PubMed:32978364 JSONTXT

{"project":"hydroxychloroquine","denotations":[{"id":"T1","span":{"begin":109,"end":137},"obj":"Phenotype"},{"id":"T2","span":{"begin":287,"end":315},"obj":"Phenotype"},{"id":"T3","span":{"begin":317,"end":320},"obj":"Phenotype"},{"id":"T4","span":{"begin":515,"end":525},"obj":"Phenotype"},{"id":"T5","span":{"begin":527,"end":532},"obj":"Phenotype"},{"id":"T6","span":{"begin":534,"end":545},"obj":"Phenotype"},{"id":"T7","span":{"begin":547,"end":555},"obj":"Phenotype"},{"id":"T8","span":{"begin":557,"end":566},"obj":"Phenotype"},{"id":"T9","span":{"begin":572,"end":578},"obj":"Phenotype"},{"id":"T10","span":{"begin":632,"end":635},"obj":"Phenotype"},{"id":"T11","span":{"begin":727,"end":736},"obj":"Phenotype"},{"id":"T12","span":{"begin":738,"end":746},"obj":"Phenotype"},{"id":"T13","span":{"begin":752,"end":760},"obj":"Phenotype"},{"id":"T14","span":{"begin":881,"end":889},"obj":"Phenotype"},{"id":"T15","span":{"begin":891,"end":899},"obj":"Phenotype"},{"id":"T16","span":{"begin":901,"end":910},"obj":"Phenotype"},{"id":"T17","span":{"begin":912,"end":922},"obj":"Phenotype"},{"id":"T18","span":{"begin":928,"end":935},"obj":"Phenotype"},{"id":"T19","span":{"begin":1019,"end":1022},"obj":"Phenotype"},{"id":"T20","span":{"begin":1042,"end":1049},"obj":"Phenotype"},{"id":"T21","span":{"begin":1051,"end":1061},"obj":"Phenotype"},{"id":"T22","span":{"begin":1063,"end":1074},"obj":"Phenotype"},{"id":"T23","span":{"begin":1076,"end":1086},"obj":"Phenotype"},{"id":"T24","span":{"begin":1088,"end":1095},"obj":"Phenotype"},{"id":"T25","span":{"begin":1097,"end":1105},"obj":"Phenotype"},{"id":"T26","span":{"begin":1111,"end":1116},"obj":"Phenotype"},{"id":"T27","span":{"begin":1251,"end":1261},"obj":"Phenotype"},{"id":"T28","span":{"begin":1263,"end":1268},"obj":"Phenotype"},{"id":"T29","span":{"begin":1274,"end":1281},"obj":"Phenotype"},{"id":"T30","span":{"begin":1507,"end":1510},"obj":"Phenotype"}],"attributes":[{"id":"A19","pred":"hp_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/HP_0002725"},{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0032043"},{"id":"A9","pred":"hp_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/HP_0025143"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0002725"},{"id":"A14","pred":"hp_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/HP_0025406"},{"id":"A22","pred":"hp_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/HP_0032043"},{"id":"A17","pred":"hp_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/HP_0000224"},{"id":"A24","pred":"hp_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/HP_0000458"},{"id":"A30","pred":"hp_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/HP_0002725"},{"id":"A21","pred":"hp_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/HP_0100749"},{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0001945"},{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0031246"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0002725"},{"id":"A16","pred":"hp_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/HP_0002315"},{"id":"A15","pred":"hp_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/HP_0003326"},{"id":"A10","pred":"hp_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/HP_0002725"},{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0025406"},{"id":"A23","pred":"hp_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/HP_0000224"},{"id":"A18","pred":"hp_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/HP_0000458"},{"id":"A11","pred":"hp_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/HP_0031246"},{"id":"A29","pred":"hp_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/HP_0002094"},{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0002725"},{"id":"A13","pred":"hp_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/HP_0003326"},{"id":"A28","pred":"hp_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/HP_0001945"},{"id":"A12","pred":"hp_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/HP_0025406"},{"id":"A26","pred":"hp_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/HP_0001945"},{"id":"A25","pred":"hp_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/HP_0002014"},{"id":"A20","pred":"hp_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/HP_0002094"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0100749"},{"id":"A27","pred":"hp_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/HP_0100749"}],"text":"SARS-CoV-2 Infection and COVID-19 in 5 Patients in Ecuador After Prior Treatment with Hydroxychloroquine for Systemic Lupus Erythematosus.\nBACKGROUND This case series describes 5 patients with SARS-CoV-2 infection and COVID-19 in Ecuador who had been treated with hydroxychloroquine for systemic lupus erythematosus (SLE) prior to their COVID-19 illness. CASE REPORT Case #1 reports a 29-year-old woman who had been treated with 200 mg of hydroxychloroquine per day for 1 year and presented with flu-like symptoms, chest pain, fever, odynophagia, asthenia, dry cough, and chills. Case #2 was a 34-year-old woman whose treatment for SLE included 200 mg of hydroxychloroquine per day since 2017. She arrived at the clinic with a dry cough, asthenia, and myalgias. Case #3 was a 24-year-old woman who had been using 200 mg of hydroxychloroquine per day since 2010. She presented with asthenia, myalgias, headaches, hypogeusia, and anosmia. Case #4 was a 39-year-old woman taking 200 mg of hydroxychloroquine every day for SLE who presented with dyspnea, chest pain, odynophagia, hypogeusia, anosmia, diarrhea, and fever. Case #5 was a 46-year-old woman who had been taking 200 mg of hydroxychloroquine since 2019. She came to our hospital complaining of chest pain, fever, and dyspnea. In all 5 patients, SARS-CoV-2 infection was confirmed with a nasopharyngeal SARS-CoV-2 reverse transcription-polymerase chain reaction (RT-PCR) test using the Cepheid/GeneXpert system. CONCLUSIONS All 5 of our patients with SLE who were taking hydroxychloroquine presented with SARS-CoV-2 infection and symptoms of COVID-19. This case series provides support for a lack of prevention of COVID-19 by hydroxychloroquine."}