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LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 736-747 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T2 924-936 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acids

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 691-698 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T2 775-780 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T3 879-884 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 14-23 Disease denotes Influenza http://purl.obolibrary.org/obo/MONDO_0005812
T2 106-115 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T3 208-227 Disease denotes respiratory disease http://purl.obolibrary.org/obo/MONDO_0005087
T4 1415-1423 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 24-31 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes Viruses
T2 35-40 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T3 41-47 http://purl.obolibrary.org/obo/UBERON_0001005 denotes Airway
T4 116-117 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T5 118-125 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T6 140-141 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 164-169 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T8 331-337 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T9 386-393 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T10 448-449 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 484-485 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T12 494-500 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T13 641-647 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T14 775-780 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15 782-785 http://purl.obolibrary.org/obo/CLO_0051582 denotes HAs
T16 791-796 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T17 811-816 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T18 879-895 http://purl.obolibrary.org/obo/CLO_0000031 denotes cells lining the
T19 896-901 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T20 902-908 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T21 1005-1008 http://purl.obolibrary.org/obo/CLO_0051582 denotes HAs
T22 1020-1027 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T23 1147-1152 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T24 1179-1184 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T25 1290-1295 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T26 1366-1369 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T27 1388-1393 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T28 1508-1515 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T29 1521-1527 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T30 1649-1655 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T31 1686-1691 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T32 1772-1777 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T33 1818-1821 http://purl.obolibrary.org/obo/CLO_0051582 denotes HAs

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 691-698 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T2 715-717 Chemical denotes HA http://purl.obolibrary.org/obo/CHEBI_73924
T3 736-747 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T4 743-747 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T5 759-766 Chemical denotes glycans http://purl.obolibrary.org/obo/CHEBI_18154
T6 868-875 Chemical denotes glycans http://purl.obolibrary.org/obo/CHEBI_18154
T7 924-936 Chemical denotes sialic acids http://purl.obolibrary.org/obo/CHEBI_26667
T8 931-936 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T9 977-982 Chemical denotes NeuAc http://purl.obolibrary.org/obo/CHEBI_17012
T10 986-989 Chemical denotes Gal http://purl.obolibrary.org/obo/CHEBI_28260
T11 1078-1083 Chemical denotes NeuAc http://purl.obolibrary.org/obo/CHEBI_17012
T12 1087-1090 Chemical denotes Gal http://purl.obolibrary.org/obo/CHEBI_28260

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2 14-31 Species denotes Influenza Viruses Tax:11308
3 35-40 Species denotes Human Tax:9606
25 106-115 Species denotes influenza Tax:11308
26 164-169 Species denotes human Tax:9606
27 208-227 Disease denotes respiratory disease MESH:D012140
28 331-337 Species denotes humans Tax:9606
29 494-500 Species denotes humans Tax:9606
30 565-573 Disease denotes zoonotic MESH:D015047
31 641-647 Species denotes humans Tax:9606
32 736-747 Chemical denotes sialic acid MESH:D019158
33 759-766 Chemical denotes glycans MESH:D011134
34 791-796 Species denotes human Tax:9606
35 811-816 Species denotes human Tax:9606
36 868-875 Chemical denotes glycans MESH:D011134
37 896-901 Species denotes human Tax:9606
38 924-936 Chemical denotes sialic acids MESH:D012794
39 1147-1152 Species denotes human Tax:9606
40 1179-1184 Species denotes human Tax:9606
41 1290-1295 Species denotes human Tax:9606
42 1415-1425 Species denotes SARS-CoV-2 Tax:2697049
43 1649-1655 Species denotes humans Tax:9606
44 1686-1691 Species denotes human Tax:9606
45 1772-1777 Species denotes human Tax:9606

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 736-747 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T2 924-936 Glycan_Motif denotes sialic acids https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-58 Sentence denotes Adaptation of Influenza Viruses to Human Airway Receptors.
T2 59-228 Sentence denotes Through annual epidemics and global pandemics, influenza A viruses (IAVs) remain a significant threat to human health as the leading cause of severe respiratory disease.
T3 229-394 Sentence denotes Within the last century, four global pandemics have resulted from the introduction of novel IAVs into humans, with components of each originating from avian viruses.
T4 395-584 Sentence denotes IAVs infect many avian species wherein they maintain a diverse natural reservoir, posing a risk to humans through the occasional emergence of novel strains with enhanced zoonotic potential.
T5 585-781 Sentence denotes One natural barrier for transmission of avian IAVs into humans is the specificity of the receptor-binding protein, hemagglutinin (HA), that recognizes sialic acid-containing glycans on host cells.
T6 782-991 Sentence denotes HAs from human IAVs exhibit "human-type" receptor specificity, binding exclusively to glycans on cells lining the human airway where terminal sialic acids are attached in the α2-6 configuration (NeuAcα2-6Gal).
T7 992-1168 Sentence denotes In contrast, HAs from avian viruses exhibit specificity for "avian-type" α2-3-linked (NeuAcα2-3Gal) receptors, and thus require adaptive mutations to bind human-type receptors.
T8 1169-1352 Sentence denotes Since all human IAV pandemics can be traced to avian origins, there remains ever-present concern over emerging IAVs with human-adaptive potential that might lead to the next pandemic.
T9 1353-1536 Sentence denotes This concern has been brought into focus through emergence of SARS-CoV-2, aligning both scientific and public attention to the threat of novel respiratory viruses from animal sources.
T10 1537-1822 Sentence denotes In this review we summarize receptor-binding adaptations underlying the emergence of all prior IAV pandemics in humans, maintenance and evolution of human-type receptor specificity in subsequent seasonal IAVs, and potential for future human-type receptor adaptation in novel avian HAs.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 736-747 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T2 924-936 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acids

sentences

Id Subject Object Predicate Lexical cue
T1 0-58 Sentence denotes Adaptation of Influenza Viruses to Human Airway Receptors.
T2 59-228 Sentence denotes Through annual epidemics and global pandemics, influenza A viruses (IAVs) remain a significant threat to human health as the leading cause of severe respiratory disease.
T3 229-394 Sentence denotes Within the last century, four global pandemics have resulted from the introduction of novel IAVs into humans, with components of each originating from avian viruses.
T4 395-584 Sentence denotes IAVs infect many avian species wherein they maintain a diverse natural reservoir, posing a risk to humans through the occasional emergence of novel strains with enhanced zoonotic potential.
T5 585-781 Sentence denotes One natural barrier for transmission of avian IAVs into humans is the specificity of the receptor-binding protein, hemagglutinin (HA), that recognizes sialic acid-containing glycans on host cells.
T6 782-991 Sentence denotes HAs from human IAVs exhibit "human-type" receptor specificity, binding exclusively to glycans on cells lining the human airway where terminal sialic acids are attached in the α2-6 configuration (NeuAcα2-6Gal).
T7 992-1168 Sentence denotes In contrast, HAs from avian viruses exhibit specificity for "avian-type" α2-3-linked (NeuAcα2-3Gal) receptors, and thus require adaptive mutations to bind human-type receptors.
T8 1169-1352 Sentence denotes Since all human IAV pandemics can be traced to avian origins, there remains ever-present concern over emerging IAVs with human-adaptive potential that might lead to the next pandemic.
T9 1353-1536 Sentence denotes This concern has been brought into focus through emergence of SARS-CoV-2, aligning both scientific and public attention to the threat of novel respiratory viruses from animal sources.
T10 1537-1822 Sentence denotes In this review we summarize receptor-binding adaptations underlying the emergence of all prior IAV pandemics in humans, maintenance and evolution of human-type receptor specificity in subsequent seasonal IAVs, and potential for future human-type receptor adaptation in novel avian HAs.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 14-23 Disease denotes Influenza http://purl.obolibrary.org/obo/MONDO_0005812
T2 106-115 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T3 208-227 Disease denotes respiratory disease http://purl.obolibrary.org/obo/MONDO_0005087
T4 1415-1425 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 977-982 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T2 1078-1083 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 14-23 Disease denotes Influenza http://purl.obolibrary.org/obo/MONDO_0005812
T2 106-115 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T3 208-227 Disease denotes respiratory disease http://purl.obolibrary.org/obo/MONDO_0005087
T4 1415-1425 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 35-40 OrganismTaxon denotes Human 9606
T2 106-125 OrganismTaxon denotes influenza A viruses 11320
T3 127-131 OrganismTaxon denotes IAVs 11320
T4 164-169 OrganismTaxon denotes human 9606
T5 321-325 OrganismTaxon denotes IAVs 11320
T6 380-385 OrganismTaxon denotes avian 8782
T7 395-399 OrganismTaxon denotes IAVs 11320
T8 412-417 OrganismTaxon denotes avian 8782
T9 625-630 OrganismTaxon denotes avian 8782
T10 631-635 OrganismTaxon denotes IAVs 11320
T11 791-796 OrganismTaxon denotes human 9606
T12 797-801 OrganismTaxon denotes IAVs 11320
T13 811-816 OrganismTaxon denotes human 9606
T14 896-901 OrganismTaxon denotes human 9606
T15 1014-1019 OrganismTaxon denotes avian 8782
T16 1053-1058 OrganismTaxon denotes avian 8782
T17 1147-1152 OrganismTaxon denotes human 9606
T18 1179-1184 OrganismTaxon denotes human 9606
T19 1216-1221 OrganismTaxon denotes avian 8782
T20 1280-1284 OrganismTaxon denotes IAVs 11320
T21 1290-1295 OrganismTaxon denotes human 9606
T22 1415-1423 OrganismTaxon denotes SARS-CoV 694009
T23 1686-1691 OrganismTaxon denotes human 9606
T24 1741-1745 OrganismTaxon denotes IAVs 11320
T25 1772-1777 OrganismTaxon denotes human 9606
T26 1812-1817 OrganismTaxon denotes avian 8782

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 41-47 Body_part denotes Airway http://purl.obolibrary.org/obo/UBERON_0000117|http://purl.obolibrary.org/obo/UBERON_0001005
T3 902-908 Body_part denotes airway http://purl.obolibrary.org/obo/UBERON_0000117|http://purl.obolibrary.org/obo/UBERON_0001005

sentences

Id Subject Object Predicate Lexical cue
T1 0-58 Sentence denotes Adaptation of Influenza Viruses to Human Airway Receptors.
T2 59-228 Sentence denotes Through annual epidemics and global pandemics, influenza A viruses (IAVs) remain a significant threat to human health as the leading cause of severe respiratory disease.
T3 229-394 Sentence denotes Within the last century, four global pandemics have resulted from the introduction of novel IAVs into humans, with components of each originating from avian viruses.
T4 395-584 Sentence denotes IAVs infect many avian species wherein they maintain a diverse natural reservoir, posing a risk to humans through the occasional emergence of novel strains with enhanced zoonotic potential.
T5 585-781 Sentence denotes One natural barrier for transmission of avian IAVs into humans is the specificity of the receptor-binding protein, hemagglutinin (HA), that recognizes sialic acid-containing glycans on host cells.
T6 782-991 Sentence denotes HAs from human IAVs exhibit "human-type" receptor specificity, binding exclusively to glycans on cells lining the human airway where terminal sialic acids are attached in the α2-6 configuration (NeuAcα2-6Gal).
T7 992-1168 Sentence denotes In contrast, HAs from avian viruses exhibit specificity for "avian-type" α2-3-linked (NeuAcα2-3Gal) receptors, and thus require adaptive mutations to bind human-type receptors.
T8 1169-1352 Sentence denotes Since all human IAV pandemics can be traced to avian origins, there remains ever-present concern over emerging IAVs with human-adaptive potential that might lead to the next pandemic.
T9 1353-1536 Sentence denotes This concern has been brought into focus through emergence of SARS-CoV-2, aligning both scientific and public attention to the threat of novel respiratory viruses from animal sources.
T10 1537-1822 Sentence denotes In this review we summarize receptor-binding adaptations underlying the emergence of all prior IAV pandemics in humans, maintenance and evolution of human-type receptor specificity in subsequent seasonal IAVs, and potential for future human-type receptor adaptation in novel avian HAs.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-58 Sentence denotes Adaptation of Influenza Viruses to Human Airway Receptors.
T2 59-228 Sentence denotes Through annual epidemics and global pandemics, influenza A viruses (IAVs) remain a significant threat to human health as the leading cause of severe respiratory disease.
T3 229-394 Sentence denotes Within the last century, four global pandemics have resulted from the introduction of novel IAVs into humans, with components of each originating from avian viruses.
T4 395-584 Sentence denotes IAVs infect many avian species wherein they maintain a diverse natural reservoir, posing a risk to humans through the occasional emergence of novel strains with enhanced zoonotic potential.
T5 585-781 Sentence denotes One natural barrier for transmission of avian IAVs into humans is the specificity of the receptor-binding protein, hemagglutinin (HA), that recognizes sialic acid-containing glycans on host cells.
T6 782-991 Sentence denotes HAs from human IAVs exhibit "human-type" receptor specificity, binding exclusively to glycans on cells lining the human airway where terminal sialic acids are attached in the α2-6 configuration (NeuAcα2-6Gal).
T7 992-1168 Sentence denotes In contrast, HAs from avian viruses exhibit specificity for "avian-type" α2-3-linked (NeuAcα2-3Gal) receptors, and thus require adaptive mutations to bind human-type receptors.
T8 1169-1352 Sentence denotes Since all human IAV pandemics can be traced to avian origins, there remains ever-present concern over emerging IAVs with human-adaptive potential that might lead to the next pandemic.
T9 1353-1536 Sentence denotes This concern has been brought into focus through emergence of SARS-CoV-2, aligning both scientific and public attention to the threat of novel respiratory viruses from animal sources.
T10 1537-1822 Sentence denotes In this review we summarize receptor-binding adaptations underlying the emergence of all prior IAV pandemics in humans, maintenance and evolution of human-type receptor specificity in subsequent seasonal IAVs, and potential for future human-type receptor adaptation in novel avian HAs.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 977-982 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T2 1078-1083 Glycan denotes NeuAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 35-40 OrganismTaxon denotes Human 9606
T2 106-125 OrganismTaxon denotes influenza A viruses 11320
T3 127-131 OrganismTaxon denotes IAVs 11320
T4 164-169 OrganismTaxon denotes human 9606
T5 321-325 OrganismTaxon denotes IAVs 11320
T6 380-385 OrganismTaxon denotes avian 8782
T7 395-399 OrganismTaxon denotes IAVs 11320
T8 412-417 OrganismTaxon denotes avian 8782
T9 625-630 OrganismTaxon denotes avian 8782
T10 631-635 OrganismTaxon denotes IAVs 11320
T11 791-796 OrganismTaxon denotes human 9606
T12 797-801 OrganismTaxon denotes IAVs 11320
T13 811-816 OrganismTaxon denotes human 9606
T14 896-901 OrganismTaxon denotes human 9606
T15 1014-1019 OrganismTaxon denotes avian 8782
T16 1053-1058 OrganismTaxon denotes avian 8782
T17 1147-1152 OrganismTaxon denotes human 9606
T18 1179-1184 OrganismTaxon denotes human 9606
T19 1216-1221 OrganismTaxon denotes avian 8782
T20 1280-1284 OrganismTaxon denotes IAVs 11320
T21 1290-1295 OrganismTaxon denotes human 9606
T22 1415-1423 OrganismTaxon denotes SARS-CoV 694009
T23 1686-1691 OrganismTaxon denotes human 9606
T24 1741-1745 OrganismTaxon denotes IAVs 11320
T25 1772-1777 OrganismTaxon denotes human 9606
T26 1812-1817 OrganismTaxon denotes avian 8782

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 41-47 Body_part denotes Airway http://purl.obolibrary.org/obo/UBERON_0000117|http://purl.obolibrary.org/obo/UBERON_0001005
T3 902-908 Body_part denotes airway http://purl.obolibrary.org/obo/UBERON_0000117|http://purl.obolibrary.org/obo/UBERON_0001005