id":"A83","pred":"Memo","subj":"T11","obj":"MESH:D000072417"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"BioProject","uri":"https://www.ncbi.nlm.nih.gov/bioproject/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"},{"prefix":"HP","uri":"https://hpo.jax.org/app/browse/term/HP:"},{"prefix":"BioSample","uri":"https://www.ncbi.nlm.nih.gov/biosample/"}],"text":"Thus, this same three residue sequence acts as a stabilizer of the RBD in the Up conformation through its interactions with its neighboring NTD chain and a kind of latch in the Down state conformation through its interactions with its own SD1 domain."}