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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 60-66 Body_part denotes Kidney http://purl.org/sig/ont/fma/fma7203
T2 564-570 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T3 1566-1572 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 60-66 Body_part denotes Kidney http://purl.obolibrary.org/obo/UBERON_0002113
T2 564-570 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T3 1566-1572 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 233-261 Disease denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0007915
T2 242-261 Disease denotes lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0004670
T3 263-266 Disease denotes SLE http://purl.obolibrary.org/obo/MONDO_0007915
T4 272-283 Disease denotes scleroderma http://purl.obolibrary.org/obo/MONDO_0019340
T5 358-366 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T6 598-601 Disease denotes SLE http://purl.obolibrary.org/obo/MONDO_0007915
T7 605-616 Disease denotes scleroderma http://purl.obolibrary.org/obo/MONDO_0019340
T8 766-769 Disease denotes MPA http://purl.obolibrary.org/obo/MONDO_0019124
T9 821-824 Disease denotes MPA http://purl.obolibrary.org/obo/MONDO_0019124
T10 1094-1105 Disease denotes arrhythmias http://purl.obolibrary.org/obo/MONDO_0007263
T11 1193-1196 Disease denotes MPA http://purl.obolibrary.org/obo/MONDO_0019124
T12 1256-1267 Disease denotes arrhythmias http://purl.obolibrary.org/obo/MONDO_0007263
T13 1319-1331 Disease denotes pancytopenia http://purl.obolibrary.org/obo/MONDO_0001529
T14 1669-1680 Disease denotes arrhythmias http://purl.obolibrary.org/obo/MONDO_0007263

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 60-66 http://purl.obolibrary.org/obo/UBERON_0002113 denotes Kidney
T2 60-66 http://www.ebi.ac.uk/efo/EFO_0000927 denotes Kidney
T3 60-66 http://www.ebi.ac.uk/efo/EFO_0000929 denotes Kidney
T4 564-570 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T5 564-570 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T6 564-570 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T7 973-976 http://purl.obolibrary.org/obo/CLO_0001562 denotes a 2
T8 973-976 http://purl.obolibrary.org/obo/CLO_0001563 denotes a 2
T9 1566-1572 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T10 1566-1572 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T11 1566-1572 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 171-183 Chemical denotes antimalarial http://purl.obolibrary.org/obo/CHEBI_38068
T2 184-188 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T3 289-298 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T4 474-488 Chemical denotes pharmaceutical http://purl.obolibrary.org/obo/CHEBI_52217
T5 730-740 Chemical denotes tacrolimus http://purl.obolibrary.org/obo/CHEBI_61049|http://purl.obolibrary.org/obo/CHEBI_61057
T7 742-745 Chemical denotes Tac http://purl.obolibrary.org/obo/CHEBI_61049
T8 747-764 Chemical denotes mycophenolic acid http://purl.obolibrary.org/obo/CHEBI_168396
T9 760-764 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T10 766-769 Chemical denotes MPA http://purl.obolibrary.org/obo/CHEBI_6716|http://purl.obolibrary.org/obo/CHEBI_138016|http://purl.obolibrary.org/obo/CHEBI_168396
T13 771-781 Chemical denotes prednisone http://purl.obolibrary.org/obo/CHEBI_8382
T14 783-787 Chemical denotes Pred http://purl.obolibrary.org/obo/CHEBI_8382
T15 799-804 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T16 817-820 Chemical denotes Tac http://purl.obolibrary.org/obo/CHEBI_61049
T17 821-824 Chemical denotes MPA http://purl.obolibrary.org/obo/CHEBI_6716|http://purl.obolibrary.org/obo/CHEBI_138016|http://purl.obolibrary.org/obo/CHEBI_168396
T20 825-829 Chemical denotes Pred http://purl.obolibrary.org/obo/CHEBI_8382
T21 910-915 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T22 1009-1012 Chemical denotes ECG http://purl.obolibrary.org/obo/CHEBI_70255
T23 1189-1192 Chemical denotes Tac http://purl.obolibrary.org/obo/CHEBI_61049
T24 1193-1196 Chemical denotes MPA http://purl.obolibrary.org/obo/CHEBI_6716|http://purl.obolibrary.org/obo/CHEBI_138016|http://purl.obolibrary.org/obo/CHEBI_168396
T27 1197-1201 Chemical denotes Pred http://purl.obolibrary.org/obo/CHEBI_8382

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1 0-18 Chemical denotes Hydroxychloroquine MESH:D006886
37 140-158 Chemical denotes Hydroxychloroquine MESH:D006886
38 160-163 Chemical denotes HCQ MESH:D006886
39 233-261 Disease denotes systemic lupus erythematosus MESH:D008180
40 263-266 Disease denotes SLE MESH:D008180
41 272-283 Disease denotes scleroderma MESH:C543759
42 310-313 Chemical denotes HCQ MESH:D006886
43 358-366 Disease denotes COVID-19 MESH:C000657245
44 533-536 Chemical denotes HCQ MESH:D006886
45 598-601 Disease denotes SLE MESH:D008180
46 605-616 Disease denotes scleroderma MESH:C543759
47 730-740 Chemical denotes tacrolimus MESH:D016559
48 742-745 Chemical denotes Tac MESH:D016559
49 747-764 Chemical denotes mycophenolic acid MESH:D009173
50 766-769 Chemical denotes MPA MESH:D009173
51 771-781 Chemical denotes prednisone MESH:D011241
52 783-787 Chemical denotes Pred MESH:D011241
53 817-820 Chemical denotes Tac MESH:D016559
54 821-824 Chemical denotes MPA MESH:D009173
55 825-829 Chemical denotes Pred MESH:D011241
56 830-833 Chemical denotes HCQ MESH:D006886
57 873-876 Chemical denotes HCQ MESH:D006886
58 965-968 Chemical denotes HCQ MESH:D006886
59 1016-1031 Disease denotes QT prolongation MESH:D008133
60 1082-1105 Disease denotes ventricular arrhythmias MESH:D001145
61 1189-1192 Chemical denotes Tac MESH:D016559
62 1193-1196 Chemical denotes MPA MESH:D009173
63 1202-1205 Chemical denotes HCQ MESH:D006886
64 1244-1267 Disease denotes ventricular arrhythmias MESH:D001145
65 1319-1331 Disease denotes pancytopenia MESH:D010198
66 1423-1426 Chemical denotes HCQ MESH:D006886
67 1437-1440 Chemical denotes HCQ MESH:D006886
68 1507-1512 Disease denotes death MESH:D003643
69 1516-1529 Disease denotes graft failure MESH:D006333
70 1531-1534 Chemical denotes HCQ MESH:D006886
71 1669-1680 Disease denotes arrhythmias MESH:D001145

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-89 Sentence denotes Hydroxychloroquine and Maintenance Immunosuppression Use in Kidney Transplant Recipients:
T2 90-113 Sentence denotes Analysis of Linked U.S.
T3 114-139 Sentence denotes Registry and Claims Data.
T4 140-284 Sentence denotes Hydroxychloroquine (HCQ) is an antimalarial drug with immunomodulatory effects used to treat systemic lupus erythematosus (SLE) and scleroderma.
T5 285-410 Sentence denotes The antiviral effects of HCQ have raised attention in the context of the COVID-19 pandemic, although safety is controversial.
T6 411-638 Sentence denotes We examined linkages of national transplant registry data with pharmaceutical claims and Medicare billing claims to study HCQ use among Medicare-insured kidney transplant recipients with SLE or scleroderma (2008-2017; N=1,820).
T7 639-726 Sentence denotes We compared three groups based on immunosuppression regimen 7-12 months posttransplant:
T8 727-884 Sentence denotes 1) tacrolimus (Tac)+mycophenolic acid (MPA)+prednisone (Pred) (referent group, 77.7%); 2) Tac+MPA+Pred+HCQ (16.5%); or 3) other immunosuppression+HCQ (5.7%).
T9 885-1188 Sentence denotes Compared to the referent group, recipients treated with other immunosuppression+HCQ had a 2-fold increased risk of abnormal ECG or QT prolongation (18.9% vs. 10.7%; aHR,1.12 1.963.42 , p=0.02) and ventricular arrhythmias (15.2% vs. 11.4%; aHR,1.00 1.813.29 , p=0.05) in the >1-to-3 years posttransplant.
T10 1189-1427 Sentence denotes Tac+MPA+Pred+HCQ was associated with increased risk of ventricular arrhythmias (13.5% vs. 11.4%; aHR,1.02 1.54 2.31 , p=0.04) and pancytopenia (35.9% vs. 31.4%; aHR,1.03 1.311.68 , p=0.03) compared to triple immunosuppression without HCQ.
T11 1428-1530 Sentence denotes However, HCQ-containing regimens were not associated with an increased risk of death or graft failure.
T12 1531-1694 Sentence denotes HCQ may be used safely in selected kidney transplant recipients in addition to their maintenance immunosuppression, although attention to arrhythmias is warranted.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 233-261 Phenotype denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/HP_0002725
T2 263-266 Phenotype denotes SLE http://purl.obolibrary.org/obo/HP_0002725
T3 272-283 Phenotype denotes scleroderma http://purl.obolibrary.org/obo/HP_0100324
T4 598-601 Phenotype denotes SLE http://purl.obolibrary.org/obo/HP_0002725
T5 605-616 Phenotype denotes scleroderma http://purl.obolibrary.org/obo/HP_0100324
T6 1000-1012 Phenotype denotes abnormal ECG http://purl.obolibrary.org/obo/HP_0003115
T7 1082-1105 Phenotype denotes ventricular arrhythmias http://purl.obolibrary.org/obo/HP_0004308
T8 1244-1267 Phenotype denotes ventricular arrhythmias http://purl.obolibrary.org/obo/HP_0004308
T9 1319-1331 Phenotype denotes pancytopenia http://purl.obolibrary.org/obo/HP_0001876
T10 1669-1680 Phenotype denotes arrhythmias http://purl.obolibrary.org/obo/HP_0011675

hydroxychloroquine

Id Subject Object Predicate Lexical cue hp_id
T1 233-261 Phenotype denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/HP_0002725
T2 263-266 Phenotype denotes SLE http://purl.obolibrary.org/obo/HP_0002725
T3 272-283 Phenotype denotes scleroderma http://purl.obolibrary.org/obo/HP_0100324
T4 598-601 Phenotype denotes SLE http://purl.obolibrary.org/obo/HP_0002725
T5 605-616 Phenotype denotes scleroderma http://purl.obolibrary.org/obo/HP_0100324
T6 1000-1012 Phenotype denotes abnormal ECG http://purl.obolibrary.org/obo/HP_0003115
T7 1082-1105 Phenotype denotes ventricular arrhythmias http://purl.obolibrary.org/obo/HP_0004308
T8 1244-1267 Phenotype denotes ventricular arrhythmias http://purl.obolibrary.org/obo/HP_0004308
T9 1319-1331 Phenotype denotes pancytopenia http://purl.obolibrary.org/obo/HP_0001876
T10 1669-1680 Phenotype denotes arrhythmias http://purl.obolibrary.org/obo/HP_0011675