PubMed:32960100
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T1 | 2564-2571 | Body_part | denotes | Glucose | http://purl.org/sig/ont/fma/fma82743 |
| T2 | 2602-2607 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T3 | 2608-2615 | Body_part | denotes | glucose | http://purl.org/sig/ont/fma/fma82743 |
| T4 | 3396-3403 | Body_part | denotes | glucose | http://purl.org/sig/ont/fma/fma82743 |
| T5 | 3937-3943 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T6 | 3954-3963 | Body_part | denotes | extremity | http://purl.org/sig/ont/fma/fma7182 |
| T7 | 4397-4404 | Body_part | denotes | glucose | http://purl.org/sig/ont/fma/fma82743 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 2602-2607 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 250-270 | Disease | denotes | rheumatoid arthritis | http://purl.obolibrary.org/obo/MONDO_0008383 |
| T2 | 261-270 | Disease | denotes | arthritis | http://purl.obolibrary.org/obo/MONDO_0005578 |
| T3 | 275-303 | Disease | denotes | systemic lupus erythematosus | http://purl.obolibrary.org/obo/MONDO_0007915 |
| T4 | 284-303 | Disease | denotes | lupus erythematosus | http://purl.obolibrary.org/obo/MONDO_0004670 |
| T5 | 422-469 | Disease | denotes | severe acute respiratory syndrome coronavirus 2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T6 | 422-455 | Disease | denotes | severe acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T7 | 471-479 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T8 | 518-542 | Disease | denotes | coronavirus disease 2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T9 | 544-552 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T10 | 564-572 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T11 | 1496-1504 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T12 | 1608-1616 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T13 | 1622-1630 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T14 | 1877-1885 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T15 | 2515-2523 | Disease | denotes | diarrhea | http://purl.obolibrary.org/obo/MONDO_0001673 |
| T16 | 2792-2800 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T17 | 3048-3072 | Disease | denotes | Stevens-Johnson syndrome | http://purl.obolibrary.org/obo/MONDO_0018229 |
| T18 | 3056-3072 | Disease | denotes | Johnson syndrome | http://purl.obolibrary.org/obo/MONDO_0019419 |
| T19 | 3078-3104 | Disease | denotes | toxic epidermal necrolysis | http://purl.obolibrary.org/obo/MONDO_0019810 |
| T20 | 3362-3368 | Disease | denotes | anemia | http://purl.obolibrary.org/obo/MONDO_0002280 |
| T21 | 3456-3464 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T22 | 3620-3631 | Disease | denotes | Retinopathy | http://purl.obolibrary.org/obo/MONDO_0005283 |
| T23 | 3633-3644 | Disease | denotes | Retinopathy | http://purl.obolibrary.org/obo/MONDO_0005283 |
| T24 | 3862-3876 | Disease | denotes | cardiomyopathy | http://purl.obolibrary.org/obo/MONDO_0004994 |
| T25 | 3902-3915 | Disease | denotes | Neurotoxicity | http://purl.obolibrary.org/obo/MONDO_0005527 |
| T26 | 3924-3932 | Disease | denotes | myositis | http://purl.obolibrary.org/obo/MONDO_0008054|http://purl.obolibrary.org/obo/MONDO_0021167 |
| T28 | 4204-4213 | Disease | denotes | psychosis | http://purl.obolibrary.org/obo/MONDO_0005485 |
| T29 | 4532-4540 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T30 | 4588-4599 | Disease | denotes | retinopathy | http://purl.obolibrary.org/obo/MONDO_0005283 |
| T31 | 4665-4679 | Disease | denotes | cardiomyopathy | http://purl.obolibrary.org/obo/MONDO_0004994 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 119-120 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T2 | 144-147 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T3 | 341-342 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T4 | 397-398 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T5 | 619-628 | http://purl.obolibrary.org/obo/BFO_0000030 | denotes | OBJECTIVE |
| T6 | 1110-1115 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | Human |
| T7 | 1887-1889 | http://purl.obolibrary.org/obo/CLO_0001302 | denotes | 34 |
| T8 | 2002-2003 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T9 | 2602-2607 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T10 | 2602-2607 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T11 | 3305-3307 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 48 |
| T12 | 3534-3536 | http://purl.obolibrary.org/obo/PR_000010213 | denotes | MB |
| T13 | 3537-3547 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
| T14 | 3811-3814 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T15 | 3937-3943 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
| T16 | 3937-3943 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
| T17 | 3937-3943 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
| T18 | 3937-3943 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
| T19 | 3954-3963 | http://www.ebi.ac.uk/efo/EFO_0000876 | denotes | extremity |
| T20 | 4277-4278 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T1 | 12-23 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T2 | 28-46 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T3 | 106-117 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T4 | 135-142 | Chemical | denotes | quinine | http://purl.obolibrary.org/obo/CHEBI_137041|http://purl.obolibrary.org/obo/CHEBI_15854 |
| T6 | 164-176 | Chemical | denotes | antimalarial | http://purl.obolibrary.org/obo/CHEBI_38068 |
| T7 | 191-209 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T8 | 314-332 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T9 | 357-368 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T10 | 669-687 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T11 | 692-703 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T12 | 890-901 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T13 | 1457-1475 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T14 | 1479-1490 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T15 | 1547-1558 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T16 | 1923-1927 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T17 | 2146-2157 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T18 | 2164-2182 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T19 | 2208-2212 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T20 | 2225-2230 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T21 | 2251-2255 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T22 | 2458-2469 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T23 | 2473-2491 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T24 | 2564-2571 | Chemical | denotes | Glucose | http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167|http://purl.obolibrary.org/obo/CHEBI_42758 |
| T27 | 2608-2615 | Chemical | denotes | glucose | http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167 |
| T29 | 2646-2664 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T30 | 2898-2910 | Chemical | denotes | azithromycin | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T31 | 3313-3317 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T32 | 3396-3403 | Chemical | denotes | glucose | http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167 |
| T34 | 3406-3415 | Chemical | denotes | phosphate | http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474 |
| T38 | 3431-3442 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T39 | 3498-3506 | Chemical | denotes | creatine | http://purl.obolibrary.org/obo/CHEBI_16919|http://purl.obolibrary.org/obo/CHEBI_57947 |
| T41 | 3518-3526 | Chemical | denotes | creatine | http://purl.obolibrary.org/obo/CHEBI_16919|http://purl.obolibrary.org/obo/CHEBI_57947 |
| T43 | 3584-3589 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T44 | 4397-4404 | Chemical | denotes | glucose | http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 250-270 | Phenotype | denotes | rheumatoid arthritis | http://purl.obolibrary.org/obo/HP_0001370 |
| T2 | 275-303 | Phenotype | denotes | systemic lupus erythematosus | http://purl.obolibrary.org/obo/HP_0002725 |
| T3 | 2493-2509 | Phenotype | denotes | Nausea, vomiting | http://purl.obolibrary.org/obo/HP_0002017 |
| T4 | 2515-2523 | Phenotype | denotes | diarrhea | http://purl.obolibrary.org/obo/HP_0002014 |
| T5 | 3009-3036 | Phenotype | denotes | cutaneous hyperpigmentation | http://purl.obolibrary.org/obo/HP_0000953 |
| T6 | 3038-3046 | Phenotype | denotes | pruritis | http://purl.obolibrary.org/obo/HP_0000989 |
| T7 | 3261-3275 | Phenotype | denotes | disorientation | http://purl.obolibrary.org/obo/HP_0001289 |
| T8 | 3281-3294 | Phenotype | denotes | hallucination | http://purl.obolibrary.org/obo/HP_0000738 |
| T9 | 3362-3368 | Phenotype | denotes | anemia | http://purl.obolibrary.org/obo/HP_0001903 |
| T10 | 3485-3513 | Phenotype | denotes | elevation in creatine kinase | http://purl.obolibrary.org/obo/HP_0003236 |
| T11 | 3620-3631 | Phenotype | denotes | Retinopathy | http://purl.obolibrary.org/obo/HP_0000488 |
| T12 | 3633-3644 | Phenotype | denotes | Retinopathy | http://purl.obolibrary.org/obo/HP_0000488 |
| T13 | 3862-3876 | Phenotype | denotes | cardiomyopathy | http://purl.obolibrary.org/obo/HP_0001638 |
| T14 | 3924-3932 | Phenotype | denotes | myositis | http://purl.obolibrary.org/obo/HP_0100614 |
| T15 | 3937-3952 | Phenotype | denotes | muscle weakness | http://purl.obolibrary.org/obo/HP_0001324 |
| T16 | 4123-4143 | Phenotype | denotes | cardiovascular shock | http://purl.obolibrary.org/obo/HP_0030149 |
| T17 | 4204-4213 | Phenotype | denotes | psychosis | http://purl.obolibrary.org/obo/HP_0000709 |
| T18 | 4218-4225 | Phenotype | denotes | seizure | http://purl.obolibrary.org/obo/HP_0001250 |
| T19 | 4588-4599 | Phenotype | denotes | retinopathy | http://purl.obolibrary.org/obo/HP_0000488 |
| T20 | 4665-4679 | Phenotype | denotes | cardiomyopathy | http://purl.obolibrary.org/obo/HP_0001638 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-85 | Sentence | denotes | Toxicity of chloroquine and hydroxychloroquine following therapeutic use or overdose. |
| T2 | 86-99 | Sentence | denotes | INTRODUCTION: |
| T3 | 100-304 | Sentence | denotes | While chloroquine, a derivative of quinine, has been used as an antimalarial for 70 years, hydroxychloroquine is now used to treat conditions such as rheumatoid arthritis and systemic lupus erythematosus. |
| T4 | 305-483 | Sentence | denotes | In 2020, hydroxychloroquine (and to a lesser extent chloroquine) also received attention as a possible treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). |
| T5 | 484-618 | Sentence | denotes | During investigation for treating coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2, concerns for serious adverse events arose. |
| T6 | 619-629 | Sentence | denotes | OBJECTIVE: |
| T7 | 630-754 | Sentence | denotes | We review the toxicity associated with hydroxychloroquine and chloroquine use both short-term and long-term and in overdose. |
| T8 | 755-763 | Sentence | denotes | METHODS: |
| T9 | 764-1032 | Sentence | denotes | Medline (via OVID) was searched from its inception through June 7 2020 using the following as either MeSH or keyword terms: ("Chloroquine/" or "Hydroxychloroquine/") AND ("Adverse Drug Event/" or "Toxicities, Drug/" or "Toxic.mp." or "Toxicity.mp." or "Overdose.mp."). |
| T10 | 1033-1125 | Sentence | denotes | We limited resultant articles to those published in English and reporting on Human subjects. |
| T11 | 1126-1186 | Sentence | denotes | This search yielded 330 articles, of which 57 were included. |
| T12 | 1187-1306 | Sentence | denotes | Articles were excluded due to lack of relevance, not reporting desired outcomes, or being duplicative in their content. |
| T13 | 1307-1405 | Sentence | denotes | Twenty-five additional articles were identified through screening references of included articles. |
| T14 | 1406-1635 | Sentence | denotes | To identify toxicities in individuals treated with hydroxychloroquine or chloroquine with COVID-19, we searched PubMed on June 10th, 2020: ("Chloroquine" or "Hydroxychloroquine") AND ("Coronavirus" or "COVID-19" or "SARS-CoV-2"). |
| T15 | 1636-1673 | Sentence | denotes | This search resulted in 638 articles. |
| T16 | 1674-1741 | Sentence | denotes | We reviewed articles for reporting of adverse events or toxicities. |
| T17 | 1742-1914 | Sentence | denotes | Most citations were excluded because they did not include original investigations or extrapolated data from subjects that did not have COVID-19; 34 citations were relevant. |
| T18 | 1915-2068 | Sentence | denotes | For the drug-interactions section, relevant classes and agents were identified through a screen of the https://www.covid19-druginteractions.org/ website. |
| T19 | 2069-2297 | Sentence | denotes | We then conducted targeted searches of PubMed up to June 7th 2020 combining "chloroquine" and "hydroxychloroquine" with terms for specific drug classes and drugs identified from the drug-interaction site as potentially relevant. |
| T20 | 2298-2328 | Sentence | denotes | We found 29 relevant articles. |
| T21 | 2329-2358 | Sentence | denotes | TOXICITY WITH SHORT-TERM USE: |
| T22 | 2359-2376 | Sentence | denotes | Gastrointestinal: |
| T23 | 2377-2492 | Sentence | denotes | Gastrointestinal toxicities are the most common to occur following initiation of chloroquine or hydroxychloroquine. |
| T24 | 2493-2563 | Sentence | denotes | Nausea, vomiting, and diarrhea account for most reported intolerances. |
| T25 | 2564-2586 | Sentence | denotes | Glucose abnormalities: |
| T26 | 2587-2708 | Sentence | denotes | Alterations in blood glucose concentrations may occur with hydroxychloroquine but are rare with standard therapeutic use. |
| T27 | 2709-2724 | Sentence | denotes | Cardiotoxicity: |
| T28 | 2725-2777 | Sentence | denotes | Short-term use can produce conduction abnormalities. |
| T29 | 2778-2956 | Sentence | denotes | Evidence from COVID-19 treatment suggests QT/QTc prolongation is of concern, particularly when used in combination with azithromycin, although disagreement exists across studies. |
| T30 | 2957-2970 | Sentence | denotes | Dermatologic: |
| T31 | 2971-3205 | Sentence | denotes | Drug eruptions or rashes, followed by cutaneous hyperpigmentation, pruritis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, may occur within days to weeks of exposure but usually resolve with the discontinuation of therapy. |
| T32 | 3206-3223 | Sentence | denotes | Neuropsychiatric: |
| T33 | 3224-3329 | Sentence | denotes | Reported symptoms include confusion, disorientation, and hallucination within 24-48 h of drug initiation. |
| T34 | 3330-3347 | Sentence | denotes | Other toxicities: |
| T35 | 3348-3430 | Sentence | denotes | Hemolysis and anemia may occur in patients with glucose-6-phosphate dehydrogenase. |
| T36 | 3431-3590 | Sentence | denotes | Chloroquine treatment of COVID-19 was associated with elevation in creatine kinase and creatine kinase-MB activities with more events in the higher-dose group. |
| T37 | 3591-3619 | Sentence | denotes | TOXICITY WITH LONG-TERM USE: |
| T38 | 3620-3632 | Sentence | denotes | Retinopathy: |
| T39 | 3633-3780 | Sentence | denotes | Retinopathy is the major dose-limiting toxicity associated with long-term use; the risk is higher with increasing age, dose, and duration of usage. |
| T40 | 3781-3796 | Sentence | denotes | Cardiotoxicity: |
| T41 | 3797-3901 | Sentence | denotes | Long-term use has been associated with conduction abnormalities, cardiomyopathy, and valvular disorders. |
| T42 | 3902-3916 | Sentence | denotes | Neurotoxicity: |
| T43 | 3917-4016 | Sentence | denotes | Rarely myositis and muscle weakness, extremity weakness, and pseudoparkinsonism have been reported. |
| T44 | 4017-4038 | Sentence | denotes | TOXICITY IN OVERDOSE: |
| T45 | 4039-4176 | Sentence | denotes | Symptoms in overdose manifest rapidly (minutes to hours) and cardiotoxicity such as cardiovascular shock and collapse are most prominent. |
| T46 | 4177-4241 | Sentence | denotes | Neurotoxic effects such as psychosis and seizure may also occur. |
| T47 | 4242-4254 | Sentence | denotes | CONCLUSIONS: |
| T48 | 4255-4315 | Sentence | denotes | Hydroxychloroquine is a generally well-tolerated medication. |
| T49 | 4316-4472 | Sentence | denotes | Short-term (days to weeks) toxicity includes gastrointestinal effects and rarely glucose abnormalities, dermatologic reactions, and neuropsychiatric events. |
| T50 | 4473-4550 | Sentence | denotes | Cardiotoxicity became of increased concern with its use in COVID-19 patients. |
| T51 | 4551-4681 | Sentence | denotes | Long-term (years) toxicities include retinopathy, neuromyotoxicity, and cardiotoxicity (conduction abnormalities, cardiomyopathy). |
| T52 | 4682-4751 | Sentence | denotes | Deaths from overdoses most often result from cardiovascular collapse. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 4 | 0-8 | Disease | denotes | Toxicity | MESH:D064420 |
| 5 | 12-23 | Chemical | denotes | chloroquine | MESH:D002738 |
| 6 | 28-46 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 7 | 76-84 | Disease | denotes | overdose | MESH:D062787 |
| 104 | 106-117 | Chemical | denotes | chloroquine | MESH:D002738 |
| 105 | 135-142 | Chemical | denotes | quinine | MESH:D011803 |
| 106 | 191-209 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 107 | 250-270 | Disease | denotes | rheumatoid arthritis | MESH:D001172 |
| 108 | 275-303 | Disease | denotes | systemic lupus erythematosus | MESH:D008180 |
| 109 | 314-332 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 110 | 357-368 | Chemical | denotes | chloroquine | MESH:D002738 |
| 111 | 422-469 | Species | denotes | severe acute respiratory syndrome coronavirus 2 | Tax:2697049 |
| 112 | 471-481 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 113 | 518-542 | Disease | denotes | coronavirus disease 2019 | MESH:C000657245 |
| 114 | 544-552 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 115 | 564-574 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 116 | 644-652 | Disease | denotes | toxicity | MESH:D064420 |
| 117 | 669-687 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 118 | 692-703 | Chemical | denotes | chloroquine | MESH:D002738 |
| 119 | 745-753 | Disease | denotes | overdose | MESH:D062787 |
| 120 | 777-781 | Disease | denotes | OVID | |
| 121 | 890-901 | Chemical | denotes | Chloroquine | MESH:D002738 |
| 122 | 908-926 | Chemical | denotes | Hydroxychloroquine | MESH:D006886 |
| 123 | 961-971 | Disease | denotes | Toxicities | MESH:D064420 |
| 124 | 999-1007 | Disease | denotes | Toxicity | MESH:D064420 |
| 125 | 1017-1025 | Disease | denotes | Overdose | MESH:D062787 |
| 126 | 1110-1115 | Species | denotes | Human | Tax:9606 |
| 127 | 1418-1428 | Disease | denotes | toxicities | MESH:D064420 |
| 128 | 1457-1475 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 129 | 1479-1490 | Chemical | denotes | chloroquine | MESH:D002738 |
| 130 | 1496-1504 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 131 | 1547-1558 | Chemical | denotes | Chloroquine | MESH:D002738 |
| 132 | 1564-1582 | Chemical | denotes | Hydroxychloroquine | MESH:D006886 |
| 133 | 1591-1602 | Species | denotes | Coronavirus | Tax:11118 |
| 134 | 1608-1616 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 135 | 1622-1632 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 136 | 1730-1740 | Disease | denotes | toxicities | MESH:D064420 |
| 137 | 1877-1885 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 138 | 2146-2157 | Chemical | denotes | chloroquine | MESH:D002738 |
| 139 | 2164-2182 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 140 | 2329-2337 | Disease | denotes | TOXICITY | MESH:D064420 |
| 141 | 2377-2404 | Disease | denotes | Gastrointestinal toxicities | MESH:D005767 |
| 142 | 2458-2469 | Chemical | denotes | chloroquine | MESH:D002738 |
| 143 | 2473-2491 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 144 | 2493-2499 | Disease | denotes | Nausea | MESH:D009325 |
| 145 | 2501-2509 | Disease | denotes | vomiting | MESH:D014839 |
| 146 | 2515-2523 | Disease | denotes | diarrhea | MESH:D003967 |
| 147 | 2564-2585 | Disease | denotes | Glucose abnormalities | MESH:D044882 |
| 148 | 2602-2615 | Disease | denotes | blood glucose | MESH:D007022 |
| 149 | 2646-2664 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 150 | 2709-2723 | Disease | denotes | Cardiotoxicity | MESH:D066126 |
| 151 | 2752-2776 | Disease | denotes | conduction abnormalities | MESH:D054537 |
| 152 | 2792-2800 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 153 | 2823-2839 | Disease | denotes | QTc prolongation | MESH:D008133 |
| 154 | 2898-2910 | Chemical | denotes | azithromycin | MESH:D017963 |
| 155 | 2971-2995 | Disease | denotes | Drug eruptions or rashes | MESH:D005076 |
| 156 | 3009-3036 | Disease | denotes | cutaneous hyperpigmentation | MESH:D017495 |
| 157 | 3038-3046 | Disease | denotes | pruritis | MESH:D011537 |
| 158 | 3048-3072 | Disease | denotes | Stevens-Johnson syndrome | MESH:D013262 |
| 159 | 3281-3294 | Disease | denotes | hallucination | MESH:D006212 |
| 160 | 3336-3346 | Disease | denotes | toxicities | MESH:D064420 |
| 161 | 3348-3357 | Disease | denotes | Hemolysis | MESH:D006461 |
| 162 | 3362-3368 | Disease | denotes | anemia | MESH:D000740 |
| 163 | 3382-3390 | Species | denotes | patients | Tax:9606 |
| 164 | 3396-3429 | Gene | denotes | glucose-6-phosphate dehydrogenase | Gene:2539 |
| 165 | 3431-3442 | Chemical | denotes | Chloroquine | MESH:D002738 |
| 166 | 3456-3464 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 167 | 3591-3599 | Disease | denotes | TOXICITY | MESH:D064420 |
| 168 | 3620-3631 | Disease | denotes | Retinopathy | MESH:D012164 |
| 169 | 3633-3644 | Disease | denotes | Retinopathy | MESH:D012164 |
| 170 | 3672-3680 | Disease | denotes | toxicity | MESH:D064420 |
| 171 | 3781-3795 | Disease | denotes | Cardiotoxicity | MESH:D066126 |
| 172 | 3836-3860 | Disease | denotes | conduction abnormalities | MESH:D054537 |
| 173 | 3862-3876 | Disease | denotes | cardiomyopathy | MESH:D009202 |
| 174 | 3882-3900 | Disease | denotes | valvular disorders | MESH:D006349 |
| 175 | 3902-3915 | Disease | denotes | Neurotoxicity | MESH:D020258 |
| 176 | 3924-3932 | Disease | denotes | myositis | MESH:D009220 |
| 177 | 3937-3952 | Disease | denotes | muscle weakness | MESH:D018908 |
| 178 | 3954-3972 | Disease | denotes | extremity weakness | MESH:D018908 |
| 179 | 3978-3996 | Disease | denotes | pseudoparkinsonism | |
| 180 | 4017-4025 | Disease | denotes | TOXICITY | MESH:D064420 |
| 181 | 4051-4059 | Disease | denotes | overdose | MESH:D062787 |
| 182 | 4100-4114 | Disease | denotes | cardiotoxicity | MESH:D066126 |
| 183 | 4123-4143 | Disease | denotes | cardiovascular shock | MESH:D002318 |
| 184 | 4177-4187 | Disease | denotes | Neurotoxic | MESH:D020258 |
| 185 | 4204-4213 | Disease | denotes | psychosis | MESH:D011605 |
| 186 | 4218-4225 | Disease | denotes | seizure | MESH:D012640 |
| 187 | 4255-4273 | Chemical | denotes | Hydroxychloroquine | MESH:D006886 |
| 188 | 4343-4351 | Disease | denotes | toxicity | MESH:D064420 |
| 189 | 4397-4418 | Disease | denotes | glucose abnormalities | MESH:D044882 |
| 190 | 4473-4487 | Disease | denotes | Cardiotoxicity | MESH:D066126 |
| 191 | 4532-4540 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 192 | 4541-4549 | Species | denotes | patients | Tax:9606 |
| 193 | 4569-4579 | Disease | denotes | toxicities | MESH:D064420 |
| 194 | 4588-4599 | Disease | denotes | retinopathy | MESH:D012164 |
| 195 | 4601-4617 | Disease | denotes | neuromyotoxicity | |
| 196 | 4623-4637 | Disease | denotes | cardiotoxicity | MESH:D066126 |
| 197 | 4639-4663 | Disease | denotes | conduction abnormalities | MESH:D054537 |
| 198 | 4665-4679 | Disease | denotes | cardiomyopathy | MESH:D009202 |
| 199 | 4682-4688 | Disease | denotes | Deaths | MESH:D003643 |
LitCovid_AGAC_only
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| p186545s5 | 530-542 | Disease | denotes | disease 2019 |