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PubMed:3301849 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-118 Sentence denotes Receptor binding properties and insulin-like effects of human growth hormone and its 20 kDa-variant in rat adipocytes.
T2 119-335 Sentence denotes The natural 20 kDa-variant of human growth hormone (hGH) binds with high affinity to IM-9 human lymphocyte receptors, in agreement with its potency in biological assays for growth promoting and lactogenic activities.
T3 336-476 Sentence denotes In contrast, 20 kDa-hGH has only 3% of the potency of 22 kDa-hGH in binding to the receptors of normal and hypophysectomized rat adipocytes.
T4 477-662 Sentence denotes In agreement with the binding potency, 20 kDa-hGH is only 3% as potent as 22 kDa-hGH in stimulating lipogenesis in normal rat adipocytes preincubated for a few hours in hGH-free medium.
T5 663-783 Sentence denotes The 20 kDa-hGH is also much weaker than 22 kDa-hGH in stimulating lipogenesis in adipocytes from hypophysectomized rats.
T6 784-979 Sentence denotes These data strongly support the concept that the rat adipocyte receptor, which mediates the insulin-like effects of growth hormone, is different from the receptor found on human IM-9 lymphocytes.
T7 980-1251 Sentence denotes Preincubation of rat adipocytes with hGH induces a refractoriness to subsequent activation of lipogenesis by hGH but does not abolish the response to insulin, while preincubation with insulin slightly potentiates the hGH response and does not change the insulin response.
T8 1252-1426 Sentence denotes Additivity studies and a detailed comparison of the lipogenic effects of insulin and hGH suggest that hGH shares only a subset of the metabolic pathways activated by insulin.
T1 0-118 Sentence denotes Receptor binding properties and insulin-like effects of human growth hormone and its 20 kDa-variant in rat adipocytes.
T2 119-335 Sentence denotes The natural 20 kDa-variant of human growth hormone (hGH) binds with high affinity to IM-9 human lymphocyte receptors, in agreement with its potency in biological assays for growth promoting and lactogenic activities.
T3 336-476 Sentence denotes In contrast, 20 kDa-hGH has only 3% of the potency of 22 kDa-hGH in binding to the receptors of normal and hypophysectomized rat adipocytes.
T4 477-662 Sentence denotes In agreement with the binding potency, 20 kDa-hGH is only 3% as potent as 22 kDa-hGH in stimulating lipogenesis in normal rat adipocytes preincubated for a few hours in hGH-free medium.
T5 663-783 Sentence denotes The 20 kDa-hGH is also much weaker than 22 kDa-hGH in stimulating lipogenesis in adipocytes from hypophysectomized rats.
T6 784-979 Sentence denotes These data strongly support the concept that the rat adipocyte receptor, which mediates the insulin-like effects of growth hormone, is different from the receptor found on human IM-9 lymphocytes.
T7 980-1251 Sentence denotes Preincubation of rat adipocytes with hGH induces a refractoriness to subsequent activation of lipogenesis by hGH but does not abolish the response to insulin, while preincubation with insulin slightly potentiates the hGH response and does not change the insulin response.
T8 1252-1426 Sentence denotes Additivity studies and a detailed comparison of the lipogenic effects of insulin and hGH suggest that hGH shares only a subset of the metabolic pathways activated by insulin.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 56-61 OrganismTaxon denotes human 9606
T2 103-106 OrganismTaxon denotes rat 10114|10116
T4 149-154 OrganismTaxon denotes human 9606
T5 209-214 OrganismTaxon denotes human 9606
T6 461-464 OrganismTaxon denotes rat 10114|10116
T8 599-602 OrganismTaxon denotes rat 10114|10116
T10 778-782 OrganismTaxon denotes rats 10114|10116
T12 833-836 OrganismTaxon denotes rat 10114|10116
T14 956-961 OrganismTaxon denotes human 9606
T15 997-1000 OrganismTaxon denotes rat 10114|10116

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 107-117 Body_part denotes adipocytes http://purl.obolibrary.org/obo/CL_0000136
T2 215-225 Body_part denotes lymphocyte http://purl.obolibrary.org/obo/CL_0000542
T3 465-475 Body_part denotes adipocytes http://purl.obolibrary.org/obo/CL_0000136
T4 603-613 Body_part denotes adipocytes http://purl.obolibrary.org/obo/CL_0000136
T5 744-754 Body_part denotes adipocytes http://purl.obolibrary.org/obo/CL_0000136
T6 837-846 Body_part denotes adipocyte http://purl.obolibrary.org/obo/CL_0000136
T7 967-978 Body_part denotes lymphocytes http://purl.obolibrary.org/obo/CL_0000542
T8 1001-1011 Body_part denotes adipocytes http://purl.obolibrary.org/obo/CL_0000136

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 107-117 Cell denotes adipocytes http://purl.obolibrary.org/obo/CL:0000136
T2 215-225 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542
T3 465-475 Cell denotes adipocytes http://purl.obolibrary.org/obo/CL:0000136
T4 603-613 Cell denotes adipocytes http://purl.obolibrary.org/obo/CL:0000136
T5 744-754 Cell denotes adipocytes http://purl.obolibrary.org/obo/CL:0000136
T6 837-846 Cell denotes adipocyte http://purl.obolibrary.org/obo/CL:0000136
T7 967-978 Cell denotes lymphocytes http://purl.obolibrary.org/obo/CL:0000542
T8 1001-1011 Cell denotes adipocytes http://purl.obolibrary.org/obo/CL:0000136