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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 42-49 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T2 530-537 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T3 661-668 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 25-33 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 101-134 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T3 148-156 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T4 311-319 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T5 513-521 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 635-643 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T7 875-883 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 948-956 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 959-968 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T10 1064-1072 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 81-89 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T2 160-163 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T3 175-176 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 226-231 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T5 326-327 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 603-611 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T7 696-704 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T8 730-737 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T9 985-993 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 42-49 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T2 232-243 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T3 394-408 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T6 394-405 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T7 406-408 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T8 530-537 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T9 661-668 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T10 730-737 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 64-89 http://purl.obolibrary.org/obo/GO_0004180 denotes carboxypeptidase activity
T2 420-434 http://purl.obolibrary.org/obo/GO_0042311 denotes vasodilatation

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3 25-35 Species denotes SARS-CoV-2 Tax:2697049
4 36-41 Gene denotes spike Gene:43740568
5 59-63 Gene denotes ACE2 Gene:59272
30 101-146 Species denotes severe acute respiratory syndrome coronavirus Tax:694009
31 148-158 Species denotes SARS-CoV-2 Tax:2697049
32 226-231 Species denotes Human Tax:9606
33 232-263 Gene denotes angiotensin-converting enzyme 2 Gene:59272
34 264-268 Gene denotes ACE2 Gene:59272
35 311-321 Species denotes SARS-CoV-2 Tax:2697049
36 346-350 Gene denotes ACE2 Gene:59272
37 394-408 Gene denotes angiotensin II Gene:183
38 504-508 Gene denotes ACE2 Gene:59272
39 513-523 Species denotes SARS-CoV-2 Tax:2697049
40 524-529 Gene denotes spike Gene:43740568
41 615-619 Gene denotes ACE2 Gene:59272
42 635-645 Species denotes SARS-CoV-2 Tax:2697049
43 655-660 Gene denotes spike Gene:43740568
44 679-683 Gene denotes ACE2 Gene:59272
45 758-767 Gene denotes caspase-1 Gene:834
46 782-792 Gene denotes Bradykinin Gene:3827
47 820-824 Gene denotes ACE2 Gene:59272
48 875-885 Species denotes SARS-CoV-2 Tax:2697049
49 886-891 Gene denotes spike Gene:43740568
50 948-968 Disease denotes SARS-CoV-2 infection MESH:C000657245
51 980-984 Gene denotes ACE2 Gene:59272
52 1024-1047 Disease denotes cardiovascular symptoms MESH:D051271
53 1064-1072 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-90 Sentence denotes High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity.
T2 91-225 Sentence denotes The novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has emerged to a pandemic and caused global public health crisis.
T3 226-322 Sentence denotes Human angiotensin-converting enzyme 2(ACE2) was identified as the entry receptor for SARS-CoV-2.
T4 323-461 Sentence denotes As a carboxypeptidase, ACE2 cleaves many biological substrates besides angiotensin II to control vasodilatation and vascular permeability.
T5 462-620 Sentence denotes Given the nanomolar high affinity between ACE2 and SARS-CoV-2 spike protein, we investigated how this interaction would affect the enzymatic activity of ACE2.
T6 621-800 Sentence denotes Surprisingly, SARS-CoV-2 trimeric spike protein increased ACE2 proteolytic activity ~3-10 fold against model peptide substrates, such as caspase-1 substrate and Bradykinin-analog.
T7 801-903 Sentence denotes The enhancement in ACE2 enzymatic function was mediated by the binding of SARS-CoV-2 spike RBD domain.
T8 904-1073 Sentence denotes These results highlighted the potential for SARS-CoV-2 infection to enhance ACE2 activity, which may be relevant to the cardiovascular symptoms associated with COVID-19.

LitCovid_AGAC_only

Id Subject Object Predicate Lexical cue
p261841s11 50-58 PosReg denotes enhances
p261841s12 59-80 MPA denotes ACE2 carboxypeptidase
p261841s14 81-89 MPA denotes activity
p261846s10 669-678 PosReg denotes increased
p261846s11 679-704 MPA denotes ACE2 proteolytic activity

sentences

Id Subject Object Predicate Lexical cue
T1 0-90 Sentence denotes High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity.
T2 91-225 Sentence denotes The novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has emerged to a pandemic and caused global public health crisis.
T3 226-322 Sentence denotes Human angiotensin-converting enzyme 2(ACE2) was identified as the entry receptor for SARS-CoV-2.
T4 323-461 Sentence denotes As a carboxypeptidase, ACE2 cleaves many biological substrates besides angiotensin II to control vasodilatation and vascular permeability.
T5 462-620 Sentence denotes Given the nanomolar high affinity between ACE2 and SARS-CoV-2 spike protein, we investigated how this interaction would affect the enzymatic activity of ACE2.
T6 621-800 Sentence denotes Surprisingly, SARS-CoV-2 trimeric spike protein increased ACE2 proteolytic activity ~3-10 fold against model peptide substrates, such as caspase-1 substrate and Bradykinin-analog.
T7 801-903 Sentence denotes The enhancement in ACE2 enzymatic function was mediated by the binding of SARS-CoV-2 spike RBD domain.
T8 904-1073 Sentence denotes These results highlighted the potential for SARS-CoV-2 infection to enhance ACE2 activity, which may be relevant to the cardiovascular symptoms associated with COVID-19.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 25-35 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T2 101-134 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T3 148-158 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T4 311-321 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T5 513-523 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T6 635-645 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T7 875-885 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T8 948-958 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T9 959-968 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T10 1064-1072 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 892-895 Phenotype denotes RBD HP:5200291

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 25-33 OrganismTaxon denotes SARS-CoV 694009
T2 101-134 OrganismTaxon denotes severe acute respiratory syndrome 694009
T3 148-156 OrganismTaxon denotes SARS-CoV 694009
T4 226-231 OrganismTaxon denotes Human 9606
T5 311-319 OrganismTaxon denotes SARS-CoV 694009
T6 513-521 OrganismTaxon denotes SARS-CoV 694009
T7 635-643 OrganismTaxon denotes SARS-CoV 694009
T8 875-883 OrganismTaxon denotes SARS-CoV 694009
T9 948-956 OrganismTaxon denotes SARS-CoV 694009