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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 1199-1214 Body_part denotes coronary artery http://purl.org/sig/ont/fma/fma49893

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1199-1214 Body_part denotes coronary artery http://purl.obolibrary.org/obo/UBERON_0001621
T2 1208-1214 Body_part denotes artery http://purl.obolibrary.org/obo/UBERON_0001637

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 61-69 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T2 272-280 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T3 378-381 Disease denotes EBM http://purl.obolibrary.org/obo/MONDO_0010540
T4 510-518 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T5 812-822 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T6 832-846 Disease denotes cardiac arrest http://purl.obolibrary.org/obo/MONDO_0000745
T7 1029-1040 Disease denotes arrhythmias http://purl.obolibrary.org/obo/MONDO_0007263
T8 1199-1222 Disease denotes coronary artery disease http://purl.obolibrary.org/obo/MONDO_0005010
T9 1208-1222 Disease denotes artery disease http://purl.obolibrary.org/obo/MONDO_0000473
T10 1224-1236 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T11 1238-1246 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T12 1413-1421 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T13 1558-1572 Disease denotes cardiac arrest http://purl.obolibrary.org/obo/MONDO_0000745
T14 1648-1656 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T15 1666-1674 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 80-81 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T2 130-139 http://purl.obolibrary.org/obo/BFO_0000030 denotes Objective
T3 466-468 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T4 630-631 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 717-718 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T6 744-745 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 886-888 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T8 1059-1061 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T9 1132-1134 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T10 1148-1150 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T11 1208-1214 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
T12 1208-1214 http://www.ebi.ac.uk/efo/EFO_0000814 denotes artery
T13 1465-1466 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 24-35 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T2 206-217 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T3 219-221 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T4 227-245 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T5 541-543 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T6 568-580 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T7 826-828 Chemical denotes VT http://purl.obolibrary.org/obo/CHEBI_90330
T8 878-880 Chemical denotes I2 http://purl.obolibrary.org/obo/CHEBI_17606
T9 995-997 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T10 1064-1066 Chemical denotes I2 http://purl.obolibrary.org/obo/CHEBI_17606
T11 1174-1176 Chemical denotes I2 http://purl.obolibrary.org/obo/CHEBI_17606
T12 1436-1438 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T13 1487-1491 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T14 1555-1557 Chemical denotes VT http://purl.obolibrary.org/obo/CHEBI_90330
T15 1705-1718 Chemical denotes antimalarials http://purl.obolibrary.org/obo/CHEBI_38068

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
5 4-20 Disease denotes Cardiac Toxicity MESH:D066126
6 24-35 Chemical denotes Chloroquine MESH:D002738
7 39-57 Chemical denotes Hydroxychloroquine MESH:D006886
8 61-69 Disease denotes COVID-19 MESH:C000657245
9 70-78 Species denotes Patients Tax:9606
46 206-217 Chemical denotes Chloroquine MESH:D002738
47 219-221 Chemical denotes CQ MESH:D002738
48 227-245 Chemical denotes hydroxychloroquine MESH:D006886
49 247-250 Chemical denotes HCQ MESH:D006886
50 260-268 Disease denotes toxicity MESH:D064420
51 272-280 Disease denotes COVID-19 MESH:C000657245
52 281-289 Species denotes patients Tax:9606
53 510-518 Disease denotes COVID-19 MESH:C000657245
54 519-527 Species denotes patients Tax:9606
55 541-543 Chemical denotes CQ MESH:D002738
56 547-550 Chemical denotes HCQ MESH:D006886
57 568-580 Chemical denotes azithromycin MESH:D017963
58 597-615 Disease denotes cardiac toxicities MESH:D066126
59 760-768 Species denotes patients Tax:9606
60 808-822 Disease denotes TdP arrhythmia MESH:D001145
61 826-828 Disease denotes VT MESH:D017180
62 832-846 Disease denotes cardiac arrest MESH:D006323
63 907-915 Species denotes patients Tax:9606
64 942-950 Species denotes patients Tax:9606
65 995-997 Chemical denotes CQ MESH:D002738
66 1001-1004 Chemical denotes HCQ MESH:D006886
67 1029-1040 Disease denotes arrhythmias MESH:D001145
68 1199-1222 Disease denotes coronary artery disease MESH:D003324
69 1224-1236 Disease denotes hypertension MESH:D006973
70 1238-1246 Disease denotes diabetes MESH:D003920
71 1413-1421 Disease denotes COVID-19 MESH:C000657245
72 1422-1430 Species denotes patients Tax:9606
73 1436-1438 Chemical denotes CQ MESH:D002738
74 1442-1445 Chemical denotes HCQ MESH:D006886
75 1500-1515 Disease denotes QT prolongation MESH:D008133
76 1551-1554 Disease denotes TdP MESH:D016171
77 1555-1557 Disease denotes VT MESH:D017180
78 1558-1572 Disease denotes cardiac arrest MESH:D006323
79 1648-1656 Disease denotes COVID-19 MESH:C000657245
80 1666-1674 Disease denotes COVID-19 MESH:C000657245
81 1675-1683 Species denotes patients Tax:9606

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-79 Sentence denotes The Cardiac Toxicity of Chloroquine or Hydroxychloroquine in COVID-19 Patients:
T2 80-129 Sentence denotes A Systematic Review and Meta-regression Analysis.
T3 130-140 Sentence denotes Objective:
T4 141-290 Sentence denotes To systematically review the literature and estimate the risk of Chloroquine (CQ) and hydroxychloroquine (HCQ) cardiac toxicity in COVID-19 patients.
T5 291-299 Sentence denotes Methods:
T6 300-475 Sentence denotes We searched multiple data sources including PubMed/MEDLINE, Ovid Embase, Ovid EBM Reviews, Scopus, and Web of Science, and medrxiv.org from November 2019 through May 27, 2020.
T7 476-616 Sentence denotes We included studies that enrolled COVID-19 patients treated with CQ or HCQ, with or without azithromycin and reported on cardiac toxicities.
T8 617-707 Sentence denotes We performed a meta-analysis using the arcsine transformation of the different incidences.
T9 708-716 Sentence denotes Results:
T10 717-783 Sentence denotes A total of 19 studies with a total of 5652 patients were included.
T11 784-916 Sentence denotes The pooled incidence of TdP arrhythmia or VT or cardiac arrest was 3 per 1000, 95% CI (0-21), I2=96%, 18 studies with 3725 patients.
T12 917-1071 Sentence denotes Among 13 studies of 4334 patients, the pooled incidence of discontinuation of CQ or HCQ due to prolonged QTc or arrhythmias was 5%, 95% CI (1-11), I2=98%.
T13 1072-1181 Sentence denotes The pooled incidence of change in QTc from baseline of ≥ 60 ms or QTc ≥ 500 ms was 9%, 95% CI (3-17), I2=97%.
T14 1182-1386 Sentence denotes Mean/median age, coronary artery disease, hypertension, diabetes, concomitant QT prolonging medications, ICU care, and severity of illness in the study populations explained between-studies heterogeneity.
T15 1387-1399 Sentence denotes Conclusions:
T16 1400-1573 Sentence denotes Treatment of COVID-19 patients with CQ or HCQ is associated with a significant risk of drug-induced QT prolongation and relatively higher incidence of TdP/VT/cardiac arrest.
T17 1574-1665 Sentence denotes Therefore, these agents should not be used routinely in the management of COVID-19 disease.
T18 1666-1772 Sentence denotes COVID-19 patients who are treated with antimalarials for other indications should be adequately monitored.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 812-822 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T2 832-846 Phenotype denotes cardiac arrest http://purl.obolibrary.org/obo/HP_0001695
T3 1029-1040 Phenotype denotes arrhythmias http://purl.obolibrary.org/obo/HP_0011675
T4 1224-1236 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T5 1558-1572 Phenotype denotes cardiac arrest http://purl.obolibrary.org/obo/HP_0001695