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PubMed:33149259 JSONTXT

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mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 58-73 Disease denotes prostate cancer http://purl.obolibrary.org/obo/MONDO_0008315
T2 145-160 Disease denotes prostate cancer http://purl.obolibrary.org/obo/MONDO_0008315
T3 162-165 Disease denotes PCa http://purl.obolibrary.org/obo/MONDO_0008315
T4 261-264 Disease denotes PCa http://purl.obolibrary.org/obo/MONDO_0008315
T5 294-297 Disease denotes PCa http://purl.obolibrary.org/obo/MONDO_0008315
T6 342-345 Disease denotes PCa http://purl.obolibrary.org/obo/MONDO_0008315
T7 550-553 Disease denotes PCa http://purl.obolibrary.org/obo/MONDO_0008315
T8 673-676 Disease denotes PCa http://purl.obolibrary.org/obo/MONDO_0008315
T9 1153-1156 Disease denotes PCa http://purl.obolibrary.org/obo/MONDO_0008315
T10 1359-1362 Disease denotes PCa http://purl.obolibrary.org/obo/MONDO_0008315
T11 1434-1437 Disease denotes PCa http://purl.obolibrary.org/obo/MONDO_0008315
T12 1530-1533 Disease denotes PCa http://purl.obolibrary.org/obo/MONDO_0008315

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 1100-1106 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 47-57 Phenotype denotes aggressive HP:0000718
T2 58-73 Phenotype denotes prostate cancer HP:0012125
T3 145-160 Phenotype denotes prostate cancer HP:0012125
T4 162-165 Phenotype denotes PCa HP:0012125
T5 261-264 Phenotype denotes PCa HP:0012125
T6 283-293 Phenotype denotes aggressive HP:0000718
T7 294-297 Phenotype denotes PCa HP:0012125
T8 342-345 Phenotype denotes PCa HP:0012125
T9 550-553 Phenotype denotes PCa HP:0012125
T10 554-568 Phenotype denotes aggressiveness HP:0000718
T11 662-672 Phenotype denotes aggressive HP:0000718
T12 673-676 Phenotype denotes PCa HP:0012125
T13 1142-1152 Phenotype denotes aggressive HP:0000718
T14 1153-1156 Phenotype denotes PCa HP:0012125
T15 1348-1358 Phenotype denotes aggressive HP:0000718
T16 1359-1362 Phenotype denotes PCa HP:0012125
T17 1423-1433 Phenotype denotes aggressive HP:0000718
T18 1434-1437 Phenotype denotes PCa HP:0012125
T19 1530-1533 Phenotype denotes PCa HP:0012125

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 1100-1106 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 58-73 Phenotype denotes prostate cancer HP:0012125
T2 145-160 Phenotype denotes prostate cancer HP:0012125
T3 162-165 Phenotype denotes PCa HP:0012125
T4 261-264 Phenotype denotes PCa HP:0012125
T5 294-297 Phenotype denotes PCa HP:0012125
T6 342-345 Phenotype denotes PCa HP:0012125
T7 550-553 Phenotype denotes PCa HP:0012125
T8 554-568 Phenotype denotes aggressiveness HP:0000718
T9 673-676 Phenotype denotes PCa HP:0012125
T10 1153-1156 Phenotype denotes PCa HP:0012125
T11 1359-1362 Phenotype denotes PCa HP:0012125
T12 1434-1437 Phenotype denotes PCa HP:0012125
T13 1530-1533 Phenotype denotes PCa HP:0012125

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 58-66 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367
T2 91-99 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367
T3 145-153 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367
T4 235-243 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367
T5 647-658 Body_part denotes blood serum http://purl.obolibrary.org/obo/UBERON_0001977
T6 757-771 Body_part denotes seminal plasma http://purl.obolibrary.org/obo/UBERON_0006530
T7 1051-1062 Body_part denotes blood serum http://purl.obolibrary.org/obo/UBERON_0001977

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 58-73 Disease denotes prostate cancer MONDO:0005159|MONDO:0008315
T3 145-160 Disease denotes prostate cancer MONDO:0005159|MONDO:0008315
T5 162-165 Disease denotes PCa MONDO:0005159|MONDO:0008315
T7 261-264 Disease denotes PCa MONDO:0005159|MONDO:0008315
T9 294-297 Disease denotes PCa MONDO:0005159|MONDO:0008315
T11 342-345 Disease denotes PCa MONDO:0005159|MONDO:0008315
T13 550-553 Disease denotes PCa MONDO:0005159|MONDO:0008315
T15 673-676 Disease denotes PCa MONDO:0005159|MONDO:0008315
T17 1153-1156 Disease denotes PCa MONDO:0005159|MONDO:0008315
T19 1359-1362 Disease denotes PCa MONDO:0005159|MONDO:0008315
T21 1434-1437 Disease denotes PCa MONDO:0005159|MONDO:0008315
T23 1530-1533 Disease denotes PCa MONDO:0005159|MONDO:0008315

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 677-685 Organism denotes patients 9606
T2 1157-1165 Organism denotes patients 9606

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-74 Sentence denotes Characterisation of the main PSA glycoforms in aggressive prostate cancer.
T2 75-177 Sentence denotes Serum levels of prostate specific antigen (PSA) are commonly used for prostate cancer (PCa) detection.
T3 178-357 Sentence denotes However, their lack of specificity to distinguish benign prostate pathologies from PCa, or indolent from aggressive PCa have prompted the study of new non-invasive PCa biomarkers.
T4 358-569 Sentence denotes Aberrant glycosylation is involved in neoplastic progression and specific changes in PSA glycosylation pattern, as the reduction in the percentage of α2,6-sialic acid (SA) are associated with PCa aggressiveness.
T5 570-772 Sentence denotes In this study, we have characterised the main sialylated PSA glycoforms from blood serum of aggressive PCa patients and have compared with those of standard PSA from healthy individuals' seminal plasma.
T6 773-885 Sentence denotes PSA was immunoprecipitated and α2,6-SA were separated from α2,3-SA glycoforms using SNA affinity chromatography.
T7 886-1026 Sentence denotes PSA N-glycans were released, labelled and analysed by hydrophilic interaction liquid chromatography combined with exoglycosidase digestions.
T8 1027-1363 Sentence denotes The results showed that blood serum PSA sialylated glycoforms containing GalNAc residues were largely increased in aggressive PCa patients, whereas the disialylated core fucosylated biantennary structures with α2,6-SA, which are the major PSA glycoforms in standard PSA from healthy individuals, were markedly reduced in aggressive PCa.
T9 1364-1554 Sentence denotes The identification of these main PSA glycoforms altered in aggressive PCa opens the way to design specific strategies to target them, which will be useful to improve PCa risk stratification.

GlyCosmos15-Lectin-Jamboree

Id Subject Object Predicate Lexical cue glycosmos_id
T1 29-32 Lectin denotes PSA GL_000021
T2 118-121 Lectin denotes PSA GL_000021
T3 443-446 Lectin denotes PSA GL_000021
T4 627-630 Lectin denotes PSA GL_000021
T5 727-730 Lectin denotes PSA GL_000021
T6 773-776 Lectin denotes PSA GL_000021
T7 857-860 Lectin denotes SNA GL_003701
T8 886-889 Lectin denotes PSA GL_000021
T9 1063-1066 Lectin denotes PSA GL_000021
T10 1266-1269 Lectin denotes PSA GL_000021
T11 1293-1296 Lectin denotes PSA GL_000021
T12 1397-1400 Lectin denotes PSA GL_000021

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 58-66 Body_part denotes prostate FMA:9600
T2 75-80 Body_part denotes Serum FMA:63083
T3 91-99 Body_part denotes prostate FMA:9600
T4 145-153 Body_part denotes prostate FMA:9600
T5 235-243 Body_part denotes prostate FMA:9600
T6 647-658 Body_part denotes blood serum FMA:63083
T7 765-771 Body_part denotes plasma FMA:62970
T8 1051-1062 Body_part denotes blood serum FMA:63083

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 58-66 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078
T2 91-99 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078
T3 145-153 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078
T4 235-243 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078
T5 647-652 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000315
T6 1051-1056 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000315

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 58-66 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078
T2 91-99 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078
T3 145-153 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078
T4 235-243 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078
T5 647-652 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315
T7 1051-1056 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 58-66 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367
T2 91-99 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367
T3 145-153 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367
T4 235-243 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367
T5 647-658 Body_part denotes blood serum http://purl.obolibrary.org/obo/UBERON_0001977
T6 757-771 Body_part denotes seminal plasma http://purl.obolibrary.org/obo/UBERON_0006530
T7 1051-1062 Body_part denotes blood serum http://purl.obolibrary.org/obo/UBERON_0001977