PubMed:33147270
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T1 | 0-5 | Body_part | denotes | Liver | http://purl.org/sig/ont/fma/fma7197 |
| T2 | 177-182 | Body_part | denotes | Liver | http://purl.org/sig/ont/fma/fma7197 |
| T3 | 332-337 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T4 | 563-568 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T5 | 607-612 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T6 | 659-666 | Body_part | denotes | alanine | http://purl.org/sig/ont/fma/fma82749 |
| T7 | 1212-1219 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T8 | 1299-1304 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T9 | 1908-1913 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 0-5 | Body_part | denotes | Liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T2 | 177-182 | Body_part | denotes | Liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T3 | 332-337 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T4 | 563-568 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T5 | 607-612 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T6 | 1299-1304 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T7 | 1908-1913 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 66-75 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T2 | 594-620 | Phenotype | denotes | elevation of liver enzymes | http://purl.obolibrary.org/obo/HP_0002910 |
| T3 | 915-924 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T4 | 1134-1142 | Phenotype | denotes | diarrhea | http://purl.obolibrary.org/obo/HP_0002014 |
| T5 | 1148-1154 | Phenotype | denotes | nausea | http://purl.obolibrary.org/obo/HP_0002018 |
| T6 | 1405-1414 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T7 | 1425-1434 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T8 | 1978-1987 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 6-12 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T2 | 18-26 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T3 | 66-75 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T4 | 106-130 | Disease | denotes | coronavirus disease 2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T5 | 132-140 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T6 | 183-189 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T7 | 223-231 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T8 | 338-344 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T9 | 421-429 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T10 | 464-472 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T11 | 569-575 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T12 | 906-914 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T13 | 915-924 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T14 | 1106-1108 | Disease | denotes | GS | http://purl.obolibrary.org/obo/MONDO_0005773 |
| T15 | 1134-1142 | Disease | denotes | diarrhea | http://purl.obolibrary.org/obo/MONDO_0001673 |
| T16 | 1268-1270 | Disease | denotes | GS | http://purl.obolibrary.org/obo/MONDO_0005773 |
| T17 | 1305-1311 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T18 | 1405-1414 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T19 | 1425-1434 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T20 | 1455-1457 | Disease | denotes | GS | http://purl.obolibrary.org/obo/MONDO_0005773 |
| T21 | 1891-1899 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T22 | 1914-1920 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T23 | 1959-1961 | Disease | denotes | GS | http://purl.obolibrary.org/obo/MONDO_0005773 |
| T24 | 1978-1987 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-5 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | Liver |
| T2 | 0-5 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | Liver |
| T3 | 97-100 | http://purl.obolibrary.org/obo/PR_000001343 | denotes | AIM |
| T4 | 153-154 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T5 | 177-182 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | Liver |
| T6 | 177-182 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | Liver |
| T7 | 332-337 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T8 | 332-337 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T9 | 360-361 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T10 | 563-568 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T11 | 563-568 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T12 | 607-612 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T13 | 607-612 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T14 | 828-829 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T15 | 872-874 | http://purl.obolibrary.org/obo/CLO_0053794 | denotes | 41 |
| T16 | 1044-1045 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T17 | 1055-1057 | http://purl.obolibrary.org/obo/CLO_0050509 | denotes | 27 |
| T18 | 1156-1157 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T19 | 1299-1304 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T20 | 1299-1304 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T21 | 1750-1752 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 48 |
| T22 | 1908-1913 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T23 | 1908-1913 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T1 | 97-100 | Chemical | denotes | AIM | http://purl.obolibrary.org/obo/CHEBI_3416 |
| T2 | 622-631 | Chemical | denotes | aspartate | http://purl.obolibrary.org/obo/CHEBI_132943|http://purl.obolibrary.org/obo/CHEBI_29995|http://purl.obolibrary.org/obo/CHEBI_72314 |
| T5 | 650-653 | Chemical | denotes | AST | http://purl.obolibrary.org/obo/CHEBI_76649 |
| T6 | 659-666 | Chemical | denotes | alanine | http://purl.obolibrary.org/obo/CHEBI_16449 |
| T7 | 1106-1108 | Chemical | denotes | GS | http://purl.obolibrary.org/obo/CHEBI_73516 |
| T8 | 1212-1219 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T9 | 1268-1270 | Chemical | denotes | GS | http://purl.obolibrary.org/obo/CHEBI_73516 |
| T10 | 1381-1386 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T11 | 1416-1421 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T12 | 1455-1457 | Chemical | denotes | GS | http://purl.obolibrary.org/obo/CHEBI_73516 |
| T13 | 1463-1468 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T14 | 1611-1614 | Chemical | denotes | AST | http://purl.obolibrary.org/obo/CHEBI_76649 |
| T15 | 1692-1695 | Chemical | denotes | AST | http://purl.obolibrary.org/obo/CHEBI_76649 |
| T16 | 1745-1748 | Chemical | denotes | AST | http://purl.obolibrary.org/obo/CHEBI_76649 |
| T17 | 1802-1805 | Chemical | denotes | AST | http://purl.obolibrary.org/obo/CHEBI_76649 |
| T18 | 1959-1961 | Chemical | denotes | GS | http://purl.obolibrary.org/obo/CHEBI_73516 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-85 | Sentence | denotes | Liver injury with COVID-19 based on gastrointestinal symptoms and pneumonia severity. |
| T2 | 86-101 | Sentence | denotes | BACKGROUND/AIM: |
| T3 | 102-176 | Sentence | denotes | The coronavirus disease 2019 (COVID-19) had become a big threat worldwide. |
| T4 | 177-278 | Sentence | denotes | Liver injury is not uncommon in patients with COVID-19, and clarifying its characteristics is needed. |
| T5 | 279-430 | Sentence | denotes | This study aimed to identify factors associated with liver injury and to develop a new classification of predictive severity in patients with COVID-19. |
| T6 | 431-439 | Sentence | denotes | METHODS: |
| T7 | 440-547 | Sentence | denotes | Confirmed patients with COVID-19 (n = 60) were recruited retrospectively from Musashino Red Cross Hospital. |
| T8 | 548-705 | Sentence | denotes | The factors of liver injury especially on the elevation of liver enzymes (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]) were analyzed. |
| T9 | 706-811 | Sentence | denotes | Grading was assessed according to the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. |
| T10 | 812-820 | Sentence | denotes | RESULTS: |
| T11 | 821-925 | Sentence | denotes | During a median hospitalization follow-up of 15 (4-41) days, 51 (85.0%) patients had COVID-19 pneumonia. |
| T12 | 926-1043 | Sentence | denotes | In clinical courses, oxygenation was needed for 25 (41.6%) patients and intubation was needed for 9 (15.0%) patients. |
| T13 | 1044-1155 | Sentence | denotes | A total of 27 (45.0%) patients had gastrointestinal symptoms (GS), such as appetite loss, diarrhea, and nausea. |
| T14 | 1156-1312 | Sentence | denotes | A logistic regression analysis revealed that C-reactive protein (CRP) at baseline, oxygenation, intubation, and GS were significant factors of liver injury. |
| T15 | 1313-1483 | Sentence | denotes | Based on these results, patients were classified into three groups: group 1, no oxygenation pneumonia; group 2, pneumonia with oxygenation or GS; and group 3, intubation. |
| T16 | 1484-1598 | Sentence | denotes | We classified 25 (41.7%), 26 (43.3%), and 9 (15.0%) patients into mild, moderate, and severe groups, respectively. |
| T17 | 1599-1878 | Sentence | denotes | The peak of AST and ALT levels was significantly stratified with this criteria (mild [median AST, 28 IU/L; median ALT, 33 IU/L], moderate [median AST, 48 IU/L; median ALT, 47.5 IU/L], and severe [median AST, 109 IU/L; median ALT, 106 IU/L]; P<0.001 and P = 0.0114, respectively). |
| T18 | 1879-1988 | Sentence | denotes | CONCLUSION: COVID-19-related liver injury was significantly stratified based on GS and severity of pneumonia. |