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LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 15-22 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 15-22 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T3 238-245 https://glytoucan.org/Structures/Glycans/G00021MO denotes Heparin
T4 238-245 https://glytoucan.org/Structures/Glycans/G54161DR denotes Heparin
T5 415-422 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T6 415-422 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T7 563-570 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T8 563-570 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T9 674-681 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T10 674-681 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T11 734-742 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparins
T12 734-742 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparins
T13 929-936 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T14 929-936 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T15 1331-1338 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T16 1331-1338 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T17 1403-1410 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T18 1403-1410 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T19 1553-1561 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparins
T20 1553-1561 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparins

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 15-22 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T2 58-62 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T3 238-245 Body_part denotes Heparin http://purl.org/sig/ont/fma/fma82839
T4 415-422 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T5 563-570 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T6 674-681 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T7 734-742 Body_part denotes heparins http://purl.org/sig/ont/fma/fma82839
T8 907-912 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T9 929-936 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T10 948-955 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T11 1061-1068 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T12 1331-1338 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T13 1370-1377 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T14 1403-1410 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T15 1466-1473 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T16 1553-1561 Body_part denotes heparins http://purl.org/sig/ont/fma/fma82839
T17 1694-1701 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T18 1720-1727 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 47-55 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 228-236 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T3 325-333 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T4 450-458 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T5 602-610 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 828-836 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T7 1599-1607 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 1853-1861 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 58-62 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 471-472 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 494-495 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T4 806-814 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T5 868-869 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 899-912 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T7 1050-1055 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T8 1206-1208 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T9 1212-1216 http://purl.obolibrary.org/obo/CLO_0007735 denotes ml-1
T10 1290-1294 http://purl.obolibrary.org/obo/CLO_0007735 denotes ml-1
T11 1455-1460 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T12 1572-1575 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T13 1620-1628 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T14 1709-1714 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T15 1813-1814 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 15-22 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T2 196-206 Chemical denotes antivirals http://purl.obolibrary.org/obo/CHEBI_22587
T3 238-245 Chemical denotes Heparin http://purl.obolibrary.org/obo/CHEBI_28304
T4 298-311 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T5 415-422 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T6 535-544 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T7 563-570 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T8 674-681 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T9 734-742 Chemical denotes heparins http://purl.obolibrary.org/obo/CHEBI_24505
T10 796-805 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T11 929-936 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T12 948-955 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T13 1061-1068 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T14 1151-1160 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T15 1331-1338 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T16 1370-1377 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T17 1403-1410 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T18 1466-1473 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T19 1553-1561 Chemical denotes heparins http://purl.obolibrary.org/obo/CHEBI_24505
T20 1610-1619 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T21 1694-1701 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T22 1720-1727 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 1669-1684 http://purl.obolibrary.org/obo/GO_0051100 denotes inhibit binding

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2 15-22 Chemical denotes heparin MESH:D006493
3 47-57 Species denotes SARS-CoV-2 Tax:2697049
38 228-236 Disease denotes COVID-19 MESH:C000657245
39 238-245 Chemical denotes Heparin MESH:D006493
40 325-333 Disease denotes COVID-19 MESH:C000657245
41 334-342 Species denotes patients Tax:9606
42 415-422 Chemical denotes heparin MESH:D006493
43 424-427 Chemical denotes UFH MESH:D006493
44 450-458 Disease denotes COVID-19 MESH:C000657245
45 459-467 Species denotes patients Tax:9606
46 563-570 Chemical denotes heparin MESH:D006493
47 602-612 Species denotes SARS-CoV-2 Tax:2697049
48 674-681 Chemical denotes heparin MESH:D006493
49 705-708 Chemical denotes UFH MESH:D006493
50 713-742 Chemical denotes low molecular weight heparins MESH:D006495
51 764-770 Species denotes bovine Tax:9913
52 828-838 Species denotes SARS-CoV-2 Tax:2697049
53 929-936 Chemical denotes heparin MESH:D006493
54 1050-1055 Species denotes human Tax:9606
55 1056-1060 Gene denotes ACE2 Gene:59272
56 1123-1126 Chemical denotes UFH MESH:D006493
57 1212-1216 Gene denotes ml-1 Gene:112744
58 1290-1294 Gene denotes ml-1 Gene:112744
59 1331-1338 Chemical denotes heparin MESH:D006493
60 1403-1410 Chemical denotes heparin MESH:D006493
61 1455-1460 Species denotes human Tax:9606
62 1461-1465 Gene denotes ACE2 Gene:59272
63 1553-1561 Chemical denotes heparins MESH:D006493
64 1568-1571 Chemical denotes UFH MESH:D006493
65 1599-1609 Species denotes SARS-CoV-2 Tax:2697049
66 1648-1651 Chemical denotes UFH MESH:D006493
67 1709-1714 Species denotes human Tax:9606
68 1715-1719 Gene denotes ACE2 Gene:59272
69 1806-1809 Chemical denotes UFH MESH:D006493
70 1839-1847 Species denotes patients Tax:9606
71 1853-1861 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-118 Sentence denotes Unfractionated heparin inhibits live wild-type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations.
T2 119-142 Sentence denotes BACKGROUND AND PURPOSE:
T3 143-237 Sentence denotes Currently there are no licensed vaccines and limited antivirals for the treatment of COVID-19.
T4 238-343 Sentence denotes Heparin (delivered systemically) is currently used to treat anticoagulant anomalies in COVID-19 patients.
T5 344-493 Sentence denotes In addition, in the UK, Brazil and Australia, nebulised unfractionated heparin (UFH) is being trialled in COVID-19 patients as a potential treatment.
T6 494-634 Sentence denotes A systematic comparison of the potential antiviral effect of various heparin preparations on live wild-type SARS-CoV-2, in vitro, is needed.
T7 635-657 Sentence denotes EXPERIMENTAL APPROACH:
T8 658-913 Sentence denotes Seven different heparin preparations including UFH and low molecular weight heparins (LMWH) of porcine or bovine origin were screened for antiviral activity against live SARS-CoV-2 (Australia/VIC01/2020) using a plaque inhibition assay with Vero E6 cells.
T9 914-1101 Sentence denotes Interaction of heparin with spike protein RBD was studied using differential scanning fluorimetry, and the inhibition of RBD binding to human ACE2 protein using ELISA assays was examined.
T10 1102-1114 Sentence denotes KEY RESULTS:
T11 1115-1297 Sentence denotes All the UFH preparations had potent antiviral effects, with IC50 values ranging between 25-41 μg ml-1 whereas LMWHs were less inhibitory by ~150-fold (IC50 range 3.4 - 7.8 mg ml-1 ).
T12 1298-1483 Sentence denotes Mechanistically we observed that heparin binds and destabilizes the RBD protein, and furthermore we show heparin directly inhibits the binding of RBD to the human ACE2 protein receptor.
T13 1484-1513 Sentence denotes CONCLUSIONS AND IMPLICATIONS:
T14 1514-1647 Sentence denotes This comparison of clinically relevant heparins shows UFH has significantly stronger SARS-CoV-2 antiviral activity compared to LMWHs.
T15 1648-1737 Sentence denotes UFH acts to directly inhibit binding of spike protein to the human ACE2 protein receptor.
T16 1738-1862 Sentence denotes Overall the data strongly support further clinical investigation of UFH as a potential treatment for patients with COVID-19.