PubMed:33163895
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T1 | 1199-1214 | Body_part | denotes | coronary artery | http://purl.org/sig/ont/fma/fma49893 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 1199-1214 | Body_part | denotes | coronary artery | http://purl.obolibrary.org/obo/UBERON_0001621 |
T2 | 1208-1214 | Body_part | denotes | artery | http://purl.obolibrary.org/obo/UBERON_0001637 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 61-69 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T2 | 272-280 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T3 | 378-381 | Disease | denotes | EBM | http://purl.obolibrary.org/obo/MONDO_0010540 |
T4 | 510-518 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T5 | 812-822 | Disease | denotes | arrhythmia | http://purl.obolibrary.org/obo/MONDO_0007263 |
T6 | 832-846 | Disease | denotes | cardiac arrest | http://purl.obolibrary.org/obo/MONDO_0000745 |
T7 | 1029-1040 | Disease | denotes | arrhythmias | http://purl.obolibrary.org/obo/MONDO_0007263 |
T8 | 1199-1222 | Disease | denotes | coronary artery disease | http://purl.obolibrary.org/obo/MONDO_0005010 |
T9 | 1208-1222 | Disease | denotes | artery disease | http://purl.obolibrary.org/obo/MONDO_0000473 |
T10 | 1224-1236 | Disease | denotes | hypertension | http://purl.obolibrary.org/obo/MONDO_0005044 |
T11 | 1238-1246 | Disease | denotes | diabetes | http://purl.obolibrary.org/obo/MONDO_0005015 |
T12 | 1413-1421 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T13 | 1558-1572 | Disease | denotes | cardiac arrest | http://purl.obolibrary.org/obo/MONDO_0000745 |
T14 | 1648-1656 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T15 | 1666-1674 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 80-81 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T2 | 130-139 | http://purl.obolibrary.org/obo/BFO_0000030 | denotes | Objective |
T3 | 466-468 | http://purl.obolibrary.org/obo/CLO_0050509 | denotes | 27 |
T4 | 630-631 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T5 | 717-718 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T6 | 744-745 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T7 | 886-888 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
T8 | 1059-1061 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
T9 | 1132-1134 | http://purl.obolibrary.org/obo/CLO_0007874 | denotes | ms |
T10 | 1148-1150 | http://purl.obolibrary.org/obo/CLO_0007874 | denotes | ms |
T11 | 1208-1214 | http://purl.obolibrary.org/obo/UBERON_0001637 | denotes | artery |
T12 | 1208-1214 | http://www.ebi.ac.uk/efo/EFO_0000814 | denotes | artery |
T13 | 1465-1466 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T1 | 24-35 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
T2 | 206-217 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
T3 | 219-221 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
T4 | 227-245 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
T5 | 541-543 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
T6 | 568-580 | Chemical | denotes | azithromycin | http://purl.obolibrary.org/obo/CHEBI_2955 |
T7 | 826-828 | Chemical | denotes | VT | http://purl.obolibrary.org/obo/CHEBI_90330 |
T8 | 878-880 | Chemical | denotes | I2 | http://purl.obolibrary.org/obo/CHEBI_17606 |
T9 | 995-997 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
T10 | 1064-1066 | Chemical | denotes | I2 | http://purl.obolibrary.org/obo/CHEBI_17606 |
T11 | 1174-1176 | Chemical | denotes | I2 | http://purl.obolibrary.org/obo/CHEBI_17606 |
T12 | 1436-1438 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
T13 | 1487-1491 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T14 | 1555-1557 | Chemical | denotes | VT | http://purl.obolibrary.org/obo/CHEBI_90330 |
T15 | 1705-1718 | Chemical | denotes | antimalarials | http://purl.obolibrary.org/obo/CHEBI_38068 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
5 | 4-20 | Disease | denotes | Cardiac Toxicity | MESH:D066126 |
6 | 24-35 | Chemical | denotes | Chloroquine | MESH:D002738 |
7 | 39-57 | Chemical | denotes | Hydroxychloroquine | MESH:D006886 |
8 | 61-69 | Disease | denotes | COVID-19 | MESH:C000657245 |
9 | 70-78 | Species | denotes | Patients | Tax:9606 |
46 | 206-217 | Chemical | denotes | Chloroquine | MESH:D002738 |
47 | 219-221 | Chemical | denotes | CQ | MESH:D002738 |
48 | 227-245 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
49 | 247-250 | Chemical | denotes | HCQ | MESH:D006886 |
50 | 260-268 | Disease | denotes | toxicity | MESH:D064420 |
51 | 272-280 | Disease | denotes | COVID-19 | MESH:C000657245 |
52 | 281-289 | Species | denotes | patients | Tax:9606 |
53 | 510-518 | Disease | denotes | COVID-19 | MESH:C000657245 |
54 | 519-527 | Species | denotes | patients | Tax:9606 |
55 | 541-543 | Chemical | denotes | CQ | MESH:D002738 |
56 | 547-550 | Chemical | denotes | HCQ | MESH:D006886 |
57 | 568-580 | Chemical | denotes | azithromycin | MESH:D017963 |
58 | 597-615 | Disease | denotes | cardiac toxicities | MESH:D066126 |
59 | 760-768 | Species | denotes | patients | Tax:9606 |
60 | 808-822 | Disease | denotes | TdP arrhythmia | MESH:D001145 |
61 | 826-828 | Disease | denotes | VT | MESH:D017180 |
62 | 832-846 | Disease | denotes | cardiac arrest | MESH:D006323 |
63 | 907-915 | Species | denotes | patients | Tax:9606 |
64 | 942-950 | Species | denotes | patients | Tax:9606 |
65 | 995-997 | Chemical | denotes | CQ | MESH:D002738 |
66 | 1001-1004 | Chemical | denotes | HCQ | MESH:D006886 |
67 | 1029-1040 | Disease | denotes | arrhythmias | MESH:D001145 |
68 | 1199-1222 | Disease | denotes | coronary artery disease | MESH:D003324 |
69 | 1224-1236 | Disease | denotes | hypertension | MESH:D006973 |
70 | 1238-1246 | Disease | denotes | diabetes | MESH:D003920 |
71 | 1413-1421 | Disease | denotes | COVID-19 | MESH:C000657245 |
72 | 1422-1430 | Species | denotes | patients | Tax:9606 |
73 | 1436-1438 | Chemical | denotes | CQ | MESH:D002738 |
74 | 1442-1445 | Chemical | denotes | HCQ | MESH:D006886 |
75 | 1500-1515 | Disease | denotes | QT prolongation | MESH:D008133 |
76 | 1551-1554 | Disease | denotes | TdP | MESH:D016171 |
77 | 1555-1557 | Disease | denotes | VT | MESH:D017180 |
78 | 1558-1572 | Disease | denotes | cardiac arrest | MESH:D006323 |
79 | 1648-1656 | Disease | denotes | COVID-19 | MESH:C000657245 |
80 | 1666-1674 | Disease | denotes | COVID-19 | MESH:C000657245 |
81 | 1675-1683 | Species | denotes | patients | Tax:9606 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-79 | Sentence | denotes | The Cardiac Toxicity of Chloroquine or Hydroxychloroquine in COVID-19 Patients: |
T2 | 80-129 | Sentence | denotes | A Systematic Review and Meta-regression Analysis. |
T3 | 130-140 | Sentence | denotes | Objective: |
T4 | 141-290 | Sentence | denotes | To systematically review the literature and estimate the risk of Chloroquine (CQ) and hydroxychloroquine (HCQ) cardiac toxicity in COVID-19 patients. |
T5 | 291-299 | Sentence | denotes | Methods: |
T6 | 300-475 | Sentence | denotes | We searched multiple data sources including PubMed/MEDLINE, Ovid Embase, Ovid EBM Reviews, Scopus, and Web of Science, and medrxiv.org from November 2019 through May 27, 2020. |
T7 | 476-616 | Sentence | denotes | We included studies that enrolled COVID-19 patients treated with CQ or HCQ, with or without azithromycin and reported on cardiac toxicities. |
T8 | 617-707 | Sentence | denotes | We performed a meta-analysis using the arcsine transformation of the different incidences. |
T9 | 708-716 | Sentence | denotes | Results: |
T10 | 717-783 | Sentence | denotes | A total of 19 studies with a total of 5652 patients were included. |
T11 | 784-916 | Sentence | denotes | The pooled incidence of TdP arrhythmia or VT or cardiac arrest was 3 per 1000, 95% CI (0-21), I2=96%, 18 studies with 3725 patients. |
T12 | 917-1071 | Sentence | denotes | Among 13 studies of 4334 patients, the pooled incidence of discontinuation of CQ or HCQ due to prolonged QTc or arrhythmias was 5%, 95% CI (1-11), I2=98%. |
T13 | 1072-1181 | Sentence | denotes | The pooled incidence of change in QTc from baseline of ≥ 60 ms or QTc ≥ 500 ms was 9%, 95% CI (3-17), I2=97%. |
T14 | 1182-1386 | Sentence | denotes | Mean/median age, coronary artery disease, hypertension, diabetes, concomitant QT prolonging medications, ICU care, and severity of illness in the study populations explained between-studies heterogeneity. |
T15 | 1387-1399 | Sentence | denotes | Conclusions: |
T16 | 1400-1573 | Sentence | denotes | Treatment of COVID-19 patients with CQ or HCQ is associated with a significant risk of drug-induced QT prolongation and relatively higher incidence of TdP/VT/cardiac arrest. |
T17 | 1574-1665 | Sentence | denotes | Therefore, these agents should not be used routinely in the management of COVID-19 disease. |
T18 | 1666-1772 | Sentence | denotes | COVID-19 patients who are treated with antimalarials for other indications should be adequately monitored. |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 812-822 | Phenotype | denotes | arrhythmia | http://purl.obolibrary.org/obo/HP_0011675 |
T2 | 832-846 | Phenotype | denotes | cardiac arrest | http://purl.obolibrary.org/obo/HP_0001695 |
T3 | 1029-1040 | Phenotype | denotes | arrhythmias | http://purl.obolibrary.org/obo/HP_0011675 |
T4 | 1224-1236 | Phenotype | denotes | hypertension | http://purl.obolibrary.org/obo/HP_0000822 |
T5 | 1558-1572 | Phenotype | denotes | cardiac arrest | http://purl.obolibrary.org/obo/HP_0001695 |