PubMed:33035581 / 1307-1727 JSONTXT

{"project":"Inflammaging","denotations":[{"id":"T9","span":{"begin":0,"end":420},"obj":"Sentence"},{"id":"T9","span":{"begin":0,"end":420},"obj":"Sentence"}],"text":"Such endosomal toll-like receptors could be inhibited by the use of pharmacological agents which increase endosomal pH, thereby reducing the activity of acid-dependent endosomal proteases required for their activity and/or assembly, leading to suppression of antigen-presenting cell activity, decreased autoantibody secretion, decreased nuclear factor-kappa B activity and decreased pro-inflammatory cytokine production."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T14","span":{"begin":5,"end":14},"obj":"Body_part"},{"id":"T15","span":{"begin":106,"end":115},"obj":"Body_part"},{"id":"T16","span":{"begin":168,"end":177},"obj":"Body_part"},{"id":"T17","span":{"begin":259,"end":282},"obj":"Body_part"},{"id":"T18","span":{"begin":278,"end":282},"obj":"Body_part"},{"id":"T19","span":{"begin":400,"end":408},"obj":"Body_part"}],"attributes":[{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma67180"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma67180"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma67180"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma273565"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"Such endosomal toll-like receptors could be inhibited by the use of pharmacological agents which increase endosomal pH, thereby reducing the activity of acid-dependent endosomal proteases required for their activity and/or assembly, leading to suppression of antigen-presenting cell activity, decreased autoantibody secretion, decreased nuclear factor-kappa B activity and decreased pro-inflammatory cytokine production."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T10","span":{"begin":141,"end":149},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T11","span":{"begin":207,"end":215},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T12","span":{"begin":278,"end":282},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T13","span":{"begin":283,"end":291},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T14","span":{"begin":358,"end":359},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T15","span":{"begin":360,"end":368},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"Such endosomal toll-like receptors could be inhibited by the use of pharmacological agents which increase endosomal pH, thereby reducing the activity of acid-dependent endosomal proteases required for their activity and/or assembly, leading to suppression of antigen-presenting cell activity, decreased autoantibody secretion, decreased nuclear factor-kappa B activity and decreased pro-inflammatory cytokine production."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T2","span":{"begin":153,"end":157},"obj":"Chemical"},{"id":"T3","span":{"begin":259,"end":266},"obj":"Chemical"}],"attributes":[{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"}],"text":"Such endosomal toll-like receptors could be inhibited by the use of pharmacological agents which increase endosomal pH, thereby reducing the activity of acid-dependent endosomal proteases required for their activity and/or assembly, leading to suppression of antigen-presenting cell activity, decreased autoantibody secretion, decreased nuclear factor-kappa B activity and decreased pro-inflammatory cytokine production."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T4","span":{"begin":316,"end":325},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T5","span":{"begin":400,"end":419},"obj":"http://purl.obolibrary.org/obo/GO_0001816"}],"text":"Such endosomal toll-like receptors could be inhibited by the use of pharmacological agents which increase endosomal pH, thereby reducing the activity of acid-dependent endosomal proteases required for their activity and/or assembly, leading to suppression of antigen-presenting cell activity, decreased autoantibody secretion, decreased nuclear factor-kappa B activity and decreased pro-inflammatory cytokine production."}

{"project":"LitCovid-sentences","denotations":[{"id":"T9","span":{"begin":0,"end":420},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Such endosomal toll-like receptors could be inhibited by the use of pharmacological agents which increase endosomal pH, thereby reducing the activity of acid-dependent endosomal proteases required for their activity and/or assembly, leading to suppression of antigen-presenting cell activity, decreased autoantibody secretion, decreased nuclear factor-kappa B activity and decreased pro-inflammatory cytokine production."}

{"project":"LitCovid_AGAC_only","denotations":[{"id":"p219955s49","span":{"begin":293,"end":302},"obj":"NegReg"},{"id":"p219955s50","span":{"begin":303,"end":325},"obj":"MPA"},{"id":"p219955s53","span":{"begin":327,"end":336},"obj":"NegReg"},{"id":"p219955s54","span":{"begin":337,"end":368},"obj":"MPA"},{"id":"p219955s61","span":{"begin":373,"end":382},"obj":"NegReg"},{"id":"p219955s62","span":{"begin":383,"end":419},"obj":"MPA"}],"text":"Such endosomal toll-like receptors could be inhibited by the use of pharmacological agents which increase endosomal pH, thereby reducing the activity of acid-dependent endosomal proteases required for their activity and/or assembly, leading to suppression of antigen-presenting cell activity, decreased autoantibody secretion, decreased nuclear factor-kappa B activity and decreased pro-inflammatory cytokine production."}