PubMed:33038252
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T1 | 364-391 | Body_part | denotes | ribonucleoprotein complexes | http://purl.org/sig/ont/fma/fma84762 |
T2 | 1066-1070 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 30-34 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T2 | 540-548 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T3 | 870-878 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T4 | 1241-1249 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T5 | 1575-1583 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 60-61 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T2 | 203-204 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T3 | 331-341 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T4 | 402-403 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T5 | 612-613 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T6 | 789-794 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tests |
T7 | 1066-1070 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
T8 | 1105-1106 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T9 | 1121-1125 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | test |
T10 | 1141-1142 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T11 | 1270-1275 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T12 | 1378-1379 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T13 | 1461-1468 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | testing |
T14 | 1597-1604 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | testing |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 239-252 | http://purl.obolibrary.org/obo/GO_0003968 | denotes | transcriptase |
T2 | 239-252 | http://purl.obolibrary.org/obo/GO_0003899 | denotes | transcriptase |
T3 | 322-341 | http://purl.obolibrary.org/obo/GO_0032075 | denotes | nuclease activation |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
1 | 30-48 | Species | denotes | SARS coronavirus-2 | Tax:2697049 |
11 | 540-548 | Disease | denotes | COVID-19 | MESH:C000657245 |
12 | 556-563 | Species | denotes | patient | Tax:9606 |
13 | 573-580 | Species | denotes | Patient | Tax:9606 |
14 | 722-729 | Species | denotes | patient | Tax:9606 |
15 | 870-880 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
16 | 1241-1251 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
17 | 1270-1275 | Species | denotes | human | Tax:9606 |
18 | 1276-1289 | Species | denotes | coronaviruses | Tax:11118 |
19 | 1575-1585 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-136 | Sentence | denotes | Rapid, sensitive and specific SARS coronavirus-2 detection: a multi-center comparison between standard qRT-PCR and CRISPR based DETECTR. |
T2 | 137-490 | Sentence | denotes | Recent advances in CRISPR-based diagnostics suggest that DETECTR, a combination of isothermal reverse transcriptase loop mediated amplification (RT-LAMP) and subsequent Cas12 bystander nuclease activation by amplicon targeting ribonucleoprotein complexes, could be a faster and cheaper alternative to qRT-PCR without sacrificing sensitivity/specificity. |
T3 | 491-572 | Sentence | denotes | Here we compare DETECTR with qRT-PCR to diagnose COVID-19 on 378 patient samples. |
T4 | 573-795 | Sentence | denotes | Patient sample dilution assays suggest a higher analytical sensitivity of DETECTR compared to qRT-PCR, however, this was not confirmed in this large patient cohort, were we report 95% reproducibility between the two tests. |
T5 | 796-959 | Sentence | denotes | These data showed that both techniques are equally sensitive in detecting SARS-CoV-2 providing additional value of DETECTR to the currently used qRT-PCR platforms. |
T6 | 960-1071 | Sentence | denotes | For DETECTR, different gRNAs can be used simultaneously to obviate negative results due to mutations in N-gene. |
T7 | 1072-1197 | Sentence | denotes | Lateral flow strips, suitable as a point of care test (POCT), showed a 100% correlation to the high-throughput DETECTR assay. |
T8 | 1198-1290 | Sentence | denotes | Importantly, DETECTR was 100% specific for SARS-CoV-2 relative to other human coronaviruses. |
T9 | 1291-1605 | Sentence | denotes | As there is no need for specialized equipment, DETECTR could be rapidly implemented as a complementary technically independent approach to qRT-PCR thereby increasing the testing capacity of medical microbiological laboratories and relieving the existent PCR-platforms for routine non-SARS-CoV-2 diagnostic testing. |