PubMed:33021626
Annnotations
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 76-92 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | Heparan Sulfates |
| T2 | 127-142 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T3 | 144-146 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | HS |
| T4 | 495-497 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | HS |
| T5 | 853-855 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | HS |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-107 | Sentence | denotes | Structure, Dynamics, and Interactions of GPI-Anchored Human Glypican-1 with Heparan Sulfates in a Membrane. |
| T2 | 108-250 | Sentence | denotes | Glypican-1 and its heparan sulfate (HS) chains play important roles in modulating many biological processes including growth factor signaling. |
| T3 | 251-341 | Sentence | denotes | Glypican-1 is bound to a membrane surface via a glycosylphosphatidylinositol (GPI)-anchor. |
| T4 | 342-526 | Sentence | denotes | In this study, we used all-atom molecular modeling and simulation to explore the structure, dynamics, and interactions of GPI-anchored glypican-1, three HS chains, membranes, and ions. |
| T5 | 527-762 | Sentence | denotes | The folded glypican-1 core structure is stable, but has substantial degrees of freedom in terms of movement and orientation with respect to the membrane due to the long unstructured C-terminal region linking the core to the GPI-anchor. |
| T6 | 763-954 | Sentence | denotes | With unique structural features depending on the extent of sulfation, high flexibility of HS chains can promote multi-site interactions with surrounding molecules near and above the membrane. |
| T7 | 955-1136 | Sentence | denotes | This study is a first step toward all-atom molecular modeling and simulation of the glycocalyx, as well as its modulation of interactions between growth factors and their receptors. |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 54-59 | OrganismTaxon | denotes | Human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 98-106 | Body_part | denotes | Membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T4 | 276-284 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T7 | 506-515 | Body_part | denotes | membranes | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T10 | 671-679 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T13 | 945-953 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |