PubMed:33106671
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/33106671","sourcedb":"PubMed","sourceid":"33106671","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/33106671","text":"Spike mutation D614G alters SARS-CoV-2 fitness.\nA spike protein mutation D614G became dominant in SARS-CoV-2 during the COVID-19 pandemic1,2. However, the impact on viral spread and vaccine efficacy remains to be defined. Here, we engineer the D614G mutation in the USA-WA1/2020 strain and characterize its effect. D614G enhances replication on human lung epithelial cells and primary human airway tissues through an improved infectivity of virions. Hamsters infected with the G614 variant produced higher infectious titers in the nasal washes and trachea, but not lungs, confirming clinical evidence that the D614G mutation enhances viral loads in the upper respiratory tract of COVID-19 patients and may increases transmission. Sera from D614-infected hamsters exhibit modestly higher neutralization titers against G614 virus than against D614 virus, indicating that (i) the mutation may not reduce the ability of vaccines in clinical trials to protect against COVID-19 and (ii) therapeutic antibodies should be tested against the circulating G614 virus. Together with clinical findings, our work underscores the importance of this mutation in viral spread, vaccine efficacy, and antibody therapy.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":56,"end":63},"obj":"Body_part"},{"id":"T2","span":{"begin":351,"end":355},"obj":"Body_part"},{"id":"T3","span":{"begin":356,"end":372},"obj":"Body_part"},{"id":"T4","span":{"begin":367,"end":372},"obj":"Body_part"},{"id":"T5","span":{"begin":398,"end":405},"obj":"Body_part"},{"id":"T6","span":{"begin":548,"end":555},"obj":"Body_part"},{"id":"T7","span":{"begin":565,"end":570},"obj":"Body_part"},{"id":"T8","span":{"begin":653,"end":676},"obj":"Body_part"},{"id":"T9","span":{"begin":1182,"end":1190},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma7394"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma68877"},{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma45661"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma62871"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":351,"end":355},"obj":"Body_part"},{"id":"T2","span":{"begin":548,"end":555},"obj":"Body_part"},{"id":"T3","span":{"begin":653,"end":676},"obj":"Body_part"},{"id":"T4","span":{"begin":659,"end":676},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0003126"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0001557"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":28,"end":36},"obj":"Disease"},{"id":"T2","span":{"begin":98,"end":106},"obj":"Disease"},{"id":"T3","span":{"begin":120,"end":128},"obj":"Disease"},{"id":"T4","span":{"begin":506,"end":516},"obj":"Disease"},{"id":"T5","span":{"begin":680,"end":688},"obj":"Disease"},{"id":"T6","span":{"begin":963,"end":971},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":48,"end":49},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T2","span":{"begin":345,"end":350},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T3","span":{"begin":351,"end":372},"obj":"http://purl.obolibrary.org/obo/CL_0000082"},{"id":"T4","span":{"begin":385,"end":390},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T5","span":{"begin":391,"end":397},"obj":"http://purl.obolibrary.org/obo/UBERON_0001005"},{"id":"T6","span":{"begin":450,"end":458},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10026"},{"id":"T7","span":{"begin":565,"end":570},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T8","span":{"begin":754,"end":762},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10026"},{"id":"T9","span":{"begin":822,"end":827},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T10","span":{"begin":846,"end":851},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T11","span":{"begin":1014,"end":1020},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T12","span":{"begin":1050,"end":1055},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":56,"end":63},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"3","span":{"begin":0,"end":5},"obj":"Gene"},{"id":"4","span":{"begin":15,"end":20},"obj":"Mutation"},{"id":"5","span":{"begin":28,"end":38},"obj":"Species"},{"id":"21","span":{"begin":50,"end":55},"obj":"Gene"},{"id":"22","span":{"begin":73,"end":78},"obj":"Mutation"},{"id":"23","span":{"begin":98,"end":108},"obj":"Species"},{"id":"24","span":{"begin":120,"end":128},"obj":"Disease"},{"id":"25","span":{"begin":244,"end":249},"obj":"Mutation"},{"id":"26","span":{"begin":315,"end":320},"obj":"Mutation"},{"id":"27","span":{"begin":345,"end":350},"obj":"Species"},{"id":"28","span":{"begin":385,"end":390},"obj":"Species"},{"id":"29","span":{"begin":459,"end":467},"obj":"Disease"},{"id":"30","span":{"begin":548,"end":555},"obj":"Disease"},{"id":"31","span":{"begin":610,"end":615},"obj":"Mutation"},{"id":"32","span":{"begin":680,"end":688},"obj":"Disease"},{"id":"33","span":{"begin":689,"end":697},"obj":"Species"},{"id":"34","span":{"begin":745,"end":753},"obj":"Disease"},{"id":"35","span":{"begin":963,"end":971},"obj":"Disease"}],"attributes":[{"id":"A3","pred":"tao:has_database_id","subj":"3","obj":"Gene:43740568"},{"id":"A4","pred":"tao:has_standard_notation","subj":"4","obj":"p.D614G"},{"id":"A5","pred":"tao:has_database_id","subj":"5","obj":"Tax:2697049"},{"id":"A21","pred":"tao:has_database_id","subj":"21","obj":"Gene:43740568"},{"id":"A22","pred":"tao:has_standard_notation","subj":"22","obj":"p.D614G"},{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"Tax:2697049"},{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"MESH:C000657245"},{"id":"A25","pred":"tao:has_standard_notation","subj":"25","obj":"p.D614G"},{"id":"A26","pred":"tao:has_standard_notation","subj":"26","obj":"p.D614G"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"Tax:9606"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"Tax:9606"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"MESH:D007239"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"MESH:C557675"},{"id":"A31","pred":"tao:has_standard_notation","subj":"31","obj":"p.D614G"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"MESH:C000657245"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"Tax:9606"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"MESH:D007239"},{"id":"A35","pred":"tao:has_database_id","subj":"35","obj":"MESH:C000657245"},{"subj":"3","pred":"source","obj":"LitCovid-PubTator"},{"subj":"4","pred":"source","obj":"LitCovid-PubTator"},{"subj":"5","pred":"source","obj":"LitCovid-PubTator"},{"subj":"21","pred":"source","obj":"LitCovid-PubTator"},{"subj":"22","pred":"source","obj":"LitCovid-PubTator"},{"subj":"23","pred":"source","obj":"LitCovid-PubTator"},{"subj":"24","pred":"source","obj":"LitCovid-PubTator"},{"subj":"25","pred":"source","obj":"LitCovid-PubTator"},{"subj":"26","pred":"source","obj":"LitCovid-PubTator"},{"subj":"27","pred":"source","obj":"LitCovid-PubTator"},{"subj":"28","pred":"source","obj":"LitCovid-PubTator"},{"subj":"29","pred":"source","obj":"LitCovid-PubTator"},{"subj":"30","pred":"source","obj":"LitCovid-PubTator"},{"subj":"31","pred":"source","obj":"LitCovid-PubTator"},{"subj":"32","pred":"source","obj":"LitCovid-PubTator"},{"subj":"33","pred":"source","obj":"LitCovid-PubTator"},{"subj":"34","pred":"source","obj":"LitCovid-PubTator"},{"subj":"35","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":47},"obj":"Sentence"},{"id":"T2","span":{"begin":48,"end":141},"obj":"Sentence"},{"id":"T3","span":{"begin":142,"end":221},"obj":"Sentence"},{"id":"T4","span":{"begin":222,"end":314},"obj":"Sentence"},{"id":"T5","span":{"begin":315,"end":449},"obj":"Sentence"},{"id":"T6","span":{"begin":450,"end":729},"obj":"Sentence"},{"id":"T7","span":{"begin":730,"end":1056},"obj":"Sentence"},{"id":"T8","span":{"begin":1057,"end":1199},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-sentences"},{"subj":"T2","pred":"source","obj":"LitCovid-sentences"},{"subj":"T3","pred":"source","obj":"LitCovid-sentences"},{"subj":"T4","pred":"source","obj":"LitCovid-sentences"},{"subj":"T5","pred":"source","obj":"LitCovid-sentences"},{"subj":"T6","pred":"source","obj":"LitCovid-sentences"},{"subj":"T7","pred":"source","obj":"LitCovid-sentences"},{"subj":"T8","pred":"source","obj":"LitCovid-sentences"}]},{"project":"Covid19_manual_annotation_v2","denotations":[{"id":"21","span":{"begin":50,"end":55},"obj":"Gene"},{"id":"22","span":{"begin":64,"end":78},"obj":"Variation"},{"id":"23","span":{"begin":98,"end":108},"obj":"Species"},{"id":"24","span":{"begin":120,"end":128},"obj":"Disease"},{"id":"25","span":{"begin":244,"end":258},"obj":"Variation"},{"id":"26","span":{"begin":315,"end":320},"obj":"Variation"},{"id":"27","span":{"begin":345,"end":350},"obj":"Species"},{"id":"28","span":{"begin":385,"end":390},"obj":"Species"},{"id":"29","span":{"begin":459,"end":467},"obj":"Disease"},{"id":"3","span":{"begin":0,"end":5},"obj":"Gene"},{"id":"30","span":{"begin":548,"end":555},"obj":"Anatomy"},{"id":"31","span":{"begin":610,"end":624},"obj":"Variation"},{"id":"32","span":{"begin":680,"end":688},"obj":"Disease"},{"id":"33","span":{"begin":689,"end":697},"obj":"Species"},{"id":"34","span":{"begin":745,"end":753},"obj":"Disease"},{"id":"35","span":{"begin":963,"end":971},"obj":"Disease"},{"id":"4","span":{"begin":6,"end":20},"obj":"Variation"},{"id":"5","span":{"begin":28,"end":38},"obj":"Species"},{"id":"T1","span":{"begin":129,"end":137},"obj":"Outbreak"},{"id":"T10","span":{"begin":477,"end":481},"obj":"Variation"},{"id":"T11","span":{"begin":1045,"end":1049},"obj":"Variation"},{"id":"T12","span":{"begin":841,"end":845},"obj":"Variation"},{"id":"T13","span":{"begin":740,"end":744},"obj":"Variation"},{"id":"T15","span":{"begin":441,"end":448},"obj":"Species"},{"id":"T16","span":{"begin":426,"end":437},"obj":"Infection"},{"id":"T17","span":{"begin":417,"end":425},"obj":"PositiveRegulation"},{"id":"T18","span":{"begin":330,"end":341},"obj":"Phenomena"},{"id":"T19","span":{"begin":321,"end":329},"obj":"PositiveRegulation"},{"id":"T2","span":{"begin":266,"end":278},"obj":"Species"},{"id":"T20","span":{"begin":450,"end":458},"obj":"Species"},{"id":"T21","span":{"begin":499,"end":505},"obj":"High"},{"id":"T22","span":{"begin":506,"end":523},"obj":"Index"},{"id":"T23","span":{"begin":531,"end":543},"obj":"Biological"},{"id":"T24","span":{"begin":561,"end":564},"obj":"Without"},{"id":"T26","span":{"begin":506,"end":523},"obj":"Index"},{"id":"T28","span":{"begin":634,"end":639},"obj":"Species"},{"id":"T29","span":{"begin":640,"end":645},"obj":"PositiveRegulation"},{"id":"T3","span":{"begin":351,"end":355},"obj":"Anatomy"},{"id":"T30","span":{"begin":625,"end":633},"obj":"PositiveRegulation"},{"id":"T31","span":{"begin":706,"end":715},"obj":"PositiveRegulation"},{"id":"T32","span":{"begin":716,"end":728},"obj":"Infection"},{"id":"T34","span":{"begin":754,"end":762},"obj":"Species"},{"id":"T35","span":{"begin":1191,"end":1198},"obj":"Therapy"},{"id":"T36","span":{"begin":1160,"end":1167},"obj":"Chemical"},{"id":"T37","span":{"begin":182,"end":189},"obj":"Chemical"},{"id":"T38","span":{"begin":916,"end":924},"obj":"Chemical"},{"id":"T39","span":{"begin":1182,"end":1190},"obj":"Type"},{"id":"T4","span":{"begin":565,"end":570},"obj":"Anatomy"},{"id":"T41","span":{"begin":877,"end":885},"obj":"Variation"},{"id":"T42","span":{"begin":890,"end":893},"obj":"NegativeRegulation"},{"id":"T43","span":{"begin":894,"end":900},"obj":"NegativeRegulation"},{"id":"T44","span":{"begin":780,"end":786},"obj":"High"},{"id":"T45","span":{"begin":787,"end":808},"obj":"Index"},{"id":"T46","span":{"begin":822,"end":827},"obj":"Species"},{"id":"T47","span":{"begin":846,"end":851},"obj":"Species"},{"id":"T48","span":{"begin":730,"end":734},"obj":"Anatomy"},{"id":"T49","span":{"begin":50,"end":55},"obj":"Gene"},{"id":"T5","span":{"begin":356,"end":372},"obj":"Anatomy"},{"id":"T50","span":{"begin":50,"end":55},"obj":"Gene"},{"id":"T51","span":{"begin":50,"end":55},"obj":"Gene"},{"id":"T52","span":{"begin":50,"end":55},"obj":"Gene"},{"id":"T53","span":{"begin":266,"end":278},"obj":"Species"},{"id":"T54","span":{"begin":266,"end":278},"obj":"Species"},{"id":"T55","span":{"begin":50,"end":55},"obj":"Gene"},{"id":"T56","span":{"begin":50,"end":55},"obj":"Gene"},{"id":"T6","span":{"begin":377,"end":384},"obj":"Condition"},{"id":"T7","span":{"begin":391,"end":405},"obj":"Anatomy"},{"id":"T8","span":{"begin":653,"end":676},"obj":"Anatomy"},{"id":"T9","span":{"begin":817,"end":821},"obj":"Variation"}],"relations":[{"id":"R67","pred":"has_a","subj":"T20","obj":"T26"},{"id":"R68","pred":"of_a","subj":"31","obj":"T50"},{"id":"R69","pred":"of_a","subj":"T2","obj":"T50"},{"id":"R7","pred":"is_a","subj":"T15","obj":"T16"},{"id":"R70","pred":"is_a","subj":"T50","obj":"T30"},{"id":"R71","pred":"is_a","subj":"T50","obj":"T31"},{"id":"R1","pred":"of_a","subj":"23","obj":"21"},{"id":"R10","pred":"of_a","subj":"T3","obj":"T5"},{"id":"R12","pred":"of_a","subj":"27","obj":"T5"},{"id":"R13","pred":"of_a","subj":"28","obj":"T7"},{"id":"R14","pred":"has_status","subj":"T7","obj":"T6"},{"id":"R15","pred":"cause_of","subj":"T17","obj":"T19"},{"id":"R17","pred":"of_a","subj":"T21","obj":"T22"},{"id":"R19","pred":"of_a","subj":"T24","obj":"T26"},{"id":"R2","pred":"of_a","subj":"5","obj":"3"},{"id":"R20","pred":"in","subj":"T23","obj":"T22"},{"id":"R21","pred":"in","subj":"30","obj":"T22"},{"id":"R22","pred":"in","subj":"T4","obj":"T26"},{"id":"R23","pred":"has_a","subj":"29","obj":"T20"},{"id":"R27","pred":"is_a","subj":"T30","obj":"T29"},{"id":"R29","pred":"on","subj":"T8","obj":"T29"},{"id":"R3","pred":"of_a","subj":"4","obj":"3"},{"id":"R30","pred":"has_a","subj":"32","obj":"33"},{"id":"R31","pred":"of_a","subj":"33","obj":"T8"},{"id":"R33","pred":"is_a","subj":"T31","obj":"T32"},{"id":"R34","pred":"in","subj":"T8","obj":"T32"},{"id":"R35","pred":"is_a","subj":"T28","obj":"T32"},{"id":"R37","pred":"is_a","subj":"T42","obj":"T43"},{"id":"R4","pred":"of_a","subj":"22","obj":"21"},{"id":"R40","pred":"against","subj":"35","obj":"T38"},{"id":"R41","pred":"coreference","subj":"T41","obj":"31"},{"id":"R42","pred":"of_a","subj":"T39","obj":"T35"},{"id":"R43","pred":"is_a","subj":"T43","obj":"T38"},{"id":"R44","pred":"has_a","subj":"34","obj":"T34"},{"id":"R46","pred":"of_a","subj":"T44","obj":"T45"},{"id":"R48","pred":"coreference","subj":"T28","obj":"T15"},{"id":"R49","pred":"coreference","subj":"T46","obj":"T28"},{"id":"R53","pred":"of_a","subj":"T46","obj":"T45"},{"id":"R54","pred":"against","subj":"T47","obj":"T45"},{"id":"R55","pred":"of_a","subj":"T34","obj":"T48"},{"id":"R58","pred":"is_a","subj":"T29","obj":"T28"},{"id":"R59","pred":"on","subj":"T7","obj":"T18"},{"id":"R6","pred":"is_a","subj":"T17","obj":"T16"},{"id":"R60","pred":"coreference","subj":"T29","obj":"T18"},{"id":"R61","pred":"of_a","subj":"26","obj":"T49"},{"id":"R62","pred":"of_a","subj":"T2","obj":"T49"},{"id":"R63","pred":"is_a","subj":"T49","obj":"T17"},{"id":"R64","pred":"coreference","subj":"T15","obj":"T2"},{"id":"R65","pred":"cause_of","subj":"T2","obj":"29"},{"id":"R66","pred":"has_a","subj":"T20","obj":"T22"},{"id":"R72","pred":"coreference","subj":"T28","obj":"T2"},{"id":"R73","pred":"of_a","subj":"T13","obj":"T51"},{"id":"R74","pred":"of_a","subj":"T53","obj":"T51"},{"id":"R75","pred":"cause_of","subj":"T53","obj":"34"},{"id":"R76","pred":"has_a","subj":"T34","obj":"T45"},{"id":"R78","pred":"coreference","subj":"T47","obj":"23"},{"id":"R79","pred":"of_a","subj":"T41","obj":"T52"},{"id":"R8","pred":"is_a","subj":"T19","obj":"T18"},{"id":"R80","pred":"of_a","subj":"T54","obj":"T52"},{"id":"R81","pred":"is_a","subj":"T54","obj":"T42"},{"id":"R82","pred":"of_a","subj":"T52","obj":"T13"},{"id":"R84","pred":"of_a","subj":"T46","obj":"T55"},{"id":"R85","pred":"of_a","subj":"T9","obj":"T55"},{"id":"R86","pred":"of_a","subj":"T12","obj":"T56"},{"id":"R87","pred":"of_a","subj":"T47","obj":"T56"},{"id":"R9","pred":"on","subj":"T5","obj":"T18"}],"attributes":[{"id":"A21","pred":"tao:has_database_id","subj":"21","obj":"Gene:43740568"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"Tax:9606"},{"id":"A38","pred":"tao:has_database_id","subj":"T15","obj":"BioSample:SAMN14384141"},{"id":"A26","pred":"tao:has_standard_notation","subj":"26","obj":"p.D614G"},{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"Tax:2697049"},{"id":"A52","pred":"tao:has_database_id","subj":"30","obj":"MESH:D014132"},{"id":"A82","pred":"tao:has_database_id","subj":"T53","obj":"BioSample:SAMN14384141"},{"id":"A84","pred":"tao:has_database_id","subj":"T47","obj":"Tax:2697049"},{"id":"A59","pred":"tao:has_standard_notation","subj":"T10","obj":"p.G614"},{"id":"A49","pred":"ForCovid19","subj":"T37","obj":"drug"},{"id":"A54","pred":"tao:has_database_id","subj":"T37","obj":"MESH:D014612"},{"id":"A36","pred":"tao:has_database_id","subj":"T1","obj":"MESH:D058873"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"Tax:9606"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"MESH:C000657245"},{"id":"A31","pred":"tao:has_standard_notation","subj":"31","obj":"p.D614G"},{"id":"A39","pred":"tao:has_database_id","subj":"T20","obj":"Tax:10035"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"MESH:D007239"},{"id":"A35","pred":"tao:has_database_id","subj":"35","obj":"MESH:C000657245"},{"id":"A25","pred":"tao:has_standard_notation","subj":"25","obj":"p.D614G"},{"id":"A37","pred":"tao:has_database_id","subj":"T2","obj":"BioSample:SAMN14384141"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"Tax:9606"},{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"MESH:C000657245"},{"id":"A22","pred":"tao:has_standard_notation","subj":"22","obj":"p.D614G"},{"id":"A3","pred":"tao:has_database_id","subj":"3","obj":"Gene:43740568"},{"id":"A86","pred":"tao:has_database_id","subj":"T55","obj":"Gene:43740568"},{"id":"A50","pred":"tao:has_database_id","subj":"T3","obj":"MESH:D008168"},{"id":"A60","pred":"tao:has_standard_notation","subj":"T9","obj":"p.G614"},{"id":"A64","pred":"Memo","subj":"T45","obj":"MESH:D009500"},{"id":"A48","pred":"tao:has_standard_notation","subj":"T41","obj":"p.D614G"},{"id":"A77","pred":"Memo","subj":"T41","obj":"MESH:D009154"},{"id":"A58","pred":"tao:has_database_id","subj":"T5","obj":"MESH:D004847"},{"id":"A76","pred":"Memo","subj":"31","obj":"MESH:D009154"},{"id":"A80","pred":"tao:has_database_id","subj":"T51","obj":"Gene:43740568"},{"id":"A79","pred":"tao:has_database_id","subj":"T50","obj":"Gene:43740568"},{"id":"A4","pred":"tao:has_standard_notation","subj":"4","obj":"p.D614G"},{"id":"A72","pred":"Memo","subj":"4","obj":"MESH:D009154"},{"id":"A74","pred":"Memo","subj":"25","obj":"MESH:D009154"},{"id":"A87","pred":"tao:has_database_id","subj":"T56","obj":"Gene:43740568"},{"id":"A83","pred":"tao:has_database_id","subj":"T46","obj":"BioSample:SAMN14384141"},{"id":"A61","pred":"tao:has_standard_notation","subj":"T11","obj":"p.G614"},{"id":"A62","pred":"tao:has_standard_notation","subj":"T12","obj":"p.D614"},{"id":"A66","pred":"Memo","subj":"T16","obj":"MESH:D012327"},{"id":"A81","pred":"tao:has_database_id","subj":"T52","obj":"Gene:43740568"},{"id":"A40","pred":"tao:has_database_id","subj":"T28","obj":"BioSample:SAMN14384141"},{"id":"A57","pred":"tao:has_database_id","subj":"T18","obj":"MESH:D014779"},{"id":"A73","pred":"Memo","subj":"22","obj":"MESH:D009154"},{"id":"A46","pred":"ForCovid19","subj":"T38","obj":"drug"},{"id":"A55","pred":"tao:has_database_id","subj":"T38","obj":"MESH:D014612"},{"id":"A63","pred":"tao:has_standard_notation","subj":"T13","obj":"p.D614"},{"id":"A65","pred":"tao:has_database_id","subj":"T48","obj":"MESH:D044967"},{"id":"A85","pred":"tao:has_database_id","subj":"T54","obj":"BioSample:SAMN14384141"},{"id":"A41","pred":"tao:has_database_id","subj":"T34","obj":"Tax:10035"},{"id":"A51","pred":"tao:has_database_id","subj":"T4","obj":"MESH:D008168"},{"id":"A47","pred":"ForCovid19","subj":"T36","obj":"drug"},{"id":"A56","pred":"tao:has_database_id","subj":"T36","obj":"MESH:D014612"},{"id":"A75","pred":"Memo","subj":"26","obj":"MESH:D009154"},{"id":"A53","pred":"tao:has_database_id","subj":"T23","obj":"MESH:D017817"},{"id":"A70","pred":"Memo","subj":"T32","obj":"MESH:D012327"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"MESH:D007239"},{"id":"A78","pred":"tao:has_database_id","subj":"T49","obj":"Gene:43740568"},{"id":"A5","pred":"tao:has_database_id","subj":"5","obj":"Tax:2697049"},{"subj":"21","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"22","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"23","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"24","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"25","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"26","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"27","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"28","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"29","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"3","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"30","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"31","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"32","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"33","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"34","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"35","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"4","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"5","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T1","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T10","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T11","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T12","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T13","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T15","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T16","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T17","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T18","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T19","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T2","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T20","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T21","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T22","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T23","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T24","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T26","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T28","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T29","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T3","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T30","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T31","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T32","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T34","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T35","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T36","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T37","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T38","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T39","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T4","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T41","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T42","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T43","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T44","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T45","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T46","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T47","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T48","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T49","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T5","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T50","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T51","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T52","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T53","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T54","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T55","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T56","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T6","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T7","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T8","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T9","pred":"source","obj":"Covid19_manual_annotation_v2"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"BioProject","uri":"https://www.ncbi.nlm.nih.gov/bioproject/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"},{"prefix":"HP","uri":"https://hpo.jax.org/app/browse/term/HP:"},{"prefix":"BioSample","uri":"https://www.ncbi.nlm.nih.gov/biosample/"}]},{"project":"MyTest","denotations":[{"id":"21","span":{"begin":50,"end":55},"obj":"Gene"},{"id":"22","span":{"begin":64,"end":78},"obj":"Variation"},{"id":"23","span":{"begin":98,"end":108},"obj":"Species"},{"id":"24","span":{"begin":120,"end":128},"obj":"Disease"},{"id":"25","span":{"begin":244,"end":258},"obj":"Variation"},{"id":"26","span":{"begin":315,"end":320},"obj":"Variation"},{"id":"27","span":{"begin":345,"end":350},"obj":"Species"},{"id":"28","span":{"begin":385,"end":390},"obj":"Species"},{"id":"29","span":{"begin":459,"end":467},"obj":"Disease"},{"id":"3","span":{"begin":0,"end":5},"obj":"Gene"},{"id":"30","span":{"begin":548,"end":555},"obj":"Anatomy"},{"id":"31","span":{"begin":610,"end":624},"obj":"Variation"},{"id":"32","span":{"begin":680,"end":688},"obj":"Disease"},{"id":"33","span":{"begin":689,"end":697},"obj":"Species"},{"id":"34","span":{"begin":745,"end":753},"obj":"Disease"},{"id":"35","span":{"begin":963,"end":971},"obj":"Disease"},{"id":"4","span":{"begin":6,"end":20},"obj":"Variation"},{"id":"5","span":{"begin":28,"end":38},"obj":"Species"},{"id":"T1","span":{"begin":129,"end":137},"obj":"Outbreak"},{"id":"T10","span":{"begin":477,"end":481},"obj":"Variation"},{"id":"T11","span":{"begin":1045,"end":1049},"obj":"Variation"},{"id":"T12","span":{"begin":841,"end":845},"obj":"Variation"},{"id":"T13","span":{"begin":740,"end":744},"obj":"Variation"},{"id":"T15","span":{"begin":441,"end":448},"obj":"Species"},{"id":"T16","span":{"begin":426,"end":437},"obj":"Infection"},{"id":"T17","span":{"begin":417,"end":425},"obj":"PositiveRegulation"},{"id":"T18","span":{"begin":330,"end":341},"obj":"Phenomena"},{"id":"T19","span":{"begin":321,"end":329},"obj":"PositiveRegulation"},{"id":"T2","span":{"begin":266,"end":278},"obj":"Species"},{"id":"T20","span":{"begin":450,"end":458},"obj":"Species"},{"id":"T21","span":{"begin":499,"end":505},"obj":"High"},{"id":"T22","span":{"begin":506,"end":523},"obj":"Index"},{"id":"T23","span":{"begin":531,"end":543},"obj":"Biological"},{"id":"T24","span":{"begin":561,"end":564},"obj":"Without"},{"id":"T26","span":{"begin":506,"end":523},"obj":"Index"},{"id":"T28","span":{"begin":634,"end":639},"obj":"Species"},{"id":"T29","span":{"begin":640,"end":645},"obj":"PositiveRegulation"},{"id":"T3","span":{"begin":351,"end":355},"obj":"Anatomy"},{"id":"T30","span":{"begin":625,"end":633},"obj":"PositiveRegulation"},{"id":"T31","span":{"begin":706,"end":715},"obj":"PositiveRegulation"},{"id":"T32","span":{"begin":716,"end":728},"obj":"Infection"},{"id":"T34","span":{"begin":754,"end":762},"obj":"Species"},{"id":"T35","span":{"begin":1191,"end":1198},"obj":"Therapy"},{"id":"T36","span":{"begin":1160,"end":1167},"obj":"Chemical"},{"id":"T37","span":{"begin":182,"end":189},"obj":"Chemical"},{"id":"T38","span":{"begin":916,"end":924},"obj":"Chemical"},{"id":"T39","span":{"begin":1182,"end":1190},"obj":"Type"},{"id":"T4","span":{"begin":565,"end":570},"obj":"Anatomy"},{"id":"T41","span":{"begin":877,"end":885},"obj":"Variation"},{"id":"T42","span":{"begin":890,"end":893},"obj":"NegativeRegulation"},{"id":"T43","span":{"begin":894,"end":900},"obj":"NegativeRegulation"},{"id":"T44","span":{"begin":780,"end":786},"obj":"High"},{"id":"T45","span":{"begin":787,"end":808},"obj":"Index"},{"id":"T46","span":{"begin":822,"end":827},"obj":"Species"},{"id":"T47","span":{"begin":846,"end":851},"obj":"Species"},{"id":"T48","span":{"begin":730,"end":734},"obj":"Anatomy"},{"id":"T49","span":{"begin":50,"end":55},"obj":"Gene"},{"id":"T5","span":{"begin":356,"end":372},"obj":"Anatomy"},{"id":"T50","span":{"begin":50,"end":55},"obj":"Gene"},{"id":"T51","span":{"begin":50,"end":55},"obj":"Gene"},{"id":"T52","span":{"begin":50,"end":55},"obj":"Gene"},{"id":"T53","span":{"begin":266,"end":278},"obj":"Species"},{"id":"T54","span":{"begin":266,"end":278},"obj":"Species"},{"id":"T55","span":{"begin":50,"end":55},"obj":"Gene"},{"id":"T56","span":{"begin":50,"end":55},"obj":"Gene"},{"id":"T6","span":{"begin":377,"end":384},"obj":"Condition"},{"id":"T7","span":{"begin":391,"end":405},"obj":"Anatomy"},{"id":"T8","span":{"begin":653,"end":676},"obj":"Anatomy"},{"id":"T9","span":{"begin":817,"end":821},"obj":"Variation"}],"relations":[{"id":"R1","pred":"of_a","subj":"23","obj":"21"},{"id":"R10","pred":"of_a","subj":"T3","obj":"T5"},{"id":"R12","pred":"of_a","subj":"27","obj":"T5"},{"id":"R13","pred":"of_a","subj":"28","obj":"T7"},{"id":"R23","pred":"has_a","subj":"29","obj":"T20"},{"id":"R27","pred":"is_a","subj":"T30","obj":"T29"},{"id":"R29","pred":"on","subj":"T8","obj":"T29"},{"id":"R3","pred":"of_a","subj":"4","obj":"3"},{"id":"R30","pred":"has_a","subj":"32","obj":"33"},{"id":"R31","pred":"of_a","subj":"33","obj":"T8"},{"id":"R33","pred":"is_a","subj":"T31","obj":"T32"},{"id":"R34","pred":"in","subj":"T8","obj":"T32"},{"id":"R35","pred":"is_a","subj":"T28","obj":"T32"},{"id":"R37","pred":"is_a","subj":"T42","obj":"T43"},{"id":"R4","pred":"of_a","subj":"22","obj":"21"},{"id":"R40","pred":"against","subj":"35","obj":"T38"},{"id":"R41","pred":"coreference","subj":"T41","obj":"31"},{"id":"R42","pred":"of_a","subj":"T39","obj":"T35"},{"id":"R43","pred":"is_a","subj":"T43","obj":"T38"},{"id":"R46","pred":"of_a","subj":"T44","obj":"T45"},{"id":"R48","pred":"coreference","subj":"T28","obj":"T15"},{"id":"R49","pred":"coreference","subj":"T46","obj":"T28"},{"id":"R53","pred":"of_a","subj":"T46","obj":"T45"},{"id":"R55","pred":"of_a","subj":"T34","obj":"T48"},{"id":"R64","pred":"coreference","subj":"T15","obj":"T2"},{"id":"R65","pred":"cause_of","subj":"T2","obj":"29"},{"id":"R66","pred":"has_a","subj":"T20","obj":"T22"},{"id":"R67","pred":"has_a","subj":"T20","obj":"T26"},{"id":"R68","pred":"of_a","subj":"31","obj":"T50"},{"id":"R69","pred":"of_a","subj":"T2","obj":"T50"},{"id":"R7","pred":"is_a","subj":"T15","obj":"T16"},{"id":"R70","pred":"is_a","subj":"T50","obj":"T30"},{"id":"R71","pred":"is_a","subj":"T50","obj":"T31"},{"id":"R72","pred":"coreference","subj":"T28","obj":"T2"},{"id":"R73","pred":"of_a","subj":"T13","obj":"T51"},{"id":"R74","pred":"of_a","subj":"T53","obj":"T51"},{"id":"R14","pred":"has_status","subj":"T7","obj":"T6"},{"id":"R15","pred":"cause_of","subj":"T17","obj":"T19"},{"id":"R17","pred":"of_a","subj":"T21","obj":"T22"},{"id":"R19","pred":"of_a","subj":"T24","obj":"T26"},{"id":"R2","pred":"of_a","subj":"5","obj":"3"},{"id":"R20","pred":"in","subj":"T23","obj":"T22"},{"id":"R21","pred":"in","subj":"30","obj":"T22"},{"id":"R22","pred":"in","subj":"T4","obj":"T26"},{"id":"R44","pred":"has_a","subj":"34","obj":"T34"},{"id":"R54","pred":"against","subj":"T47","obj":"T45"},{"id":"R58","pred":"is_a","subj":"T29","obj":"T28"},{"id":"R59","pred":"on","subj":"T7","obj":"T18"},{"id":"R6","pred":"is_a","subj":"T17","obj":"T16"},{"id":"R60","pred":"coreference","subj":"T29","obj":"T18"},{"id":"R61","pred":"of_a","subj":"26","obj":"T49"},{"id":"R62","pred":"of_a","subj":"T2","obj":"T49"},{"id":"R63","pred":"is_a","subj":"T49","obj":"T17"},{"id":"R75","pred":"cause_of","subj":"T53","obj":"34"},{"id":"R76","pred":"has_a","subj":"T34","obj":"T45"},{"id":"R78","pred":"coreference","subj":"T47","obj":"23"},{"id":"R79","pred":"of_a","subj":"T41","obj":"T52"},{"id":"R8","pred":"is_a","subj":"T19","obj":"T18"},{"id":"R80","pred":"of_a","subj":"T54","obj":"T52"},{"id":"R81","pred":"is_a","subj":"T54","obj":"T42"},{"id":"R82","pred":"of_a","subj":"T52","obj":"T13"},{"id":"R84","pred":"of_a","subj":"T46","obj":"T55"},{"id":"R85","pred":"of_a","subj":"T9","obj":"T55"},{"id":"R86","pred":"of_a","subj":"T12","obj":"T56"},{"id":"R87","pred":"of_a","subj":"T47","obj":"T56"},{"id":"R9","pred":"on","subj":"T5","obj":"T18"}],"attributes":[{"id":"A55","pred":"tao:has_database_id","subj":"T38","obj":"MESH:D014612"},{"id":"A65","pred":"tao:has_database_id","subj":"T48","obj":"MESH:D044967"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"MESH:D007239"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"MESH:C000657245"},{"id":"A48","pred":"tao:has_standard_notation","subj":"T41","obj":"p.D614G"},{"id":"A77","pred":"Memo","subj":"T41","obj":"MESH:D009154"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"Tax:9606"},{"id":"A4","pred":"tao:has_standard_notation","subj":"4","obj":"p.D614G"},{"id":"A40","pred":"tao:has_database_id","subj":"T28","obj":"BioSample:SAMN14384141"},{"id":"A72","pred":"Memo","subj":"4","obj":"MESH:D009154"},{"id":"A59","pred":"tao:has_standard_notation","subj":"T10","obj":"p.G614"},{"id":"A39","pred":"tao:has_database_id","subj":"T20","obj":"Tax:10035"},{"id":"A51","pred":"tao:has_database_id","subj":"T4","obj":"MESH:D008168"},{"id":"A61","pred":"tao:has_standard_notation","subj":"T11","obj":"p.G614"},{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"Tax:2697049"},{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"MESH:C000657245"},{"id":"A37","pred":"tao:has_database_id","subj":"T2","obj":"BioSample:SAMN14384141"},{"id":"A35","pred":"tao:has_database_id","subj":"35","obj":"MESH:C000657245"},{"id":"A70","pred":"Memo","subj":"T32","obj":"MESH:D012327"},{"id":"A22","pred":"tao:has_standard_notation","subj":"22","obj":"p.D614G"},{"id":"A49","pred":"ForCovid19","subj":"T37","obj":"drug"},{"id":"A54","pred":"tao:has_database_id","subj":"T37","obj":"MESH:D014612"},{"id":"A57","pred":"tao:has_database_id","subj":"T18","obj":"MESH:D014779"},{"id":"A73","pred":"Memo","subj":"22","obj":"MESH:D009154"},{"id":"A21","pred":"tao:has_database_id","subj":"21","obj":"Gene:43740568"},{"id":"A3","pred":"tao:has_database_id","subj":"3","obj":"Gene:43740568"},{"id":"A63","pred":"tao:has_standard_notation","subj":"T13","obj":"p.D614"},{"id":"A41","pred":"tao:has_database_id","subj":"T34","obj":"Tax:10035"},{"id":"A66","pred":"Memo","subj":"T16","obj":"MESH:D012327"},{"id":"A62","pred":"tao:has_standard_notation","subj":"T12","obj":"p.D614"},{"id":"A26","pred":"tao:has_standard_notation","subj":"26","obj":"p.D614G"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"Tax:9606"},{"id":"A50","pred":"tao:has_database_id","subj":"T3","obj":"MESH:D008168"},{"id":"A75","pred":"Memo","subj":"26","obj":"MESH:D009154"},{"id":"A31","pred":"tao:has_standard_notation","subj":"31","obj":"p.D614G"},{"id":"A76","pred":"Memo","subj":"31","obj":"MESH:D009154"},{"id":"A5","pred":"tao:has_database_id","subj":"5","obj":"Tax:2697049"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"MESH:D007239"},{"id":"A47","pred":"ForCovid19","subj":"T36","obj":"drug"},{"id":"A56","pred":"tao:has_database_id","subj":"T36","obj":"MESH:D014612"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"Tax:9606"},{"id":"A53","pred":"tao:has_database_id","subj":"T23","obj":"MESH:D017817"},{"id":"A60","pred":"tao:has_standard_notation","subj":"T9","obj":"p.G614"},{"id":"A36","pred":"tao:has_database_id","subj":"T1","obj":"MESH:D058873"},{"id":"A58","pred":"tao:has_database_id","subj":"T5","obj":"MESH:D004847"},{"id":"A52","pred":"tao:has_database_id","subj":"30","obj":"MESH:D014132"},{"id":"A64","pred":"Memo","subj":"T45","obj":"MESH:D009500"},{"id":"A46","pred":"ForCovid19","subj":"T38","obj":"drug"},{"id":"A81","pred":"tao:has_database_id","subj":"T52","obj":"Gene:43740568"},{"id":"A86","pred":"tao:has_database_id","subj":"T55","obj":"Gene:43740568"},{"id":"A80","pred":"tao:has_database_id","subj":"T51","obj":"Gene:43740568"},{"id":"A78","pred":"tao:has_database_id","subj":"T49","obj":"Gene:43740568"},{"id":"A83","pred":"tao:has_database_id","subj":"T46","obj":"BioSample:SAMN14384141"},{"id":"A85","pred":"tao:has_database_id","subj":"T54","obj":"BioSample:SAMN14384141"},{"id":"A82","pred":"tao:has_database_id","subj":"T53","obj":"BioSample:SAMN14384141"},{"id":"A79","pred":"tao:has_database_id","subj":"T50","obj":"Gene:43740568"},{"id":"A84","pred":"tao:has_database_id","subj":"T47","obj":"Tax:2697049"},{"id":"A25","pred":"tao:has_standard_notation","subj":"25","obj":"p.D614G"},{"id":"A38","pred":"tao:has_database_id","subj":"T15","obj":"BioSample:SAMN14384141"},{"id":"A74","pred":"Memo","subj":"25","obj":"MESH:D009154"},{"id":"A87","pred":"tao:has_database_id","subj":"T56","obj":"Gene:43740568"},{"subj":"21","pred":"source","obj":"MyTest"},{"subj":"22","pred":"source","obj":"MyTest"},{"subj":"23","pred":"source","obj":"MyTest"},{"subj":"24","pred":"source","obj":"MyTest"},{"subj":"25","pred":"source","obj":"MyTest"},{"subj":"26","pred":"source","obj":"MyTest"},{"subj":"27","pred":"source","obj":"MyTest"},{"subj":"28","pred":"source","obj":"MyTest"},{"subj":"29","pred":"source","obj":"MyTest"},{"subj":"3","pred":"source","obj":"MyTest"},{"subj":"30","pred":"source","obj":"MyTest"},{"subj":"31","pred":"source","obj":"MyTest"},{"subj":"32","pred":"source","obj":"MyTest"},{"subj":"33","pred":"source","obj":"MyTest"},{"subj":"34","pred":"source","obj":"MyTest"},{"subj":"35","pred":"source","obj":"MyTest"},{"subj":"4","pred":"source","obj":"MyTest"},{"subj":"5","pred":"source","obj":"MyTest"},{"subj":"T1","pred":"source","obj":"MyTest"},{"subj":"T10","pred":"source","obj":"MyTest"},{"subj":"T11","pred":"source","obj":"MyTest"},{"subj":"T12","pred":"source","obj":"MyTest"},{"subj":"T13","pred":"source","obj":"MyTest"},{"subj":"T15","pred":"source","obj":"MyTest"},{"subj":"T16","pred":"source","obj":"MyTest"},{"subj":"T17","pred":"source","obj":"MyTest"},{"subj":"T18","pred":"source","obj":"MyTest"},{"subj":"T19","pred":"source","obj":"MyTest"},{"subj":"T2","pred":"source","obj":"MyTest"},{"subj":"T20","pred":"source","obj":"MyTest"},{"subj":"T21","pred":"source","obj":"MyTest"},{"subj":"T22","pred":"source","obj":"MyTest"},{"subj":"T23","pred":"source","obj":"MyTest"},{"subj":"T24","pred":"source","obj":"MyTest"},{"subj":"T26","pred":"source","obj":"MyTest"},{"subj":"T28","pred":"source","obj":"MyTest"},{"subj":"T29","pred":"source","obj":"MyTest"},{"subj":"T3","pred":"source","obj":"MyTest"},{"subj":"T30","pred":"source","obj":"MyTest"},{"subj":"T31","pred":"source","obj":"MyTest"},{"subj":"T32","pred":"source","obj":"MyTest"},{"subj":"T34","pred":"source","obj":"MyTest"},{"subj":"T35","pred":"source","obj":"MyTest"},{"subj":"T36","pred":"source","obj":"MyTest"},{"subj":"T37","pred":"source","obj":"MyTest"},{"subj":"T38","pred":"source","obj":"MyTest"},{"subj":"T39","pred":"source","obj":"MyTest"},{"subj":"T4","pred":"source","obj":"MyTest"},{"subj":"T41","pred":"source","obj":"MyTest"},{"subj":"T42","pred":"source","obj":"MyTest"},{"subj":"T43","pred":"source","obj":"MyTest"},{"subj":"T44","pred":"source","obj":"MyTest"},{"subj":"T45","pred":"source","obj":"MyTest"},{"subj":"T46","pred":"source","obj":"MyTest"},{"subj":"T47","pred":"source","obj":"MyTest"},{"subj":"T48","pred":"source","obj":"MyTest"},{"subj":"T49","pred":"source","obj":"MyTest"},{"subj":"T5","pred":"source","obj":"MyTest"},{"subj":"T50","pred":"source","obj":"MyTest"},{"subj":"T51","pred":"source","obj":"MyTest"},{"subj":"T52","pred":"source","obj":"MyTest"},{"subj":"T53","pred":"source","obj":"MyTest"},{"subj":"T54","pred":"source","obj":"MyTest"},{"subj":"T55","pred":"source","obj":"MyTest"},{"subj":"T56","pred":"source","obj":"MyTest"},{"subj":"T6","pred":"source","obj":"MyTest"},{"subj":"T7","pred":"source","obj":"MyTest"},{"subj":"T8","pred":"source","obj":"MyTest"},{"subj":"T9","pred":"source","obj":"MyTest"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}]},{"project":"LitCovid_AGAC_only","denotations":[{"id":"p253597s2","span":{"begin":15,"end":19},"obj":"Var"},{"id":"p253597s3","span":{"begin":19,"end":20},"obj":"Var"},{"id":"p253597s4","span":{"begin":21,"end":27},"obj":"Reg"},{"id":"p253597s5","span":{"begin":28,"end":32},"obj":"MPA"},{"id":"p253597s6","span":{"begin":32,"end":38},"obj":"Protein"},{"id":"p253597s10","span":{"begin":39,"end":46},"obj":"MPA"},{"id":"p253601s0","span":{"begin":315,"end":319},"obj":"Var"},{"id":"p253601s1","span":{"begin":319,"end":320},"obj":"Var"},{"id":"p253602s4","span":{"begin":477,"end":481},"obj":"Var"},{"id":"p253602s5","span":{"begin":482,"end":489},"obj":"Var"},{"id":"p253602s7","span":{"begin":499,"end":505},"obj":"PosReg"},{"id":"p253602s8","span":{"begin":506,"end":523},"obj":"MPA"},{"id":"p253602s26","span":{"begin":610,"end":614},"obj":"Var"},{"id":"p253602s27","span":{"begin":614,"end":615},"obj":"Var"},{"id":"p253602s29","span":{"begin":625,"end":633},"obj":"PosReg"},{"id":"p253602s30","span":{"begin":634,"end":645},"obj":"MPA"},{"id":"p253602s44","span":{"begin":706,"end":715},"obj":"PosReg"},{"id":"p253602s45","span":{"begin":716,"end":728},"obj":"MPA"}],"attributes":[{"subj":"p253597s2","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p253597s3","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p253597s4","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p253597s5","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p253597s6","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p253597s10","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p253601s0","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p253601s1","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p253602s4","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p253602s5","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p253602s7","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p253602s8","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p253602s26","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p253602s27","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p253602s29","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p253602s30","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p253602s44","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p253602s45","pred":"source","obj":"LitCovid_AGAC_only"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ec93a2","default":true},{"id":"LitCovid-PD-UBERON","color":"#93bcec"},{"id":"LitCovid-PD-MONDO","color":"#d6ec93"},{"id":"LitCovid-PD-CLO","color":"#e893ec"},{"id":"LitCovid-PD-CHEBI","color":"#93ecce"},{"id":"LitCovid-PubTator","color":"#ecb493"},{"id":"LitCovid-sentences","color":"#9a93ec"},{"id":"Covid19_manual_annotation_v2","color":"#a5ec93"},{"id":"MyTest","color":"#ec93bf"},{"id":"LitCovid_AGAC_only","color":"#93d9ec"}]}]}}