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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 35-47 Cell denotes granulocytes http://purl.obolibrary.org/obo/CL:0000094
T2 260-267 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T3 326-338 Cell denotes granulocytes http://purl.obolibrary.org/obo/CL:0000094
T4 424-436 Cell denotes immune cells http://purl.obolibrary.org/obo/CL:0000738
T5 481-493 Cell denotes granulocytes http://purl.obolibrary.org/obo/CL:0000094
T6 739-750 Cell denotes granulocyte http://purl.obolibrary.org/obo/CL:0000094
T7 1407-1417 Cell denotes neutrophil http://purl.obolibrary.org/obo/CL:0000775
T8 1491-1503 Cell denotes immune cells http://purl.obolibrary.org/obo/CL:0000738
T9 1678-1690 Cell denotes granulocytes http://purl.obolibrary.org/obo/CL:0000094
T10 1854-1865 Cell denotes granulocyte http://purl.obolibrary.org/obo/CL:0000094
T11 1986-1996 Cell denotes neutrophil http://purl.obolibrary.org/obo/CL:0000775
T12 2154-2166 Cell denotes granulocytes http://purl.obolibrary.org/obo/CL:0000094
T13 2203-2215 Cell denotes immune cells http://purl.obolibrary.org/obo/CL:0000738
T14 2323-2335 Cell denotes granulocytes http://purl.obolibrary.org/obo/CL:0000094
T15 2344-2350 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 1959-1968 Glycan_Motif denotes I antigen https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56045WU|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46055MA|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G45207BM|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G26929DQ

sentences

Id Subject Object Predicate Lexical cue
T1 0-124 Sentence denotes Deviant proteome profile of equine granulocytes associates to latent activation status in organ specific autoimmune disease.
T2 125-250 Sentence denotes Equine recurrent uveitis (ERU) is a spontaneous, remitting-relapsing autoimmune disease driven by the adaptive immune system.
T3 251-387 Sentence denotes Although T cells are described as the main effector cells in pathogenesis, granulocytes have also emerged as possible disease mediators.
T4 388-551 Sentence denotes To explore the role of these innate immune cells, we investigated the whole cell proteome of granulocytes from equine recurrent uveitis cases and healthy controls.
T5 552-760 Sentence denotes Among the 2362 proteins identified by mass spectrometry, we found 96 proteins with significantly changed abundance between groups (p < 0.05, fold change >1.2), representing 4.1% of total granulocyte proteome.
T6 761-951 Sentence denotes Within these differential identifications, calgranulin B, a protein associated with pathogenesis in other autoimmune diseases, showed highest abundance in equine recurrent uveitis (18 fold).
T7 952-1108 Sentence denotes For a better interpretation of the results from our hypothesis-generating approach, we added a threshold for biological significance (ratio ERU/controls >2:
T8 1109-1274 Sentence denotes 36 proteins) to the proteins with increased abundance in equine recurrent uveitis and analyzed their allocation to the subsets within the Immune System superpathway.
T9 1275-1515 Sentence denotes The 36 differentially abundant proteins predominantly associated to RAF/MAP kinase cascade, MHC-I-mediated antigen presentation and neutrophil degranulation, suggesting a latently activated phenotype of these innate immune cells in disease.
T10 1516-1585 Sentence denotes Raw data are available via ProteomeXchange with identifier PXD013648.
T11 1586-1599 Sentence denotes SIGNIFICANCE:
T12 1600-1840 Sentence denotes Our study provides new insights into the protein repertoire of primary equine granulocytes and identifies protein abundance changes associated to equine recurrent uveitis (ERU), an organ specific, spontaneously occurring autoimmune disease.
T13 1841-2075 Sentence denotes We show that granulocyte proteins with increased abundance in ERU strongly associate to RAF/MAP kinase signaling, MHC-I antigen presentation and neutrophil degranulation, pointing to a more activated state of these cells in ERU cases.
T14 2076-2223 Sentence denotes Since cells were obtained in quiescent stage of disease, latent activation of granulocytes underlines the role of these innate immune cells in ERU.
T15 2224-2377 Sentence denotes These findings are highly relevant for veterinary medicine, further establishing the importance of granulocytes in this T cell-driven autoimmune disease.
T16 2378-2528 Sentence denotes Moreover, they have translational quality for autoimmune uveitis in man, due to strong similarity in disease occurrence, progression and pathogenesis.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 1959-1968 https://glytoucan.org/Structures/Glycans/G26929DQ denotes I antigen

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 1959-1968 http://www.glycoepitope.jp/epitopes/EP0138 denotes I antigen

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 105-123 Phenotype denotes autoimmune disease HP:0002960
T2 142-149 Phenotype denotes uveitis HP:0000554
T3 194-212 Phenotype denotes autoimmune disease HP:0002960
T4 516-523 Phenotype denotes uveitis HP:0000554
T5 867-886 Phenotype denotes autoimmune diseases HP:0002960
T6 933-940 Phenotype denotes uveitis HP:0000554
T7 1183-1190 Phenotype denotes uveitis HP:0000554
T8 1763-1770 Phenotype denotes uveitis HP:0000554
T9 1821-1839 Phenotype denotes autoimmune disease HP:0002960
T10 2358-2376 Phenotype denotes autoimmune disease HP:0002960
T11 2435-2442 Phenotype denotes uveitis HP:0000554

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 105-123 Disease denotes autoimmune disease http://purl.obolibrary.org/obo/MONDO_0007179
T2 142-149 Disease denotes uveitis http://purl.obolibrary.org/obo/MONDO_0020283
T3 194-212 Disease denotes autoimmune disease http://purl.obolibrary.org/obo/MONDO_0007179
T4 516-523 Disease denotes uveitis http://purl.obolibrary.org/obo/MONDO_0020283
T5 867-886 Disease denotes autoimmune diseases http://purl.obolibrary.org/obo/MONDO_0007179
T6 933-940 Disease denotes uveitis http://purl.obolibrary.org/obo/MONDO_0020283
T7 1183-1190 Disease denotes uveitis http://purl.obolibrary.org/obo/MONDO_0020283
T8 1763-1770 Disease denotes uveitis http://purl.obolibrary.org/obo/MONDO_0020283
T9 1821-1839 Disease denotes autoimmune disease http://purl.obolibrary.org/obo/MONDO_0007179
T10 2358-2376 Disease denotes autoimmune disease http://purl.obolibrary.org/obo/MONDO_0007179
T11 2424-2442 Disease denotes autoimmune uveitis http://purl.obolibrary.org/obo/MONDO_0031012

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 1959-1968 Glycan denotes I antigen https://api.glycosmos.org/wurcs2image/latest/png/binary/G56045WU

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 1959-1968 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes I antigen http://www.glycoepitope.jp/epitopes/EP0138

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 105-123 Phenotype denotes autoimmune disease HP:0002960
T2 142-149 Phenotype denotes uveitis HP:0000554
T3 194-212 Phenotype denotes autoimmune disease HP:0002960
T4 516-523 Phenotype denotes uveitis HP:0000554
T5 867-886 Phenotype denotes autoimmune diseases HP:0002960
T6 933-940 Phenotype denotes uveitis HP:0000554
T7 1183-1190 Phenotype denotes uveitis HP:0000554
T8 1763-1770 Phenotype denotes uveitis HP:0000554
T9 1821-1839 Phenotype denotes autoimmune disease HP:0002960
T10 2358-2376 Phenotype denotes autoimmune disease HP:0002960
T11 2435-2442 Phenotype denotes uveitis HP:0000554

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 105-123 Disease denotes autoimmune disease http://purl.obolibrary.org/obo/MONDO_0007179
T2 142-149 Disease denotes uveitis http://purl.obolibrary.org/obo/MONDO_0020283
T3 194-212 Disease denotes autoimmune disease http://purl.obolibrary.org/obo/MONDO_0007179
T4 516-523 Disease denotes uveitis http://purl.obolibrary.org/obo/MONDO_0020283
T5 867-886 Disease denotes autoimmune diseases http://purl.obolibrary.org/obo/MONDO_0007179
T6 933-940 Disease denotes uveitis http://purl.obolibrary.org/obo/MONDO_0020283
T7 1183-1190 Disease denotes uveitis http://purl.obolibrary.org/obo/MONDO_0020283
T8 1763-1770 Disease denotes uveitis http://purl.obolibrary.org/obo/MONDO_0020283
T9 1821-1839 Disease denotes autoimmune disease http://purl.obolibrary.org/obo/MONDO_0007179
T10 2358-2376 Disease denotes autoimmune disease http://purl.obolibrary.org/obo/MONDO_0007179
T11 2424-2442 Disease denotes autoimmune uveitis http://purl.obolibrary.org/obo/MONDO_0031012

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 28-34 OrganismTaxon denotes equine 9796
T2 125-131 OrganismTaxon denotes Equine 9796
T3 499-505 OrganismTaxon denotes equine 9796
T4 916-922 OrganismTaxon denotes equine 9796
T5 1166-1172 OrganismTaxon denotes equine 9796
T6 1671-1677 OrganismTaxon denotes equine 9796
T7 1746-1752 OrganismTaxon denotes equine 9796

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 35-47 Cell denotes granulocytes http://purl.obolibrary.org/obo/CL:0000094
T2 260-267 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T3 326-338 Cell denotes granulocytes http://purl.obolibrary.org/obo/CL:0000094
T4 424-436 Cell denotes immune cells http://purl.obolibrary.org/obo/CL:0000738
T5 481-493 Cell denotes granulocytes http://purl.obolibrary.org/obo/CL:0000094
T6 739-750 Cell denotes granulocyte http://purl.obolibrary.org/obo/CL:0000094
T7 1407-1417 Cell denotes neutrophil http://purl.obolibrary.org/obo/CL:0000775
T8 1491-1503 Cell denotes immune cells http://purl.obolibrary.org/obo/CL:0000738
T9 1678-1690 Cell denotes granulocytes http://purl.obolibrary.org/obo/CL:0000094
T10 1854-1865 Cell denotes granulocyte http://purl.obolibrary.org/obo/CL:0000094
T11 1986-1996 Cell denotes neutrophil http://purl.obolibrary.org/obo/CL:0000775
T12 2154-2166 Cell denotes granulocytes http://purl.obolibrary.org/obo/CL:0000094
T13 2203-2215 Cell denotes immune cells http://purl.obolibrary.org/obo/CL:0000738
T14 2323-2335 Cell denotes granulocytes http://purl.obolibrary.org/obo/CL:0000094
T15 2344-2350 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 35-47 Body_part denotes granulocytes http://purl.obolibrary.org/obo/CL_0000094
T2 90-95 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062|http://purl.obolibrary.org/obo/UBERON_0003103
T4 236-249 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T5 326-338 Body_part denotes granulocytes http://purl.obolibrary.org/obo/CL_0000094
T6 424-436 Body_part denotes immune cells http://purl.obolibrary.org/obo/CL_0000738
T7 481-493 Body_part denotes granulocytes http://purl.obolibrary.org/obo/CL_0000094
T8 739-750 Body_part denotes granulocyte http://purl.obolibrary.org/obo/CL_0000094
T9 1247-1260 Body_part denotes Immune System http://purl.obolibrary.org/obo/UBERON_0002405
T10 1407-1417 Body_part denotes neutrophil http://purl.obolibrary.org/obo/CL_0000775
T11 1491-1503 Body_part denotes immune cells http://purl.obolibrary.org/obo/CL_0000738
T12 1678-1690 Body_part denotes granulocytes http://purl.obolibrary.org/obo/CL_0000094
T13 1781-1786 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062|http://purl.obolibrary.org/obo/UBERON_0003103
T15 1854-1865 Body_part denotes granulocyte http://purl.obolibrary.org/obo/CL_0000094
T16 1986-1996 Body_part denotes neutrophil http://purl.obolibrary.org/obo/CL_0000775
T17 2154-2166 Body_part denotes granulocytes http://purl.obolibrary.org/obo/CL_0000094
T18 2203-2215 Body_part denotes immune cells http://purl.obolibrary.org/obo/CL_0000738
T19 2323-2335 Body_part denotes granulocytes http://purl.obolibrary.org/obo/CL_0000094
T20 2344-2350 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084

sentences

Id Subject Object Predicate Lexical cue
T1 0-124 Sentence denotes Deviant proteome profile of equine granulocytes associates to latent activation status in organ specific autoimmune disease.
T2 125-250 Sentence denotes Equine recurrent uveitis (ERU) is a spontaneous, remitting-relapsing autoimmune disease driven by the adaptive immune system.
T3 251-387 Sentence denotes Although T cells are described as the main effector cells in pathogenesis, granulocytes have also emerged as possible disease mediators.
T4 388-551 Sentence denotes To explore the role of these innate immune cells, we investigated the whole cell proteome of granulocytes from equine recurrent uveitis cases and healthy controls.
T5 552-760 Sentence denotes Among the 2362 proteins identified by mass spectrometry, we found 96 proteins with significantly changed abundance between groups (p < 0.05, fold change >1.2), representing 4.1% of total granulocyte proteome.
T6 761-951 Sentence denotes Within these differential identifications, calgranulin B, a protein associated with pathogenesis in other autoimmune diseases, showed highest abundance in equine recurrent uveitis (18 fold).
T7 952-1108 Sentence denotes For a better interpretation of the results from our hypothesis-generating approach, we added a threshold for biological significance (ratio ERU/controls >2:
T8 1109-1274 Sentence denotes 36 proteins) to the proteins with increased abundance in equine recurrent uveitis and analyzed their allocation to the subsets within the Immune System superpathway.
T9 1275-1515 Sentence denotes The 36 differentially abundant proteins predominantly associated to RAF/MAP kinase cascade, MHC-I-mediated antigen presentation and neutrophil degranulation, suggesting a latently activated phenotype of these innate immune cells in disease.
T10 1516-1585 Sentence denotes Raw data are available via ProteomeXchange with identifier PXD013648.
T11 1586-1599 Sentence denotes SIGNIFICANCE:
T12 1600-1840 Sentence denotes Our study provides new insights into the protein repertoire of primary equine granulocytes and identifies protein abundance changes associated to equine recurrent uveitis (ERU), an organ specific, spontaneously occurring autoimmune disease.
T13 1841-2075 Sentence denotes We show that granulocyte proteins with increased abundance in ERU strongly associate to RAF/MAP kinase signaling, MHC-I antigen presentation and neutrophil degranulation, pointing to a more activated state of these cells in ERU cases.
T14 2076-2223 Sentence denotes Since cells were obtained in quiescent stage of disease, latent activation of granulocytes underlines the role of these innate immune cells in ERU.
T15 2224-2377 Sentence denotes These findings are highly relevant for veterinary medicine, further establishing the importance of granulocytes in this T cell-driven autoimmune disease.
T16 2378-2528 Sentence denotes Moreover, they have translational quality for autoimmune uveitis in man, due to strong similarity in disease occurrence, progression and pathogenesis.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-124 Sentence denotes Deviant proteome profile of equine granulocytes associates to latent activation status in organ specific autoimmune disease.
T2 125-250 Sentence denotes Equine recurrent uveitis (ERU) is a spontaneous, remitting-relapsing autoimmune disease driven by the adaptive immune system.
T3 251-387 Sentence denotes Although T cells are described as the main effector cells in pathogenesis, granulocytes have also emerged as possible disease mediators.
T4 388-551 Sentence denotes To explore the role of these innate immune cells, we investigated the whole cell proteome of granulocytes from equine recurrent uveitis cases and healthy controls.
T5 552-760 Sentence denotes Among the 2362 proteins identified by mass spectrometry, we found 96 proteins with significantly changed abundance between groups (p < 0.05, fold change >1.2), representing 4.1% of total granulocyte proteome.
T6 761-951 Sentence denotes Within these differential identifications, calgranulin B, a protein associated with pathogenesis in other autoimmune diseases, showed highest abundance in equine recurrent uveitis (18 fold).
T7 952-1108 Sentence denotes For a better interpretation of the results from our hypothesis-generating approach, we added a threshold for biological significance (ratio ERU/controls >2:
T8 1109-1274 Sentence denotes 36 proteins) to the proteins with increased abundance in equine recurrent uveitis and analyzed their allocation to the subsets within the Immune System superpathway.
T9 1275-1515 Sentence denotes The 36 differentially abundant proteins predominantly associated to RAF/MAP kinase cascade, MHC-I-mediated antigen presentation and neutrophil degranulation, suggesting a latently activated phenotype of these innate immune cells in disease.
T10 1516-1585 Sentence denotes Raw data are available via ProteomeXchange with identifier PXD013648.
T11 1586-1599 Sentence denotes SIGNIFICANCE:
T12 1600-1840 Sentence denotes Our study provides new insights into the protein repertoire of primary equine granulocytes and identifies protein abundance changes associated to equine recurrent uveitis (ERU), an organ specific, spontaneously occurring autoimmune disease.
T13 1841-2075 Sentence denotes We show that granulocyte proteins with increased abundance in ERU strongly associate to RAF/MAP kinase signaling, MHC-I antigen presentation and neutrophil degranulation, pointing to a more activated state of these cells in ERU cases.
T14 2076-2223 Sentence denotes Since cells were obtained in quiescent stage of disease, latent activation of granulocytes underlines the role of these innate immune cells in ERU.
T15 2224-2377 Sentence denotes These findings are highly relevant for veterinary medicine, further establishing the importance of granulocytes in this T cell-driven autoimmune disease.
T16 2378-2528 Sentence denotes Moreover, they have translational quality for autoimmune uveitis in man, due to strong similarity in disease occurrence, progression and pathogenesis.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 1959-1968 Glycan denotes I antigen https://api.glycosmos.org/wurcs2image/latest/png/binary/G56045WU

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 1959-1968 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes I antigen http://www.glycoepitope.jp/epitopes/EP0138

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 28-34 OrganismTaxon denotes equine 9796
T2 125-131 OrganismTaxon denotes Equine 9796
T3 499-505 OrganismTaxon denotes equine 9796
T4 916-922 OrganismTaxon denotes equine 9796
T5 1166-1172 OrganismTaxon denotes equine 9796
T6 1671-1677 OrganismTaxon denotes equine 9796
T7 1746-1752 OrganismTaxon denotes equine 9796

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 35-47 Body_part denotes granulocytes http://purl.obolibrary.org/obo/CL_0000094
T2 90-95 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062|http://purl.obolibrary.org/obo/UBERON_0003103
T4 236-249 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T5 326-338 Body_part denotes granulocytes http://purl.obolibrary.org/obo/CL_0000094
T6 424-436 Body_part denotes immune cells http://purl.obolibrary.org/obo/CL_0000738
T7 481-493 Body_part denotes granulocytes http://purl.obolibrary.org/obo/CL_0000094
T8 739-750 Body_part denotes granulocyte http://purl.obolibrary.org/obo/CL_0000094
T9 1247-1260 Body_part denotes Immune System http://purl.obolibrary.org/obo/UBERON_0002405
T10 1407-1417 Body_part denotes neutrophil http://purl.obolibrary.org/obo/CL_0000775
T11 1491-1503 Body_part denotes immune cells http://purl.obolibrary.org/obo/CL_0000738
T12 1678-1690 Body_part denotes granulocytes http://purl.obolibrary.org/obo/CL_0000094
T13 1781-1786 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062|http://purl.obolibrary.org/obo/UBERON_0003103
T15 1854-1865 Body_part denotes granulocyte http://purl.obolibrary.org/obo/CL_0000094
T16 1986-1996 Body_part denotes neutrophil http://purl.obolibrary.org/obo/CL_0000775
T17 2154-2166 Body_part denotes granulocytes http://purl.obolibrary.org/obo/CL_0000094
T18 2203-2215 Body_part denotes immune cells http://purl.obolibrary.org/obo/CL_0000738
T19 2323-2335 Body_part denotes granulocytes http://purl.obolibrary.org/obo/CL_0000094
T20 2344-2350 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084