PubMed:33123093 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/33123093","sourcedb":"PubMed","sourceid":"33123093","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/33123093","text":"The Impact of COVID-19 on Blood Glucose: A Systematic Review and Meta-Analysis.\nBackground: Diabetes mellitus is considered a common comorbidity of COVID-19, which has a wide spectrum of clinical manifestations ranging from asymptomatic infection to severe respiratory symptoms and even death. However, the impact of COVID-19 on blood glucose has not been fully understood. This meta-analysis aimed to summarize available data on the association between glycemic parameters and severity of COVID-19. Methods: PubMed, EMBASE, and Cochrane Library were searched from December 1, 2019 to May 15, 2020. Observational studies investigating blood glucose or glycated hemoglobin A1c (HbA1c) according to the severity of COVID-19 were considered for inclusion. Two independent researchers extracted data from eligible studies using a standardized data extraction sheet and then proceeded to cross check the results. Data were pooled using a fixed- or random-effects model to calculate the weighted mean differences (WMDs) and 95% confidence intervals (CIs). Results: Three studies reported blood glucose and HbA1c according to the severity of COVID-19 and were included in this meta-analysis. The combined results showed that severe COVID-19 was associated with higher blood glucose (WMD 2.21, 95% CI: 1.30-3.13, P \u003c 0.001). In addition, HbA1c was slightly higher in patients with severe COVID-19 than those with mild COVID-19, yet this difference did not reach significance (WMD 0.29, 95% CI: -0.59 to 1.16, P = 0.52). Conclusions: This meta-analysis provides evidence that severe COVID-19 is associated with increased blood glucose. This highlights the need to effectively monitor blood glucose to improve prognosis in patients infected with COVID-19.","tracks":[{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":32,"end":39},"obj":"https://glytoucan.org/Structures/Glycans/G15021LG"},{"id":"T2","span":{"begin":335,"end":342},"obj":"https://glytoucan.org/Structures/Glycans/G15021LG"},{"id":"T3","span":{"begin":641,"end":648},"obj":"https://glytoucan.org/Structures/Glycans/G15021LG"},{"id":"T4","span":{"begin":1088,"end":1095},"obj":"https://glytoucan.org/Structures/Glycans/G15021LG"},{"id":"T5","span":{"begin":1267,"end":1274},"obj":"https://glytoucan.org/Structures/Glycans/G15021LG"},{"id":"T6","span":{"begin":1618,"end":1625},"obj":"https://glytoucan.org/Structures/Glycans/G15021LG"},{"id":"T7","span":{"begin":1681,"end":1688},"obj":"https://glytoucan.org/Structures/Glycans/G15021LG"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T2","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T3","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T4","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T5","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T6","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T7","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":26,"end":31},"obj":"Body_part"},{"id":"T2","span":{"begin":32,"end":39},"obj":"Body_part"},{"id":"T3","span":{"begin":329,"end":334},"obj":"Body_part"},{"id":"T4","span":{"begin":335,"end":342},"obj":"Body_part"},{"id":"T5","span":{"begin":635,"end":640},"obj":"Body_part"},{"id":"T6","span":{"begin":641,"end":648},"obj":"Body_part"},{"id":"T7","span":{"begin":661,"end":671},"obj":"Body_part"},{"id":"T8","span":{"begin":1082,"end":1087},"obj":"Body_part"},{"id":"T9","span":{"begin":1088,"end":1095},"obj":"Body_part"},{"id":"T10","span":{"begin":1261,"end":1266},"obj":"Body_part"},{"id":"T11","span":{"begin":1267,"end":1274},"obj":"Body_part"},{"id":"T12","span":{"begin":1612,"end":1617},"obj":"Body_part"},{"id":"T13","span":{"begin":1618,"end":1625},"obj":"Body_part"},{"id":"T14","span":{"begin":1675,"end":1680},"obj":"Body_part"},{"id":"T15","span":{"begin":1681,"end":1688},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma82743"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma82743"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma82743"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma62293"},{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma82743"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma82743"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma82743"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma82743"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":26,"end":31},"obj":"Body_part"},{"id":"T2","span":{"begin":329,"end":334},"obj":"Body_part"},{"id":"T3","span":{"begin":635,"end":640},"obj":"Body_part"},{"id":"T4","span":{"begin":1082,"end":1087},"obj":"Body_part"},{"id":"T5","span":{"begin":1261,"end":1266},"obj":"Body_part"},{"id":"T6","span":{"begin":1612,"end":1617},"obj":"Body_part"},{"id":"T7","span":{"begin":1675,"end":1680},"obj":"Body_part"}],"attributes":[{"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