PubMed:33091817
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T1 | 105-109 | Body_part | denotes | skin | http://purl.org/sig/ont/fma/fma7163 |
| T2 | 193-197 | Body_part | denotes | skin | http://purl.org/sig/ont/fma/fma7163 |
| T3 | 374-378 | Body_part | denotes | skin | http://purl.org/sig/ont/fma/fma7163 |
| T4 | 597-602 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
| T5 | 1066-1071 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 105-109 | Body_part | denotes | skin | http://purl.obolibrary.org/obo/UBERON_0000014 |
| T2 | 193-197 | Body_part | denotes | skin | http://purl.obolibrary.org/obo/UBERON_0000014 |
| T3 | 374-378 | Body_part | denotes | skin | http://purl.obolibrary.org/obo/UBERON_0000014 |
| T4 | 597-602 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
| T5 | 1066-1071 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 0-42 | Disease | denotes | Acute generalized exanthematous pustulosis | http://purl.obolibrary.org/obo/MONDO_0017384 |
| T2 | 131-173 | Disease | denotes | Acute generalized exanthematous pustulosis | http://purl.obolibrary.org/obo/MONDO_0017384 |
| T3 | 175-179 | Disease | denotes | AGEP | http://purl.obolibrary.org/obo/MONDO_0017384 |
| T4 | 355-359 | Disease | denotes | AGEP | http://purl.obolibrary.org/obo/MONDO_0017384 |
| T5 | 479-483 | Disease | denotes | AGEP | http://purl.obolibrary.org/obo/MONDO_0017384 |
| T6 | 826-846 | Disease | denotes | rheumatoid arthritis | http://purl.obolibrary.org/obo/MONDO_0008383 |
| T7 | 837-846 | Disease | denotes | arthritis | http://purl.obolibrary.org/obo/MONDO_0005578 |
| T8 | 851-859 | Disease | denotes | diabetes | http://purl.obolibrary.org/obo/MONDO_0005015 |
| T9 | 989-993 | Disease | denotes | AGEP | http://purl.obolibrary.org/obo/MONDO_0017384 |
| T10 | 1933-1937 | Disease | denotes | AGEP | http://purl.obolibrary.org/obo/MONDO_0017384 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 48-49 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T2 | 50-55 | http://purl.obolibrary.org/obo/CLO_0009985 | denotes | focus |
| T3 | 79-83 | http://purl.obolibrary.org/obo/CLO_0001550 | denotes | A 10 |
| T4 | 103-104 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T5 | 105-109 | http://purl.obolibrary.org/obo/UBERON_0000014 | denotes | skin |
| T6 | 105-109 | http://purl.obolibrary.org/obo/UBERON_0001003 | denotes | skin |
| T7 | 105-109 | http://purl.obolibrary.org/obo/UBERON_0002097 | denotes | skin |
| T8 | 105-109 | http://purl.obolibrary.org/obo/UBERON_0002199 | denotes | skin |
| T9 | 105-109 | http://www.ebi.ac.uk/efo/EFO_0000962 | denotes | skin |
| T10 | 120-129 | http://purl.obolibrary.org/obo/BFO_0000030 | denotes | OBJECTIVE |
| T11 | 184-185 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T12 | 193-197 | http://purl.obolibrary.org/obo/UBERON_0000014 | denotes | skin |
| T13 | 193-197 | http://purl.obolibrary.org/obo/UBERON_0001003 | denotes | skin |
| T14 | 193-197 | http://purl.obolibrary.org/obo/UBERON_0002097 | denotes | skin |
| T15 | 193-197 | http://purl.obolibrary.org/obo/UBERON_0002199 | denotes | skin |
| T16 | 193-197 | http://www.ebi.ac.uk/efo/EFO_0000962 | denotes | skin |
| T17 | 363-364 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T18 | 374-378 | http://purl.obolibrary.org/obo/UBERON_0000014 | denotes | skin |
| T19 | 374-378 | http://purl.obolibrary.org/obo/UBERON_0001003 | denotes | skin |
| T20 | 374-378 | http://purl.obolibrary.org/obo/UBERON_0002097 | denotes | skin |
| T21 | 374-378 | http://purl.obolibrary.org/obo/UBERON_0002199 | denotes | skin |
| T22 | 374-378 | http://www.ebi.ac.uk/efo/EFO_0000962 | denotes | skin |
| T23 | 565-570 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tests |
| T24 | 597-602 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
| T25 | 713-715 | http://purl.obolibrary.org/obo/CLO_0050509 | denotes | 27 |
| T26 | 724-725 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T27 | 1066-1071 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
| T28 | 1239-1240 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T29 | 1429-1431 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T30 | 1735-1736 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T31 | 1899-1900 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T1 | 59-77 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T2 | 207-211 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T3 | 526-530 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T4 | 874-892 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T5 | 894-907 | Chemical | denotes | cephalosporin | http://purl.obolibrary.org/obo/CHEBI_23066 |
| T6 | 913-924 | Chemical | denotes | amoxicillin | http://purl.obolibrary.org/obo/CHEBI_2676 |
| T7 | 1021-1026 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T8 | 1219-1231 | Chemical | denotes | prednisolone | http://purl.obolibrary.org/obo/CHEBI_8378 |
| T9 | 1346-1364 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T10 | 1365-1370 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T11 | 1389-1394 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T12 | 1814-1832 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 2 | 18-42 | Disease | denotes | exanthematous pustulosis | MESH:D056150 |
| 3 | 59-77 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 24 | 149-173 | Disease | denotes | exanthematous pustulosis | MESH:D056150 |
| 25 | 341-349 | Species | denotes | patients | Tax:9606 |
| 26 | 455-463 | Species | denotes | patients | Tax:9606 |
| 27 | 666-674 | Species | denotes | patients | Tax:9606 |
| 28 | 689-694 | Species | denotes | women | Tax:9606 |
| 29 | 708-711 | Species | denotes | men | Tax:9606 |
| 30 | 812-820 | Species | denotes | patients | Tax:9606 |
| 31 | 826-846 | Disease | denotes | rheumatoid arthritis | MESH:D001172 |
| 32 | 851-859 | Disease | denotes | diabetes | MESH:D003920 |
| 33 | 874-892 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 34 | 894-907 | Chemical | denotes | cephalosporin | MESH:D002511 |
| 35 | 913-924 | Chemical | denotes | amoxicillin | MESH:D000658 |
| 36 | 1044-1052 | Species | denotes | patients | Tax:9606 |
| 37 | 1192-1200 | Species | denotes | patients | Tax:9606 |
| 38 | 1219-1231 | Chemical | denotes | prednisolone | MESH:D011239 |
| 39 | 1346-1364 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 40 | 1518-1526 | Species | denotes | patients | Tax:9606 |
| 41 | 1629-1637 | Species | denotes | patients | Tax:9606 |
| 42 | 1814-1832 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 43 | 1849-1854 | Disease | denotes | fever | MESH:D005334 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-78 | Sentence | denotes | Acute generalized exanthematous pustulosis with a focus on hydroxychloroquine: |
| T2 | 79-119 | Sentence | denotes | A 10-year experience in a skin hospital. |
| T3 | 120-130 | Sentence | denotes | OBJECTIVE: |
| T4 | 131-268 | Sentence | denotes | Acute generalized exanthematous pustulosis (AGEP) is a severe skin pustular drug reaction that can lead to life-threatening consequences. |
| T5 | 269-388 | Sentence | denotes | In this study, we have investigated the characteristics and outcomes of patients with AGEP in a tertiary skin hospital. |
| T6 | 389-397 | Sentence | denotes | METHODS: |
| T7 | 398-499 | Sentence | denotes | From March 2007 to December 2019, medical records of all patients diagnosed with AGEP, were assessed. |
| T8 | 500-643 | Sentence | denotes | Demographic data, culprit drug, past medical history, laboratory tests, recurrence, and systemic organ involvement were all documented as well. |
| T9 | 644-652 | Sentence | denotes | RESULTS: |
| T10 | 653-771 | Sentence | denotes | Seventy-four patients, including 54 women (73%) and 20 men (27%), with a mean age of 44.3 ± 16.5 years were evaluated. |
| T11 | 772-860 | Sentence | denotes | The most common comorbidities among the patients were rheumatoid arthritis and diabetes. |
| T12 | 861-1004 | Sentence | denotes | In addition, hydroxychloroquine, cephalosporin, and amoxicillin were found as the three most common medications associated with AGEP induction. |
| T13 | 1005-1187 | Sentence | denotes | Among the study group, seventeen (23%) patients had systemic organ involvement (nine (12.2%), six (8.1%), and five (6.8%) had hepatic, renal and pulmonary involvement, respectively). |
| T14 | 1188-1284 | Sentence | denotes | All patients responded to oral prednisolone within a median of five days (IQR = 4; ranged 2-14). |
| T15 | 1285-1438 | Sentence | denotes | The median duration of treatment was significantly longer in hydroxychloroquine group compared to other drugs (8 versus 5 days; HR 0.57,95%CI 0·35-0.91). |
| T16 | 1439-1601 | Sentence | denotes | Likewise, the median duration of treatment was significantly longer in febrile patients compared to the afebrile ones (7 versus 4 days; HR 0.46, 95%CI 0.25-0.85). |
| T17 | 1602-1688 | Sentence | denotes | Recurrence occurred in six patients after resuming treatment with the same medication. |
| T18 | 1689-1766 | Sentence | denotes | The mean Naranjo score was 7.6 ± 0.9 denoting a probable causal relationship. |
| T19 | 1767-1778 | Sentence | denotes | CONCLUSION: |
| T20 | 1779-1938 | Sentence | denotes | In this study, we found that using hydroxychloroquine and presence of fever are the risk factors potentially leading to a prolonged treatment duration of AGEP. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 826-846 | Phenotype | denotes | rheumatoid arthritis | http://purl.obolibrary.org/obo/HP_0001370 |
| T2 | 1849-1854 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |
hydroxychloroquine
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 826-846 | Phenotype | denotes | rheumatoid arthritis | http://purl.obolibrary.org/obo/HP_0001370 |
| T2 | 1849-1854 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |