PubMed:33041824
Annnotations
LitCovid_Glycan-Motif-Structure
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 508-515 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
T2 | 508-515 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
T3 | 547-554 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
T4 | 547-554 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
T5 | 737-744 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
T6 | 737-744 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
T7 | 753-760 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
T8 | 753-760 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
T9 | 879-886 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
T10 | 879-886 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
T11 | 919-926 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
T12 | 919-926 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
T13 | 935-942 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
T14 | 935-942 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
T15 | 1013-1020 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
T16 | 1013-1020 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
T17 | 1143-1150 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
T18 | 1143-1150 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
Inflammaging
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-98 | Sentence | denotes | Use of Enoxaparin to Counteract COVID-19 Infection and Reduce Thromboembolic Venous Complications: |
T2 | 99-132 | Sentence | denotes | A Review of the Current Evidence. |
T3 | 133-245 | Sentence | denotes | The impact of the COVID-19 pandemic has been dramatic worldwide, with China, Italy, and now US at its epicenter. |
T4 | 246-385 | Sentence | denotes | Researchers and clinicians are studying and testing different approaches in the attempt to prevent the infection and minimize its severity. |
T5 | 386-599 | Sentence | denotes | Major efforts are focused on optimizing mechanical ventilation, antiviral, and supportive treatment; however, the role of heparin and low molecular weight (LMW) heparin in this setting has been largely overlooked. |
T6 | 600-1101 | Sentence | denotes | This review summarizes the available evidence about the role of heparan sulfate as a key entry mechanism for SARS-CoV-2; the efficacy of heparin and LMW heparin in counteracting its entry into the cell, the recent experimental findings obtained in in vitro studies using the LMW heparin enoxaparin Inhixa®, the role of heparin and LMW heparin in modulating the cytokine storm, and the evidence for the use of LMW heparin in the prevention and treatment of the thromboembolic complications of COVID-19. |
T7 | 1102-1208 | Sentence | denotes | The available evidence suggests that LMW heparin appears as a promising tool in the treatment of COVID-19. |
T8 | 1209-1381 | Sentence | denotes | Whether its systematic use is associated with a reduction in complications and ultimately mortality of these patients is being tested in several studies starting worldwide. |
T1 | 0-98 | Sentence | denotes | Use of Enoxaparin to Counteract COVID-19 Infection and Reduce Thromboembolic Venous Complications: |
T2 | 99-132 | Sentence | denotes | A Review of the Current Evidence. |
T3 | 133-245 | Sentence | denotes | The impact of the COVID-19 pandemic has been dramatic worldwide, with China, Italy, and now US at its epicenter. |
T4 | 246-385 | Sentence | denotes | Researchers and clinicians are studying and testing different approaches in the attempt to prevent the infection and minimize its severity. |
T5 | 386-599 | Sentence | denotes | Major efforts are focused on optimizing mechanical ventilation, antiviral, and supportive treatment; however, the role of heparin and low molecular weight (LMW) heparin in this setting has been largely overlooked. |
T6 | 600-1101 | Sentence | denotes | This review summarizes the available evidence about the role of heparan sulfate as a key entry mechanism for SARS-CoV-2; the efficacy of heparin and LMW heparin in counteracting its entry into the cell, the recent experimental findings obtained in in vitro studies using the LMW heparin enoxaparin Inhixa®, the role of heparin and LMW heparin in modulating the cytokine storm, and the evidence for the use of LMW heparin in the prevention and treatment of the thromboembolic complications of COVID-19. |
T7 | 1102-1208 | Sentence | denotes | The available evidence suggests that LMW heparin appears as a promising tool in the treatment of COVID-19. |
T8 | 1209-1381 | Sentence | denotes | Whether its systematic use is associated with a reduction in complications and ultimately mortality of these patients is being tested in several studies starting worldwide. |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T1 | 508-515 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
T2 | 547-554 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
T3 | 664-679 | Body_part | denotes | heparan sulfate | http://purl.org/sig/ont/fma/fma63023 |
T4 | 737-744 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
T5 | 753-760 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
T6 | 797-801 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T7 | 879-886 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
T8 | 919-926 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
T9 | 935-942 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
T10 | 961-969 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T11 | 1013-1020 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
T12 | 1143-1150 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 32-40 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T2 | 41-50 | Disease | denotes | Infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T3 | 151-159 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T4 | 349-358 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T5 | 709-717 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T6 | 1092-1100 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T7 | 1199-1207 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 99-100 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T2 | 169-172 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T3 | 290-297 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | testing |
T4 | 404-411 | http://purl.obolibrary.org/obo/CLO_0009985 | denotes | focused |
T5 | 571-574 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T6 | 683-684 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T7 | 797-801 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T8 | 1162-1163 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T9 | 1255-1256 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T10 | 1336-1342 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T1 | 7-17 | Chemical | denotes | Enoxaparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
T2 | 450-459 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
T3 | 508-515 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
T4 | 547-554 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
T5 | 664-679 | Chemical | denotes | heparan sulfate | http://purl.obolibrary.org/obo/CHEBI_28815 |
T6 | 664-671 | Chemical | denotes | heparan | http://purl.obolibrary.org/obo/CHEBI_24500 |
T7 | 672-679 | Chemical | denotes | sulfate | http://purl.obolibrary.org/obo/CHEBI_16189 |
T8 | 737-744 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
T9 | 753-760 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
T10 | 879-886 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
T11 | 919-926 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
T12 | 935-942 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
T13 | 1013-1020 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
T14 | 1143-1150 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
4 | 7-17 | Chemical | denotes | Enoxaparin | MESH:D017984 |
5 | 32-40 | Disease | denotes | COVID-19 | MESH:C000657245 |
6 | 41-50 | Disease | denotes | Infection | MESH:D007239 |
7 | 62-97 | Disease | denotes | Thromboembolic Venous Complications | MESH:D054556 |
26 | 151-159 | Disease | denotes | COVID-19 | MESH:C000657245 |
27 | 349-358 | Disease | denotes | infection | MESH:D007239 |
28 | 508-515 | Chemical | denotes | heparin | MESH:D006493 |
29 | 520-540 | Chemical | denotes | low molecular weight | |
30 | 547-554 | Chemical | denotes | heparin | MESH:D006493 |
31 | 709-719 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
32 | 737-744 | Chemical | denotes | heparin | MESH:D006493 |
33 | 749-760 | Chemical | denotes | LMW heparin | MESH:D006495 |
34 | 875-886 | Chemical | denotes | LMW heparin | MESH:D006495 |
35 | 919-926 | Chemical | denotes | heparin | MESH:D006493 |
36 | 931-942 | Chemical | denotes | LMW heparin | MESH:D006495 |
37 | 1009-1020 | Chemical | denotes | LMW heparin | MESH:D006495 |
38 | 1060-1074 | Disease | denotes | thromboembolic | MESH:D013923 |
39 | 1092-1100 | Disease | denotes | COVID-19 | MESH:C000657245 |
40 | 1139-1150 | Chemical | denotes | LMW heparin | MESH:D006495 |
41 | 1199-1207 | Disease | denotes | COVID-19 | MESH:C000657245 |
42 | 1299-1308 | Disease | denotes | mortality | MESH:D003643 |
43 | 1318-1326 | Species | denotes | patients | Tax:9606 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-98 | Sentence | denotes | Use of Enoxaparin to Counteract COVID-19 Infection and Reduce Thromboembolic Venous Complications: |
T2 | 99-132 | Sentence | denotes | A Review of the Current Evidence. |
T3 | 133-245 | Sentence | denotes | The impact of the COVID-19 pandemic has been dramatic worldwide, with China, Italy, and now US at its epicenter. |
T4 | 246-385 | Sentence | denotes | Researchers and clinicians are studying and testing different approaches in the attempt to prevent the infection and minimize its severity. |
T5 | 386-599 | Sentence | denotes | Major efforts are focused on optimizing mechanical ventilation, antiviral, and supportive treatment; however, the role of heparin and low molecular weight (LMW) heparin in this setting has been largely overlooked. |
T6 | 600-1101 | Sentence | denotes | This review summarizes the available evidence about the role of heparan sulfate as a key entry mechanism for SARS-CoV-2; the efficacy of heparin and LMW heparin in counteracting its entry into the cell, the recent experimental findings obtained in in vitro studies using the LMW heparin enoxaparin Inhixa®, the role of heparin and LMW heparin in modulating the cytokine storm, and the evidence for the use of LMW heparin in the prevention and treatment of the thromboembolic complications of COVID-19. |
T7 | 1102-1208 | Sentence | denotes | The available evidence suggests that LMW heparin appears as a promising tool in the treatment of COVID-19. |
T8 | 1209-1381 | Sentence | denotes | Whether its systematic use is associated with a reduction in complications and ultimately mortality of these patients is being tested in several studies starting worldwide. |
LitCovid-PD-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
---|---|---|---|---|---|
T1 | 664-679 | GlycoEpitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 62-76 | Phenotype | denotes | Thromboembolic | http://purl.obolibrary.org/obo/HP_0001907 |
T2 | 961-975 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
T3 | 1060-1074 | Phenotype | denotes | thromboembolic | http://purl.obolibrary.org/obo/HP_0001907 |