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GlyCosmos6-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 652-661 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T2 1084-1088 Body_part denotes cell http://purl.obolibrary.org/obo/CL_0000000
T3 1097-1103 Body_part denotes system http://purl.obolibrary.org/obo/UBERON_0000467
T4 1145-1149 Body_part denotes cell http://purl.obolibrary.org/obo/CL_0000000

sentences

Id Subject Object Predicate Lexical cue
T1 0-84 Sentence denotes The iminosugars celgosivir, castanospermine and UV-4 inhibit SARS-CoV-2 replication.
T2 85-230 Sentence denotes The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic poses an unprecedented challenge for healthcare and the global economy.
T3 231-382 Sentence denotes Repurposing drugs that have shown promise in inhibiting other viral infections could allow for more rapid dispensation of urgently needed therapeutics.
T4 383-507 Sentence denotes The Spike protein of SARS-CoV-2 is extensively glycosylated with 22 occupied N glycan sites and is required for viral entry.
T5 508-767 Sentence denotes In other glycosylated viral proteins, glycosylation is required for interaction with calnexin and chaperone-mediated folding in the endoplasmic reticulum, and prevention of this interaction leads to unfolded viral proteins and thus inhibits viral replication.
T6 768-935 Sentence denotes As such, we investigated two iminosugars, celgosivir, a pro-drug of castanospermine, and UV-4, or N-(9-methoxynonyl)-1-deoxynojirimycin, a deoxynojirimycin derivative.
T7 936-1104 Sentence denotes Iminosugars are known inhibitors of the α-glucosidase I and II enzymes and were effective at inhibiting authentic SARS-CoV-2 viral replication in a cell culture system.
T8 1105-1268 Sentence denotes Celgosivir prevented SARS-CoV-2-induced cell death and reduced viral replication and Spike protein levels in a dose-dependent manner in culture with Vero E6 cells.
T9 1269-1429 Sentence denotes Castanospermine, the active form of celgosivir, was also able to inhibit SARS-CoV-2, confirming the canonical castanospermine mechanism of action of celgosivir.
T10 1430-1612 Sentence denotes The monocyclic UV-4 also prevented SARS-CoV-2-induced death and reduced viral replication after 24 hours of treatment, although the reduction in viral copies was lost after 48 hours.
T11 1613-1718 Sentence denotes Our findings suggest that iminosugars should be urgently investigated as potential SARS-CoV-2 inhibitors.
T1 0-84 Sentence denotes The iminosugars celgosivir, castanospermine and UV-4 inhibit SARS-CoV-2 replication.
T2 85-230 Sentence denotes The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic poses an unprecedented challenge for healthcare and the global economy.
T3 231-382 Sentence denotes Repurposing drugs that have shown promise in inhibiting other viral infections could allow for more rapid dispensation of urgently needed therapeutics.
T4 383-507 Sentence denotes The Spike protein of SARS-CoV-2 is extensively glycosylated with 22 occupied N glycan sites and is required for viral entry.
T5 508-767 Sentence denotes In other glycosylated viral proteins, glycosylation is required for interaction with calnexin and chaperone-mediated folding in the endoplasmic reticulum, and prevention of this interaction leads to unfolded viral proteins and thus inhibits viral replication.
T6 768-935 Sentence denotes As such, we investigated two iminosugars, celgosivir, a pro-drug of castanospermine, and UV-4, or N-(9-methoxynonyl)-1-deoxynojirimycin, a deoxynojirimycin derivative.
T7 936-1104 Sentence denotes Iminosugars are known inhibitors of the α-glucosidase I and II enzymes and were effective at inhibiting authentic SARS-CoV-2 viral replication in a cell culture system.
T8 1105-1268 Sentence denotes Celgosivir prevented SARS-CoV-2-induced cell death and reduced viral replication and Spike protein levels in a dose-dependent manner in culture with Vero E6 cells.
T9 1269-1429 Sentence denotes Castanospermine, the active form of celgosivir, was also able to inhibit SARS-CoV-2, confirming the canonical castanospermine mechanism of action of celgosivir.
T10 1430-1612 Sentence denotes The monocyclic UV-4 also prevented SARS-CoV-2-induced death and reduced viral replication after 24 hours of treatment, although the reduction in viral copies was lost after 48 hours.
T11 1613-1718 Sentence denotes Our findings suggest that iminosugars should be urgently investigated as potential SARS-CoV-2 inhibitors.

GlyCosmos6-CLO

Id Subject Object Predicate Lexical cue
T1 1082-1088 http://purl.obolibrary.org/obo/CLO_0001020 denotes a cell
T2 1084-1088 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 1145-1149 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 1254-1267 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T5 1254-1258 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T6 1254-1258 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T7 1262-1267 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8 1290-1296 http://purl.obolibrary.org/obo/CLO_0001658 denotes active

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 61-71 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T2 89-136 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T3 138-148 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T4 293-309 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T5 404-414 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T6 1050-1060 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T7 1126-1136 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T8 1342-1352 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T9 1465-1475 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T10 1696-1706 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 61-71 OrganismTaxon denotes SARS-CoV-2 NCBItxid:2697049
T2 89-136 OrganismTaxon denotes severe acute respiratory syndrome coronavirus 2 NCBItxid:2697049
T3 138-148 OrganismTaxon denotes SARS-CoV-2 NCBItxid:2697049
T4 404-414 OrganismTaxon denotes SARS-CoV-2 NCBItxid:2697049
T5 1050-1060 OrganismTaxon denotes SARS-CoV-2 NCBItxid:2697049
T6 1126-1136 OrganismTaxon denotes SARS-CoV-2 NCBItxid:2697049
T7 1342-1352 OrganismTaxon denotes SARS-CoV-2 NCBItxid:2697049
T8 1465-1475 OrganismTaxon denotes SARS-CoV-2 NCBItxid:2697049
T9 1696-1706 OrganismTaxon denotes SARS-CoV-2 NCBItxid:2697049